CA1060804A - Dialyser cartridge with double helix tubular membrane wound on core - Google Patents

Dialyser cartridge with double helix tubular membrane wound on core

Info

Publication number
CA1060804A
CA1060804A CA186,216A CA186216A CA1060804A CA 1060804 A CA1060804 A CA 1060804A CA 186216 A CA186216 A CA 186216A CA 1060804 A CA1060804 A CA 1060804A
Authority
CA
Canada
Prior art keywords
membrane
membrane tube
support material
blood
tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA186,216A
Other languages
French (fr)
Other versions
CA186216S (en
Inventor
Libero Luppi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Application granted granted Critical
Publication of CA1060804A publication Critical patent/CA1060804A/en
Expired legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/24Dialysis ; Membrane extraction
    • B01D61/28Apparatus therefor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D63/00Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/10Spiral-wound membrane modules

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • External Artificial Organs (AREA)

Abstract

ABSTRACT

The invention concerns a novel dialyser cartridge comprising a flat membrane tube through which blood to be dialysed may be passed, membrane support material over the outer surfaces of the membrane tube, a split core between which a central portion of the membrane tube and membrane support material is located and about which core said membrane tube and membrane support material are outwardly spirally wound so that the free ends of the membrane tube and membrane support material are situated at the outer periphery of the winding, a hollow cylindrically walled casing encasing the split core and spirally wound membrane tube and membrane support material, blood inlet means for connection to an arterial line and blood outlet means for connection to a blood venous line leading through the cir-cumferential wall of the casing into the ends of the membrane tube, and a pair of end covers fixed to the ends of the hollow cylindrical casing, one end cover having a dialysate inlet for connection to a dialysate supply line and the other end cover having a dialysate outlet for connection to a dialysate take-off line.

Description

The invention concerns a dialyser cartridge parti-cularly suita~le for extracorporeal dialysis of blood.
Dialyser cartridges of the coil type which comprise a central hollow core about which a membrane tube and membrane support material is wound in a s:ingle spiral are in use. In such devices, the blood inlet (our outlet) leads into the membrane tube through the central hollow core and the blood outlet (or inlet) leads out of the membrane tube at or towards the outer periphery of the spiralled membrane tube and membrane support material. Connection of the blood inlet and outlet lines to the membrane tube has, in known devices, involved practical difficulties in that, for example, a confined space needs to be worked in when connecting up blood lines to the membrane tube through the central hollow core.
An object of the present invention is to provide a coil-type dialyser of a construction enabling both blood inlet and outlet connection at the outer periphery of the spiral and furthermore to provide a dialyser of the coil type in which there are no free spaces through which preferen-tial flow of dialysate, necessitating recirculation of dialysate, can take place.
In accordance with the invention, there is provided a dialyser cartridge comprising a flat membrane tube through which blood to be dialysed may be passed, membrane support material over the outer surfaces of the membrane tube, a split core between which a central portion of the membrane tube and membrane support material is located and about which core said membrane tube and membrane support material are outwardly spirally wound so that the free ends of the membrane tube ~o~

and membrane support material are situated at the outer peri phery of the winding, a hollow cylindrically walled casing encasing the split core and spirally wound membrane tube and membrane support material, two longltudinal slots in said hollow cylindrically walled casing Eor the passage of said membrane towards the outside, blood inlet means for connection to an arterial line and blood outlet means for connection to a blood venous line leading through the circumferential wall of the casing into the ends of the membrane tube, and a pair of end covers fixed to the ends of the hollow cylindrical casing, one end cover having a dialysate inlet for connection to a dialysate supply line and the other end cover having a dialysate outlet for connection to a dialysate take-off line.
The membrane support material may comprise a series of spaced apart parallel elements lying against the outer surfaces of the membrane tube, the parallel members against one side of the membrane tube being at an angle relative to the series of parallel members against the other side of khe membrane tube. The membrane support material may comprise bands of sheet material having on one side a series of spaced apart parallel ribs which then constitute the parallel members, the membrane tube being sandwiched between a pair of such bands with their ribs facing inwardly towards one another. The parallel members against one side of the membrane tube may be at an ac~te angle relative to the axis of the cylindrical casing, and the parallel members against the other side of the membrane tube may be at the sa~e but opposite acute angle relative to said axis. The parallel members may have a series of spaced grooves, the grooves in adjacent parallel members being subs-tantially parallel to the length of the membrane tube.
The split defined by the split core may be of substan-tially S-section, and the split core as a whole may be of subs-tantially circular section. In this maoner, presuming that ~, .

6(~80~

the split core sections are closed-ended, little or no free space, through which preferential flow of dialysis liquid would take place is defined.
The hollow cylindrically walled casing may have at its inner surface a pair of radially directed abutment ~ace of a breadth corresponding to the thickness of the membrane support material to abut against the free ends of the membrane support material at the outer periphery of the spiral. The purpose of these abutment faces, it will be appreciated is as with the S-sectioned split core, to eliminate any free space through which preferential flow of dialysis liquid would take place.
The blood inlet and blood outlet means may comprise connector elements having means for connection to an arterial line and venous line respectively and may have flat convex-sectioned hollow mouth sections sealingly located in the ends of the flat membrane tube between its adjacent sheets.
The ends of the membrane tube and the blood inlet and blood outlet means may be located between seals provided in the circumferential walls of the casing.
The invention will now be described with reference to the accompanying drawings showing, by way of example, an embodiment of the invention.
In the drawings:
Figure 1 shows a perspective exploded view of a coil dialyser, wherein the membrane tube and membrane support mate-rial have not yet been wound about the split core;
Figure 2 shows a partly broken away side elevation of the dialyser cartridge of Figure 1, in assembled condition, Figure 3 shows an enlarged detail of the membrane support material, ~o~
Figure 4 shows an edge-on view of the membrane support material viewing as indicated by IV-IV in Figure 3; and Figure 5 shows a plan cross-section of the coil dialyser in assembled condition, the form of the casing being slightly modified from that shown in Figure 1.
Referring to the drawings, reference numeral 10 refers generally to a dialyser cartridge, which comprises a flat membrane tube 12 through which blood to be dialysed may be passed, and membrane support material 14 over the outer surfaces of the membrane tube 12. The membrane support material com-prises bands of sheet material having on one side a series of spaced apart parallel ribs 16. The ribs 16 against one side of the membrane tube 12 are at an angle relative to the series of ribs against the other side of the membrane tube. In the embodiment shown, the ribs are at an acute angle relative to the axis of the cylindrical casing, the one set of ribs against the one side of the membrane tube 12 being at the same but - opposite acute angle relative to said axis as the other set of ribs against the other side of the membrane tube.
Referring to Figures 3 and 4 of the drawings, the ribs 16 have a series of spaced grooves 18, the grooves being substantially parallel to the length of the membrane tube 12.
These grooves 18 allow small ~uantities of blood to flow pa-rallel to the length of the membrane tube 12 instead of only in the well-known criss-cross turbulent flow which arises in dialyser arrangements having membrane supports comprising ribs or strands at an angle relative to one another on either side of the membrane tube 12.
A split core referred to generally by reference numeral 20 is provided at the centre of the dialyser cartridge 10, between which a central portion of the membrane tube 12 6~
and membrane to support material 14 is located. The membrane support material 14 is outwardly spirally wound about the split core 20 (refer Figure 5) so that the free ends of the membrane tube 12 and membrane support material 14 is situated at the outer periphery of the winding. I'he split defined by the split core is of substantially S-section, and the split core as a whole is of substantially circular section. As can be seen from Figure 5, no free spaces, through which preferential flow of dialysate can take place, are formed.
A hollow cylindrically walled casing 22 encases the split core 20 and spirally wound membrane tube 12 and memhrane support material 14. Reinforcing elements 24 are provided to strengthen the cylindrical casing and to prevent such from bulging or collapsing under positive or negative pressure.
The hollow cylindrically walled casing 22 comprises two longitudinal slots 29 the purpose of which is to enable said membrane 12 to pass to the outside.
Blood inlet means 26 and blood outlet means, also numbered 26 since blood inle,t and blood outlet are interchange-able, are provided for connection to an arterial line and venousline respectively. The blood inlet and blood outlet means lead through the circumferential wall of cylindrical casing 22 into the ends of the membrane tube 12. The cylindrical casing 22 comprises a pair of wedge-sectioned cover plate 28 which mate with and are secured to the wall of the cylindrical casing by means of screws 30. The wall of the cylindrical casing and cover plates 28 in combination form a seat for seating the blood inlet and blood outlet 26, and furthermore each carry a seal 32 to seal the free ends of the membrane tube 12 with the blood inlet and blood outlet means 26 at the ends of the membrane tube between its adjacent sheets. A pair of end covers 34 ( see Figure 2) are fixed to the ends of the hollow cylindrical casing 8~

22, one end cover having a dialysate inlet 36 (normally at the top) for connection to dialysate supply line (not shown) and the other end cover 34 having a dialysate outlet 38 for connec-tion to a dialysate take-off line (not shown).
The hollow cylindrical walled casing has at its inner surface, in the embodiment shown on the cover plates 28, a pair of radially directed abutment faces 40 corresponding to the thickness of the membrane support material 14 to abut against the free ends of the support material at the outer periphery of the spiral. As can be seen from Figure 5, no free spaces through which preferential flow of dialysate can take place, are formed.
The dialyser cartridge of the invention can be employ-ed in conventional manner. Thus, blood is pumped through the membrane tube 12, whilst dialysate flows over the outer sur-faces thereof through the passages defined by the surface of the membrane tube itself and the surface of the membrane support material 14, between adjacent ribs 16. Blood flows through the membrane tube 12 spirally inwardly to the centre of the split core 20 and then spirally outwardly to the blood outlet at the outer periphery of the winding~

Claims (9)

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:
1. A dialyser cartridge comprising a flat membrane tube through which blood to be dialysed may be passed, membrane sup-port material over the outer surfaces of the membrane tube, a split core between which a central portion of the membrane tube and membrane support material is located and about which core said membrane tube and membrane support material are outwardly spirally wound so that the free ends of the membrane tube and membrane support material are situated at the outer periphery of the winding, a hollow cylindrically walled casing encasing the split core and spirally wound membrane tube and membrane support material, two longitudinal slots in said hollow cylin-drically walled casing for the passage of said membrane towards the outside, blood inlet means for connection to an arterial line and blood outlet means for connection to a blood venous line leading through the circumferential wall of the casing into the ends of the membrane tube, and a pair of end covers fixed to the ends of the hollow cylindrical casing, one end cover having a dialysate inlet for connection to a dialysate supply line and the other end cover having a dialysate outlet for connection to a dialysate take-off line.
2. A dialyser cartridge according to claim 1, wherein the membrane support material comprises a series of spaced apart parallel elements lying against the outer surfaces of the membrane tube, the parallel members against one side of the membrane tube being at an angle relative to the series of parallel members against the other side of the membrane tube.
3. A dialyser cartridge according to claim 2, wherein the membrane support material comprises bands of sheet material having on one side a series of spaced apart parallel ribs which then constitute the parallel members, the membrane tube being sandwiched between a pair of bands with their ribs facing inwardly towards one another.
4. A dialyser cartridge according to claim 2, wherein the parallel members against one side of the membrane tube are at an acute angle relative to the axis of the cylindrical casing, and wherein the parallel members against the other side of the membrane tube are at the same but opposite acute angle relative to said axis.
5. A dialyser cartridge according to claim 4, wherein the parallel members have a series of spaced grooves in adjacent parallel members, said grooves being substantially parallel to the length of the membrane tube.
6. A dialyser cartridge according to claim 1, wherein the split defined by the split core is of substantially S-section, and wherein the split core as a whole is of substan-tially circular section.
7. A dialyser cartridge according to claim 1, wherein the hollow cylindrically walled casing has at its inner surface a pair of radially directed abutment faces of a breadth corres-ponding to the thickness of the membrane support material to abut against the free ends of the membrane support material at the outer periphery of the spiral.
8. A dialyser cartridge according to claim 1, wherein the blood inlet and blood outlet means comprise connector ele-ments having means for connection to an arterial line and venous line respectively and having flat convex-sectioned hollow mouth sections sealingly located in the ends of the flat mem-brane tube between its adjacent sheets.
9. A dialyser cartridge according to claim 1, wherein the ends of the membrane tube and the blood inlet and blood outlet means are located between seals provided in the circum-ferential walls of the casing.
CA186,216A 1973-06-22 1973-11-20 Dialyser cartridge with double helix tubular membrane wound on core Expired CA1060804A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT25766/73A IT990683B (en) 1973-06-22 1973-06-22 PARTICULARLY DIALIZING CARTRIDGE FOR ARTIFICIAL KIDNEYS EXTRA BODY

Publications (1)

Publication Number Publication Date
CA1060804A true CA1060804A (en) 1979-08-21

Family

ID=11217668

Family Applications (1)

Application Number Title Priority Date Filing Date
CA186,216A Expired CA1060804A (en) 1973-06-22 1973-11-20 Dialyser cartridge with double helix tubular membrane wound on core

Country Status (10)

Country Link
JP (1) JPS587300B2 (en)
BE (1) BE807643A (en)
CA (1) CA1060804A (en)
CH (1) CH572345A5 (en)
DE (1) DE2357760A1 (en)
ES (1) ES420790A1 (en)
FR (1) FR2234013B1 (en)
GB (1) GB1435985A (en)
IT (1) IT990683B (en)
NL (1) NL7315969A (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1568731A (en) * 1976-09-30 1980-06-04 Japan Found Artificial Organs Blood-gas exchanger units
FR2400380B1 (en) * 1978-12-21 1982-04-09 Rhone Poulenc Ind
US8961790B2 (en) 2008-10-17 2015-02-24 General Electric Company Separator assembly
US20100096319A1 (en) * 2008-10-17 2010-04-22 General Electric Company Separator assembly
US8021550B2 (en) 2008-10-17 2011-09-20 General Electric Company Central core element for a separator assembly
US8968566B2 (en) 2008-10-17 2015-03-03 General Electric Company Separator assembly
US9795924B2 (en) 2011-10-31 2017-10-24 General Electric Company Central core element for a separator assembly
CN113456914B (en) * 2021-07-06 2023-11-07 广州市恩德氏医疗制品实业有限公司 Flat plate winding type dialyzer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1300140A (en) * 1961-04-27 1962-08-03 Usifroid Dialyzer
DE1491741A1 (en) * 1965-12-16 1969-07-24 Dr Med J Hoeltzenbein Artificial kidney
FR1527944A (en) * 1967-04-05 1968-06-07 Commissariat Energie Atomique Dialysis device, especially for artificial kidneys
BE759362A (en) * 1969-11-25 1971-05-24 Dow Corning ARTIFICIAL ORGANS WITH A DIFFUSION MEMBRANE

Also Published As

Publication number Publication date
GB1435985A (en) 1976-05-19
BE807643A (en) 1974-03-15
CH572345A5 (en) 1976-02-13
JPS5052873A (en) 1975-05-10
DE2357760A1 (en) 1975-03-13
IT990683B (en) 1975-07-10
FR2234013A1 (en) 1975-01-17
ES420790A1 (en) 1976-03-16
FR2234013B1 (en) 1978-02-24
NL7315969A (en) 1974-12-24
JPS587300B2 (en) 1983-02-09

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