CA1164346A - Enhancer of anti-tumor effect - Google Patents
Enhancer of anti-tumor effectInfo
- Publication number
- CA1164346A CA1164346A CA000405511A CA405511A CA1164346A CA 1164346 A CA1164346 A CA 1164346A CA 000405511 A CA000405511 A CA 000405511A CA 405511 A CA405511 A CA 405511A CA 1164346 A CA1164346 A CA 1164346A
- Authority
- CA
- Canada
- Prior art keywords
- tumor
- dado
- enhancer
- acyl
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 238000012986 modification Methods 0.000 description 1
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- QZGIWPZCWHMVQL-UIYAJPBUSA-N neocarzinostatin chromophore Chemical compound O1[C@H](C)[C@H](O)[C@H](O)[C@@H](NC)[C@H]1O[C@@H]1C/2=C/C#C[C@H]3O[C@@]3([C@@H]3OC(=O)OC3)C#CC\2=C[C@H]1OC(=O)C1=C(O)C=CC2=C(C)C=C(OC)C=C12 QZGIWPZCWHMVQL-UIYAJPBUSA-N 0.000 description 1
- KPMKNHGAPDCYLP-UHFFFAOYSA-N nimustine hydrochloride Chemical compound Cl.CC1=NC=C(CNC(=O)N(CCCl)N=O)C(N)=N1 KPMKNHGAPDCYLP-UHFFFAOYSA-N 0.000 description 1
- OSTGTTZJOCZWJG-UHFFFAOYSA-N nitrosourea Chemical compound NC(=O)N=NO OSTGTTZJOCZWJG-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229960005010 orotic acid Drugs 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000011300 routine therapy Methods 0.000 description 1
- 230000001235 sensitizing effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 230000005909 tumor killing Effects 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- 229950009268 zinostatin Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP94676/1981 | 1981-06-18 | ||
| JP56094676A JPS57209225A (en) | 1981-06-18 | 1981-06-18 | Antitumor activity intensifier |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1164346A true CA1164346A (en) | 1984-03-27 |
Family
ID=14116819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000405511A Expired CA1164346A (en) | 1981-06-18 | 1982-06-18 | Enhancer of anti-tumor effect |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0068268B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JPS57209225A (cg-RX-API-DMAC10.html) |
| AU (1) | AU552409B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA1164346A (cg-RX-API-DMAC10.html) |
| DE (1) | DE3263372D1 (cg-RX-API-DMAC10.html) |
| IT (1) | IT1157211B (cg-RX-API-DMAC10.html) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5679648A (en) * | 1994-11-30 | 1997-10-21 | The University Hospital | Methods for the treatment and prevention of fungal infections by administration of 3'-deoxypurine nucleosides |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6174873B1 (en) * | 1998-11-04 | 2001-01-16 | Supergen, Inc. | Oral administration of adenosine analogs |
| CN101574362B (zh) * | 2009-06-03 | 2012-05-23 | 西南大学 | N-烷酰基虫草素在制备治疗肿瘤疾病的药物中的应用 |
| CN103254195B (zh) * | 2013-03-26 | 2016-08-03 | 内蒙古医科大学 | 7-氨基-四氮唑[1,5-a]并嘧啶-5-醇（化合物II）及其合成路线 |
| NZ760790A (en) * | 2014-02-07 | 2022-11-25 | Neurocrine Biosciences Inc | Pharmaceutical compositions comprising an antipsychotic drug and a vmat2 inhibitor and uses thereof |
| HRP20240304T1 (hr) | 2015-10-30 | 2024-05-10 | Neurocrine Biosciences, Inc. | Soli valbenazin dihidroklorida i njihovi polimorfi |
| CN108925135B (zh) | 2015-12-23 | 2025-09-19 | 纽罗克里生物科学有限公司 | 制备(S)-(2R,3R,11bR)-3-异丁基-9,10-二甲氧基-2,3,4,6,7,11b-六氢-1H-吡啶并[2,1-a]异喹啉-2-基2-氨基-3-甲基丁酸酯二(4-甲基苯磺酸盐)的合成方法 |
| MY195934A (en) | 2017-01-27 | 2023-02-27 | Neurocrine Biosciences Inc | Methods for the Administration of Certain VMAT2 Inhibitors |
| CN111372567B (zh) | 2017-09-21 | 2024-03-15 | 纽罗克里生物科学有限公司 | 高剂量的缬苯那嗪制剂和与其相关的组合物、方法和试剂盒 |
| KR20250070134A (ko) | 2017-10-10 | 2025-05-20 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 특정 vmat2 억제제의 투여 방법 |
| CN111836543A (zh) | 2017-10-10 | 2020-10-27 | 纽罗克里生物科学有限公司 | 施用某些vmat2抑制剂的方法 |
| BR112021000019A2 (pt) | 2018-08-15 | 2021-04-06 | Neurocrine Biosciences Inc. | Métodos para administração de certos inibidores de vmat2 |
| US10940141B1 (en) | 2019-08-23 | 2021-03-09 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
| CN113563401A (zh) * | 2021-07-14 | 2021-10-29 | 河南牧业经济学院 | 一种新型虫草素烷酰胺衍生物及其制备方法和应用 |
-
1981
- 1981-06-18 JP JP56094676A patent/JPS57209225A/ja active Granted
-
1982
- 1982-06-14 DE DE8282105194T patent/DE3263372D1/de not_active Expired
- 1982-06-14 EP EP82105194A patent/EP0068268B1/en not_active Expired
- 1982-06-16 IT IT48651/82A patent/IT1157211B/it active
- 1982-06-18 CA CA000405511A patent/CA1164346A/en not_active Expired
- 1982-06-18 AU AU85007/82A patent/AU552409B2/en not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5679648A (en) * | 1994-11-30 | 1997-10-21 | The University Hospital | Methods for the treatment and prevention of fungal infections by administration of 3'-deoxypurine nucleosides |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS57209225A (en) | 1982-12-22 |
| EP0068268A1 (en) | 1983-01-05 |
| EP0068268B1 (en) | 1985-05-02 |
| JPS637164B2 (cg-RX-API-DMAC10.html) | 1988-02-15 |
| IT1157211B (it) | 1987-02-11 |
| IT8248651A0 (it) | 1982-06-16 |
| AU552409B2 (en) | 1986-05-29 |
| DE3263372D1 (en) | 1985-06-05 |
| AU8500782A (en) | 1982-12-23 |
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