CA1183751A - Bone marrow transplant method and apparatus - Google Patents
Bone marrow transplant method and apparatusInfo
- Publication number
- CA1183751A CA1183751A CA000400714A CA400714A CA1183751A CA 1183751 A CA1183751 A CA 1183751A CA 000400714 A CA000400714 A CA 000400714A CA 400714 A CA400714 A CA 400714A CA 1183751 A CA1183751 A CA 1183751A
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- CA
- Canada
- Prior art keywords
- bone marrow
- pump
- chamber
- infusion
- syringe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Abstract of the Disclosure A method of and apparatus for recovering or replacing bone marrow comprising a syringe pump connected to an aspiration needle and a collection bag, and also to a second needle and a source of intravenous solution, whereby activation of the pump aspirates bone marrow and selectively directs it to the collection bag while the intravenous solution is infused into the bone marrow cavity.
Description
3~
Field of -the Invention This invention relates -to appara-tus for recovering or replacing bone marrow.
~ackground of the Invention In certain medical procedures, e.g., some types of chemotherapy, healthy bone marrow is removed from a patien-t prior to the treatment, which might otherwise injure or destroy the bone marrow, and reinfused after the -treatmen-t is over. In other procedures, healthy bone marrow taken from a donor is infused into a pa-tient who lacks or is unable to reproduce the necessary bone marrow cells. In either case, in the prior art, these transplants take a long time due -to the fact that it is usually necessary to insert a needle between fifteen to seventy times into different locations in order to recover acceptable quantities of bone marrow. Moreover, the empty:ing of the bone marrow cavity may causes the nerve stretch receptors to extend, which is believed to cause the patient to experience considerable pain.
Another problem is that a large volume of sinusoidal blood is collected with the bone marrow cells and as the marrow cavity
Field of -the Invention This invention relates -to appara-tus for recovering or replacing bone marrow.
~ackground of the Invention In certain medical procedures, e.g., some types of chemotherapy, healthy bone marrow is removed from a patien-t prior to the treatment, which might otherwise injure or destroy the bone marrow, and reinfused after the -treatmen-t is over. In other procedures, healthy bone marrow taken from a donor is infused into a pa-tient who lacks or is unable to reproduce the necessary bone marrow cells. In either case, in the prior art, these transplants take a long time due -to the fact that it is usually necessary to insert a needle between fifteen to seventy times into different locations in order to recover acceptable quantities of bone marrow. Moreover, the empty:ing of the bone marrow cavity may causes the nerve stretch receptors to extend, which is believed to cause the patient to experience considerable pain.
Another problem is that a large volume of sinusoidal blood is collected with the bone marrow cells and as the marrow cavity
2~ is small, it is usually necessary in replacing or transfusing the bone marrow and blood, to inject the collected material into a vein and depend upon the bone marrow cells to find their way back into the marrow of the pa-tient.
Summary of the Invention The present invention is an apparatus for removing bone marrow quickly and relatively painlessly, and replacing bone 7~
marrow directly into the marrow cavity.
Basically, according to the invention, there is provided a bone marrow transplant appara-tus comprising: pump means connected to a bone marrow collecting means, a storage means, and a solution rneans, said solution means adapted to be connected to a source of marrow-replacing solution, and incl.uding an infusion means connec-ted to said pump means, said infusion means adapted to be inserted at the same bone marrow site as said bone marrow collecting means, and a pump control means for activating said pump means which on one cycle selectively aspirates bone marrow through said bone marrow collecting means and infuses marrow-replacing solution through said infusion means into the same si-te and on an alternate cycle selectively directs the collected marrow into said storage means.
_ the Preferred Embodiment Drawings Figure 1 is a top view of a clisposable a.ssembly of -the nven t lon;
E`igure 2 is a cross-sectional view ta]sen at lines 2-2 of Figure l;
Figure 3 is a cross--sectional view taken at lines 3-3 of Figure 1;
Figure 4 is a cross-sectional view taken at lines 4-4 of Figure l;
Figure 5 is a top view of the cabinet of this inven-tion;
Figure 6 is a cross-sectional view of the cabine-t of Figure 5;
Figure 7 is a front view of a control panel of -the apparatus;
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Figure 8 is a cross-sectional view of another pump for the apparatus; and Figure 9 is a schematic diagram of the electrical control system for the apparatus.
Structure The apparatus of the invention comprises a cabinet 10 ~best shown in Figures 5 and 6) and a disposable assembly 12 (best shown in Figures 1 and 2).
Re~erring to Figures 5 and 6, the cabinet 10 has a shallow receptacle 14 for receiving the assembly 12, which receptacle has a transparent bottom panel 15 with a lamp 16 mounted thereunder~ The panel 15 has a shallow groove 30 extending across the width of the receptacle 14. The groove 30, which has dovetailed sides 31, holds a slide 32 with an external handle 40 with finger openings 41 at one end. The slide 32 comprises a plate 34 having a pair of brackets 35 and 35', which are offset from each other. The bracket 35 extends upwardly from the plate 34, and comprises a pair of wall sections 36 and 37 spaced apart by a recess 38.
Wall section 37 is solid, while wall section 36 has a channel therein. Bracket 35' is identical to bracket 35, and each is aligned with a narrow slot 39 and 3~', respectively, in the plate 34.
The cabinet 10 has a removable cover plate 20, and five solenoid-operated control valves Vl, V2, V3, V4 and V5 are mounted beneath it. Each solenoid valve Vl - V5 is associated with an elongated grouve Gl to G5, respectively, which groves are designed to carry tubing (not shown). Also beneath the cover 20, the cabinet 10 contains a power source and a circuit board section 24 (shown schematically in Figure g) as well as a transformer section 22. A cavity 42 for placement of ballast is beneath the receptacle 14. The cabinet 10 also has hand grips 26 at each end.
.
~3~
Referring to Figures 1 and 2, the disposable assembly 12, which fits in the cabinet 10, comprises a tray 50 having side walls 52 and 53, the tops of which walls are El~sh with the cabinet cover 20 when the assembly 12 is in place. ~osses 56 are positioned at spaced intervals aro~nd -the periphery of the tray and at the center of the tray to receive fastener screws (not shown) which hold a clear plastic cover (also not shown) over the assembly 12.
As best shown in Figure 1, three locator blocks 54 r each having a series of three upstanding loca~or pins 55, are provided at various locations in the tray.
A number of locator pins 58 also project upwardly from the bottom of the tray 50 and the pins 5~ snugly secure a pair of syringes 60 and 61, which face in opposite directions on the tray 50. The syringe 61 has a generally cylindrical body having a forward tapered end 63 connected to a tube 64. The opposite end of the body is bounded by a flange 65. Internally, the syringe 61 has a plunger 67 with an enlarged head 62. The plunger has an X-shaped cross section, and the variable-length portion 68 extending o~tside the syringe body is bounded by a handle 69. Syringe 60 is identical (wherein 66 designates the plunger structure). The syringes may be Becton~Dickinson "Monoject'~20cc syringes.
A rectangular hole 70 is located in the bottom of the tray 50 behind the flange 65 of syringe 61. A
similar hole is positioned behind the flange of syringe 60. When the assembly 12 is in place, the handle 69 of the plunger 67 of syringe 61 fits thro~gh the hole 70 and into the groove 38 in the bracket 35 on the slide 32. The wall sections 36, 37 hold the syringe handle 69 in place. Similarly, the handle of syringe 60 is held by bracket 35'. Because of the spaced relationship of 37~D~
the brackets 35, 35', syr.inge 60 would have its plunger extended, while the plunger 67 of syrlnge 61 woul~ be retracted.
The X-shaped cross-section of the extended portion 68 of the plunger 67 is supported by a V-shaped pin 74, shown in Figure 3, extendi.ng from the tray 50 at the end of the hole 70 nearest to the syringe. The support pin 74 prevents accidental rotation of the plunger 67 as it is extended and retracted. As shown in Figure 4, syringe 60 has an identical pin 74.
The tray 50 has five plastic input-output tubes, Ll, L2/ L3, L~ and L5. Tubes Ll and L2 are joined at a first junction 75 to a common line 76 which in turn is joined at a second junction 78 to tube L3. A
line 80 also is connected to the second junction 78, and line 80 is connected by sleeve 82 to the tube 64 of syringe 61. The junctions 75, 78 are supported by the locator pins 55 of blocl~s 54. Tubes L4 and L5 are joined at a third junction 84 to line ~6 which is secured by a sleeve 88 to the tube on the end of syringe 60. Locator ribs 90 align Ll - L5 with the tube carrying grooves Gl - G5 of the cabinet cover 20 when the assembly .is in place. ~ther ribs 92, position tube L3 and lines 80, 86 on the tray 50.
When the assembly 14 is in place, the tubes Ll - L5 are inserted in grooves Gl - G5, respectively, in the cabinet cover 20. Each solenoid valve Vl - V5, associated with the grooves Gl - G5, controls flow through the tube (Ll - L5) in its groove by means of an armature 9~ carrying a movable pin 96 which projects upwardly through a slot 97 (identified for valve V3 only) in the cover plate 20. As also shown for valve V3, a block 98 with an upper surface 100 having a stationary pin 102 is positioned below the groove G3, so that pin 102 is also in slot 97 opposite movable pin 96. When the valve V3 is energi~ed, the movable pin 96 7~
moves towards stationary pin 102, as shown for valve V5, with the ~ube L5 pinched closed therebetween.
As Eor the external connection of the tubes Ll - L5, tube Ll is connected to an intravenous drip chamber 106, and a source of intravenous solution (not shown). Tube L2 has a splke connector 107 for a collection bag ~not shown). The collection bag may be a Ba~ No. 4R6308 made be Travenol Labs of Deer~ieldl Illinois. Tubes L3 and L4 end in releasable Luer Lock fittings 108, 109 for connection to aspiration and infusion needles (not shown). Line L5 is connected to a seond intravenous drip chamber 110, and another source of intravenous solution (not shown).
The valves Vl - V5 are controlled by the circuit 150 of Figure 9. As shown in Figure 9; power source 140 is connected through transformer 142 and bridge circuit 143 to a heat sink 144. The power supply 140 is connected to the fluorescent lamp 16 and through line 145 from the heat sink 144 to the valve control circuit 150. The manually depressable buttons of the control panel are shown as switches 142, which when closed, connect the power supply to a gating circuit 154 for each of the valves~ Each gating circuit 154 has its output connected to a transistor circuit 155 which ln turn leads into a solenoid activation circuit for each respective valve.
O~ ation In operation, tubes L3 and L4 are connected to aspiration and infusion needles of the conventional type, while tubes Ll and L5 are connected to intravenous solution sourcesO The intravenous solution used may be a saline or electrolyte solution of 4 units of heparin per cc. Initially, the tubes Ll - L5 are purged of any air. Referring to Figure 7, the "PRIME 1'l button on a control panel 23 of Figure 7 is depressed, which opens 33t7~
valves Vl and V4 (to the intravenous solution sources) and closes valves V2, V3, and V5 (to the needles and the collection bag). The lights 1-5 on the control panel indicate which valves are open. The slide 32 is reciprocated, which causes the syringes 60, 61 to draw the intraveneous fluid into the tubes, though not at the same time, as only one syringe creates a negative pressure when the slide is moved in one direction. The "PRIME 2'i button is then depressed, which reverses the positions of all the valves, and the slide 32 is reciprocated again. This forces the fluid into the formerly closed tubes to the needles and to the collection bag~ This sequence is repeated until there are no air bubbles in any of the lines.
The bone marrow cavity, usually the iliac crest, is anti-coagulated with 2000 units of heparin.
The "CLAMP" button is then depressed to eliminate leakage prior to actual insertion of the actual bone marrow needles into the patient. 'rhe "CLAMP" button causes valves V2 - V5 to close (to the collection bag and needles). The needles are then inserted into the patient at the desired site. As a next step, the "PRIME
ASPIRATE" button is depressed, which keeps open valves Vl and V5 and closes the remainin~ valves. The slide 3Z
then is partially pulled out so that intravenous solution from drip chamber 106 enters the tubesO The "ASPIRATE" button is then depressed so that valves V3 and V4 (to the needles) are opened and the other valves are closed. The slide 32 is then fully withdrawn. The negative pressure created by syringe 61 draws a flow of bone marrow and sinusoidal blood into tube L3. At the same time, syringe 60 forces intravenous solution from line I.4 into the bone marrow cavity, preventing actvation of the nerve stretch receptions. After the syringe 61 has been filled, the "HARVEST" button is depressed, which opens valves V2 (to the collection bag) 375~
and V5 and c]oses valves Vl, V3 and V~. The slide 32 ls then pushed in so as to depress the plunger of syringe 61, forcing the mixture of bone marrow, sinusoidal blood and in-travenous solution through the line L2 into -the collection bag~ The process is repeated until a satisfactory amount of bone marrow is collected, with the syringe acting as a pump throughout.
Other Embodiments .
A modified syringe pump is shown in Figure 8.
The modified syringe has an outer cylinder 120 having a first port 121 at one end and a second port 122 in the sidewall at its opposite end. An 0-ring seal 124 disposed across the end surface of a plug 126 which seals the cylinder 120. A central bore 127 in the plug 126 holds a close-fitting plunger 128. Plunger 128 has an external handle 130 and a piston head 131, which head 131 divided the interior of the cylinder into a forward chamber 133 and a rear chamber 134. The forward chamber 133 is in communcation with the end port 1~1 and the rearward chamber 134 is in communication with the sidewall port 122 Reciprocating the plunger 128 creates a positive pressure at one port and a negative pressure at the other. Accordingly, the modiied syringe may be substituted for the two syringes of the preferred embodiment by connecting tube 86 to one port and tube 80 to the other, while the handle 130 is attached to a slide bracket. The apparatus is then operated as beEore.
In order to collect bone marrow as quickly as possible, it is preferred that both needles (usually inserted at different sites) aspirate bone marrow. This is done in two ways. First, syringe 60 is reversed so that it points in the same direction as syringe 61, and the position of the bracket on the slide 32 is modified accordingly to receive the handle of syringe 60 as ~ L837~
g before. Accordingly, when the slide 32 is pulled out, both syringes aspirate bone marrow, thereby simultaneousl~ collecting about twice as much as before. The bone marrow is then directed to collection bags, a new bag beiny connected to the lines associated with syringe 60. Alternatelyl the syringes may be left as they are in Figure 1, and aspirate bone marrow on alternate pushes and pulls of the slide 32. A new collection bag or a connection to the old bag would be added to this variation as well. As a result bone marrow is harvested quickly.
Other variations will occur to those skilled in the art.
Summary of the Invention The present invention is an apparatus for removing bone marrow quickly and relatively painlessly, and replacing bone 7~
marrow directly into the marrow cavity.
Basically, according to the invention, there is provided a bone marrow transplant appara-tus comprising: pump means connected to a bone marrow collecting means, a storage means, and a solution rneans, said solution means adapted to be connected to a source of marrow-replacing solution, and incl.uding an infusion means connec-ted to said pump means, said infusion means adapted to be inserted at the same bone marrow site as said bone marrow collecting means, and a pump control means for activating said pump means which on one cycle selectively aspirates bone marrow through said bone marrow collecting means and infuses marrow-replacing solution through said infusion means into the same si-te and on an alternate cycle selectively directs the collected marrow into said storage means.
_ the Preferred Embodiment Drawings Figure 1 is a top view of a clisposable a.ssembly of -the nven t lon;
E`igure 2 is a cross-sectional view ta]sen at lines 2-2 of Figure l;
Figure 3 is a cross--sectional view taken at lines 3-3 of Figure 1;
Figure 4 is a cross-sectional view taken at lines 4-4 of Figure l;
Figure 5 is a top view of the cabinet of this inven-tion;
Figure 6 is a cross-sectional view of the cabine-t of Figure 5;
Figure 7 is a front view of a control panel of -the apparatus;
33'7'~
Figure 8 is a cross-sectional view of another pump for the apparatus; and Figure 9 is a schematic diagram of the electrical control system for the apparatus.
Structure The apparatus of the invention comprises a cabinet 10 ~best shown in Figures 5 and 6) and a disposable assembly 12 (best shown in Figures 1 and 2).
Re~erring to Figures 5 and 6, the cabinet 10 has a shallow receptacle 14 for receiving the assembly 12, which receptacle has a transparent bottom panel 15 with a lamp 16 mounted thereunder~ The panel 15 has a shallow groove 30 extending across the width of the receptacle 14. The groove 30, which has dovetailed sides 31, holds a slide 32 with an external handle 40 with finger openings 41 at one end. The slide 32 comprises a plate 34 having a pair of brackets 35 and 35', which are offset from each other. The bracket 35 extends upwardly from the plate 34, and comprises a pair of wall sections 36 and 37 spaced apart by a recess 38.
Wall section 37 is solid, while wall section 36 has a channel therein. Bracket 35' is identical to bracket 35, and each is aligned with a narrow slot 39 and 3~', respectively, in the plate 34.
The cabinet 10 has a removable cover plate 20, and five solenoid-operated control valves Vl, V2, V3, V4 and V5 are mounted beneath it. Each solenoid valve Vl - V5 is associated with an elongated grouve Gl to G5, respectively, which groves are designed to carry tubing (not shown). Also beneath the cover 20, the cabinet 10 contains a power source and a circuit board section 24 (shown schematically in Figure g) as well as a transformer section 22. A cavity 42 for placement of ballast is beneath the receptacle 14. The cabinet 10 also has hand grips 26 at each end.
.
~3~
Referring to Figures 1 and 2, the disposable assembly 12, which fits in the cabinet 10, comprises a tray 50 having side walls 52 and 53, the tops of which walls are El~sh with the cabinet cover 20 when the assembly 12 is in place. ~osses 56 are positioned at spaced intervals aro~nd -the periphery of the tray and at the center of the tray to receive fastener screws (not shown) which hold a clear plastic cover (also not shown) over the assembly 12.
As best shown in Figure 1, three locator blocks 54 r each having a series of three upstanding loca~or pins 55, are provided at various locations in the tray.
A number of locator pins 58 also project upwardly from the bottom of the tray 50 and the pins 5~ snugly secure a pair of syringes 60 and 61, which face in opposite directions on the tray 50. The syringe 61 has a generally cylindrical body having a forward tapered end 63 connected to a tube 64. The opposite end of the body is bounded by a flange 65. Internally, the syringe 61 has a plunger 67 with an enlarged head 62. The plunger has an X-shaped cross section, and the variable-length portion 68 extending o~tside the syringe body is bounded by a handle 69. Syringe 60 is identical (wherein 66 designates the plunger structure). The syringes may be Becton~Dickinson "Monoject'~20cc syringes.
A rectangular hole 70 is located in the bottom of the tray 50 behind the flange 65 of syringe 61. A
similar hole is positioned behind the flange of syringe 60. When the assembly 12 is in place, the handle 69 of the plunger 67 of syringe 61 fits thro~gh the hole 70 and into the groove 38 in the bracket 35 on the slide 32. The wall sections 36, 37 hold the syringe handle 69 in place. Similarly, the handle of syringe 60 is held by bracket 35'. Because of the spaced relationship of 37~D~
the brackets 35, 35', syr.inge 60 would have its plunger extended, while the plunger 67 of syrlnge 61 woul~ be retracted.
The X-shaped cross-section of the extended portion 68 of the plunger 67 is supported by a V-shaped pin 74, shown in Figure 3, extendi.ng from the tray 50 at the end of the hole 70 nearest to the syringe. The support pin 74 prevents accidental rotation of the plunger 67 as it is extended and retracted. As shown in Figure 4, syringe 60 has an identical pin 74.
The tray 50 has five plastic input-output tubes, Ll, L2/ L3, L~ and L5. Tubes Ll and L2 are joined at a first junction 75 to a common line 76 which in turn is joined at a second junction 78 to tube L3. A
line 80 also is connected to the second junction 78, and line 80 is connected by sleeve 82 to the tube 64 of syringe 61. The junctions 75, 78 are supported by the locator pins 55 of blocl~s 54. Tubes L4 and L5 are joined at a third junction 84 to line ~6 which is secured by a sleeve 88 to the tube on the end of syringe 60. Locator ribs 90 align Ll - L5 with the tube carrying grooves Gl - G5 of the cabinet cover 20 when the assembly .is in place. ~ther ribs 92, position tube L3 and lines 80, 86 on the tray 50.
When the assembly 14 is in place, the tubes Ll - L5 are inserted in grooves Gl - G5, respectively, in the cabinet cover 20. Each solenoid valve Vl - V5, associated with the grooves Gl - G5, controls flow through the tube (Ll - L5) in its groove by means of an armature 9~ carrying a movable pin 96 which projects upwardly through a slot 97 (identified for valve V3 only) in the cover plate 20. As also shown for valve V3, a block 98 with an upper surface 100 having a stationary pin 102 is positioned below the groove G3, so that pin 102 is also in slot 97 opposite movable pin 96. When the valve V3 is energi~ed, the movable pin 96 7~
moves towards stationary pin 102, as shown for valve V5, with the ~ube L5 pinched closed therebetween.
As Eor the external connection of the tubes Ll - L5, tube Ll is connected to an intravenous drip chamber 106, and a source of intravenous solution (not shown). Tube L2 has a splke connector 107 for a collection bag ~not shown). The collection bag may be a Ba~ No. 4R6308 made be Travenol Labs of Deer~ieldl Illinois. Tubes L3 and L4 end in releasable Luer Lock fittings 108, 109 for connection to aspiration and infusion needles (not shown). Line L5 is connected to a seond intravenous drip chamber 110, and another source of intravenous solution (not shown).
The valves Vl - V5 are controlled by the circuit 150 of Figure 9. As shown in Figure 9; power source 140 is connected through transformer 142 and bridge circuit 143 to a heat sink 144. The power supply 140 is connected to the fluorescent lamp 16 and through line 145 from the heat sink 144 to the valve control circuit 150. The manually depressable buttons of the control panel are shown as switches 142, which when closed, connect the power supply to a gating circuit 154 for each of the valves~ Each gating circuit 154 has its output connected to a transistor circuit 155 which ln turn leads into a solenoid activation circuit for each respective valve.
O~ ation In operation, tubes L3 and L4 are connected to aspiration and infusion needles of the conventional type, while tubes Ll and L5 are connected to intravenous solution sourcesO The intravenous solution used may be a saline or electrolyte solution of 4 units of heparin per cc. Initially, the tubes Ll - L5 are purged of any air. Referring to Figure 7, the "PRIME 1'l button on a control panel 23 of Figure 7 is depressed, which opens 33t7~
valves Vl and V4 (to the intravenous solution sources) and closes valves V2, V3, and V5 (to the needles and the collection bag). The lights 1-5 on the control panel indicate which valves are open. The slide 32 is reciprocated, which causes the syringes 60, 61 to draw the intraveneous fluid into the tubes, though not at the same time, as only one syringe creates a negative pressure when the slide is moved in one direction. The "PRIME 2'i button is then depressed, which reverses the positions of all the valves, and the slide 32 is reciprocated again. This forces the fluid into the formerly closed tubes to the needles and to the collection bag~ This sequence is repeated until there are no air bubbles in any of the lines.
The bone marrow cavity, usually the iliac crest, is anti-coagulated with 2000 units of heparin.
The "CLAMP" button is then depressed to eliminate leakage prior to actual insertion of the actual bone marrow needles into the patient. 'rhe "CLAMP" button causes valves V2 - V5 to close (to the collection bag and needles). The needles are then inserted into the patient at the desired site. As a next step, the "PRIME
ASPIRATE" button is depressed, which keeps open valves Vl and V5 and closes the remainin~ valves. The slide 3Z
then is partially pulled out so that intravenous solution from drip chamber 106 enters the tubesO The "ASPIRATE" button is then depressed so that valves V3 and V4 (to the needles) are opened and the other valves are closed. The slide 32 is then fully withdrawn. The negative pressure created by syringe 61 draws a flow of bone marrow and sinusoidal blood into tube L3. At the same time, syringe 60 forces intravenous solution from line I.4 into the bone marrow cavity, preventing actvation of the nerve stretch receptions. After the syringe 61 has been filled, the "HARVEST" button is depressed, which opens valves V2 (to the collection bag) 375~
and V5 and c]oses valves Vl, V3 and V~. The slide 32 ls then pushed in so as to depress the plunger of syringe 61, forcing the mixture of bone marrow, sinusoidal blood and in-travenous solution through the line L2 into -the collection bag~ The process is repeated until a satisfactory amount of bone marrow is collected, with the syringe acting as a pump throughout.
Other Embodiments .
A modified syringe pump is shown in Figure 8.
The modified syringe has an outer cylinder 120 having a first port 121 at one end and a second port 122 in the sidewall at its opposite end. An 0-ring seal 124 disposed across the end surface of a plug 126 which seals the cylinder 120. A central bore 127 in the plug 126 holds a close-fitting plunger 128. Plunger 128 has an external handle 130 and a piston head 131, which head 131 divided the interior of the cylinder into a forward chamber 133 and a rear chamber 134. The forward chamber 133 is in communcation with the end port 1~1 and the rearward chamber 134 is in communication with the sidewall port 122 Reciprocating the plunger 128 creates a positive pressure at one port and a negative pressure at the other. Accordingly, the modiied syringe may be substituted for the two syringes of the preferred embodiment by connecting tube 86 to one port and tube 80 to the other, while the handle 130 is attached to a slide bracket. The apparatus is then operated as beEore.
In order to collect bone marrow as quickly as possible, it is preferred that both needles (usually inserted at different sites) aspirate bone marrow. This is done in two ways. First, syringe 60 is reversed so that it points in the same direction as syringe 61, and the position of the bracket on the slide 32 is modified accordingly to receive the handle of syringe 60 as ~ L837~
g before. Accordingly, when the slide 32 is pulled out, both syringes aspirate bone marrow, thereby simultaneousl~ collecting about twice as much as before. The bone marrow is then directed to collection bags, a new bag beiny connected to the lines associated with syringe 60. Alternatelyl the syringes may be left as they are in Figure 1, and aspirate bone marrow on alternate pushes and pulls of the slide 32. A new collection bag or a connection to the old bag would be added to this variation as well. As a result bone marrow is harvested quickly.
Other variations will occur to those skilled in the art.
Claims (10)
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A bone marrow transplant apparatus comprising:
pump means connected to a bone marrow collecting means, a storage means, and a solution means, said solution means adapted to be connected to a source of marrow-replacing solution, and including an infusion means connected to said pump means, said infusion means adapted to be inserted at the same bone marrow site as said bone marrow collecting means, and a pump control means for activating said pump means which on one cycle selectively aspirates bone marrow through said bone marrow collecting means and infuses marrow-replacing solution through said infusion means into the same site and on an alter-nate cycle selectively directs the collected marrow into said storage means.
pump means connected to a bone marrow collecting means, a storage means, and a solution means, said solution means adapted to be connected to a source of marrow-replacing solution, and including an infusion means connected to said pump means, said infusion means adapted to be inserted at the same bone marrow site as said bone marrow collecting means, and a pump control means for activating said pump means which on one cycle selectively aspirates bone marrow through said bone marrow collecting means and infuses marrow-replacing solution through said infusion means into the same site and on an alter-nate cycle selectively directs the collected marrow into said storage means.
2. The apparatus of claim 1 wherein said bone marrow collecting means comprises at least one aspiration tube connected to at least one aspiration needle.
3. The apparatus of claim 1 wherein said bone marrow collecting means comprises a pair of tubes connected to a pair of aspiration needles, both said needles adapted to aspirate bone marrow either simultaneously or on alternate cycles.
4. The apparatus of claim 1 wherein said solution means comprises an infusion tube and aninfusion needle, said infusion needle adapted to be inserted in the same general bone marrow cavity as said bone marrow collecting means.
5. The apparatus of claim 4 wherein said pump means forces intravenous solution into the bone marrow site by applying positive pressure through said infusion needle while simultaneously aspirating bone marrow by applying negative pressure through said collection means.
6. The apparatus of claim 5 further comprising valve means, said valve means connected to an aspiration tube so that when said valve means is in one position, said pump means aspirates bone marrow into said aspiration tube and when said valve means is in another position, said pump means forces the aspirated bone marrow into said storage means.
7. The apparatus of claim 6 wherein said pump means comprises a first chamber and a second chamber, said first chamber being connected to said aspiration tube, and said second chamber being connected to said infusion tube.
8. The apparatus of claim 7 wherein said pump control means comprises a movable slide which reciprocates a plunger means for said first and second chambers, whereby the size of one of said chambers increases while the size of the other said chamber decreases.
9. The apparatus of claim 8 wherein said pump means com-prises a single syringe pump.
10. The apparatus of claim 9 wherein said pump means comprises a first and a second syringe, said first syringe con-taining said first chamber and said second pump containing said second chamber.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000400714A CA1183751A (en) | 1982-04-08 | 1982-04-08 | Bone marrow transplant method and apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000400714A CA1183751A (en) | 1982-04-08 | 1982-04-08 | Bone marrow transplant method and apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1183751A true CA1183751A (en) | 1985-03-12 |
Family
ID=4122537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000400714A Expired CA1183751A (en) | 1982-04-08 | 1982-04-08 | Bone marrow transplant method and apparatus |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA1183751A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9226732B2 (en) | 2011-11-23 | 2016-01-05 | Harvest Technologies Corporation | Bone marrow aspiration device and needle |
-
1982
- 1982-04-08 CA CA000400714A patent/CA1183751A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9226732B2 (en) | 2011-11-23 | 2016-01-05 | Harvest Technologies Corporation | Bone marrow aspiration device and needle |
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