CA1127091A - Disposable filter cell for membrane plasmapheresis - Google Patents
Disposable filter cell for membrane plasmapheresisInfo
- Publication number
- CA1127091A CA1127091A CA340,251A CA340251A CA1127091A CA 1127091 A CA1127091 A CA 1127091A CA 340251 A CA340251 A CA 340251A CA 1127091 A CA1127091 A CA 1127091A
- Authority
- CA
- Canada
- Prior art keywords
- membranes
- sheets
- plasma
- roughened
- filter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/20—Accessories; Auxiliary operations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/08—Flat membrane modules
- B01D63/082—Flat membrane modules comprising a stack of flat membranes
- B01D63/084—Flat membrane modules comprising a stack of flat membranes at least one flow duct intersecting the membranes
Abstract
DISPOSABLE FILTER CELL FOR
MEMBRANE PLASMAPHERESIS
James H. De Vries Gaylord L. Berry James R. Hitchcock ABSTRACT OF THE DISCLOSURE
A disposable filter cell is provided for membrane plasmapheresis. The filter cell includes a pair of extruded flexible plastic sheets each having a roughened surface which faces one membrane of a pair of membranes that is sandwiched between the flexible sheets. Each flexible sheet and its respective membrane form a plasma filtrate volume therebetween and the two membranes form a blood flow path therebetween. The flexible sheets include portions spaced from the filter membranes which define a plasma collection chamber. Blood inlet and outlet ports communicate with the blood flow path and a plasma outlet port communicates with the plasma collection chamber.
MEMBRANE PLASMAPHERESIS
James H. De Vries Gaylord L. Berry James R. Hitchcock ABSTRACT OF THE DISCLOSURE
A disposable filter cell is provided for membrane plasmapheresis. The filter cell includes a pair of extruded flexible plastic sheets each having a roughened surface which faces one membrane of a pair of membranes that is sandwiched between the flexible sheets. Each flexible sheet and its respective membrane form a plasma filtrate volume therebetween and the two membranes form a blood flow path therebetween. The flexible sheets include portions spaced from the filter membranes which define a plasma collection chamber. Blood inlet and outlet ports communicate with the blood flow path and a plasma outlet port communicates with the plasma collection chamber.
Description
~L~27~
BACKGROUND OF THE INVENTION --This invention concerns a novel device for membrane plasmapheresis, and more particularly, a disposable filter cell for membrane plasmapheresis.
T~pical plasmapheresis techniques utilize th~
collection of whole blood from donors in bag~, and removal of the bays to a centrifuge where the plasma is separated from the whole blood. The plasma is withdrawn from the bag and the remaining blood is returned to the donor.
More recently, automated centrifuges have been devised which continuously withdraw whole blood from the donor, centrifuge the whole blood ~o separate the plasma, harvest the plasma, and return the remaining blood in its plasma-poor condition to the donor in a continuous fashion.
It has been proposed that plasmapheresis be carried out without using a centrifuge, because of the inherent complexity and cost of centrifugation equipment. To this end, the filtration of cells from whole blood using a microporous membrane has been disclosed, for example, in Blatt, et al. U.S. Patent No. 3,705,100. It has been found that a membrane-type plasmapheresis device yields platelet-free plasma while centrifuge-devices yield plasma containing some platelets. Further, it has been found that the membrane plasmapheresis devices can also be designed to yield much greater ~uantities of plasma in shorter times than the centrifuge devices. ~ 3 ~n co-pending application Serial No.~ rT, filed ~ e ~ ~ and entitled "Apparatus For Membrane Plasmapheresis", a parallel membrane type of membrane plasmapheresis apparatus is disclosed. An advan-tage of the type of membrane plasmapheresis apparatus ~1~7~
f~')C~ ,3s3 disclosed in application Serial No. ~42,~'17 is that such apparatus is capable of comprising an inexpensive, dis-posable package and, in addition, the apparatus utilizes a substantially large amount of membrane surface area.
The present invention is an improvement upon the membrane plasmapheresis apparatus of application Serial No. 5-42~-077 in that the present invention concerns a disposable filter cell fox memhrane plasmapheresis which is extremely simple in construction and inexpensive to produce, yet the filter cell of the present invention is capable of achieving efficient plasmapheresis.
Other objects and advantages of the present inven-tion will become apparent as the description proceeds.
SUMMARY OF THE INVENTION
In accordance with the present invention, a disposable filter cell i5 provided for membrane plasma-pheresis. The filter cell includes a first flexible sheet having a roughened undersurface and a second flexible sheet having a roughened upper surface. A pair of filter membranes are provided, having pore sizes of about 0.l micron to ~ microns, and these filter membranes are posi-tioned adjacent each other to orm a blood flow path therebetween.
The first and second flexible sheets are posi-tioned on opposite sides of the membranes to sandwich the membranes between the flexible sheets, with the roughened surface of each flexible sheet facing the respective membrane.
The first flexible sheet and the first filter 3~ membrane define a plasma filtrate volume, and the second flexible sheet and the second filter membrane define a ~z~
plasma filtrate volume. The first and second flexible sheets include poxtions spaced from the filter membranes which portions define a plasma collection chamber.
Blood inlet and outlet ports communicate with the blood flow path and a plasma outlet port is in communica-tion with the plasma collection chamber.
In the illustrative embodiment, the sheets and filter membranes have three aligned edges and the sheets have larger surface areas than the membranes~ In this manner, the plasma collection chamber is formed by portions of the sheets that are not aligned with portions of the membranes.
In the illustrative embodiment, the flexible sheets each comprise plastic sheets which are extruded with the roughened surfaces formed in the extrudate.
A more detailed explanation of the invention is provided in the following description and claims, and is illustrated in the accompanying drawings.
BRIEF DESCRIPTION OF THE DRAWINGS
FIGURE 1 is an exploded perspective view of a disposable filter cell constructed in accordance with the principles of the present invention; and FIGURE 2 is a perspective view of a disposable filter cell constructed in accordance with the principles of the present invention, with portions broken away for clarit~.
DETAILED DESCRIPTION OF T~IE
ILLUSTRATIVE EMBODIMENT
Referring to the drawings, a disposable filter cell for membrane plasmapheresis is shown therein l~.Z'7~
comprising a first flexible sheet 4, a second flexible sheet 6, a first filter membrane 8, and a second filter membrane 10.
Flexible sheet 4 has a roughened undersurface that coxresponds to the roughened upper surface 12 o flexible sheet 6. Sheets 4 and 6 are preferably formed of flexible plastic material, such as polyethylene or PVC that has been extruded and has a thickness of about 0.015 inch, with the roughened surface comprising a plurality of longitudinal grooves defined by the extrudate with each of the grooves being about 0.010 inch deep.
It is to be understood that the roughened under-surface of sheet 4 and the roughened surface 12 of sheet 6 could comprise any type of roughened surface that allows for the flow of plasma to a plasma collection chamber, as will be described below. The roughened surface, therefore, could comprise a criss-cross grooved configuration, a plurality of spaced projections, a mesh screen member in contact with the flexible sheet material, or a combination of these.
Although for economy it is preferred that flexible sheets 4 and 6 be formed of an extruded plastic material, it may be desired to form flexible sheets 4 and 6 of a metallic sheet material, such as aluminum foil. In addi-tion, the aluminum foil may have a roughened surface defined by the aluminum foil itself or may be coated with a plastic material to form the roughened surface.
Membranes 8 and 10 are each formed of a sheet-like microporous membrane having a pore size that permits the iltration of plasma from whole blood, preferably between about 0.1 micron and 2 microns, with the average pore size preferably being about 0.65 micronsO The membranes 8 and 10 .
~1~7~
have a void volume of greater than 60 percent, with an average void volume of about 80 percent. The membranes are preferably formed of a polymeric material, with the pores defining a relatively tortuous path. The thickness of each of the membranes is preferabl~ between 0.002 inch and 0.008 inch.
Sheets 4 and 6 and membranes 8 and 10 are recti-linear as illustrated, with sheets 4 and 6 having a greater surface area than membranes 8 and 10~ As illustrated in FIGURE 1, three of the edges A, B and C of sheets 4 and 6 and membranes B and 10 are aligned with each other, while edges D of sheets 4 and 6 are aligned with each other and edges E of membranes 8 and 10 are sealed to each other or, if desired, the seal may comprise a fold defined by a single sheet which forms membranes 8 and 10. Edges A of sheets 4 and 6 and membranes 8 and 10 are sealed to each other as are edges B and C of these sheets and membranes.
Edges D of sheets 4 and 6 are sealed to each other and a compact unit, such as illustrated in FIGURE 2, is formed.
The membrane package, which comprises membranes 8 and 10 with their outer edges sealed to each other, defines a blood flow path 14 between the membranes. Membrane 8 defines openings 16 and 18 and sheet 4 carries a blood inlet port 20 which communicates with opening 16 (and is sealed around opening 15) and a blood outlet port 22 which communicates with opening 18 (and is sealed around opening 18), thereby forming communication between inlet and outlet ports 20, 22, respectively, and the blood flow path 14.
A plasma filtrate volume 24 is formed between membrane 8 and sheet 4, while a plasma filtrate volume 26 is formed between membrane 10 and sheet 6. Because of 7g~
the larger surface area of sheets 4 and 6 than the surface areas of membranes 8 and 1~, a plasma collection chamber 28 is formed between the surface portions of sheets 4 and 6 which are not aligned with membranes 8 and 10. A plasma outlet port 30 is provided in communication with plasma collection chamber 28 for connection to a suitable conduit to which the plasma is removed.
It is preferred that the sheets 4 and 6 and membranes 8 and lQ be formed of a thermoplastic material so that the seals mentioned above may be heat seals.
Alternatively, these seals may be formed of bonding materials, sonic welds, or other types of fluid-tight seals.
In operation, the disposable filter cell is placed in a preferably permanent fixture and the conduit is coupled to port 20 into which blood is introduced from the patient's vein, a conduit is coupled to port 22 for forming a red blood cell return line and a plasma recovery conduit is coupled to port 30. The plasmapheresis filter cell described above may be used in the system illustrated and described in co-pending application Serial No.
filed Se~te ~ ~r~ g~.
Although an illustrative embodiment of the inven-tion has been shown and described, it is to be understood that various modifications and substitutions may be made by those skilled in the art without departing from the novel spirit and scope of the present invention.
BACKGROUND OF THE INVENTION --This invention concerns a novel device for membrane plasmapheresis, and more particularly, a disposable filter cell for membrane plasmapheresis.
T~pical plasmapheresis techniques utilize th~
collection of whole blood from donors in bag~, and removal of the bays to a centrifuge where the plasma is separated from the whole blood. The plasma is withdrawn from the bag and the remaining blood is returned to the donor.
More recently, automated centrifuges have been devised which continuously withdraw whole blood from the donor, centrifuge the whole blood ~o separate the plasma, harvest the plasma, and return the remaining blood in its plasma-poor condition to the donor in a continuous fashion.
It has been proposed that plasmapheresis be carried out without using a centrifuge, because of the inherent complexity and cost of centrifugation equipment. To this end, the filtration of cells from whole blood using a microporous membrane has been disclosed, for example, in Blatt, et al. U.S. Patent No. 3,705,100. It has been found that a membrane-type plasmapheresis device yields platelet-free plasma while centrifuge-devices yield plasma containing some platelets. Further, it has been found that the membrane plasmapheresis devices can also be designed to yield much greater ~uantities of plasma in shorter times than the centrifuge devices. ~ 3 ~n co-pending application Serial No.~ rT, filed ~ e ~ ~ and entitled "Apparatus For Membrane Plasmapheresis", a parallel membrane type of membrane plasmapheresis apparatus is disclosed. An advan-tage of the type of membrane plasmapheresis apparatus ~1~7~
f~')C~ ,3s3 disclosed in application Serial No. ~42,~'17 is that such apparatus is capable of comprising an inexpensive, dis-posable package and, in addition, the apparatus utilizes a substantially large amount of membrane surface area.
The present invention is an improvement upon the membrane plasmapheresis apparatus of application Serial No. 5-42~-077 in that the present invention concerns a disposable filter cell fox memhrane plasmapheresis which is extremely simple in construction and inexpensive to produce, yet the filter cell of the present invention is capable of achieving efficient plasmapheresis.
Other objects and advantages of the present inven-tion will become apparent as the description proceeds.
SUMMARY OF THE INVENTION
In accordance with the present invention, a disposable filter cell i5 provided for membrane plasma-pheresis. The filter cell includes a first flexible sheet having a roughened undersurface and a second flexible sheet having a roughened upper surface. A pair of filter membranes are provided, having pore sizes of about 0.l micron to ~ microns, and these filter membranes are posi-tioned adjacent each other to orm a blood flow path therebetween.
The first and second flexible sheets are posi-tioned on opposite sides of the membranes to sandwich the membranes between the flexible sheets, with the roughened surface of each flexible sheet facing the respective membrane.
The first flexible sheet and the first filter 3~ membrane define a plasma filtrate volume, and the second flexible sheet and the second filter membrane define a ~z~
plasma filtrate volume. The first and second flexible sheets include poxtions spaced from the filter membranes which portions define a plasma collection chamber.
Blood inlet and outlet ports communicate with the blood flow path and a plasma outlet port is in communica-tion with the plasma collection chamber.
In the illustrative embodiment, the sheets and filter membranes have three aligned edges and the sheets have larger surface areas than the membranes~ In this manner, the plasma collection chamber is formed by portions of the sheets that are not aligned with portions of the membranes.
In the illustrative embodiment, the flexible sheets each comprise plastic sheets which are extruded with the roughened surfaces formed in the extrudate.
A more detailed explanation of the invention is provided in the following description and claims, and is illustrated in the accompanying drawings.
BRIEF DESCRIPTION OF THE DRAWINGS
FIGURE 1 is an exploded perspective view of a disposable filter cell constructed in accordance with the principles of the present invention; and FIGURE 2 is a perspective view of a disposable filter cell constructed in accordance with the principles of the present invention, with portions broken away for clarit~.
DETAILED DESCRIPTION OF T~IE
ILLUSTRATIVE EMBODIMENT
Referring to the drawings, a disposable filter cell for membrane plasmapheresis is shown therein l~.Z'7~
comprising a first flexible sheet 4, a second flexible sheet 6, a first filter membrane 8, and a second filter membrane 10.
Flexible sheet 4 has a roughened undersurface that coxresponds to the roughened upper surface 12 o flexible sheet 6. Sheets 4 and 6 are preferably formed of flexible plastic material, such as polyethylene or PVC that has been extruded and has a thickness of about 0.015 inch, with the roughened surface comprising a plurality of longitudinal grooves defined by the extrudate with each of the grooves being about 0.010 inch deep.
It is to be understood that the roughened under-surface of sheet 4 and the roughened surface 12 of sheet 6 could comprise any type of roughened surface that allows for the flow of plasma to a plasma collection chamber, as will be described below. The roughened surface, therefore, could comprise a criss-cross grooved configuration, a plurality of spaced projections, a mesh screen member in contact with the flexible sheet material, or a combination of these.
Although for economy it is preferred that flexible sheets 4 and 6 be formed of an extruded plastic material, it may be desired to form flexible sheets 4 and 6 of a metallic sheet material, such as aluminum foil. In addi-tion, the aluminum foil may have a roughened surface defined by the aluminum foil itself or may be coated with a plastic material to form the roughened surface.
Membranes 8 and 10 are each formed of a sheet-like microporous membrane having a pore size that permits the iltration of plasma from whole blood, preferably between about 0.1 micron and 2 microns, with the average pore size preferably being about 0.65 micronsO The membranes 8 and 10 .
~1~7~
have a void volume of greater than 60 percent, with an average void volume of about 80 percent. The membranes are preferably formed of a polymeric material, with the pores defining a relatively tortuous path. The thickness of each of the membranes is preferabl~ between 0.002 inch and 0.008 inch.
Sheets 4 and 6 and membranes 8 and 10 are recti-linear as illustrated, with sheets 4 and 6 having a greater surface area than membranes 8 and 10~ As illustrated in FIGURE 1, three of the edges A, B and C of sheets 4 and 6 and membranes B and 10 are aligned with each other, while edges D of sheets 4 and 6 are aligned with each other and edges E of membranes 8 and 10 are sealed to each other or, if desired, the seal may comprise a fold defined by a single sheet which forms membranes 8 and 10. Edges A of sheets 4 and 6 and membranes 8 and 10 are sealed to each other as are edges B and C of these sheets and membranes.
Edges D of sheets 4 and 6 are sealed to each other and a compact unit, such as illustrated in FIGURE 2, is formed.
The membrane package, which comprises membranes 8 and 10 with their outer edges sealed to each other, defines a blood flow path 14 between the membranes. Membrane 8 defines openings 16 and 18 and sheet 4 carries a blood inlet port 20 which communicates with opening 16 (and is sealed around opening 15) and a blood outlet port 22 which communicates with opening 18 (and is sealed around opening 18), thereby forming communication between inlet and outlet ports 20, 22, respectively, and the blood flow path 14.
A plasma filtrate volume 24 is formed between membrane 8 and sheet 4, while a plasma filtrate volume 26 is formed between membrane 10 and sheet 6. Because of 7g~
the larger surface area of sheets 4 and 6 than the surface areas of membranes 8 and 1~, a plasma collection chamber 28 is formed between the surface portions of sheets 4 and 6 which are not aligned with membranes 8 and 10. A plasma outlet port 30 is provided in communication with plasma collection chamber 28 for connection to a suitable conduit to which the plasma is removed.
It is preferred that the sheets 4 and 6 and membranes 8 and lQ be formed of a thermoplastic material so that the seals mentioned above may be heat seals.
Alternatively, these seals may be formed of bonding materials, sonic welds, or other types of fluid-tight seals.
In operation, the disposable filter cell is placed in a preferably permanent fixture and the conduit is coupled to port 20 into which blood is introduced from the patient's vein, a conduit is coupled to port 22 for forming a red blood cell return line and a plasma recovery conduit is coupled to port 30. The plasmapheresis filter cell described above may be used in the system illustrated and described in co-pending application Serial No.
filed Se~te ~ ~r~ g~.
Although an illustrative embodiment of the inven-tion has been shown and described, it is to be understood that various modifications and substitutions may be made by those skilled in the art without departing from the novel spirit and scope of the present invention.
Claims (14)
1. A disposable filter cell for membrane plasma-pheresis which comprises:
a first flexible sheet having a roughened under-surface;
a second flexible sheet having a roughened upper surface;
a first filter membrane having a pore size of about 0.1 micron to 2 microns;
a second filter membrane having a pore size of about 0.1 micron to 2 microns;
said first and second filter membranes being positioned adjacent each other to form a blood flow path therebetween;
said first and second flexible sheets being posi-tioned on opposite sides of said membranes to sandwich the membranes between the flexible sheets, with the roughened surface of each flexible sheet facing the respective membranes;
said first flexible sheet and said first filter membrane defining a plasma filtrate volume;
said second flexible sheet and said second filter membrane defining a plasma filtrate volume;
said first and second flexible sheets including portions spaced from the filter membrane which portions define a plasma collection chamber;
a blood inlet port communicating with said blood flow path;
a blood outlet port communicating with said blood flow path, and a plasma outlet port communicating with said plasma collection chamber.
a first flexible sheet having a roughened under-surface;
a second flexible sheet having a roughened upper surface;
a first filter membrane having a pore size of about 0.1 micron to 2 microns;
a second filter membrane having a pore size of about 0.1 micron to 2 microns;
said first and second filter membranes being positioned adjacent each other to form a blood flow path therebetween;
said first and second flexible sheets being posi-tioned on opposite sides of said membranes to sandwich the membranes between the flexible sheets, with the roughened surface of each flexible sheet facing the respective membranes;
said first flexible sheet and said first filter membrane defining a plasma filtrate volume;
said second flexible sheet and said second filter membrane defining a plasma filtrate volume;
said first and second flexible sheets including portions spaced from the filter membrane which portions define a plasma collection chamber;
a blood inlet port communicating with said blood flow path;
a blood outlet port communicating with said blood flow path, and a plasma outlet port communicating with said plasma collection chamber.
2. A disposable filter cell as described in Claim 1, said first and second flexible sheets and said first and second filter membranes being rectilinear and being sealed to each other along three edges thereof.
3. A disposable filter cell as described in Claim 2, said sheets and filter membranes having three aligned edges and said sheets having larger surface areas than said membranes, whereby said plasma collection chamber is formed by portions of said sheets that are not aligned with portions of said membranes.
4. A disposable filter cell as described in Claim 1, said first and second filter membranes being sealed to each other around their peripheries.
5. A disposable filter cell as described in Claim 4, said first and second flexible sheets being sealed to each other around their peripheries.
6. A disposable filter cell as described in Claim 4, wherein at least one of said seals comprises a fold.
7. A disposable filter cell as described in Claim 1, said roughened undersurface and said roughened upper surface comprising grooves defined by the respec-tive surface.
8. A disposable filter cell as described in Claim 1, said roughened undersurface and said roughened upper surface comprising a plurality of spaced projections carried by the respective surfaces.
9. A disposable filter cell as described in Claim 1, said roughened undersurface and said roughened upper surface comprising mesh members in direct contact with the respective surfaces.
10. A disposable filter cell as described in Claim 1, said first and second flexible sheets being formed of plastic and extruded with the roughened surfaces formed in the extrudate.
11. A disposable filter cell as described in Claim 10, wherein said extrudate is about 0.015 inch thick and the roughened surface comprises longitudinal grooves about 0.010 inch deep.
12. A disposable filter cell as described in Claim 1, said first and second flexible sheets being formed of flexible sheet metal.
13. A disposable filter cell for membrane plasma-pheresis which comprises:
a first flexible sheet having a roughened under-surface;
a second flexible sheet having a roughened upper surface;
a first filter membrane having a pore size of about 0.1 micron to 2 microns;
a second filter membrane having a pore size of about 0.1 micron to 2 microns;
said first and second filter membranes being positioned adjacent each other to form a blood flow path therebetween;
said first and second flexible sheets being posi-tioned on opposite sides of said membranes to sandwich the membranes between the flexible sheets, with the roughened surface of each flexible sheet facing the respective membrane;
said first flexible sheet and said first filter membrane defining a plasma filtrate volume;
said second flexible sheet and said second filter membrane defining a plasma filtrate volume;
said first and second flexible sheets including portions spaced from the filter membranes which portions define a plasma collection chamber;
said sheets and filter membranes having three aligned edges and said sheets having larger surface areas than said membranes, whereby said plasma collection chamber is formed by portions of said sheets that are not aligned with portions of said membranes; and said first and second flexible sheets and said first and second filter membranes being rectilinear with said first and second flexible sheets being sealed to each other around their peripheries and said first and second filter membranes being sealed to each other around their peripheries;
a blood inlet port communicating with said blood flow path;
a blood outlet port communicating with said blood flow path, and a plasma outlet port communicating with said plasma collection chamber.
a first flexible sheet having a roughened under-surface;
a second flexible sheet having a roughened upper surface;
a first filter membrane having a pore size of about 0.1 micron to 2 microns;
a second filter membrane having a pore size of about 0.1 micron to 2 microns;
said first and second filter membranes being positioned adjacent each other to form a blood flow path therebetween;
said first and second flexible sheets being posi-tioned on opposite sides of said membranes to sandwich the membranes between the flexible sheets, with the roughened surface of each flexible sheet facing the respective membrane;
said first flexible sheet and said first filter membrane defining a plasma filtrate volume;
said second flexible sheet and said second filter membrane defining a plasma filtrate volume;
said first and second flexible sheets including portions spaced from the filter membranes which portions define a plasma collection chamber;
said sheets and filter membranes having three aligned edges and said sheets having larger surface areas than said membranes, whereby said plasma collection chamber is formed by portions of said sheets that are not aligned with portions of said membranes; and said first and second flexible sheets and said first and second filter membranes being rectilinear with said first and second flexible sheets being sealed to each other around their peripheries and said first and second filter membranes being sealed to each other around their peripheries;
a blood inlet port communicating with said blood flow path;
a blood outlet port communicating with said blood flow path, and a plasma outlet port communicating with said plasma collection chamber.
14. A disposable filter cell as described in Claim 13, wherein each of said flexible sheets comprises an extruded plastic sheet with the roughened surface formed in the extrudate and comprising a plurality of longitudinal grooves.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97190178A | 1978-12-21 | 1978-12-21 | |
| US971,901 | 1978-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1127091A true CA1127091A (en) | 1982-07-06 |
Family
ID=25518940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA340,251A Expired CA1127091A (en) | 1978-12-21 | 1979-11-20 | Disposable filter cell for membrane plasmapheresis |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPS5584168A (en) |
| BE (1) | BE880762A (en) |
| CA (1) | CA1127091A (en) |
-
1979
- 1979-11-20 CA CA340,251A patent/CA1127091A/en not_active Expired
- 1979-11-27 JP JP15414579A patent/JPS5584168A/en active Pending
- 1979-12-20 BE BE0/198670A patent/BE880762A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE880762A (en) | 1980-04-16 |
| JPS5584168A (en) | 1980-06-25 |
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| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |