CA1119959A - Skin detergent composition containing n-acyl ester sarcosinate, pvp and proteinaceous hydrolysate - Google Patents
Skin detergent composition containing n-acyl ester sarcosinate, pvp and proteinaceous hydrolysateInfo
- Publication number
- CA1119959A CA1119959A CA000321839A CA321839A CA1119959A CA 1119959 A CA1119959 A CA 1119959A CA 000321839 A CA000321839 A CA 000321839A CA 321839 A CA321839 A CA 321839A CA 1119959 A CA1119959 A CA 1119959A
- Authority
- CA
- Canada
- Prior art keywords
- skin
- composition
- sarcosinate
- weight
- ingredients
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Abstract
ABSTRACT OF THE DISCLOSURE
A pharmaceutical preparation to be applied to the skin to overcome an acne condition or excessive oilyness consists to overcome ingredients which compliment each other and produce an overall beneficial effect, the ingredients being (1) a sarcosinate which removes the skin oil without ex-cessively drying the skin, (2) a polyvinylpyrrolidone (PVP) which aids in the cleaning of the skin and also forms a pro-tective film on the skin and (3) a protein hydrolysate which serves as a natural replacement for the oil which the other ingredients remove from the skin. Other beneficial agents may be added. The three essential ingredients have not previously been combined in a single preparation.
A pharmaceutical preparation to be applied to the skin to overcome an acne condition or excessive oilyness consists to overcome ingredients which compliment each other and produce an overall beneficial effect, the ingredients being (1) a sarcosinate which removes the skin oil without ex-cessively drying the skin, (2) a polyvinylpyrrolidone (PVP) which aids in the cleaning of the skin and also forms a pro-tective film on the skin and (3) a protein hydrolysate which serves as a natural replacement for the oil which the other ingredients remove from the skin. Other beneficial agents may be added. The three essential ingredients have not previously been combined in a single preparation.
Description
g This invention relates to detergent compositions and particularly to pharmaceutical preparations for cleansing the skin of persons afflicted with acne, chronic oily skin, and other skin ailnnents associated with overactive sebaceous glands and an excessively oily skin.
PRIOR ART
The excessive secretion of sebum presents an un-sightly oily appearance on the face, especially about the nose and forehead. Removal of the sebum produces a better cosmetic appearance and is an important contributing factor toward the elimination of skin eruptions, such as acne and certain kinds of dermatitis.
The routine use of soap to remove this oily secretion is not recommended as soaps do not fully cleanse the skin unless the area is bathed at very frequent intervals and considerable frictional~ and therefore irritating pressure is applied. In fact, in some instances, it is believed that soap is acnegenic.
Synthetic detergents have been used to cleanse the skin of persons suffering from an exceptionally oily skin and its relates disorders, but they cannot be routinely and con-tinuously used as they may cause excessive dryness of the skin or irritation. Most of the pharmaceutical skin detergents cannot be used for extended periods on the face, as the skin is already inflammed to some degree and the harshness of the cletergent frequently worsens the condition or precludes the application of primary topical medication.
THE PRESENT INVENTION
The detergent compositions of the present invention simultaneously eliminate and overcome the drawbacks of both soap and synthetic detergents. The preparations possess _ 1 s~
superior skin cleaning properties while retarding the irri-tating and excessive drying action of soap or conventional skin detergents. One reason for this superiority of the present compositions is that prior detergent mixtures have included oils and so-called, "super fatting" agents as addi-tives in an attempt to replace the natural oils excessively stripped from the skin by the detergents. Such oily ingredi-ents are not only foreign to the natural skin lipids, but they are contraindicated in the treatment of acne and seborrheic conditions of the skin. The compositions of the invention eliminate the need for the inclusion of such oily, lipid substances.
The essential ingredients of the basic detergent system of the invention are: (1) water-soluble salts of N-acyl esters of sarcosine, such as formed with sodium, potassium, ammonium, and triethanolamine. Lauroyl,myristoyl and stearoyl are the preferred acyl groups; (2) povidone, which is the generic name for polyvinylpyrrolidones; (3) a protein and/or a protein hydrolysate and (4) water to produce a solution of the ingredients. Other ingredients or agents may be added as will be explained, but the ones just named are essential and a mixture of them will produce a basic effective skin cleanser.
The sarcosine compound is the primary active de-tergent which effectively removes the oil on the skin without excessively drying the skin~ It shoulcl constitute from 8 to 31% by weight preferably 15 to 20% of the basic mixture.
The povidone is a polyvinylpyrrolidone having a molecular weight with the range of 4,000 to 90,000. A pre-ferred one is povidone of average molecular weight of 30,000, sold by GAF Inc. Its function in the composition is to aid in cleansing, to form a protective Film in the skin and also act as a co-solubilizer for the total composition. As an essential ingredient of the basic composition, it should amount to from 0.1 to 5.0% by weight, preferably 1 to 3%.
The protein or protein-like ingredient is preferably a water-soluble protein hydrolysate and its purpose in the composition is to serve as a natural replacement for the oil removed from the skin, without presenting an oily appearance.
Suitable materials are soluble collagen, keratin, protein hydrolysates and peptides such as sodium salt of polypeptides and amino acids, including glycine. As an essential ingredi-ent of the basic composition, it should amount to from 0.1 to 6.0% by weight, pre-ferably 1 to 4% of the final composition.
The remainder of the hasic composition is deionized or dis-tilled water. A surprising advantage of this composition is that the combination of the three essential ingredients simul-taneously facilitates and improves the cleansing and oil removing capacity, while preventing excess dryness of the skin, even when utilized routinely, three times daily.
Although it is not essential to a satisfactory composition, it is preferable that the pH of the composition be adjusted within the range of 4.6 to ~.3 by the addition of a conventional acidifying or alkalizing agent. Its selection will largely depend on the protein or protein-like material which is used. It is preferred that the range be within the lim-its of pH 4.9 to 6.1 and for this purpose it is advisable to use buFfers such as citric and lactic acid and their salts.
This may call For the addition of an amount of the selected acid and/or salt, so that it constitutes from 0.5 to 3.0% of the final weight of the composition, so that it replaces part of the water to be used.
To make the basic compositions, the three essential ingredients are weighed out and thoroughly mixed with the measured amount of water. Some of this solution is dispensed in the hands or on a washcloth and -the face is washed in a normal manner and rinsed off with a small amount of water.
Some of the povidone and protein or protein-like material will remain on the face. As has been stated above, it is advisable to adjust the composition to a pH, as mentioned above, which is compatible with the face by addition of the agents men-tioned above.
A further surprising advantage of the basic compo-sition described above is that, to it may be added a kerato-lytic organic agent and obtain a stabilized composition. Such keratolytic agents are applied to the skin to assist in the keratolysis or softening and peeling of the thickened or horny layer of the epidermis. A Frequently used keratolytic agent is salicylic acid, but its use has been limited because in the presence of a phenolic detergent and also a solubilizing agent such as polysorbate, for the insoluble salicylic acid, a com-plexing occurs between these agents and the salicylic acid.This complex serves to deactivate or inactivate both the detergent and the salicylic acid so that both the anti-seborrheic and the keratolytic act;vities are minimized or lost.
The formation oF an undesirable complex is not pro-duced in the present composition, and solubilizing agent such as polyethylene glycol and its derivatives, and polysorbate 80 are not needed to make a clean water solution of the kerato-lytic agent. As is stated above, the basic composition of a sarcosinate, povidone and a protein or protein-like substance, is compatable with salicylic acid so that the addition of the latter results in a stable composition. The salicylic acid may constitute from 0.1 to 5.0% by weight, preferably 2 to 3%
of the total aqueous composition.
Other agents may be added to the composition, but they are not essential and representative ones are the following:
1. Foam boosters and stabilizers such as fatty alkyl amides and fatty alkyl amines and their derivatives.
Representative substances are lauric diethanolamide, mysitic diethanolamide and stearyl alkyl amine. The foam producer should amount to 1 to 3% by weight of the total composition.
PRIOR ART
The excessive secretion of sebum presents an un-sightly oily appearance on the face, especially about the nose and forehead. Removal of the sebum produces a better cosmetic appearance and is an important contributing factor toward the elimination of skin eruptions, such as acne and certain kinds of dermatitis.
The routine use of soap to remove this oily secretion is not recommended as soaps do not fully cleanse the skin unless the area is bathed at very frequent intervals and considerable frictional~ and therefore irritating pressure is applied. In fact, in some instances, it is believed that soap is acnegenic.
Synthetic detergents have been used to cleanse the skin of persons suffering from an exceptionally oily skin and its relates disorders, but they cannot be routinely and con-tinuously used as they may cause excessive dryness of the skin or irritation. Most of the pharmaceutical skin detergents cannot be used for extended periods on the face, as the skin is already inflammed to some degree and the harshness of the cletergent frequently worsens the condition or precludes the application of primary topical medication.
THE PRESENT INVENTION
The detergent compositions of the present invention simultaneously eliminate and overcome the drawbacks of both soap and synthetic detergents. The preparations possess _ 1 s~
superior skin cleaning properties while retarding the irri-tating and excessive drying action of soap or conventional skin detergents. One reason for this superiority of the present compositions is that prior detergent mixtures have included oils and so-called, "super fatting" agents as addi-tives in an attempt to replace the natural oils excessively stripped from the skin by the detergents. Such oily ingredi-ents are not only foreign to the natural skin lipids, but they are contraindicated in the treatment of acne and seborrheic conditions of the skin. The compositions of the invention eliminate the need for the inclusion of such oily, lipid substances.
The essential ingredients of the basic detergent system of the invention are: (1) water-soluble salts of N-acyl esters of sarcosine, such as formed with sodium, potassium, ammonium, and triethanolamine. Lauroyl,myristoyl and stearoyl are the preferred acyl groups; (2) povidone, which is the generic name for polyvinylpyrrolidones; (3) a protein and/or a protein hydrolysate and (4) water to produce a solution of the ingredients. Other ingredients or agents may be added as will be explained, but the ones just named are essential and a mixture of them will produce a basic effective skin cleanser.
The sarcosine compound is the primary active de-tergent which effectively removes the oil on the skin without excessively drying the skin~ It shoulcl constitute from 8 to 31% by weight preferably 15 to 20% of the basic mixture.
The povidone is a polyvinylpyrrolidone having a molecular weight with the range of 4,000 to 90,000. A pre-ferred one is povidone of average molecular weight of 30,000, sold by GAF Inc. Its function in the composition is to aid in cleansing, to form a protective Film in the skin and also act as a co-solubilizer for the total composition. As an essential ingredient of the basic composition, it should amount to from 0.1 to 5.0% by weight, preferably 1 to 3%.
The protein or protein-like ingredient is preferably a water-soluble protein hydrolysate and its purpose in the composition is to serve as a natural replacement for the oil removed from the skin, without presenting an oily appearance.
Suitable materials are soluble collagen, keratin, protein hydrolysates and peptides such as sodium salt of polypeptides and amino acids, including glycine. As an essential ingredi-ent of the basic composition, it should amount to from 0.1 to 6.0% by weight, pre-ferably 1 to 4% of the final composition.
The remainder of the hasic composition is deionized or dis-tilled water. A surprising advantage of this composition is that the combination of the three essential ingredients simul-taneously facilitates and improves the cleansing and oil removing capacity, while preventing excess dryness of the skin, even when utilized routinely, three times daily.
Although it is not essential to a satisfactory composition, it is preferable that the pH of the composition be adjusted within the range of 4.6 to ~.3 by the addition of a conventional acidifying or alkalizing agent. Its selection will largely depend on the protein or protein-like material which is used. It is preferred that the range be within the lim-its of pH 4.9 to 6.1 and for this purpose it is advisable to use buFfers such as citric and lactic acid and their salts.
This may call For the addition of an amount of the selected acid and/or salt, so that it constitutes from 0.5 to 3.0% of the final weight of the composition, so that it replaces part of the water to be used.
To make the basic compositions, the three essential ingredients are weighed out and thoroughly mixed with the measured amount of water. Some of this solution is dispensed in the hands or on a washcloth and -the face is washed in a normal manner and rinsed off with a small amount of water.
Some of the povidone and protein or protein-like material will remain on the face. As has been stated above, it is advisable to adjust the composition to a pH, as mentioned above, which is compatible with the face by addition of the agents men-tioned above.
A further surprising advantage of the basic compo-sition described above is that, to it may be added a kerato-lytic organic agent and obtain a stabilized composition. Such keratolytic agents are applied to the skin to assist in the keratolysis or softening and peeling of the thickened or horny layer of the epidermis. A Frequently used keratolytic agent is salicylic acid, but its use has been limited because in the presence of a phenolic detergent and also a solubilizing agent such as polysorbate, for the insoluble salicylic acid, a com-plexing occurs between these agents and the salicylic acid.This complex serves to deactivate or inactivate both the detergent and the salicylic acid so that both the anti-seborrheic and the keratolytic act;vities are minimized or lost.
The formation oF an undesirable complex is not pro-duced in the present composition, and solubilizing agent such as polyethylene glycol and its derivatives, and polysorbate 80 are not needed to make a clean water solution of the kerato-lytic agent. As is stated above, the basic composition of a sarcosinate, povidone and a protein or protein-like substance, is compatable with salicylic acid so that the addition of the latter results in a stable composition. The salicylic acid may constitute from 0.1 to 5.0% by weight, preferably 2 to 3%
of the total aqueous composition.
Other agents may be added to the composition, but they are not essential and representative ones are the following:
1. Foam boosters and stabilizers such as fatty alkyl amides and fatty alkyl amines and their derivatives.
Representative substances are lauric diethanolamide, mysitic diethanolamide and stearyl alkyl amine. The foam producer should amount to 1 to 3% by weight of the total composition.
2. Preservatives such as antibacterial/antifungal agents; useful ones are methyl parabens and propyl parabens.
It should constitute from 0.1 to 0.3% of the total compo-sition.
It should constitute from 0.1 to 0.3% of the total compo-sition.
3. Chelating agents such as ethylenediaminetetra-acetic acid (edetic acid) and citric acid. It should amount to from 0.05 to 0.2% of the total composition.
4. Fragrance, such as perfume, of choice.
5. Nonionic and/or anionic compatible detergents.
Any one or more of these elective, non-essential agents may be added with the water along with the essential ingredients mentioned above which make up the basic compo sition. Additional electives may be added as is obvious to those trained in the art of cosmetic and dermatologic formu-lating, etc.
Representative examples are the following.
A basic composition is the following:
_y weight TEA N-Lauroyl sarcosinate, 40% 20 Povidone K-30 2 Protein hydrolysate 2 Water, distilled or deionized 76 The amount of sarcosinate in Example 1 is as low as 8% up to as high as 31%, the amount of water being corre-spondingly increased or decreased.
In Example 1, the amount of povidone is within the range of 0.1 to 5.0% by weight.
In Example 1, the amount of protein hydrolysate is within the range of 0.1 to 6.0% by weight.
EXAMPl.E 5 %
by weight Sodium N-Lauroyl sarcosinate 20 Povidone K-30 2 Protein (Water-soluble or dispersable) 2 Water, distilled or deionized 76 TEA~ N-Lauroyl sarcosinate 15 Povidone K-30~ 1 Protein hydrolysate Lauric diethanolamide 2 Edetic acid 0.1 Methyl paraben 0.15 Water 80 75 %
by weight TEA N-Lauroyl sarcosinate 15 Povidone K-30 Protein hydrolysate Lauric diethanolamide 2 Edetic acid 0.1 Methyl paraben 0.15 Water 75.75 Salicylic acid 3 TEA N-Lauroyl sarcosinate 15 Povidone K-30 Protein hydrolysate Lauric diethanolamide 2 Edetic acid 0.1 Methyl paraben 0.15 Lactic acid 3 Water 75.75 TEA N-Lauroyl sarcosinate 15 Povidone K-30~ 1 Protein hydrolysate Lauric diethanolamide 2 Edetic acid 0.1 Methyl paraben 0.15 Citric acid 0 5 Water 80.25 99~
Tests for safety and irritation of the anti-seborrheic detergent cleanser established that the combination effectively acts as a potent antiseborrheic agent, reducing the oil level of the skin without causing the expected red flareup and dry, peeling and flaking upon prolonged usage.
The unique vehicle apparently protects the skin From over-reacting with the dissolved antiseborrheics. Theoretically3 the skin substantivity of the sarcosine-PVP-protein system is greater than the affinity of the skin for the dissolved keratolytic. This forms a protective "film" preventing residual antiseborrheic material from remaining directly on the skin in micro-quantities after rinsing. Conventional detergent systems allow keratolytics to plate out substan-tively on the skin. Trace residues left behind, after rinsing the skin, continue to dry, irritate and often peel the skin surface when used routinely.
Any one or more of these elective, non-essential agents may be added with the water along with the essential ingredients mentioned above which make up the basic compo sition. Additional electives may be added as is obvious to those trained in the art of cosmetic and dermatologic formu-lating, etc.
Representative examples are the following.
A basic composition is the following:
_y weight TEA N-Lauroyl sarcosinate, 40% 20 Povidone K-30 2 Protein hydrolysate 2 Water, distilled or deionized 76 The amount of sarcosinate in Example 1 is as low as 8% up to as high as 31%, the amount of water being corre-spondingly increased or decreased.
In Example 1, the amount of povidone is within the range of 0.1 to 5.0% by weight.
In Example 1, the amount of protein hydrolysate is within the range of 0.1 to 6.0% by weight.
EXAMPl.E 5 %
by weight Sodium N-Lauroyl sarcosinate 20 Povidone K-30 2 Protein (Water-soluble or dispersable) 2 Water, distilled or deionized 76 TEA~ N-Lauroyl sarcosinate 15 Povidone K-30~ 1 Protein hydrolysate Lauric diethanolamide 2 Edetic acid 0.1 Methyl paraben 0.15 Water 80 75 %
by weight TEA N-Lauroyl sarcosinate 15 Povidone K-30 Protein hydrolysate Lauric diethanolamide 2 Edetic acid 0.1 Methyl paraben 0.15 Water 75.75 Salicylic acid 3 TEA N-Lauroyl sarcosinate 15 Povidone K-30 Protein hydrolysate Lauric diethanolamide 2 Edetic acid 0.1 Methyl paraben 0.15 Lactic acid 3 Water 75.75 TEA N-Lauroyl sarcosinate 15 Povidone K-30~ 1 Protein hydrolysate Lauric diethanolamide 2 Edetic acid 0.1 Methyl paraben 0.15 Citric acid 0 5 Water 80.25 99~
Tests for safety and irritation of the anti-seborrheic detergent cleanser established that the combination effectively acts as a potent antiseborrheic agent, reducing the oil level of the skin without causing the expected red flareup and dry, peeling and flaking upon prolonged usage.
The unique vehicle apparently protects the skin From over-reacting with the dissolved antiseborrheics. Theoretically3 the skin substantivity of the sarcosine-PVP-protein system is greater than the affinity of the skin for the dissolved keratolytic. This forms a protective "film" preventing residual antiseborrheic material from remaining directly on the skin in micro-quantities after rinsing. Conventional detergent systems allow keratolytics to plate out substan-tively on the skin. Trace residues left behind, after rinsing the skin, continue to dry, irritate and often peel the skin surface when used routinely.
Claims (4)
1. An aqueous pharmaceutical detergent composition for cleansing oily skin which comprises the following ingredi-ents, in percent by weight:
N-Acyl ester sarcosinate salt in which the salt moiety is selected from sodium, potassium, ammonium and triethanoylamine and in which the acyl ester moiety is selected from lauroyl, myristoyl and stearoyl 8.0 to 31.0 Polyvinyl pyrrolidone having an average molecular weight of 4000 to 90,000 0.1 to 5.0 Proteinaceous material selected from protein hydrolysates 0.1 to 6.0 Water Q.S.
N-Acyl ester sarcosinate salt in which the salt moiety is selected from sodium, potassium, ammonium and triethanoylamine and in which the acyl ester moiety is selected from lauroyl, myristoyl and stearoyl 8.0 to 31.0 Polyvinyl pyrrolidone having an average molecular weight of 4000 to 90,000 0.1 to 5.0 Proteinaceous material selected from protein hydrolysates 0.1 to 6.0 Water Q.S.
2. The composition of Claim 1 in which the pH is adjusted within 4.6 and 8.3.
3. The composition of Claim 1 which also includes a keratolytic agent selected from the group consisting of salicylic acid and lactic acid in an amount to constitute from 0.1 to 6.0% by weight of the composition.
4. The composition of Claim 1 which additionally includes an agent selected from the group consisting of fatty acid amide and a fatty alkyl amine, propyl dimethyl amine oxide, citric acid, a nonionic and an anionic detergent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000321839A CA1119959A (en) | 1979-02-16 | 1979-02-16 | Skin detergent composition containing n-acyl ester sarcosinate, pvp and proteinaceous hydrolysate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000321839A CA1119959A (en) | 1979-02-16 | 1979-02-16 | Skin detergent composition containing n-acyl ester sarcosinate, pvp and proteinaceous hydrolysate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1119959A true CA1119959A (en) | 1982-03-16 |
Family
ID=4113579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000321839A Expired CA1119959A (en) | 1979-02-16 | 1979-02-16 | Skin detergent composition containing n-acyl ester sarcosinate, pvp and proteinaceous hydrolysate |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA1119959A (en) |
-
1979
- 1979-02-16 CA CA000321839A patent/CA1119959A/en not_active Expired
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4147782A (en) | Pharmaceutical detergent composition | |
| US6323166B1 (en) | Shampoo compositions | |
| JPH08509753A (en) | Cleansing composition | |
| US5869071A (en) | One-step skin cleaning composition and skin treatment method for incontinent dermatitis | |
| JPH07179320A (en) | Cleansing and conditioning composition for local application | |
| JP3602862B2 (en) | Conditioner for keratin substances | |
| US3778502A (en) | Method for combatting scaling of the scalp | |
| JPH11322551A (en) | Hair and body cleaner having reduced skin irritation | |
| JP2587262B2 (en) | Detergent composition | |
| JP2509894B2 (en) | Detergent composition | |
| US7118734B1 (en) | Non-aqueous liquid shampoo composition | |
| CA1119959A (en) | Skin detergent composition containing n-acyl ester sarcosinate, pvp and proteinaceous hydrolysate | |
| JP2000191514A (en) | Sebum remover composition | |
| CA1063029A (en) | Glycyrrhizins in hair-treating compositions | |
| JP2509896B2 (en) | Detergent composition | |
| US2756178A (en) | Residual lanolin hair shampoo | |
| JP2956268B2 (en) | Detergent composition | |
| JPH0615462B2 (en) | Hair composition | |
| JPH07309742A (en) | Creamy skin detergent | |
| JPS5942038B2 (en) | Hair shampoo - composition | |
| JPH0525024A (en) | Shampoo | |
| JPH0673395A (en) | Detergent composition | |
| JP3621441B2 (en) | Skin cleanser composition | |
| FI64185C (en) | TVAETTMEDELSKOMPOSITIONER FOER RENGOERING AV FET HUD | |
| NO149740B (en) | VERY COSMETIC DETERGENT PREPARATION |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |