CA1098430A - Method and apparatus for the detection of beta thalassaemia minor - Google Patents
Method and apparatus for the detection of beta thalassaemia minorInfo
- Publication number
- CA1098430A CA1098430A CA298,659A CA298659A CA1098430A CA 1098430 A CA1098430 A CA 1098430A CA 298659 A CA298659 A CA 298659A CA 1098430 A CA1098430 A CA 1098430A
- Authority
- CA
- Canada
- Prior art keywords
- thalassaemia
- index
- mean corpuscular
- haemoglobin
- developing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims abstract description 30
- 206010043391 Thalassaemia beta Diseases 0.000 title claims abstract description 18
- 238000001514 detection method Methods 0.000 title description 4
- 208000002903 Thalassemia Diseases 0.000 claims abstract description 48
- 210000003743 erythrocyte Anatomy 0.000 claims abstract description 19
- 210000000601 blood cell Anatomy 0.000 claims abstract 2
- 238000005259 measurement Methods 0.000 claims description 12
- 210000004369 blood Anatomy 0.000 claims description 9
- 239000008280 blood Substances 0.000 claims description 9
- 239000000969 carrier Substances 0.000 claims description 6
- 238000001962 electrophoresis Methods 0.000 claims description 5
- 238000012216 screening Methods 0.000 abstract description 6
- 210000004027 cell Anatomy 0.000 description 8
- 208000007502 anemia Diseases 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 230000002068 genetic effect Effects 0.000 description 3
- 230000002489 hematologic effect Effects 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 206010027540 Microcytosis Diseases 0.000 description 2
- 238000004820 blood count Methods 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 230000001605 fetal effect Effects 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 208000019838 Blood disease Diseases 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 208000000859 Sickle cell trait Diseases 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 150000004032 porphyrins Chemical class 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/108331—Preservative, buffer, anticoagulant or diluent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Ecology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB12779/77A GB1603643A (en) | 1978-03-06 | 1978-03-06 | Detection of blood disorders |
| GB12779/77 | 1978-03-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1098430A true CA1098430A (en) | 1981-03-31 |
Family
ID=10010968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA298,659A Expired CA1098430A (en) | 1978-03-06 | 1978-03-10 | Method and apparatus for the detection of beta thalassaemia minor |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4159895A (en:Method) |
| JP (1) | JPS5412795A (en:Method) |
| CA (1) | CA1098430A (en:Method) |
| DE (1) | DE2812988A1 (en:Method) |
| FR (1) | FR2386081A1 (en:Method) |
| GB (1) | GB1603643A (en:Method) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4244803A (en) * | 1979-11-27 | 1981-01-13 | Aladjem Frederick J | Quantitative protein analysis by immunodiffusion |
| US4453266A (en) * | 1980-04-21 | 1984-06-05 | Rush-Presbyterian-St. Luke's Medical Center | Method and apparatus for measuring mean cell volume of red blood cells |
| IT1164480B (it) * | 1982-04-29 | 1987-04-08 | Matteis Maria Concetta De | Procedimento diagnostico per l'individualizzazione di portatori del carattere beta-talassemico e mezzi per la sua attuazione |
| JPH067618B2 (ja) * | 1983-12-26 | 1994-01-26 | 株式会社東芝 | 半導体レ−ザ装置 |
| US4810391A (en) * | 1987-11-06 | 1989-03-07 | Bio-Rad Laboratories, Inc. | Separation of hemoglobin A2 from hemoglobin mixture |
| US4980058A (en) * | 1987-11-06 | 1990-12-25 | Bio-Rad Laboratories, Inc. | Separation of hemoglobin A2 from hemoglobin mixture |
| US5753094A (en) * | 1995-09-20 | 1998-05-19 | Beckman Instruments, Inc. | Borate storage buffer and sample diluent |
| CN111638261B (zh) * | 2020-04-17 | 2023-04-07 | 融智生物科技（青岛）有限公司 | 一种计算设备、存储介质和地中海贫血筛查装置及系统 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3520316A (en) * | 1963-12-12 | 1970-07-14 | Bowles Eng Corp | Pressure-to-pressure transducer |
| US3427135A (en) * | 1966-07-11 | 1969-02-11 | Technicon Instr | Hematology apparatus |
| US3459994A (en) * | 1966-10-06 | 1969-08-05 | Gen Electric | Crossed-field discharge device and improved magnetic pole structures therefor |
| US3675768A (en) * | 1969-03-17 | 1972-07-11 | Gildardo Legorreta Sanchez | Method and apparatus for classifying and segregating particles with electrical and optical means |
| US3828260A (en) * | 1973-04-02 | 1974-08-06 | Royco Instr Inc | Hematocrit measuring apparatus |
| US3923397A (en) * | 1974-05-29 | 1975-12-02 | Dolive Stephen E | Hematocrit measuring method |
| US4052596A (en) * | 1974-12-23 | 1977-10-04 | Hycel, Inc. | Automatic hematology analyzer |
| JPS5916667B2 (ja) * | 1975-02-28 | 1984-04-17 | トウアイヨウデンシ カブシキガイシヤ | 自動血液分析装置 |
| US4063309A (en) * | 1976-09-16 | 1977-12-13 | Hycel, Inc. | Mean corpuscular volume measuring apparatus and method |
-
1978
- 1978-03-06 GB GB12779/77A patent/GB1603643A/en not_active Expired
- 1978-03-10 CA CA298,659A patent/CA1098430A/en not_active Expired
- 1978-03-23 DE DE19782812988 patent/DE2812988A1/de active Granted
- 1978-03-24 FR FR7808757A patent/FR2386081A1/fr active Granted
- 1978-03-24 US US05/889,869 patent/US4159895A/en not_active Expired - Lifetime
- 1978-03-24 JP JP3479578A patent/JPS5412795A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5412795A (en) | 1979-01-30 |
| DE2812988A1 (de) | 1978-10-05 |
| US4159895A (en) | 1979-07-03 |
| DE2812988C2 (en:Method) | 1987-12-10 |
| FR2386081B1 (en:Method) | 1984-08-17 |
| JPS6133142B2 (en:Method) | 1986-07-31 |
| FR2386081A1 (fr) | 1978-10-27 |
| GB1603643A (en) | 1981-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |