CA1071102A - Tracer for circulation determinations - Google Patents
Tracer for circulation determinationsInfo
- Publication number
- CA1071102A CA1071102A CA281,024A CA281024A CA1071102A CA 1071102 A CA1071102 A CA 1071102A CA 281024 A CA281024 A CA 281024A CA 1071102 A CA1071102 A CA 1071102A
- Authority
- CA
- Canada
- Prior art keywords
- ion exchange
- cores
- exchange resin
- ions
- monomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000700 radioactive tracer Substances 0.000 title claims abstract description 16
- 238000005342 ion exchange Methods 0.000 claims abstract description 27
- 230000002285 radioactive effect Effects 0.000 claims abstract description 26
- 229920000642 polymer Polymers 0.000 claims abstract description 20
- 241001465754 Metazoa Species 0.000 claims abstract description 13
- 239000002245 particle Substances 0.000 claims description 77
- 239000000178 monomer Substances 0.000 claims description 52
- 238000000576 coating method Methods 0.000 claims description 51
- 239000011248 coating agent Substances 0.000 claims description 49
- 150000002500 ions Chemical class 0.000 claims description 42
- XPFVYQJUAUNWIW-UHFFFAOYSA-N furfuryl alcohol Chemical compound OCC1=CC=CO1 XPFVYQJUAUNWIW-UHFFFAOYSA-N 0.000 claims description 41
- 229920005989 resin Polymers 0.000 claims description 36
- 239000011347 resin Substances 0.000 claims description 36
- 239000000047 product Substances 0.000 claims description 32
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 28
- 238000006116 polymerization reaction Methods 0.000 claims description 21
- 238000002360 preparation method Methods 0.000 claims description 20
- 239000003456 ion exchange resin Substances 0.000 claims description 19
- 229920003303 ion-exchange polymer Polymers 0.000 claims description 19
- 239000002253 acid Substances 0.000 claims description 16
- 150000001768 cations Chemical class 0.000 claims description 14
- 230000002378 acidificating effect Effects 0.000 claims description 13
- 230000003197 catalytic effect Effects 0.000 claims description 11
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 10
- 150000001450 anions Chemical class 0.000 claims description 10
- 238000002386 leaching Methods 0.000 claims description 10
- VYZAMTAEIAYCRO-BJUDXGSMSA-N Chromium-51 Chemical compound [51Cr] VYZAMTAEIAYCRO-BJUDXGSMSA-N 0.000 claims description 7
- 239000003729 cation exchange resin Substances 0.000 claims description 7
- -1 Strontium35 Chemical compound 0.000 claims description 6
- 239000003957 anion exchange resin Substances 0.000 claims description 5
- 125000002091 cationic group Chemical group 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000005259 measurement Methods 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- SIXSYDAISGFNSX-OUBTZVSYSA-N scandium-46 Chemical compound [46Sc] SIXSYDAISGFNSX-OUBTZVSYSA-N 0.000 claims description 3
- 239000001667 (E)-4-furan-2-ylbut-3-en-2-one Substances 0.000 claims description 2
- GBKGJMYPQZODMI-SNAWJCMRSA-N (e)-4-(furan-2-yl)but-3-en-2-one Chemical compound CC(=O)\C=C\C1=CC=CO1 GBKGJMYPQZODMI-SNAWJCMRSA-N 0.000 claims description 2
- 229920000877 Melamine resin Polymers 0.000 claims description 2
- 229920001807 Urea-formaldehyde Polymers 0.000 claims description 2
- IVJISJACKSSFGE-UHFFFAOYSA-N formaldehyde;1,3,5-triazine-2,4,6-triamine Chemical compound O=C.NC1=NC(N)=NC(N)=N1 IVJISJACKSSFGE-UHFFFAOYSA-N 0.000 claims description 2
- QFFUJMYTIBZKQL-UHFFFAOYSA-N formaldehyde;furan-2-ylmethanol;urea Chemical compound O=C.NC(N)=O.OCC1=CC=CO1 QFFUJMYTIBZKQL-UHFFFAOYSA-N 0.000 claims description 2
- QFEQDRJNCKDYQG-UHFFFAOYSA-N furan-2-carbaldehyde;1,3,5-triazine-2,4,6-triamine Chemical compound O=CC1=CC=CO1.NC1=NC(N)=NC(N)=N1 QFEQDRJNCKDYQG-UHFFFAOYSA-N 0.000 claims description 2
- ODGAOXROABLFNM-UHFFFAOYSA-N polynoxylin Chemical compound O=C.NC(N)=O ODGAOXROABLFNM-UHFFFAOYSA-N 0.000 claims description 2
- CIOAGBVUUVVLOB-OIOBTWANSA-N strontium-85 Chemical compound [85Sr] CIOAGBVUUVVLOB-OIOBTWANSA-N 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims 4
- GWXLDORMOJMVQZ-OUBTZVSYSA-N cerium-141 Chemical compound [141Ce] GWXLDORMOJMVQZ-OUBTZVSYSA-N 0.000 claims 2
- 239000001089 [(2R)-oxolan-2-yl]methanol Substances 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- QYUIETAOPWRIPZ-UHFFFAOYSA-N formaldehyde;furan-2-carbaldehyde;phenol Chemical compound O=C.OC1=CC=CC=C1.O=CC1=CC=CO1 QYUIETAOPWRIPZ-UHFFFAOYSA-N 0.000 claims 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 claims 1
- 230000000379 polymerizing effect Effects 0.000 claims 1
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 claims 1
- 239000012530 fluid Substances 0.000 abstract description 2
- 238000001311 chemical methods and process Methods 0.000 abstract 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 30
- 238000006243 chemical reaction Methods 0.000 description 21
- 230000000694 effects Effects 0.000 description 19
- 239000000243 solution Substances 0.000 description 18
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- HYBBIBNJHNGZAN-UHFFFAOYSA-N furfural Chemical compound O=CC1=CC=CO1 HYBBIBNJHNGZAN-UHFFFAOYSA-N 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 239000000203 mixture Substances 0.000 description 12
- 239000000725 suspension Substances 0.000 description 12
- 210000000056 organ Anatomy 0.000 description 11
- 239000011324 bead Substances 0.000 description 10
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 9
- 230000017531 blood circulation Effects 0.000 description 8
- 239000012508 resin bead Substances 0.000 description 8
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 7
- 239000011541 reaction mixture Substances 0.000 description 7
- 238000009826 distribution Methods 0.000 description 6
- 239000012798 spherical particle Substances 0.000 description 6
- 230000002269 spontaneous effect Effects 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 210000004204 blood vessel Anatomy 0.000 description 5
- 210000004556 brain Anatomy 0.000 description 5
- 239000003054 catalyst Substances 0.000 description 5
- 230000001143 conditioned effect Effects 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 5
- 229920000053 polysorbate 80 Polymers 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 239000004793 Polystyrene Substances 0.000 description 4
- 241000700159 Rattus Species 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 239000004005 microsphere Substances 0.000 description 4
- 229920002223 polystyrene Polymers 0.000 description 4
- 229920005990 polystyrene resin Polymers 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- PKAUICCNAWQPAU-UHFFFAOYSA-N 2-(4-chloro-2-methylphenoxy)acetic acid;n-methylmethanamine Chemical compound CNC.CC1=CC(Cl)=CC=C1OCC(O)=O PKAUICCNAWQPAU-UHFFFAOYSA-N 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 125000000129 anionic group Chemical group 0.000 description 3
- 230000000747 cardiac effect Effects 0.000 description 3
- 238000006555 catalytic reaction Methods 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 238000011068 loading method Methods 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 125000003277 amino group Chemical group 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000005341 cation exchange Methods 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229920001568 phenolic resin Polymers 0.000 description 2
- 229920000768 polyamine Polymers 0.000 description 2
- 239000004576 sand Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 150000003440 styrenes Chemical class 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 230000004584 weight gain Effects 0.000 description 2
- 235000019786 weight gain Nutrition 0.000 description 2
- POILWHVDKZOXJZ-ARJAWSKDSA-M (z)-4-oxopent-2-en-2-olate Chemical compound C\C([O-])=C\C(C)=O POILWHVDKZOXJZ-ARJAWSKDSA-M 0.000 description 1
- VRUFTFZZSSSPML-UHFFFAOYSA-N 3-hydroxyoxolane-2-carbaldehyde Chemical compound OC1CCOC1C=O VRUFTFZZSSSPML-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 229920003261 Durez Polymers 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical compound [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- SPAGIJMPHSUYSE-UHFFFAOYSA-N Magnesium peroxide Chemical compound [Mg+2].[O-][O-] SPAGIJMPHSUYSE-UHFFFAOYSA-N 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 229910017974 NH40H Inorganic materials 0.000 description 1
- 241000047703 Nonion Species 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000012662 bulk polymerization Methods 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 238000003763 carbonization Methods 0.000 description 1
- 238000010000 carbonizing Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 150000003841 chloride salts Chemical class 0.000 description 1
- ZCDOYSPFYFSLEW-UHFFFAOYSA-N chromate(2-) Chemical compound [O-][Cr]([O-])(=O)=O ZCDOYSPFYFSLEW-UHFFFAOYSA-N 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- OJLGWNFZMTVNCX-UHFFFAOYSA-N dioxido(dioxo)tungsten;zirconium(4+) Chemical compound [Zr+4].[O-][W]([O-])(=O)=O.[O-][W]([O-])(=O)=O OJLGWNFZMTVNCX-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000007720 emulsion polymerization reaction Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- SLGWESQGEUXWJQ-UHFFFAOYSA-N formaldehyde;phenol Chemical compound O=C.OC1=CC=CC=C1 SLGWESQGEUXWJQ-UHFFFAOYSA-N 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 229940102213 injectable suspension Drugs 0.000 description 1
- 229910001410 inorganic ion Inorganic materials 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 239000012633 leachable Substances 0.000 description 1
- 210000005240 left ventricle Anatomy 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
- MEFBJEMVZONFCJ-UHFFFAOYSA-N molybdate Chemical compound [O-][Mo]([O-])(=O)=O MEFBJEMVZONFCJ-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 238000000643 oven drying Methods 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 1
- 239000005011 phenolic resin Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000004886 process control Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 238000004876 x-ray fluorescence Methods 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
- 229910000166 zirconium phosphate Inorganic materials 0.000 description 1
- LEHFSLREWWMLPU-UHFFFAOYSA-B zirconium(4+);tetraphosphate Chemical compound [Zr+4].[Zr+4].[Zr+4].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LEHFSLREWWMLPU-UHFFFAOYSA-B 0.000 description 1
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21H—OBTAINING ENERGY FROM RADIOACTIVE SOURCES; APPLICATIONS OF RADIATION FROM RADIOACTIVE SOURCES, NOT OTHERWISE PROVIDED FOR; UTILISING COSMIC RADIATION
- G21H5/00—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for
- G21H5/02—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for as tracers
Landscapes
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/706,434 US4107283A (en) | 1976-07-19 | 1976-07-19 | Tracer for circulation determinations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1071102A true CA1071102A (en) | 1980-02-05 |
Family
ID=24837548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA281,024A Expired CA1071102A (en) | 1976-07-19 | 1977-01-26 | Tracer for circulation determinations |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4107283A (ref) |
| CA (1) | CA1071102A (ref) |
| DE (1) | DE2732076C3 (ref) |
| FR (1) | FR2358880A1 (ref) |
| GB (1) | GB1586601A (ref) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4303636A (en) * | 1974-08-20 | 1981-12-01 | Gordon Robert T | Cancer treatment |
| US4390517A (en) * | 1979-12-19 | 1983-06-28 | New England Nuclear Corporation | Method, composition and kit for stabilizing radiolabeled compounds |
| US4358434A (en) * | 1979-12-19 | 1982-11-09 | New England Nuclear Corporation | Method, composition and kit for stabilizing radiolabeled compounds |
| DE3379256D1 (en) * | 1982-04-23 | 1989-04-06 | Benzon As Alfred | Composition for investigating alimentary functions |
| US4448764A (en) * | 1982-07-06 | 1984-05-15 | Pierce Chemical Company | Direct-acting iodinating reagent |
| US4446123A (en) * | 1982-10-13 | 1984-05-01 | Hahnemann University | Process of radioimaging the myocardium of mammals utilizing radiolabeled lipophilic cations |
| GB8310038D0 (en) * | 1983-04-13 | 1983-05-18 | Amersham Int Plc | Technetium-99 labelled tin colloid |
| US4505888A (en) * | 1983-05-27 | 1985-03-19 | E. I. Du Pont De Nemours & Company | Tracer for circulation determinations |
| ATE374045T1 (de) | 2003-04-30 | 2007-10-15 | Univ Ramot | Verfahren und vorrichtung für die strahlentherapie |
| NO321768B1 (no) * | 2004-06-30 | 2006-07-03 | Inst Energiteknik | System for tracerfrigjoring i en fluidstrom |
| PL2510952T3 (pl) * | 2005-07-26 | 2019-05-31 | Aplha Tau Medical Ltd | Promieniotwórcze źródło powierzchniowe i sposób jego wytwarzania |
| CA3059534A1 (en) | 2017-05-11 | 2018-11-15 | Alpha Tau Medical Ltd. | Polymer coatings for brachytherapy devices |
| JP7675422B2 (ja) | 2018-04-02 | 2025-05-13 | アルファ タウ メディカル リミテッド | 放射性核種の管理された放出 |
| IL303002A (en) | 2020-12-16 | 2023-07-01 | Alpha Tau Medical Ltd | Radiotherapy by diffuse alpha emitters with increased beta therapy |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3334050A (en) * | 1964-08-24 | 1967-08-01 | Minnesota Mining & Mfg | Organic carbonaceous matrix with radioisotope dispersed therein |
| US3492147A (en) * | 1964-10-22 | 1970-01-27 | Halliburton Co | Method of coating particulate solids with an infusible resin |
| US3663685A (en) | 1968-04-01 | 1972-05-16 | Minnesota Mining & Mfg | Biodegradable radioactive particles |
| CH594444A5 (ref) * | 1972-12-04 | 1978-01-13 | Gerd Birrenbach | |
| US4010250A (en) * | 1975-03-06 | 1977-03-01 | The United States Of America As Represented By The Secretary Of The Navy | Radioactive iodine (125I) labeling of latex particles |
-
1976
- 1976-07-19 US US05/706,434 patent/US4107283A/en not_active Expired - Lifetime
-
1977
- 1977-01-26 CA CA281,024A patent/CA1071102A/en not_active Expired
- 1977-06-28 GB GB26990/77A patent/GB1586601A/en not_active Expired
- 1977-07-15 DE DE2732076A patent/DE2732076C3/de not_active Expired
- 1977-07-18 FR FR7721913A patent/FR2358880A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FR2358880A1 (fr) | 1978-02-17 |
| DE2732076A1 (de) | 1978-01-26 |
| DE2732076B2 (de) | 1981-02-12 |
| DE2732076C3 (de) | 1981-11-12 |
| GB1586601A (en) | 1981-03-25 |
| US4107283A (en) | 1978-08-15 |
| FR2358880B1 (ref) | 1981-08-07 |
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