CA1110467A - Methods to determine a diagnostic indicator of blood sugar conditions and liquid chromotographic columns therefor (cyanide free) - Google Patents
Methods to determine a diagnostic indicator of blood sugar conditions and liquid chromotographic columns therefor (cyanide free)Info
- Publication number
- CA1110467A CA1110467A CA363,487A CA363487A CA1110467A CA 1110467 A CA1110467 A CA 1110467A CA 363487 A CA363487 A CA 363487A CA 1110467 A CA1110467 A CA 1110467A
- Authority
- CA
- Canada
- Prior art keywords
- column bed
- particles
- suspension
- equilibrated
- test sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims abstract description 44
- 210000004369 blood Anatomy 0.000 title claims abstract description 27
- 239000008280 blood Substances 0.000 title claims abstract description 27
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 title claims abstract description 24
- 239000007788 liquid Substances 0.000 title description 4
- 239000002245 particle Substances 0.000 claims abstract description 78
- 238000012360 testing method Methods 0.000 claims abstract description 71
- 108010054147 Hemoglobins Proteins 0.000 claims abstract description 58
- 102000001554 Hemoglobins Human genes 0.000 claims abstract description 58
- 239000000725 suspension Substances 0.000 claims abstract description 58
- 238000005342 ion exchange Methods 0.000 claims abstract description 20
- 238000004458 analytical method Methods 0.000 claims abstract description 17
- 239000000463 material Substances 0.000 claims abstract description 15
- 150000001450 anions Chemical class 0.000 claims abstract description 12
- 150000001768 cations Chemical class 0.000 claims abstract description 10
- 239000000758 substrate Substances 0.000 claims abstract description 5
- 241000894007 species Species 0.000 claims description 56
- 239000000243 solution Substances 0.000 claims description 42
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 claims description 18
- 229920005989 resin Polymers 0.000 claims description 17
- 239000011347 resin Substances 0.000 claims description 17
- 239000007853 buffer solution Substances 0.000 claims description 12
- 210000003743 erythrocyte Anatomy 0.000 claims description 11
- 229940116441 divinylbenzene Drugs 0.000 claims description 9
- -1 aliphatic hydrocarbon radical Chemical class 0.000 claims description 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 6
- 230000002378 acidificating effect Effects 0.000 claims description 5
- 239000004793 Polystyrene Substances 0.000 claims description 4
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 229920002223 polystyrene Polymers 0.000 claims description 4
- 125000002924 primary amino group Chemical class [H]N([H])* 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 3
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 claims description 3
- 125000001931 aliphatic group Chemical group 0.000 claims description 2
- 239000000523 sample Substances 0.000 claims 22
- 125000001302 tertiary amino group Chemical group 0.000 claims 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 1
- 239000000727 fraction Substances 0.000 claims 1
- 229940063559 methacrylic acid Drugs 0.000 claims 1
- 239000012085 test solution Substances 0.000 claims 1
- 239000000872 buffer Substances 0.000 abstract description 4
- 150000002500 ions Chemical class 0.000 description 19
- 229920002678 cellulose Polymers 0.000 description 9
- 239000001913 cellulose Substances 0.000 description 9
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 8
- INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 description 7
- 238000002156 mixing Methods 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 239000008279 sol Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 229910019142 PO4 Inorganic materials 0.000 description 4
- 238000010790 dilution Methods 0.000 description 4
- 239000012895 dilution Substances 0.000 description 4
- 238000010828 elution Methods 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 4
- 239000010452 phosphate Substances 0.000 description 4
- 101100284769 Drosophila melanogaster hemo gene Proteins 0.000 description 3
- OWMVSZAMULFTJU-UHFFFAOYSA-N bis-tris Chemical compound OCCN(CCO)C(CO)(CO)CO OWMVSZAMULFTJU-UHFFFAOYSA-N 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 241000134884 Ericales Species 0.000 description 2
- 239000007836 KH2PO4 Substances 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 230000009102 absorption Effects 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000005341 cation exchange Methods 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 229920001429 chelating resin Polymers 0.000 description 2
- 238000001311 chemical methods and process Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000031700 light absorption Effects 0.000 description 2
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 2
- 235000019796 monopotassium phosphate Nutrition 0.000 description 2
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 230000003595 spectral effect Effects 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 241000238366 Cephalopoda Species 0.000 description 1
- 241000905957 Channa melasoma Species 0.000 description 1
- 241000763212 Lype Species 0.000 description 1
- JCYZMTMYPZHVBF-UHFFFAOYSA-N Melarsoprol Chemical compound NC1=NC(N)=NC(NC=2C=CC(=CC=2)[As]2SC(CO)CS2)=N1 JCYZMTMYPZHVBF-UHFFFAOYSA-N 0.000 description 1
- 108010061951 Methemoglobin Proteins 0.000 description 1
- 241001508687 Mustela erminea Species 0.000 description 1
- 108010064719 Oxyhemoglobins Proteins 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 101150057388 Reln gene Proteins 0.000 description 1
- 241000193803 Therea Species 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 238000005349 anion exchange Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 102000018146 globin Human genes 0.000 description 1
- 108060003196 globin Proteins 0.000 description 1
- 229920001903 high density polyethylene Polymers 0.000 description 1
- 239000004700 high-density polyethylene Substances 0.000 description 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 208000007106 menorrhagia Diseases 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003512 tertiary amines Chemical group 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
- H01M50/00—Constructional details or processes of manufacture of the non-active parts of electrochemical cells other than fuel cells, e.g. hybrid cells
- H01M50/30—Arrangements for facilitating escape of gases
- H01M50/342—Non-re-sealable arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
- H01M50/00—Constructional details or processes of manufacture of the non-active parts of electrochemical cells other than fuel cells, e.g. hybrid cells
- H01M50/10—Primary casings; Jackets or wrappings
- H01M50/172—Arrangements of electric connectors penetrating the casing
- H01M50/174—Arrangements of electric connectors penetrating the casing adapted for the shape of the cells
- H01M50/182—Arrangements of electric connectors penetrating the casing adapted for the shape of the cells for cells with a collector centrally disposed in the active mass, e.g. Leclanché cells
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
- H01M50/00—Constructional details or processes of manufacture of the non-active parts of electrochemical cells other than fuel cells, e.g. hybrid cells
- H01M50/30—Arrangements for facilitating escape of gases
- H01M50/375—Vent means sensitive to or responsive to temperature
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6004—Construction of the column end pieces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
- Y02E60/10—Energy storage using batteries
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Electrochemistry (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sealing Battery Cases Or Jackets (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/090,319 US4238196A (en) | 1979-11-01 | 1979-11-01 | Methods to determine a diagnostic indicator of blood sugar conditions, and, liquid chromatographic columns therefor (cyanide free) |
| US090,319 | 1987-08-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1110467A true CA1110467A (en) | 1981-10-13 |
Family
ID=22222276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA363,487A Expired CA1110467A (en) | 1979-11-01 | 1980-10-29 | Methods to determine a diagnostic indicator of blood sugar conditions and liquid chromotographic columns therefor (cyanide free) |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4238196A (enExample) |
| JP (1) | JPS6236181B2 (enExample) |
| CA (1) | CA1110467A (enExample) |
| CH (1) | CH659527A5 (enExample) |
| GB (1) | GB2074466B (enExample) |
| WO (1) | WO1981001245A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1168705A (en) * | 1980-05-27 | 1984-06-05 | Hamish Small | Ion exchange chromatography with indirect photometric detection |
| US4649122A (en) * | 1980-09-02 | 1987-03-10 | Leeco Diagnostics, Inc. | Means for determining percentage of glycohemoglobin in whole blood |
| US4407961A (en) * | 1981-03-16 | 1983-10-04 | Sanders James L | Ion-exchange system and method for isolation and determination of glycosylated hemoglobin in human blood |
| US4468330A (en) * | 1981-04-27 | 1984-08-28 | Sekisui Kagaku Kogyo Kabushiki Kaisha | Filler for liquid chromatography useful for separating a hemoglobin variant in blood |
| JPS58760A (ja) * | 1981-06-25 | 1983-01-05 | Sekisui Chem Co Ltd | 異化ヘモグロビンの分離法 |
| WO1983003476A1 (en) * | 1982-03-25 | 1983-10-13 | James Lynn Sanders | Ion-exchange system and method for isolation and determination of glycosylated hemoglobin in human blood |
| US4409335A (en) * | 1982-05-28 | 1983-10-11 | Bio-Rad Laboratories, Inc. | Method for eliminating glucose dependent Schiff base effect from hemoglobin A1 assay |
| US4448888A (en) * | 1982-08-24 | 1984-05-15 | Bio-Rad Laboratories, Inc. | Compositions and method for correcting temperature dependence of hemoglobin assays |
| US4935346A (en) * | 1986-08-13 | 1990-06-19 | Lifescan, Inc. | Minimum procedure system for the determination of analytes |
| US4787971A (en) * | 1987-01-23 | 1988-11-29 | Alan Donald | Miniaturized column chromatography separation apparatus and method of assaying biomolecules employing the same |
| US4853338A (en) * | 1987-05-20 | 1989-08-01 | Technicon Instruments Corporation | Cyanide-free hemoglobin reagent |
| GB2220369B (en) * | 1988-06-10 | 1993-01-27 | Inst Of Child Health | Method for testing body fluids by low pressure liquid chromatography |
| AU624935B2 (en) * | 1989-04-10 | 1992-06-25 | Nippon Kayaku Kabushiki Kaisha | Method for quantitatively measuring sugar-alcohol, column and kit therefor |
| US5468380A (en) * | 1989-04-26 | 1995-11-21 | Nippon Kayaku Kabushiki Kaisha | Method for quantitatively measuring sugar-alcohol, column and kit therefor |
| US5807747A (en) * | 1989-06-13 | 1998-09-15 | Clinical Innovations Limited | Method and apparatus for determination of glycosylated protein |
| JPH0486554A (ja) * | 1990-07-30 | 1992-03-19 | Tosoh Corp | 糖化アルブミンの分析方法 |
| EP0589001B1 (en) * | 1992-03-04 | 2002-07-24 | Abbott Laboratories | Determination of glycated hemoglobin by fluorescence quenching |
| FI112545B (fi) * | 1997-05-30 | 2003-12-15 | Nokia Corp | Menetelmä ja järjestelmä potilaan veren glykosyloidun hemoglobiinikomponentin tason ennustamiseksi |
| US6177009B1 (en) * | 1998-04-03 | 2001-01-23 | Macherey, Nagel Gmbh & Co. | Apparatus for treating biomolecules |
| US6458326B1 (en) | 1999-11-24 | 2002-10-01 | Home Diagnostics, Inc. | Protective test strip platform |
| US6562625B2 (en) | 2001-02-28 | 2003-05-13 | Home Diagnostics, Inc. | Distinguishing test types through spectral analysis |
| US6525330B2 (en) | 2001-02-28 | 2003-02-25 | Home Diagnostics, Inc. | Method of strip insertion detection |
| US6541266B2 (en) | 2001-02-28 | 2003-04-01 | Home Diagnostics, Inc. | Method for determining concentration of an analyte in a test strip |
| US6761855B1 (en) * | 2001-11-05 | 2004-07-13 | Biosearch Technologies, Inc. | Column for solid phase processing |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4142857A (en) * | 1977-12-02 | 1979-03-06 | Isolab, Incorporated | Method to determine a diagnostic indicator of blood sugar condition, and, a liquid chromatographic microcolumn therefor |
| US4142855A (en) * | 1977-12-02 | 1979-03-06 | Isolab, Incorporated | Method to determine a diagnostic indicator of blood sugar condition, and, a liquid chromatographic microcolumn therefor |
| JPS5499496A (en) * | 1977-12-02 | 1979-08-06 | Isolab Inc | Method of deciding diagnosis index of blood sugar condition and its device |
| US4142858A (en) * | 1977-12-02 | 1979-03-06 | Isolab, Incorporated | Method to determine a diagnostic indicator of blood sugar condition, and, a liquid chromatographic microcolumn therefor |
| US4142856A (en) * | 1977-12-02 | 1979-03-06 | Isolab, Incorporated | Method to determine a diagnostic indicator of blood sugar condition, and, a liquid chromatographic microcolumn therefor |
-
1979
- 1979-11-01 US US06/090,319 patent/US4238196A/en not_active Expired - Lifetime
-
1980
- 1980-10-22 GB GB8108196A patent/GB2074466B/en not_active Expired
- 1980-10-22 CH CH4356/81A patent/CH659527A5/de not_active IP Right Cessation
- 1980-10-22 WO PCT/US1980/001411 patent/WO1981001245A1/en not_active Ceased
- 1980-10-29 CA CA363,487A patent/CA1110467A/en not_active Expired
-
1981
- 1981-12-02 JP JP81500132A patent/JPS6236181B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB2074466B (en) | 1983-08-03 |
| US4238196A (en) | 1980-12-09 |
| JPS6236181B2 (enExample) | 1987-08-05 |
| CH659527A5 (de) | 1987-01-30 |
| JPS57501937A (enExample) | 1982-10-28 |
| WO1981001245A1 (en) | 1981-05-14 |
| GB2074466A (en) | 1981-11-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |