CA1089252A - Optical catheter not requiring individual calibration - Google Patents
Optical catheter not requiring individual calibrationInfo
- Publication number
- CA1089252A CA1089252A CA284,615A CA284615A CA1089252A CA 1089252 A CA1089252 A CA 1089252A CA 284615 A CA284615 A CA 284615A CA 1089252 A CA1089252 A CA 1089252A
- Authority
- CA
- Canada
- Prior art keywords
- optical
- transmitting
- catheters
- aperture
- catheter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
Abstract
IMPROVED OPTICAL CATHETER NOT
REQUIRING INDIVIDUAL CALIBRATION
ABSTRACT OF THE DISCLOSURE
Catheter apparatus having transmitting and receiving optical fibers for photometric analysis of a fluid eliminates the need for individually calibrating each catheter within a population of catheters by making substantially uniform the center-to-center spacing between the outlet aperture of each and every transmitting fiber and the inlet aperture of each and every receiving fiber of an individual catheter for all catheters within a population of catheters; and by making the size and shape of all the outlet apertures of all transmitting fibers generally uniform and the size and shape of the inlet apertures of all receiving fibers generally uniform in each catheter and from catheter to catheter and that the orientation of all transmitting fibers relative to all receiving fibers be similar.
REQUIRING INDIVIDUAL CALIBRATION
ABSTRACT OF THE DISCLOSURE
Catheter apparatus having transmitting and receiving optical fibers for photometric analysis of a fluid eliminates the need for individually calibrating each catheter within a population of catheters by making substantially uniform the center-to-center spacing between the outlet aperture of each and every transmitting fiber and the inlet aperture of each and every receiving fiber of an individual catheter for all catheters within a population of catheters; and by making the size and shape of all the outlet apertures of all transmitting fibers generally uniform and the size and shape of the inlet apertures of all receiving fibers generally uniform in each catheter and from catheter to catheter and that the orientation of all transmitting fibers relative to all receiving fibers be similar.
Description
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BACKG~OUND OF THE INVENTION
Optical catheters for performing in-vivo spectro-photometric measurements in the blood stream or elsewhere within living organisms are well known in the art. (See U. S. Patents Nos. 3,847,483 and 3,068,742.) These have most commonly been used for the performance of oximetry, i.e., measuring the relative amount of the total hemoglobin within the blood stream that is in the oxygenated form. While prior art optical catheters can be used successfully for performing oximetry, they have a shortcoming which is of major importance to the medical prac-titioner in the care of critically-ill patients. The catheters of the prior art require that an individual calibration be per-Eormed for each and every individual catheter that is to be used, in order to obtain accurate oxygen saturation measurements.
To perform this calibration, commonly a sterile optical catheter is inserted through the wall of a blood vessel of interest and advanced so that its tip is at a position within the flowing blood stream where it is desired that oxygen saturation measurements be made. The patient is frecluently given a par-ticular gas mixture to breathe; commonly a mixture enrichecl in oxygen or depleted of oxygen, or two such mixtures sequentially, which causes the patient's blood to attain an oxygen saturation level in the regions of interest. Then, as blood samples are withdrawn (most commonly through an open lumen of the optical catheter) measurements are made of the relative light reflectances or transmissions at the catheter tip for the various optical wave- -lengths used by the catheter oximeter system.
The blood samples must then be taken to a separate instrument (for example, a transmission spectrophotometer located in a central laboratory) where an independent measurement " ~.
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of the oxygen saturation of the one or more blood samples is -~
made. The results of this independent measurement are then :
returned to the catheter oximeter at the patient's bedside, so that appropriate changes may be introduced into the catheter oximeter. These changes may include changes in bias levels and/or gains of various amplifiers in order to correct for the deviation between the initial oxygen saturation measurement made at the time of blood sampling and the oxygen saturation measure-ment independently determined by the separate instrument.
This requirement for individual calibration of catheters has obvious and important deficiencies. One such deficiency is the delay between the time of catheter placement and the time at wh.ich accurate measurements of oxygen saturation utilizing the optical catheter can be obtained. This delay deprives the physician of important information at a time when such infor-mation is often of the utmost importance in caring for the .
patient~ For example, at the time of delivery of a newborn infant with severe respiratory distress because of prematurity, or severe Rh Hemolytic Disease or with other disorders, the resuscitation of these sick infants (who may weigh only two tothree pounds) is frequently a precarious and difficult problem.
This resuscitation must be instituted immediately upon birth and the various therapeutic manipulations completed within a very short time period. Unfortunately, the time required to perform calibration procedures on prior art optical catheters interferes with these catheters being used to furnish blood oxygen measure-ments during the course of resuscitation to guide the physician in the resuscitation procedure.
A second deficiency associated with calibrating the optical catheters of the prior art relates to the uncertainties 1~8g25Z ~ ' ' associated with the resultant calibration. Changes in blood oxygen level occur continuously and often very rapidly, making it difficult to be certain that the blood sample and the oximeter readings are truly correlated. Further, during the process of blood sampling through the catheter tip, sign:ificant variations in flow profile of the red blood cells in the region where the -.
optical measurements are being made may introduce errors into the optical measurements. In addition, the manipulations of the blood sample required to perform oxygen saturation measure-ment with an independent instrument can introduce errors in the calibration procedure.
It is therefore highly desirable to provide catheters which do not require individual calibration, 50 that each catheter of a whole population of catheters can be used to obtain blood oxygen measurement immediately upon introduction of the catheter into a blood vessel of interest.
SUMMARY OF THE INVENTION ' In accordance with one aspect of the present invention, improved catheters which do not require individual calibration are made by using one or more transmitting optical fibers and one or more receiving optical fibers, having apertures at -the distal ends thereoE which are disposed to be immersed .
in blood under test, the apertures having centroids of cross-sectional area which are equidistantly spaced between each and every transmitting fiber and each and every receiving :.
fiber of each individual catheter and for all catheters within a population of catheters, and by making the size and shape of all -the outlet apertures of all transmitting fibers generally uniform, and the size and shape ~39~5Z
of the inlet apertures of all receiving fibers generally uniform in each catheter and from catheter to catheter in a population of catheters, and that the orientation of all transmitting fibers relative to all receiving fibers be S similar.
In accordance with another aspect of this invention there is provided a catheter for photometric analysis of a fluid, said catheter comprising a population of optical fibers; said population being selected from fiber popula-10 tions comprising tl) at least one transmitting and aplurality of receiving optical fibers, ~2) a plurality of transmitting and at least one receiving optical fibers, and ~3) a plurality of transmitting and receiving optical ~ibers;
each said optical fiber for conducting.radiant energy there-15 through from an aperture at one end thereof to an apertureat the other end thereof; each of the apertures of the transmitting and receiving optical fibers at the distal ends thereof having a centroid of area, the centroid of the aperture of the distal end of each and every transmitting 20 optical fiber being equidistant from the centroid of the aperture of the distal end of each and every receiving optical fiber.
In accordance with another aspect of this invention there is provided a population of a plural number of optical 25 catheters for photometricanalysis of a fluid wherein the catheters within the population do not require individual calibration; each catheter of said population comprising at least one trans~itting and at least one receiving optical fiber; each said fiber for conducting radiant energy there-30 through from an aperture at one end thereof to an aperture ,.~.;!~ .
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at the other end thereof; each of the apertures of thetransmitting and receiving optical fibers at the distal ends thereof having a centroid of area; the spacing of the centroid of the aperture of each and every transmitting optical fiber from the centroid of the aperture of each and every receiving optical fiber at the distal end of each catheter of said catheter population being the same.
In accordance with another aspect of.this invention there is provided a method for producing a population of a 10 plural number of optical catheters for photometric analysis .
of a fluid wherein the catheters within the population do not require individual calibration comprising the step of selecting, from a group of optical catheters, each compri-sing at least one transmitting and at least one receiving 15 optical fiber capable of conducting radiant energy there- :
through from an aperture at one end thereof to an aperture . :
at the other end thereof, each said aperture having a centroid of area, onl~ those catheters wherein the spacing of the centroid of the aperture of each and every transmit-ting fiber from the centroid of each and every receiving fiber at the distal end of said catheter is the same.
In accordance with another aspect of.this invention there is provided a method for producing a population of a plural number of optical catheters for photometric analysis of a fluid wherein the catheters within the population do not require individual calibration, comprising the steps of:
(a) selecting a plurality of transmitting and receiving optical fibers each capable of conducting radiant energy therethrough from an aperture at one end thereof to an aperture at the other end thereof, each said aperturle having a centroid of area; (b) fabricating, from the transmitting and receiving fibers selected in step ta), a plurality of . -Sa-..~,,~
- `
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- catheters comprising at least one transmitting and at least one receiving fiber wherein within any one of said fabricated catheters the spacing of the centroid of each and every transmitting fiber from each and every 5 receiving fiber at the distal end thereof is the same; and (c) selecting from the catheters fabricated in step (b) only those catheters wherein said spacing is equal to the spacing in each and every other catheter selected.
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~U8~Z52 DESCRIPTION OF THE DRAWIN _ :
Figures 1 and 2 are sectional views of the distal ends of catheters according to the present invention in which a plurality of receiving optical fibers (R) are disposed con-tiguous to the transmitting optical fiber (T) and in which thecentroid of area of each receiving optical fiber (R) is equi-distantly spaced from the centroid of area of the single trans- ~
mitting optical fiber; and Figure 3 is a sectional view of the distal end of another embodiment of a catheter according to the present invention in which each of the transmitting or receiving optical fibers is positioned remotely from a single receiving (or transmitting, respectively) optical fiber, with the centroid of area of each o;E the remotely-positioned optieal fibers disposed equidistantly from the eentroid of area of the single, centrally-located optical fiber; and .
Figures 4 and 5 are sectional views of the distal ends of still other embodiments of catheters according to the present invention in each of which the centroid of area of each of a .
pair of receiving optical fibers (R) is equidistantly disposed from the eentroid of area oE each of a pair of transmitting optical ~ibers (T); and Figure 6 is a sectional view of the distal end of another embodiment of a catheter according to the present invention in which the centroid of area of each of a plurality of rectangular receiving optical fibers (R) is equidistantly disposed from the centroid of area of a single, square trans-mitting optical fiber (T); and Figure 7 is a graph showing the distribution of light flux at different wavelengths and blood conditions as a function .. . : :
, ~89;~5Z
of distance from the centroid of area of a round transmitting optical fiber at the distal end of the catheter; and Figure 8 is a sectional view of a single embodiment of a catheter according to the present invention in which a pair of substantially cylindrical optical fibers are contiguously disposed at the distal end of the catheter; and Figure 9 is a plan view of the optica:L fibers of a catheter according to the present invention engaged with a photometric measuring device at an optically-coupled interface.
DESCRIPTION OF THE PREFERRED EMBODIMENT
Referring now to Figures 1 through 6, there is shown in each figure the end sectional view of the optical fiber position at the distal ends of optical catheters accordiny ko the present invention. In thèse Eigures, there is at least one optical fiber designated with a "T" to indicate a fiber which transmits radiation to blood under test and the end sectional view of at least one optical fiber designated with the letter "R"
to indicate a fiber which receives radiation from the blood under test. It should be understood that, with respect to Figures 1 through 6, the transmitting fibers and receiving fibers may be transposed in which case each "R" would represent an optical Eiber which transmits radiation to blood under test and each letter "T" would indicate an optical fiber which receives radiation from the blood under test. Where more than one wave-band of radiation is transmitted to the blood under test, theremay be a number of transmitting fibers at least equal to the number of wavebands of radiation being transmitted to the blood under test; or alternately, and preferably, all wavebands of radiation used may be transmitted sequentially down each transmitting fiber.
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leJsszsz Radiation that is transmitted down the transmitting fiber illuminates the blood, and the intensity of this radiation falls off with distance because of scattering and absorption.
Some portion of that light which illuminates the blood is back-scattered by the red blood cells and is collected by receivingfibers which guide this collected light back to a measuring instrument (not shown) where the light intensity is measured by a photodetector element. It is the total light collected by the entire portion of each and every receiving fiber that is measured by the photodetector. To a usable approximation, for radiation of wavelengths in the optical portion of the electro-magnekic spectrum used, and for optical fibers having dimensions o~ the order oE ten thousandths of an inch, the centroids o the areas o~ the apertures o~ the transmitting and receivin~ fibers substantially correspond with the centroids of the illuminating and the receiving light fluxes merging from and being collected by the apertures of the optical fibers. For circular fibers, as shown in Figures 1 through 4, the centroid of the cross-sectional area of each fiber is the center of the circle. However, fibers having apertures with cross-sectional shapes other than circular also have centroids of cross section and can be used. For example, for fiber apertures having rectangular cross-sectional shape at the distal end, as shown in Figures 5 and 6, the centroid of such cross section is located at the intersection of the diagonals through the corners thereof. Similarly, if the fiber apertures have a triangular cross-sectional shape (not shown), the centroids of such cross sections are located at the inter-section of the bi-sectors of the sides thereof. Of course, the fibers may have other more complex cross-sectional shapes at their apertures, and it should be understood that such apextures also have centroids of cross section.
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Referring now to Figure 7, the graph portion illustrates the intensity of received light as a function of distance from the centroid of a transmitting fiber for two different wave-lengths and two different conditions of oxygenation of blood under test.
Specifically, in Curve 17 the intensity (or light flux) measured at the 800 nanometer waveband is substantially the same for hemoglobin and oxyhemoglobin and decays with distance away from the centroid 10 of the transmitting optical fiber 11.
Curves 21 and 19 illustrate that the radiation intensity (or light flux) measured at the 670 nanometer waveband falls off with distance measured from the centroid 10 of the transmitting op-tical Eiber 11 at a more rapid rate :Eor reduced hemoglobin (Curve 21) than for oxyhemoglobin (Curve 19). From these curves it can be shown that the integral of light flux received by a receiving optical fiber 13 over the total cross section area at a given wavelength will be the same for all equidistantly-spaced locations from the transmitting optical fiber 11. These curves also illustrate that for a receiving optical fiber 13' which is placed a greater distance from transmitting optical fiber 11 than receiving optical fiber 13, the integral of light flux received at a given wavelength will be less for optical fiber 13' than for optical fiber 13. Further, the light flux received by fiber 13' compared with the optical flux received by fiber 13 will be relatively different for different wavelengths, thereby intro- :
ducing a wavelength-dependent aspect to the change in the optical properties of the catheter.
Returning now to Figure 1, it can be seen that if light at all the optical wavebands used for the measurement is trans-mitted down the single optical fiber 12, the received light 1t~8~ZSZ
intensities of each waveband relative to each other waveband will be unchanged whether one receiving fiber 14 is used or the entire array of receiving fibers 14 through 24 is used, or if some number of receivers between these two cases is selected, as long as the center-to-center spacing from the transmitting fiber to each of the receiving fibers 14 through 24 remains identical.
As a practical matter, individual fibers in a group of, say, receiving fibers may break or may have poorer or better optical transmission properties than the average. As long as the center-to-center spacing between the transmitting and re-ceiving fibers remains constant, the loss of one of a group of such receiving fibers (unless it is the only one) and the con-comitant variation in the transmitting properties oE such group of receiving fibers will not inEluence the relative light intensities measured at the various wavelengths.
Figure 4 illustrates an embodiment of the invention involving multiple transmitting and multiple receiving optical fibers. In this embodiment, as long as the center-to-center spacing between all transmitting and all receiving optical fibers remains constant, the relative light intensities measured at the various wavelengths utilized will be unchanged, despite fiber breakage and variations in fiber transmissivity.
Figures 2 and 3 illustrate embodiments of the invention in which the transmitting optical fibers and the receiving optical fibers are not the same size. However, in these embodiments, it is only necessary that all of the transmitting optical fibers be identical in size to each other and all of the receiving optical fibers be identical in size to each other, and that the center-to-center spacing between each of the transmitting optical fibers and each of the associated receiving optical fibers remains constant.
~89Z52 Figures 5 and 6 illustrate other embodiments of the invention in which all of the fibers are not circular in shape.
Rather, it is only necessary that the transmitting fibers be similar in size and shape, and that the receiving fibers be similar in size and shape, and that the orientation of all trans-mitting fibers relative to all receiving fibers be similar to maintain the advantages noted above.
Figure 3 illustrates another embodiment of the invention in which the transmitting and receiving fibers are not con--tiguous to each other. However, all of the operating advantagesnoted above may be retained by making the center-to-center spacing between each transmitting optical ~iber and each re-ceiving optical fiber substantially the same and by making khe sizes and shapes of the transmitting optical fibers substantially the same within the group thereof and by making the sizes and shapes of the receiving optical fibers substantially the same within the group thereof.
Figure 8 illustrates the simplest, most economic, and most readily manufacturable embodiment of an optical catheter according to the present invention. In this embodiment, a single transmitting optical fiber 11 and a single receiving optical fiber 13 of identical size are placed contiguous to each other.
This configuration minimizes the amour.t of fiber material re-quired, reduces the number of processes required to make the fibers, simplifies the sorting required of fibers, and readily assures the relationship between optical fibers discussed above.
Referring now to Figure 9, the improved optical catheter 26 of the present invention typically operates in conjunction with a photometric measuring device 28 which furnishes one or more wavebands of light for transmission down the transmitting ~9zsz optical fiber or fibers 30 and which has a photodetector means for measuring the intensity of light collected by the receiving optical fiber or fibers 32. Thus, at the proximal end 34 of the present optical catheter, the optical fibers must be conveniently coupleable to such a measuring device 28. To produce reliable accurate photometric measurements, a repeatable stable optical relationship between the proximal ends 34 of the transmitting and receiving optical fibers 30~ 32 of the catheter 28 and the corresponding optical channels 36 and 38 of such a measuring device 28 must be attained. While both the optical channels 36, 38 of such a measuring device and the proximal end surfaces or apertures 3~ of the corresponding optical fibers 30, 32 oE the catheter 28 are nominally flat ancl perpendicular to the axis of light transmission, certain variations in geometric normality can occur and these surfaces may be irregular and imperfect. If the coupling between the optical channels 36, 38 of such a measuring device and the proximal end surfaces of the optical fibers 30, 32 is less than intimate, specular reflections will occur wherever an air/surface interface occurs, and this introduces undesirable extraneous light-intensity variations in the signals being measured by such measuring device. In addition, less than intimate optical coupling between the optical channels of such a measuring device and the proximal end surfaces of the corre- -sponding optical fibers may produce optical interference patterns which are wavelength-dependent and which therefore can produce spurious changes in the relative light intensities measured at the various wavebands being used.
To avoid the error introduced by specular reflections and by interference patterns at the optical coupling interface 34 between a measuring device and the optical flbers 30, 32, it is 1~)8~3Z~Z
important that intimate surface contact be attained and maintained, even during use where patient motion and other extraneous factors may introduce undesirable forces which tend to misalign and disengage the optical coupling at this interface 34. In accordance with one embodiment of the present invention, intimate contact between optical channels 36, 38 and optical fibers 30, 32 at interface 34 is attained and maintained by using a material in the optical fibers 30, 32 which is softer and more compliant than the material in the optical channe:Ls 36, 38 of the measuring device 28 wi-th which they engage. In addition, the housing 40 for the optical fibers 30, 32 is made of a material that is softer and more compliant than the material of the housing 42 which surrounds the optical channels 36, 38.
Further, to atta.in and maintain this intimate optical contact between the proximal ends 34 of the optical fibers 30, 32 and the optical channels 36, 38 of the measuring device 28, it is desirable to employ means to apply an axially-aligned force 44 to the optical catheter housing 40 which will establish an axial force at the mating surfaces between the proximal ends 34 of the optical fibers 30, 32 and the optical channels 36, 38. One suitable material to use in the optical fibers 30, 32 for inter-facing with optical channels 36, 38 made of glass having the properties referred to above is styrene.
BACKG~OUND OF THE INVENTION
Optical catheters for performing in-vivo spectro-photometric measurements in the blood stream or elsewhere within living organisms are well known in the art. (See U. S. Patents Nos. 3,847,483 and 3,068,742.) These have most commonly been used for the performance of oximetry, i.e., measuring the relative amount of the total hemoglobin within the blood stream that is in the oxygenated form. While prior art optical catheters can be used successfully for performing oximetry, they have a shortcoming which is of major importance to the medical prac-titioner in the care of critically-ill patients. The catheters of the prior art require that an individual calibration be per-Eormed for each and every individual catheter that is to be used, in order to obtain accurate oxygen saturation measurements.
To perform this calibration, commonly a sterile optical catheter is inserted through the wall of a blood vessel of interest and advanced so that its tip is at a position within the flowing blood stream where it is desired that oxygen saturation measurements be made. The patient is frecluently given a par-ticular gas mixture to breathe; commonly a mixture enrichecl in oxygen or depleted of oxygen, or two such mixtures sequentially, which causes the patient's blood to attain an oxygen saturation level in the regions of interest. Then, as blood samples are withdrawn (most commonly through an open lumen of the optical catheter) measurements are made of the relative light reflectances or transmissions at the catheter tip for the various optical wave- -lengths used by the catheter oximeter system.
The blood samples must then be taken to a separate instrument (for example, a transmission spectrophotometer located in a central laboratory) where an independent measurement " ~.
~9ZSZ ~: -.:
of the oxygen saturation of the one or more blood samples is -~
made. The results of this independent measurement are then :
returned to the catheter oximeter at the patient's bedside, so that appropriate changes may be introduced into the catheter oximeter. These changes may include changes in bias levels and/or gains of various amplifiers in order to correct for the deviation between the initial oxygen saturation measurement made at the time of blood sampling and the oxygen saturation measure-ment independently determined by the separate instrument.
This requirement for individual calibration of catheters has obvious and important deficiencies. One such deficiency is the delay between the time of catheter placement and the time at wh.ich accurate measurements of oxygen saturation utilizing the optical catheter can be obtained. This delay deprives the physician of important information at a time when such infor-mation is often of the utmost importance in caring for the .
patient~ For example, at the time of delivery of a newborn infant with severe respiratory distress because of prematurity, or severe Rh Hemolytic Disease or with other disorders, the resuscitation of these sick infants (who may weigh only two tothree pounds) is frequently a precarious and difficult problem.
This resuscitation must be instituted immediately upon birth and the various therapeutic manipulations completed within a very short time period. Unfortunately, the time required to perform calibration procedures on prior art optical catheters interferes with these catheters being used to furnish blood oxygen measure-ments during the course of resuscitation to guide the physician in the resuscitation procedure.
A second deficiency associated with calibrating the optical catheters of the prior art relates to the uncertainties 1~8g25Z ~ ' ' associated with the resultant calibration. Changes in blood oxygen level occur continuously and often very rapidly, making it difficult to be certain that the blood sample and the oximeter readings are truly correlated. Further, during the process of blood sampling through the catheter tip, sign:ificant variations in flow profile of the red blood cells in the region where the -.
optical measurements are being made may introduce errors into the optical measurements. In addition, the manipulations of the blood sample required to perform oxygen saturation measure-ment with an independent instrument can introduce errors in the calibration procedure.
It is therefore highly desirable to provide catheters which do not require individual calibration, 50 that each catheter of a whole population of catheters can be used to obtain blood oxygen measurement immediately upon introduction of the catheter into a blood vessel of interest.
SUMMARY OF THE INVENTION ' In accordance with one aspect of the present invention, improved catheters which do not require individual calibration are made by using one or more transmitting optical fibers and one or more receiving optical fibers, having apertures at -the distal ends thereoE which are disposed to be immersed .
in blood under test, the apertures having centroids of cross-sectional area which are equidistantly spaced between each and every transmitting fiber and each and every receiving :.
fiber of each individual catheter and for all catheters within a population of catheters, and by making the size and shape of all -the outlet apertures of all transmitting fibers generally uniform, and the size and shape ~39~5Z
of the inlet apertures of all receiving fibers generally uniform in each catheter and from catheter to catheter in a population of catheters, and that the orientation of all transmitting fibers relative to all receiving fibers be S similar.
In accordance with another aspect of this invention there is provided a catheter for photometric analysis of a fluid, said catheter comprising a population of optical fibers; said population being selected from fiber popula-10 tions comprising tl) at least one transmitting and aplurality of receiving optical fibers, ~2) a plurality of transmitting and at least one receiving optical fibers, and ~3) a plurality of transmitting and receiving optical ~ibers;
each said optical fiber for conducting.radiant energy there-15 through from an aperture at one end thereof to an apertureat the other end thereof; each of the apertures of the transmitting and receiving optical fibers at the distal ends thereof having a centroid of area, the centroid of the aperture of the distal end of each and every transmitting 20 optical fiber being equidistant from the centroid of the aperture of the distal end of each and every receiving optical fiber.
In accordance with another aspect of this invention there is provided a population of a plural number of optical 25 catheters for photometricanalysis of a fluid wherein the catheters within the population do not require individual calibration; each catheter of said population comprising at least one trans~itting and at least one receiving optical fiber; each said fiber for conducting radiant energy there-30 through from an aperture at one end thereof to an aperture ,.~.;!~ .
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at the other end thereof; each of the apertures of thetransmitting and receiving optical fibers at the distal ends thereof having a centroid of area; the spacing of the centroid of the aperture of each and every transmitting optical fiber from the centroid of the aperture of each and every receiving optical fiber at the distal end of each catheter of said catheter population being the same.
In accordance with another aspect of.this invention there is provided a method for producing a population of a 10 plural number of optical catheters for photometric analysis .
of a fluid wherein the catheters within the population do not require individual calibration comprising the step of selecting, from a group of optical catheters, each compri-sing at least one transmitting and at least one receiving 15 optical fiber capable of conducting radiant energy there- :
through from an aperture at one end thereof to an aperture . :
at the other end thereof, each said aperture having a centroid of area, onl~ those catheters wherein the spacing of the centroid of the aperture of each and every transmit-ting fiber from the centroid of each and every receiving fiber at the distal end of said catheter is the same.
In accordance with another aspect of.this invention there is provided a method for producing a population of a plural number of optical catheters for photometric analysis of a fluid wherein the catheters within the population do not require individual calibration, comprising the steps of:
(a) selecting a plurality of transmitting and receiving optical fibers each capable of conducting radiant energy therethrough from an aperture at one end thereof to an aperture at the other end thereof, each said aperturle having a centroid of area; (b) fabricating, from the transmitting and receiving fibers selected in step ta), a plurality of . -Sa-..~,,~
- `
~39Z5Z
- catheters comprising at least one transmitting and at least one receiving fiber wherein within any one of said fabricated catheters the spacing of the centroid of each and every transmitting fiber from each and every 5 receiving fiber at the distal end thereof is the same; and (c) selecting from the catheters fabricated in step (b) only those catheters wherein said spacing is equal to the spacing in each and every other catheter selected.
-5b- :
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. .
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: .
~U8~Z52 DESCRIPTION OF THE DRAWIN _ :
Figures 1 and 2 are sectional views of the distal ends of catheters according to the present invention in which a plurality of receiving optical fibers (R) are disposed con-tiguous to the transmitting optical fiber (T) and in which thecentroid of area of each receiving optical fiber (R) is equi-distantly spaced from the centroid of area of the single trans- ~
mitting optical fiber; and Figure 3 is a sectional view of the distal end of another embodiment of a catheter according to the present invention in which each of the transmitting or receiving optical fibers is positioned remotely from a single receiving (or transmitting, respectively) optical fiber, with the centroid of area of each o;E the remotely-positioned optieal fibers disposed equidistantly from the eentroid of area of the single, centrally-located optical fiber; and .
Figures 4 and 5 are sectional views of the distal ends of still other embodiments of catheters according to the present invention in each of which the centroid of area of each of a .
pair of receiving optical fibers (R) is equidistantly disposed from the eentroid of area oE each of a pair of transmitting optical ~ibers (T); and Figure 6 is a sectional view of the distal end of another embodiment of a catheter according to the present invention in which the centroid of area of each of a plurality of rectangular receiving optical fibers (R) is equidistantly disposed from the centroid of area of a single, square trans-mitting optical fiber (T); and Figure 7 is a graph showing the distribution of light flux at different wavelengths and blood conditions as a function .. . : :
, ~89;~5Z
of distance from the centroid of area of a round transmitting optical fiber at the distal end of the catheter; and Figure 8 is a sectional view of a single embodiment of a catheter according to the present invention in which a pair of substantially cylindrical optical fibers are contiguously disposed at the distal end of the catheter; and Figure 9 is a plan view of the optica:L fibers of a catheter according to the present invention engaged with a photometric measuring device at an optically-coupled interface.
DESCRIPTION OF THE PREFERRED EMBODIMENT
Referring now to Figures 1 through 6, there is shown in each figure the end sectional view of the optical fiber position at the distal ends of optical catheters accordiny ko the present invention. In thèse Eigures, there is at least one optical fiber designated with a "T" to indicate a fiber which transmits radiation to blood under test and the end sectional view of at least one optical fiber designated with the letter "R"
to indicate a fiber which receives radiation from the blood under test. It should be understood that, with respect to Figures 1 through 6, the transmitting fibers and receiving fibers may be transposed in which case each "R" would represent an optical Eiber which transmits radiation to blood under test and each letter "T" would indicate an optical fiber which receives radiation from the blood under test. Where more than one wave-band of radiation is transmitted to the blood under test, theremay be a number of transmitting fibers at least equal to the number of wavebands of radiation being transmitted to the blood under test; or alternately, and preferably, all wavebands of radiation used may be transmitted sequentially down each transmitting fiber.
' ' ~ . ', , ~ . .
leJsszsz Radiation that is transmitted down the transmitting fiber illuminates the blood, and the intensity of this radiation falls off with distance because of scattering and absorption.
Some portion of that light which illuminates the blood is back-scattered by the red blood cells and is collected by receivingfibers which guide this collected light back to a measuring instrument (not shown) where the light intensity is measured by a photodetector element. It is the total light collected by the entire portion of each and every receiving fiber that is measured by the photodetector. To a usable approximation, for radiation of wavelengths in the optical portion of the electro-magnekic spectrum used, and for optical fibers having dimensions o~ the order oE ten thousandths of an inch, the centroids o the areas o~ the apertures o~ the transmitting and receivin~ fibers substantially correspond with the centroids of the illuminating and the receiving light fluxes merging from and being collected by the apertures of the optical fibers. For circular fibers, as shown in Figures 1 through 4, the centroid of the cross-sectional area of each fiber is the center of the circle. However, fibers having apertures with cross-sectional shapes other than circular also have centroids of cross section and can be used. For example, for fiber apertures having rectangular cross-sectional shape at the distal end, as shown in Figures 5 and 6, the centroid of such cross section is located at the intersection of the diagonals through the corners thereof. Similarly, if the fiber apertures have a triangular cross-sectional shape (not shown), the centroids of such cross sections are located at the inter-section of the bi-sectors of the sides thereof. Of course, the fibers may have other more complex cross-sectional shapes at their apertures, and it should be understood that such apextures also have centroids of cross section.
_~_ . :
~1!99~SZ
Referring now to Figure 7, the graph portion illustrates the intensity of received light as a function of distance from the centroid of a transmitting fiber for two different wave-lengths and two different conditions of oxygenation of blood under test.
Specifically, in Curve 17 the intensity (or light flux) measured at the 800 nanometer waveband is substantially the same for hemoglobin and oxyhemoglobin and decays with distance away from the centroid 10 of the transmitting optical fiber 11.
Curves 21 and 19 illustrate that the radiation intensity (or light flux) measured at the 670 nanometer waveband falls off with distance measured from the centroid 10 of the transmitting op-tical Eiber 11 at a more rapid rate :Eor reduced hemoglobin (Curve 21) than for oxyhemoglobin (Curve 19). From these curves it can be shown that the integral of light flux received by a receiving optical fiber 13 over the total cross section area at a given wavelength will be the same for all equidistantly-spaced locations from the transmitting optical fiber 11. These curves also illustrate that for a receiving optical fiber 13' which is placed a greater distance from transmitting optical fiber 11 than receiving optical fiber 13, the integral of light flux received at a given wavelength will be less for optical fiber 13' than for optical fiber 13. Further, the light flux received by fiber 13' compared with the optical flux received by fiber 13 will be relatively different for different wavelengths, thereby intro- :
ducing a wavelength-dependent aspect to the change in the optical properties of the catheter.
Returning now to Figure 1, it can be seen that if light at all the optical wavebands used for the measurement is trans-mitted down the single optical fiber 12, the received light 1t~8~ZSZ
intensities of each waveband relative to each other waveband will be unchanged whether one receiving fiber 14 is used or the entire array of receiving fibers 14 through 24 is used, or if some number of receivers between these two cases is selected, as long as the center-to-center spacing from the transmitting fiber to each of the receiving fibers 14 through 24 remains identical.
As a practical matter, individual fibers in a group of, say, receiving fibers may break or may have poorer or better optical transmission properties than the average. As long as the center-to-center spacing between the transmitting and re-ceiving fibers remains constant, the loss of one of a group of such receiving fibers (unless it is the only one) and the con-comitant variation in the transmitting properties oE such group of receiving fibers will not inEluence the relative light intensities measured at the various wavelengths.
Figure 4 illustrates an embodiment of the invention involving multiple transmitting and multiple receiving optical fibers. In this embodiment, as long as the center-to-center spacing between all transmitting and all receiving optical fibers remains constant, the relative light intensities measured at the various wavelengths utilized will be unchanged, despite fiber breakage and variations in fiber transmissivity.
Figures 2 and 3 illustrate embodiments of the invention in which the transmitting optical fibers and the receiving optical fibers are not the same size. However, in these embodiments, it is only necessary that all of the transmitting optical fibers be identical in size to each other and all of the receiving optical fibers be identical in size to each other, and that the center-to-center spacing between each of the transmitting optical fibers and each of the associated receiving optical fibers remains constant.
~89Z52 Figures 5 and 6 illustrate other embodiments of the invention in which all of the fibers are not circular in shape.
Rather, it is only necessary that the transmitting fibers be similar in size and shape, and that the receiving fibers be similar in size and shape, and that the orientation of all trans-mitting fibers relative to all receiving fibers be similar to maintain the advantages noted above.
Figure 3 illustrates another embodiment of the invention in which the transmitting and receiving fibers are not con--tiguous to each other. However, all of the operating advantagesnoted above may be retained by making the center-to-center spacing between each transmitting optical ~iber and each re-ceiving optical fiber substantially the same and by making khe sizes and shapes of the transmitting optical fibers substantially the same within the group thereof and by making the sizes and shapes of the receiving optical fibers substantially the same within the group thereof.
Figure 8 illustrates the simplest, most economic, and most readily manufacturable embodiment of an optical catheter according to the present invention. In this embodiment, a single transmitting optical fiber 11 and a single receiving optical fiber 13 of identical size are placed contiguous to each other.
This configuration minimizes the amour.t of fiber material re-quired, reduces the number of processes required to make the fibers, simplifies the sorting required of fibers, and readily assures the relationship between optical fibers discussed above.
Referring now to Figure 9, the improved optical catheter 26 of the present invention typically operates in conjunction with a photometric measuring device 28 which furnishes one or more wavebands of light for transmission down the transmitting ~9zsz optical fiber or fibers 30 and which has a photodetector means for measuring the intensity of light collected by the receiving optical fiber or fibers 32. Thus, at the proximal end 34 of the present optical catheter, the optical fibers must be conveniently coupleable to such a measuring device 28. To produce reliable accurate photometric measurements, a repeatable stable optical relationship between the proximal ends 34 of the transmitting and receiving optical fibers 30~ 32 of the catheter 28 and the corresponding optical channels 36 and 38 of such a measuring device 28 must be attained. While both the optical channels 36, 38 of such a measuring device and the proximal end surfaces or apertures 3~ of the corresponding optical fibers 30, 32 oE the catheter 28 are nominally flat ancl perpendicular to the axis of light transmission, certain variations in geometric normality can occur and these surfaces may be irregular and imperfect. If the coupling between the optical channels 36, 38 of such a measuring device and the proximal end surfaces of the optical fibers 30, 32 is less than intimate, specular reflections will occur wherever an air/surface interface occurs, and this introduces undesirable extraneous light-intensity variations in the signals being measured by such measuring device. In addition, less than intimate optical coupling between the optical channels of such a measuring device and the proximal end surfaces of the corre- -sponding optical fibers may produce optical interference patterns which are wavelength-dependent and which therefore can produce spurious changes in the relative light intensities measured at the various wavebands being used.
To avoid the error introduced by specular reflections and by interference patterns at the optical coupling interface 34 between a measuring device and the optical flbers 30, 32, it is 1~)8~3Z~Z
important that intimate surface contact be attained and maintained, even during use where patient motion and other extraneous factors may introduce undesirable forces which tend to misalign and disengage the optical coupling at this interface 34. In accordance with one embodiment of the present invention, intimate contact between optical channels 36, 38 and optical fibers 30, 32 at interface 34 is attained and maintained by using a material in the optical fibers 30, 32 which is softer and more compliant than the material in the optical channe:Ls 36, 38 of the measuring device 28 wi-th which they engage. In addition, the housing 40 for the optical fibers 30, 32 is made of a material that is softer and more compliant than the material of the housing 42 which surrounds the optical channels 36, 38.
Further, to atta.in and maintain this intimate optical contact between the proximal ends 34 of the optical fibers 30, 32 and the optical channels 36, 38 of the measuring device 28, it is desirable to employ means to apply an axially-aligned force 44 to the optical catheter housing 40 which will establish an axial force at the mating surfaces between the proximal ends 34 of the optical fibers 30, 32 and the optical channels 36, 38. One suitable material to use in the optical fibers 30, 32 for inter-facing with optical channels 36, 38 made of glass having the properties referred to above is styrene.
Claims (6)
1. A catheter for photometric analysis of a fluid, said catheter comprising a population of optical fibers;
said population being selected from fiber populations comprising (1) at least one transmitting and a plurality of receiving optical fibers, (2) a plurality of trans-mitting and at least one receiving optical fibers, and (3) a plurality of transmitting and receiving optical fibers; each said optical fiber for conducting radiant energy therethrough from an aperture at one end thereof to an aperture at the other end thereof; each of the apertures of the transmitting and receiving optical fibers at the distal ends thereof having a centroid of area, the centroid of the aperture of the distal end of each and every transmitting optical fiber being equidis-tant from the centroid of the aperture of the distal end of each and every receiving optical fiber.
said population being selected from fiber populations comprising (1) at least one transmitting and a plurality of receiving optical fibers, (2) a plurality of trans-mitting and at least one receiving optical fibers, and (3) a plurality of transmitting and receiving optical fibers; each said optical fiber for conducting radiant energy therethrough from an aperture at one end thereof to an aperture at the other end thereof; each of the apertures of the transmitting and receiving optical fibers at the distal ends thereof having a centroid of area, the centroid of the aperture of the distal end of each and every transmitting optical fiber being equidis-tant from the centroid of the aperture of the distal end of each and every receiving optical fiber.
2. A population of a plural number of optical catheters for photometric analysis of a fluid wherein the catheters within the population do not require individual calibration; each catheter of said population comprising at least one transmitting and at least one receiving optical fiber; each said fiber for conducting radiant energy therethrough from an aperture at one end thereof to an aperture at the other end thereof; each of the apertures of the transmitting and receiving optical fibers at the distals end thereof having a centroid of area; the spacing of the centroid of the aperture of each and every transmitting optical fiber from the centroid of the aperture of each and every receiving optical fiber at the distal end of each catheter of said catheter population being the same.
3. The invention according to claim 2 in combina-tion with an associated measuring device for the photo-metric analysis of a fluid wherein the apertures of said transmitting and receiving optical fibers at the proxi-mal end of each are disposed to mate in optical engage-ment with end surfaces, respectively, of transmitting and receiving optical channels of the associated measuring device; said optical fibers being made of substantially different hardness and compliance than the material of the end surfaces of the optical channels of the measuring device to allow deformation of either said optical fibers or said optical channels in response to longitudinally applied force urging said fibers and channels toward each other, whereby intimate optical coupling between said optical fibers and said optical channels results.
4. A method for producing a population of a plural number of optical catheters for photometric analysis of a fluid wherein the catheters within the population do not require individual calibration comprising the step of selecting, from a group of optical catheters, each comprising at least one transmitting and at least one receiving optical fiber capable of conducting radiant energy therethrough from an aperture at one end thereof to an aperture at the other end thereof, each said aperture having a centroid of area, only those catheters wherein the spacing of the centroid of the aperture of each and every transmitting fiber from the centroid of each and every receiving fiber at the distal end of said catheter is the same.
5. A method for producing a population of a plural number of optical catheters for photometric analysis of a fluid wherein the catheters within the population do not require individual calibration, comprising the steps of:
(a) selecting a plurality of transmitting and receiving optical fibers each capable of conducting radiant energy therethrough from an aperture at one end thereof to an aperture at the other end thereof, each said aperture having a centroid of area; (b) fabricating, from the transmitting and receiving fibers selected in step (a), a plurality of catheters comprising at least one trans-mitting and at least one receiving fiber wherein within any one of said fabricated catheters the spacing of the centroid of each and every transmitting fiber from each and every receiving fiber at the distal end thereof is the same; and (c) selecting from the catheters fabricated in step (b) only those catheters wherein said spacing is equal to the spacing in each and every other catheter selected.
(a) selecting a plurality of transmitting and receiving optical fibers each capable of conducting radiant energy therethrough from an aperture at one end thereof to an aperture at the other end thereof, each said aperture having a centroid of area; (b) fabricating, from the transmitting and receiving fibers selected in step (a), a plurality of catheters comprising at least one trans-mitting and at least one receiving fiber wherein within any one of said fabricated catheters the spacing of the centroid of each and every transmitting fiber from each and every receiving fiber at the distal end thereof is the same; and (c) selecting from the catheters fabricated in step (b) only those catheters wherein said spacing is equal to the spacing in each and every other catheter selected.
6. A method for performing photometric analysis of fluids by employing photometric analysis equipment in combination with a catheter comprising at least one trans-mitting optical fiber and at least one receiving optical fiber capable of conducting radiant energy therethrough from an aperture at one end thereof to an aperture at the other end thereof, each said aperture having a centroid of area, the method comprising: producing a population of a plural number of optical catheters according to the method claimed in claim 4; and operating the photometric analysis equipment in combination with all selected catheters in accordance with operating parameters establish-ed for at least one of the selected catheters; whereby photometric analysis of the fluid is accomplished with-out the individual calibration of each catheter of the selected catheters.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73327976A | 1976-10-18 | 1976-10-18 | |
| US733,279 | 1976-10-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1089252A true CA1089252A (en) | 1980-11-11 |
Family
ID=24946948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA284,615A Expired CA1089252A (en) | 1976-10-18 | 1977-08-12 | Optical catheter not requiring individual calibration |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS5353191A (en) |
| CA (1) | CA1089252A (en) |
| CH (1) | CH620108A5 (en) |
| DE (1) | DE2741913C3 (en) |
| FR (1) | FR2371203A1 (en) |
| GB (1) | GB1595206A (en) |
| NL (1) | NL7709209A (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3038786A1 (en) * | 1980-10-14 | 1982-04-29 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 8000 München | METHOD FOR MEASURING THE COLOR OF THE GUM |
| WO1982003460A1 (en) * | 1981-03-31 | 1982-10-14 | Coogan Clive Keith | Application of optical fibre probes |
| FI65143C (en) * | 1981-12-23 | 1984-03-12 | Valtion Teknillinen | MAETHUVUD FOER INFRAROEDHYGROMETER |
| JPS59189828A (en) * | 1983-04-08 | 1984-10-27 | 萩原 文二 | Subcateneous measuring sensor and apparatus of blood coloring matter |
| DE3313047A1 (en) * | 1983-04-12 | 1984-10-18 | Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | ARRANGEMENT FOR MEASURING DIFFUSING PARTICLES |
| US5140989A (en) | 1983-10-14 | 1992-08-25 | Somanetics Corporation | Examination instrument for optical-response diagnostic apparatus |
| US4570638A (en) | 1983-10-14 | 1986-02-18 | Somanetics Corporation | Method and apparatus for spectral transmissibility examination and analysis |
| US5139025A (en) | 1983-10-14 | 1992-08-18 | Somanetics Corporation | Method and apparatus for in vivo optical spectroscopic examination |
| US4817623A (en) | 1983-10-14 | 1989-04-04 | Somanetics Corporation | Method and apparatus for interpreting optical response data |
| DE3708031A1 (en) * | 1986-03-20 | 1987-11-12 | Wolfgang Dr Med Wagner | Measurement device or induction device with measurement device, or device for material recovery for a measurement device for metabolic states in the blood by puncturing under reduced pressure in a suction cup with displacement of the measurement zone outside the tip region of the puncturing device |
| IL107396A (en) * | 1992-11-09 | 1997-02-18 | Boehringer Mannheim Gmbh | Method and apparatus for analytical determination of glucose in a biological matrix |
| DE4314835A1 (en) * | 1993-05-05 | 1994-11-10 | Boehringer Mannheim Gmbh | Method and device for analysing glucose in a biological matrix |
| US6662033B2 (en) | 1994-04-01 | 2003-12-09 | Nellcor Incorporated | Pulse oximeter and sensor optimized for low saturation |
| US5421329A (en) | 1994-04-01 | 1995-06-06 | Nellcor, Inc. | Pulse oximeter sensor optimized for low saturation |
| JP2009507569A (en) * | 2005-09-13 | 2009-02-26 | エドワーズ ライフサイエンシーズ コーポレイション | Continuous spectroscopic measurement of total hemoglobin |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA971768A (en) * | 1972-02-01 | 1975-07-29 | Robert F. Shaw | Oximeter and method |
-
1977
- 1977-08-12 CA CA284,615A patent/CA1089252A/en not_active Expired
- 1977-08-19 NL NL7709209A patent/NL7709209A/en not_active Application Discontinuation
- 1977-09-17 DE DE19772741913 patent/DE2741913C3/en not_active Expired
- 1977-09-30 JP JP11695177A patent/JPS5353191A/en active Pending
- 1977-10-12 CH CH1247177A patent/CH620108A5/en not_active IP Right Cessation
- 1977-10-14 FR FR7730960A patent/FR2371203A1/en active Granted
- 1977-10-18 GB GB3398877A patent/GB1595206A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1595206A (en) | 1981-08-12 |
| DE2741913A1 (en) | 1978-04-20 |
| FR2371203B1 (en) | 1982-09-03 |
| DE2741913C3 (en) | 1979-12-20 |
| FR2371203A1 (en) | 1978-06-16 |
| NL7709209A (en) | 1978-04-20 |
| DE2741913B2 (en) | 1979-05-03 |
| CH620108A5 (en) | 1980-11-14 |
| JPS5353191A (en) | 1978-05-15 |
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