CA1052125A - Photometric liquid analysers - Google Patents
Photometric liquid analysersInfo
- Publication number
- CA1052125A CA1052125A CA264,538A CA264538A CA1052125A CA 1052125 A CA1052125 A CA 1052125A CA 264538 A CA264538 A CA 264538A CA 1052125 A CA1052125 A CA 1052125A
- Authority
- CA
- Canada
- Prior art keywords
- container
- liquid
- photomultiplier
- unit
- photometric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/251—Colorimeters; Construction thereof
Landscapes
- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
ABSTRACT OF THE DISCLOSURE
A photometric liquid analyser has a housing in which a liquid sample container is located in the path of light transmitted from a light source via a rotary light modulator and an interferential filter, the light transmitted through the sample being received by a photomultiplier The output of the photomultiplier is processed to provide a digital output and the analysis results are printed out by a print-out unit.
To replace the sample in the container, ducts are provided to suck liquid out of the container, and further ducts are provided to suck a new sample into the container via a probe which can be inserted into a test tube.
A photometric liquid analyser has a housing in which a liquid sample container is located in the path of light transmitted from a light source via a rotary light modulator and an interferential filter, the light transmitted through the sample being received by a photomultiplier The output of the photomultiplier is processed to provide a digital output and the analysis results are printed out by a print-out unit.
To replace the sample in the container, ducts are provided to suck liquid out of the container, and further ducts are provided to suck a new sample into the container via a probe which can be inserted into a test tube.
Description
S
This lnvention relates to photometric liquid analysexs for example for use in clinical or chemical laboratories for effecting colorimetric measurement and kinetic analysis of liquid samples According to the invention there is provided a photometric liquid analyser comprising a photometric unit :
having a light source, a rotary modulator arranged to modulate light from the light source, at least one interferential filter in or movable into the path of the modulated lightg a photomultiplier arranged to receive light from the filter, a liquid sample container unit movable into and out of an ~t analyser position, the container unit comprising a translucent ;
container which, in the analyser positior.j is located in the ~-' path of light passing between the filter and the photomultiplier, the container having inlet duct means through which liquid can . be introduced into the container in response to a reduction of . pressure within the container below that at the source of liquLd .~ and outlet duct means through which liquid can be extracted from the container in response to suction applied externally of the container, thermostatic-action means associated with :.
. ......................................................................... . .
~:i. the container unit for maintaining a desired temperature in .
the container, electronic circuit means connected to the output ~:
; . ' :' ' ! . ' ~( of the photomultiplier to receive and process signals supplied .~:
; therefrom in response to the passage of light through the ~;
~" .
s~mple container on to the photomultiplier, the photomultiplier ~ 2 - ~
.~ - ~-.
~t.~ S
being connected to a digital reading unit, progra~ing circuits for the kinetic analyisis of the sample, and a print-out unit for producing a print-out of analysis readings, Oneembodiment of a photometric liquid analyser in accordance with the present invention will now be described, by way of example, with reference to the accompanying drawings in which:-:~ Figure ]. is a side view of the two bodies of the analyser, partly cut away to show a cooling air circuit;
Figure 2 is a diagrammatic plan view;
Figure 3 is a front view of the lower body of the analyser wlth ~he superimposed parts omitted;
Figure 4 is a section taken along line IV-IV of : Figures 1 and 3;
Figure 5 is a front view of the upper body of the analyser;
Figure 6 is a section taken along line VI-VI of : -~
Figures 1 and 5;
Figure 7 is an enlarged sectional view taken approximately along line VII-VII of Figure 4; and Figure 8 iis a schematic diagram illustrating the operation of the analyser.
As can be seen from the drawings, the analyser comprises a lower body 1 containing inter alia a photometric unit and ~
~ 25 some of the electronic circuit boards, and an upper body 3 ~ .
": . ' .
.'' ~ ' ~ .,' , ,, ' :
.. ' , ~ ' ,, . ~ ~ ' .
inclined upwardly and forwardly, and containing inter alia a print-out unit and further electronic circuit boards. Between the two bodies, is an air intake housing 5 open at the rear.
This housing contains a motor 7A of a fan 7 which is located a~ an opening 9 in the cover of the lower body 1. The fan, which has a high capacity at low speed,is arrang~d to suck air ~
from the interior of the body 1, the body having air inlets ~-lOA, lOB suitably located (as shown in Figure 4) for cooling purposes, the inlet lOB being on the rear and covered with a grille. The air is discharged from the rear of the housing 5.
The structures of the two bodies 1 and 3 are similar and include lower shells lA, 3A respectively, runners lB, 3B
extending along the sides of the bodies respectively, upper ;
covers lC, 3C respectively, and front panels 12 and 14 of the lower and upper bodies respectively.
The photometric unit and a container-carrying unit are contained in the lower body 1. ~ :
The photometric unit comprises a tungsten filament lamp ;
., :
16, for example of 15 watts, whose light beam is interrupted by a rotary modulator 18, driven by a motor 18A (cooled by the air inlets lOA), which modulates the light source, for example at 1000 cycles per second, in order to render it independent of the influence of external ambient light sources.
Interferential filters, in particular of the narrow band Balzers type, are arranged on a drum 20 which can carry, for .,::' :
~ 4 .
. ~
-, . . - . ., - .: , - ., "~ .. . , . , - , . , -example, twelve such filters and is operated by a control C7.
A mirror 22 reflects through 90 ~he light beam which has been recelved from the bulb 16 via a selected one o~ the filters and directs the re1ected light beam through an optical system represented~ for illustration purposes, by a lens 26, and through the container 24 on ~o a photomultiplier 28 on which the light is focussed by the optical system The photomultiplier is of the typ~ with ultra-violet spectral sensitivity.
::
The container-carrier unit with inle~ and outlet tubes is shown in Figure 4 and in greater detail in Figure 7.
The container carrier 30 has a suction discharge tube or duct 40 connected to a duct which extends to the bottom of the container 24, the tube being flexible and connected ; 15 via a valve 44 to a suction source. The valve when open allows liquid in the container to be sucked out and discharged.
The container has a suction tube or duct 41 for creating a sufficient vacuum in the container 24 to suck the liquid to be analysed, into the container via an intake tube or duct 42 ; 20 having an inlet probe extending away from the container. The inlet end of suction tube 41 is high enough to ensure the ~illing of the container and to extract any excess quantity of liquid introduced into the container 24.
Tubes 46 lead through the body 30 for circulating thermostatic-acting liquid, in a circuit 46A to stabilize the '``' ,, , ' -~
~ ,. .. ... ,... . . . . , , ~
~ s~s ~
temperature in the body, the circuit including a heating m~an~ controlled by a thermostat. In order to attain temperatures lower than room temperature the clrcuit can include a continuous heat extraction~ i.e. a cooling circuit.
By removal of the tubes or ducts 40, 41 and 42, the container carrier 30 can be removed from the analyser and replaced if desired with a similar one or one of a different type. Such removal enables the container to be cleaned.
As shown in Figure 4, electrical connectors 48 are provided which are connected to the circuit boards accommodated -in the lower body in seatings 50 and acressible from the rear ; of the apparatus, and for connection to the upper body. In particular circuit boards A, B and C are provided in the lower body 1. The body 1 also accommodates power supply transformers 52.
The upper body 3 has a seating 54 for circuit boards `
F and G, while boards H and L are mo~mted on the front of the body 3 and other boards E and M are located at the sides of the body.
, `~ 20 A print-out unit 56 is provided of which a lower portion 56A is seen in Figures 5 and 6 combined with panel 14.
The first circuit board A provides a selective amplifier, a detector, a logarithmic amplifier, and a circuit which provides for automatic zero setting during the kinetic analysis.
A measurement signal comes from the detector 28 to the board A, 6 :~
:. ~
~: -: . . ... - . . - .. .. .. . ... . - . .. . . .. . .-........ . . .
:. : :.:. . . : . : :. : .: . - .: : . .. . . . . , : : . - .. .
::::: . . . .. :
-where it is amplified, detected (i.e. transformed from AC into DC) and converted into a logarithmic unit typical o~ the photometric measurements.
The board H is a concentration converter allowing the 5 conversion of the reading from lineariæed absorption to concentration with a multiplying fac~or between 0.01 and 9.99.
This factor is adjustable by a digital-type control C8.
Controls C9 and C10 change the operational mode of the apparatus from optical density (absorption) into concentration units and lO vice-versa.
Board D control the thermostatic unit o~ the body 30.
Board E allows the automatic calculation of the mU/I
(international milli-units or litre-units) in kinetic enzimatic measurements. Board G, forming a digital voltmeter, ef~ects the conversion from analogue units into digital units, to give the result of the measurement in numeric style. This board receives the signal provided by the controls C9 and Cll and is connected to a print-out control logic 56 and to a board L which presents a numeric display. By means of this board L, -the digitalized data which may represent absorptions, `
concentrations, milli-units and also the value of the temperature in the container, are displayed on luminous screens, of the type having seven segments, the reading being taken through a window 58 (see Figure 5).
Board B forms a voltage stabilizer, an automatic zero-.
,. .
. - ~
setting operations of the equipment, receiving the appropriate instructions from a measurement programmer (represented by board F) of the equipment. The circuits of board B ~Sample and Hold circuit) act directly on the sensitivity of the photomultiplier 28, as is seen in the scheme of Figure 8.
It is thus possible to obtain the automatic zero-setting "on the blank" and storing of said zero for about one hour Board F forms the printing programming unit, and uses timers ' to carry out the measurement cycle. The board F in an automatic manner enables programmed measurement sequences to ' be effected by controls C12 and C13 hereinafter described. ~;
Board C for the stabilizing circuits contains electronic ' circuits supplying stabilized voltages to the severaI par~s of ' ' '' the equipment, feeding the multiple-output transformers 52.
:.:
' 15 Board M contains the feéder (for the print-out unit ; 56) and a counter for numbering the print relative to the effected analysis. This board receives, from the programming ''' unit (board F) the instruction for numeric updating. The `~
print-out unit may have six printing columns, the first two ~'~
' 20 columns'serve for numbering the sample being examined, a numbering which is repeated during the several measurements effected in kinetics, the numbering being automatic from 1 to ~;
99 and being repetitive. -,~....................................................................... i, .
The controls of the apparatus are hereinafter listed, some thereof having already been stated.
,`, ' ~
~ - 8 ,~ ', ;:' ' - , :
Cl is the general "on" switch for the power supply;
C2 is a setting control, or setting the thermostatic acting temperature in the container which acts , through board D; the state of thermal balance of the thermostat is indicated by means of a lamp 38 '~
C3 is a luminous control which introduces the automatic zero circuit, C4 is a luminous control which sets the readings on the samples to be measured.
C5 is a lever switch acting on the solenoid valve 44, ',~
'` thus llowing the container to be emptied. ~`, ~' ~ C6 is a lever switch which allows the automatic ~,~
' measur~ment cycle to commence.
C7 is a selector for the interferential filters; it , 15 ' acts to rotate the ilter-carrying disc 20. '' , C8 is a digital preselector which operates to set-' ' the factor K in the range from 0.01 to 9.99 in `
board H.
, C9 is a luminous control which inserts the absorption read'ing. , C10 is a luminous control which inserts the concentration ' mU reading.
Cll is a luminous control which inserts the reading of `, ,the temperature in the container. The operation of this control automatically cuts off the controls C9 ;~ -, and C10. , . ~
.
, ~ , . . . ~ , . . : : . , ~ .
--- 11)5i~:~2S
C12 is a selector supplying a delay time to board F
before the printing of the measurement data (for instance, 5, 30, 60, 120 or 300 seconds); it is necessary to ensure in each case the required S balance un~il the steady state conditions of the contents of the container are attained, before the readings are taken.
G13 is a selector which controls the number of measurements effected on each sample, for example, selecting l, 2, 4 or 6; the result, in the case of :` kinetic measurements 3 always giving the correct value expressed in international milli-units.
C14 is a control which allows the code number of the sample to be set to zero.
C15 is the board feeding control.
C16 is a control which allows an operation at will to cause printing of the datum to appear on the display, during the automatic cycle of kinetic measurement, it is cut off, but it can be operated at the end of the cycle to repeat the latter on the same sample being examined.
~, The kinetic analysis progra-mming unit enables a delay time to be set between the insertion of the slide of the : - :
~ container and the start of the printing cycle. This delay `~ 25 time can be set, for example, at 5, 30, 60, 120 or 300 seconds.
10 ~
.
.. . . - . . .
c~ r~
Thus it is possible to have printing of the data take place automatically after such a delay time. Subsequently zero~
setting of the initial absorption value occurs ~nd then the printing of the subsequent measurement data, which in the programs 2, 4 and 6 are directly expressed in mU/I. At the end of the kinetic cycle, the program provides for automatic printing of the temperature in the container. If desired, the sequence of measurement can be repeated by pressing the control Cl provided for this purpose. .-~`' ~ . ;
~'` ~, ' , ' :
- . - - ,. . : - ~ :. ~, ~
This lnvention relates to photometric liquid analysexs for example for use in clinical or chemical laboratories for effecting colorimetric measurement and kinetic analysis of liquid samples According to the invention there is provided a photometric liquid analyser comprising a photometric unit :
having a light source, a rotary modulator arranged to modulate light from the light source, at least one interferential filter in or movable into the path of the modulated lightg a photomultiplier arranged to receive light from the filter, a liquid sample container unit movable into and out of an ~t analyser position, the container unit comprising a translucent ;
container which, in the analyser positior.j is located in the ~-' path of light passing between the filter and the photomultiplier, the container having inlet duct means through which liquid can . be introduced into the container in response to a reduction of . pressure within the container below that at the source of liquLd .~ and outlet duct means through which liquid can be extracted from the container in response to suction applied externally of the container, thermostatic-action means associated with :.
. ......................................................................... . .
~:i. the container unit for maintaining a desired temperature in .
the container, electronic circuit means connected to the output ~:
; . ' :' ' ! . ' ~( of the photomultiplier to receive and process signals supplied .~:
; therefrom in response to the passage of light through the ~;
~" .
s~mple container on to the photomultiplier, the photomultiplier ~ 2 - ~
.~ - ~-.
~t.~ S
being connected to a digital reading unit, progra~ing circuits for the kinetic analyisis of the sample, and a print-out unit for producing a print-out of analysis readings, Oneembodiment of a photometric liquid analyser in accordance with the present invention will now be described, by way of example, with reference to the accompanying drawings in which:-:~ Figure ]. is a side view of the two bodies of the analyser, partly cut away to show a cooling air circuit;
Figure 2 is a diagrammatic plan view;
Figure 3 is a front view of the lower body of the analyser wlth ~he superimposed parts omitted;
Figure 4 is a section taken along line IV-IV of : Figures 1 and 3;
Figure 5 is a front view of the upper body of the analyser;
Figure 6 is a section taken along line VI-VI of : -~
Figures 1 and 5;
Figure 7 is an enlarged sectional view taken approximately along line VII-VII of Figure 4; and Figure 8 iis a schematic diagram illustrating the operation of the analyser.
As can be seen from the drawings, the analyser comprises a lower body 1 containing inter alia a photometric unit and ~
~ 25 some of the electronic circuit boards, and an upper body 3 ~ .
": . ' .
.'' ~ ' ~ .,' , ,, ' :
.. ' , ~ ' ,, . ~ ~ ' .
inclined upwardly and forwardly, and containing inter alia a print-out unit and further electronic circuit boards. Between the two bodies, is an air intake housing 5 open at the rear.
This housing contains a motor 7A of a fan 7 which is located a~ an opening 9 in the cover of the lower body 1. The fan, which has a high capacity at low speed,is arrang~d to suck air ~
from the interior of the body 1, the body having air inlets ~-lOA, lOB suitably located (as shown in Figure 4) for cooling purposes, the inlet lOB being on the rear and covered with a grille. The air is discharged from the rear of the housing 5.
The structures of the two bodies 1 and 3 are similar and include lower shells lA, 3A respectively, runners lB, 3B
extending along the sides of the bodies respectively, upper ;
covers lC, 3C respectively, and front panels 12 and 14 of the lower and upper bodies respectively.
The photometric unit and a container-carrying unit are contained in the lower body 1. ~ :
The photometric unit comprises a tungsten filament lamp ;
., :
16, for example of 15 watts, whose light beam is interrupted by a rotary modulator 18, driven by a motor 18A (cooled by the air inlets lOA), which modulates the light source, for example at 1000 cycles per second, in order to render it independent of the influence of external ambient light sources.
Interferential filters, in particular of the narrow band Balzers type, are arranged on a drum 20 which can carry, for .,::' :
~ 4 .
. ~
-, . . - . ., - .: , - ., "~ .. . , . , - , . , -example, twelve such filters and is operated by a control C7.
A mirror 22 reflects through 90 ~he light beam which has been recelved from the bulb 16 via a selected one o~ the filters and directs the re1ected light beam through an optical system represented~ for illustration purposes, by a lens 26, and through the container 24 on ~o a photomultiplier 28 on which the light is focussed by the optical system The photomultiplier is of the typ~ with ultra-violet spectral sensitivity.
::
The container-carrier unit with inle~ and outlet tubes is shown in Figure 4 and in greater detail in Figure 7.
The container carrier 30 has a suction discharge tube or duct 40 connected to a duct which extends to the bottom of the container 24, the tube being flexible and connected ; 15 via a valve 44 to a suction source. The valve when open allows liquid in the container to be sucked out and discharged.
The container has a suction tube or duct 41 for creating a sufficient vacuum in the container 24 to suck the liquid to be analysed, into the container via an intake tube or duct 42 ; 20 having an inlet probe extending away from the container. The inlet end of suction tube 41 is high enough to ensure the ~illing of the container and to extract any excess quantity of liquid introduced into the container 24.
Tubes 46 lead through the body 30 for circulating thermostatic-acting liquid, in a circuit 46A to stabilize the '``' ,, , ' -~
~ ,. .. ... ,... . . . . , , ~
~ s~s ~
temperature in the body, the circuit including a heating m~an~ controlled by a thermostat. In order to attain temperatures lower than room temperature the clrcuit can include a continuous heat extraction~ i.e. a cooling circuit.
By removal of the tubes or ducts 40, 41 and 42, the container carrier 30 can be removed from the analyser and replaced if desired with a similar one or one of a different type. Such removal enables the container to be cleaned.
As shown in Figure 4, electrical connectors 48 are provided which are connected to the circuit boards accommodated -in the lower body in seatings 50 and acressible from the rear ; of the apparatus, and for connection to the upper body. In particular circuit boards A, B and C are provided in the lower body 1. The body 1 also accommodates power supply transformers 52.
The upper body 3 has a seating 54 for circuit boards `
F and G, while boards H and L are mo~mted on the front of the body 3 and other boards E and M are located at the sides of the body.
, `~ 20 A print-out unit 56 is provided of which a lower portion 56A is seen in Figures 5 and 6 combined with panel 14.
The first circuit board A provides a selective amplifier, a detector, a logarithmic amplifier, and a circuit which provides for automatic zero setting during the kinetic analysis.
A measurement signal comes from the detector 28 to the board A, 6 :~
:. ~
~: -: . . ... - . . - .. .. .. . ... . - . .. . . .. . .-........ . . .
:. : :.:. . . : . : :. : .: . - .: : . .. . . . . , : : . - .. .
::::: . . . .. :
-where it is amplified, detected (i.e. transformed from AC into DC) and converted into a logarithmic unit typical o~ the photometric measurements.
The board H is a concentration converter allowing the 5 conversion of the reading from lineariæed absorption to concentration with a multiplying fac~or between 0.01 and 9.99.
This factor is adjustable by a digital-type control C8.
Controls C9 and C10 change the operational mode of the apparatus from optical density (absorption) into concentration units and lO vice-versa.
Board D control the thermostatic unit o~ the body 30.
Board E allows the automatic calculation of the mU/I
(international milli-units or litre-units) in kinetic enzimatic measurements. Board G, forming a digital voltmeter, ef~ects the conversion from analogue units into digital units, to give the result of the measurement in numeric style. This board receives the signal provided by the controls C9 and Cll and is connected to a print-out control logic 56 and to a board L which presents a numeric display. By means of this board L, -the digitalized data which may represent absorptions, `
concentrations, milli-units and also the value of the temperature in the container, are displayed on luminous screens, of the type having seven segments, the reading being taken through a window 58 (see Figure 5).
Board B forms a voltage stabilizer, an automatic zero-.
,. .
. - ~
setting operations of the equipment, receiving the appropriate instructions from a measurement programmer (represented by board F) of the equipment. The circuits of board B ~Sample and Hold circuit) act directly on the sensitivity of the photomultiplier 28, as is seen in the scheme of Figure 8.
It is thus possible to obtain the automatic zero-setting "on the blank" and storing of said zero for about one hour Board F forms the printing programming unit, and uses timers ' to carry out the measurement cycle. The board F in an automatic manner enables programmed measurement sequences to ' be effected by controls C12 and C13 hereinafter described. ~;
Board C for the stabilizing circuits contains electronic ' circuits supplying stabilized voltages to the severaI par~s of ' ' '' the equipment, feeding the multiple-output transformers 52.
:.:
' 15 Board M contains the feéder (for the print-out unit ; 56) and a counter for numbering the print relative to the effected analysis. This board receives, from the programming ''' unit (board F) the instruction for numeric updating. The `~
print-out unit may have six printing columns, the first two ~'~
' 20 columns'serve for numbering the sample being examined, a numbering which is repeated during the several measurements effected in kinetics, the numbering being automatic from 1 to ~;
99 and being repetitive. -,~....................................................................... i, .
The controls of the apparatus are hereinafter listed, some thereof having already been stated.
,`, ' ~
~ - 8 ,~ ', ;:' ' - , :
Cl is the general "on" switch for the power supply;
C2 is a setting control, or setting the thermostatic acting temperature in the container which acts , through board D; the state of thermal balance of the thermostat is indicated by means of a lamp 38 '~
C3 is a luminous control which introduces the automatic zero circuit, C4 is a luminous control which sets the readings on the samples to be measured.
C5 is a lever switch acting on the solenoid valve 44, ',~
'` thus llowing the container to be emptied. ~`, ~' ~ C6 is a lever switch which allows the automatic ~,~
' measur~ment cycle to commence.
C7 is a selector for the interferential filters; it , 15 ' acts to rotate the ilter-carrying disc 20. '' , C8 is a digital preselector which operates to set-' ' the factor K in the range from 0.01 to 9.99 in `
board H.
, C9 is a luminous control which inserts the absorption read'ing. , C10 is a luminous control which inserts the concentration ' mU reading.
Cll is a luminous control which inserts the reading of `, ,the temperature in the container. The operation of this control automatically cuts off the controls C9 ;~ -, and C10. , . ~
.
, ~ , . . . ~ , . . : : . , ~ .
--- 11)5i~:~2S
C12 is a selector supplying a delay time to board F
before the printing of the measurement data (for instance, 5, 30, 60, 120 or 300 seconds); it is necessary to ensure in each case the required S balance un~il the steady state conditions of the contents of the container are attained, before the readings are taken.
G13 is a selector which controls the number of measurements effected on each sample, for example, selecting l, 2, 4 or 6; the result, in the case of :` kinetic measurements 3 always giving the correct value expressed in international milli-units.
C14 is a control which allows the code number of the sample to be set to zero.
C15 is the board feeding control.
C16 is a control which allows an operation at will to cause printing of the datum to appear on the display, during the automatic cycle of kinetic measurement, it is cut off, but it can be operated at the end of the cycle to repeat the latter on the same sample being examined.
~, The kinetic analysis progra-mming unit enables a delay time to be set between the insertion of the slide of the : - :
~ container and the start of the printing cycle. This delay `~ 25 time can be set, for example, at 5, 30, 60, 120 or 300 seconds.
10 ~
.
.. . . - . . .
c~ r~
Thus it is possible to have printing of the data take place automatically after such a delay time. Subsequently zero~
setting of the initial absorption value occurs ~nd then the printing of the subsequent measurement data, which in the programs 2, 4 and 6 are directly expressed in mU/I. At the end of the kinetic cycle, the program provides for automatic printing of the temperature in the container. If desired, the sequence of measurement can be repeated by pressing the control Cl provided for this purpose. .-~`' ~ . ;
~'` ~, ' , ' :
- . - - ,. . : - ~ :. ~, ~
Claims (4)
1. A photometric liquid analyser comprising a photometric unit having a light source, a rotary modulator arranged to modulate light from the light source, at least one interferential filter in the path of the modulated light, a photomultiplier arranged to receive light from the filter, a liquid sample container unit movable into and out of an analysis position, the container unit comprising a translucent container which, in the analysis position, is located in the path of light passing between the filter and the photomultiplier, the container having inlet duct means through which liquid can be introduced into the container in response to a reduction of pressure within the container below that at the source of liquid and outlet duct means through which liquid can be extracted from the container in response to suction applied externally of the container, thermostatic-action means associated with the container unit for maintaining a desired temperature in the container, electronic circuit means connected to the output of the photomultiplier to receive and process signals supplied therefrom in response to the passage of light through the sample container on to the photomultiplier, the photomultiplier being connected in circuit with a digital reading unit, programming circuits for the kinetic analysis of the sample, and a print-out unit for producing a print-out of analysis readings.
2. A photometric liquid analyser according to claim 1 wherein said inlet duct means through which liquid can be introduced into the container includes a probe connected to the container by a flexible tube whereby liquid can be sucked into the container from a test tube.
3. A photometric liquid analyser according to claim 1 including a solenoid operable by a lever control and effective when energised to apply suction to the outlet duct means.
4. A photometric liquid analyser according to claim 1 wherein the container unit comprises a container carrier containing ducting connected in a fluid circuit by means of which the temperature of the container can be controlled, and including a sensor for periodically sensing the temperature of the container and operable to transmit a signal to a digital voltmeter to produce a display or a read-out of the sensed temperature.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1182975 | 1975-11-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1052125A true CA1052125A (en) | 1979-04-10 |
Family
ID=11138154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA264,538A Expired CA1052125A (en) | 1975-11-07 | 1976-11-01 | Photometric liquid analysers |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE848001A (en) |
| CA (1) | CA1052125A (en) |
| ES (1) | ES453014A1 (en) |
| FR (1) | FR2337880A2 (en) |
| GB (1) | GB1495120A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1143854B (en) * | 1977-10-27 | 1986-10-22 | Sclavo Inst Sieroterapeut | SYSTEM AND RELATED EQUIPMENT FOR PHOTOMETRIC MEASUREMENTS IN THE FIELD OF THE VISIBLE AND UV BIOLOGICAL LIQUIDS OR OTHER ACTIVITY TO AVOID SYSTEMATIC ERRORS DUE TO POLLUTION |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1346766A (en) * | 1970-06-29 | 1974-02-13 | Ici Ltd | Colourimeters and fluorimeters |
| US3811780A (en) * | 1971-04-12 | 1974-05-21 | Abbott Lab | Chemical analysis cuvette |
| US3869214A (en) * | 1972-01-18 | 1975-03-04 | Labtronic Ag | Cuvette arrangement |
| FR2174340A5 (en) * | 1972-02-29 | 1973-10-12 | Roussel Uclaf | |
| ES436910A1 (en) * | 1974-05-17 | 1977-01-01 | Sclavo Inst Sieroterapeut | Photometric liquid analysers |
| US3975103A (en) * | 1975-05-14 | 1976-08-17 | Istituto Sieroterapico A Vaccinogeno Toscano "Sciavo" S.p.A. | Photometric liquid analyzers for use in clinical or chemical laboratory analysis |
-
1976
- 1976-10-29 GB GB4497576A patent/GB1495120A/en not_active Expired
- 1976-11-01 CA CA264,538A patent/CA1052125A/en not_active Expired
- 1976-11-04 BE BE6045747A patent/BE848001A/en unknown
- 1976-11-04 ES ES453014A patent/ES453014A1/en not_active Expired
- 1976-11-05 FR FR7633456A patent/FR2337880A2/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FR2337880A2 (en) | 1977-08-05 |
| BE848001A (en) | 1977-03-01 |
| GB1495120A (en) | 1977-12-14 |
| FR2337880B2 (en) | 1982-11-19 |
| ES453014A1 (en) | 1977-11-01 |
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