CA1150245A - N-trifluoroacetyladriamycin-14-o-hemiglutarate and - hemiadipate and therapeutic compositions containing same - Google Patents

N-trifluoroacetyladriamycin-14-o-hemiglutarate and - hemiadipate and therapeutic compositions containing same

Info

Publication number
CA1150245A
CA1150245A CA000379303A CA379303A CA1150245A CA 1150245 A CA1150245 A CA 1150245A CA 000379303 A CA000379303 A CA 000379303A CA 379303 A CA379303 A CA 379303A CA 1150245 A CA1150245 A CA 1150245A
Authority
CA
Canada
Prior art keywords
trifluoroacetyladriamycin
hemiadipate
hemiglutarate
preparation
trifluoroacetyldaunomycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000379303A
Other languages
English (en)
French (fr)
Inventor
Gopalakrishnan Potti
Mervyn Israel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
Original Assignee
Sidney Farber Cancer Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sidney Farber Cancer Institute Inc filed Critical Sidney Farber Cancer Institute Inc
Application granted granted Critical
Publication of CA1150245A publication Critical patent/CA1150245A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CA000379303A 1980-06-09 1981-06-08 N-trifluoroacetyladriamycin-14-o-hemiglutarate and - hemiadipate and therapeutic compositions containing same Expired CA1150245A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/157,861 US4299822A (en) 1980-06-09 1980-06-09 N-Trifluoroacetyladriamycin-14-O-hemiglutarate and -hemiadipate and therapeutic compositions containing same
US157,861 1980-06-09

Publications (1)

Publication Number Publication Date
CA1150245A true CA1150245A (en) 1983-07-19

Family

ID=22565590

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000379303A Expired CA1150245A (en) 1980-06-09 1981-06-08 N-trifluoroacetyladriamycin-14-o-hemiglutarate and - hemiadipate and therapeutic compositions containing same

Country Status (8)

Country Link
US (1) US4299822A (US07655688-20100202-C00086.png)
JP (1) JPS5767596A (US07655688-20100202-C00086.png)
CA (1) CA1150245A (US07655688-20100202-C00086.png)
CH (1) CH645387A5 (US07655688-20100202-C00086.png)
DE (1) DE3122689C2 (US07655688-20100202-C00086.png)
FR (1) FR2483928A1 (US07655688-20100202-C00086.png)
GB (1) GB2077265B (US07655688-20100202-C00086.png)
NL (1) NL184420C (US07655688-20100202-C00086.png)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4610977A (en) * 1985-04-08 1986-09-09 The University Of Tennessee Research Corporation N-alkyl and N-benzyl adriamycin derivatives
US5843903A (en) * 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
RU2758670C1 (ru) * 2020-12-30 2021-11-01 федеральное государственное бюджетное образовательное учреждение высшего образования «Приволжский исследовательский медицинский университет» Министерства здравоохранения Российской Федерации (ФГБОУ ВО "ПИМУ" Минздрава России) Новое химическое соединение 5-фторурацила и доксорубицина

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2135221A1 (en) * 1971-05-04 1972-12-15 Farmaceutici Italia Doxorubicin 14-esters prepn - by treating 14-bromodaunomycin with a salt of the corresp acid
GB1368680A (en) * 1972-12-09 1974-10-02 Farmaceutici Italia Adriamycin derivatives
US4035566A (en) * 1975-09-25 1977-07-12 Sidney Farber Cancer Institute, Inc. N-trifluoroacetyladriamycin-14-alkanoates and therapeutic compositions containing same
GB1567456A (en) * 1976-11-16 1980-05-14 Farmaceutici Italia Daunomycin derivatives

Also Published As

Publication number Publication date
FR2483928B1 (US07655688-20100202-C00086.png) 1984-01-06
FR2483928A1 (fr) 1981-12-11
NL8102730A (nl) 1982-01-04
NL184420C (nl) 1989-07-17
GB2077265A (en) 1981-12-16
JPS632440B2 (US07655688-20100202-C00086.png) 1988-01-19
DE3122689A1 (de) 1982-05-06
US4299822A (en) 1981-11-10
DE3122689C2 (de) 1985-07-04
CH645387A5 (de) 1984-09-28
GB2077265B (en) 1984-01-11
JPS5767596A (en) 1982-04-24

Similar Documents

Publication Publication Date Title
EP0151189B1 (en) Antineoplastic agent
AU621470B2 (en) Stabilized nitric oxide-primary amine complexes useful as cardiovascular agents
US4035566A (en) N-trifluoroacetyladriamycin-14-alkanoates and therapeutic compositions containing same
US20080125479A1 (en) Wortmannin analogs and methods of using same
US5036103A (en) Method of treating cancer cells in humans
RU2074185C1 (ru) Производное 4-дезокси-4-эпиподофиллотоксина или его фармацевтически приемлемая соль и фармацевтическая композиция на его основе
DE69710573T2 (de) Morpholinyl-anthracyclinderivate
DE69912058T2 (de) Proaktive antitumore Verbindungen
CA1150245A (en) N-trifluoroacetyladriamycin-14-o-hemiglutarate and - hemiadipate and therapeutic compositions containing same
EP0227844B1 (en) Antiviral drug
JPH05247078A (ja) 糖化合物、シアル酸含有糖鎖類生合成阻害剤、その製造方法、並びに新規な中間体
US4831053A (en) Composition for prophylaxis and therapy of hepatitis
US4131649A (en) Daunorubicin derivatives, their preparation and their use
US4075328A (en) Naphthacene derivatives
EP0128670A1 (en) 4-Demethoxy-3'-deamino-3'(4-morpholinyl) derivatives of anthracycline anticancer antibiotics
US4895935A (en) Platinum pharmaceuticals
EP0196330B1 (de) Verwendung von pyrrothinderivaten
US5753695A (en) Flavilium compounds and method of using
EP0378706B1 (en) 5-substituted uridine derivatives and intermediates for their preparation
US4104461A (en) 2,2'-Anhydro-β-D-arabinofuranosyl-5-fluorocytosine
US5026732A (en) Use of avarone for the control of AIDS and ARC
EP0080305A1 (en) Antiviral 2'-deoxyuridines, their preparation and use
KR100398289B1 (ko) 신규 안트라사이클린 유도체 및 그 제조방법
AU665488B2 (en) New compound, leustroducsin H, its preparation and its therapeutic use
EP0365176A1 (en) Ellipticine glycoside derivatives

Legal Events

Date Code Title Description
MKEX Expiry