CA1052785A - Preparation of 2,6-methano-benzazocines - Google Patents

Preparation of 2,6-methano-benzazocines

Info

Publication number
CA1052785A
CA1052785A CA227,350A CA227350A CA1052785A CA 1052785 A CA1052785 A CA 1052785A CA 227350 A CA227350 A CA 227350A CA 1052785 A CA1052785 A CA 1052785A
Authority
CA
Canada
Prior art keywords
compound
formula
process according
preparing
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA227,350A
Other languages
English (en)
French (fr)
Inventor
William F. Michne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/471,571 external-priority patent/US3932422A/en
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Priority to CA314,865A priority Critical patent/CA1079273A/en
Priority to CA314,868A priority patent/CA1089859A/en
Priority to CA314,866A priority patent/CA1090796A/en
Application granted granted Critical
Publication of CA1052785A publication Critical patent/CA1052785A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
CA227,350A 1974-05-20 1975-05-20 Preparation of 2,6-methano-benzazocines Expired CA1052785A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA314,865A CA1079273A (en) 1974-05-20 1978-10-30 Preparation of 2;6-methano-benzazocines
CA314,868A CA1089859A (en) 1974-05-20 1978-10-30 Preparation of 2-azabicyclo [2.2.2]-oct-5-enes
CA314,866A CA1090796A (en) 1974-05-20 1978-10-30 Preparation of 2,6-methano-benzazocines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/471,571 US3932422A (en) 1974-05-20 1974-05-20 8-Methylene-3-azabicyclo[3.3.1]non-6-en-4-ones
US57631375A 1975-05-12 1975-05-12

Publications (1)

Publication Number Publication Date
CA1052785A true CA1052785A (en) 1979-04-17

Family

ID=27043488

Family Applications (1)

Application Number Title Priority Date Filing Date
CA227,350A Expired CA1052785A (en) 1974-05-20 1975-05-20 Preparation of 2,6-methano-benzazocines

Country Status (3)

Country Link
JP (1) JPS6212221B2 (tr)
CA (1) CA1052785A (tr)
GB (2) GB1514571A (tr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4255579A (en) * 1974-05-20 1981-03-10 Sterling Drug Inc. 11-Substituted hexahydro-2,6-methano-3-benzazocines
JPS54130577A (en) * 1978-03-31 1979-10-09 Sterling Drug Inc Novel benzazosin compound and its manufacture
EP0019056A1 (en) * 1979-03-26 1980-11-26 Sterling Drug Inc. Process for preparing 11-lower alkylthio-3-oxo-lower-alkyl-hexahydro-2,6-methano-3-benzazocines

Also Published As

Publication number Publication date
GB1514572A (en) 1978-06-14
JPS6212221B2 (tr) 1987-03-17
JPS50160275A (tr) 1975-12-25
GB1514571A (en) 1978-06-14

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