CA1051801A - Bestatin, an enzyme inhibitor from streptomyces - Google Patents

Bestatin, an enzyme inhibitor from streptomyces

Info

Publication number
CA1051801A
CA1051801A CA230,530A CA230530A CA1051801A CA 1051801 A CA1051801 A CA 1051801A CA 230530 A CA230530 A CA 230530A CA 1051801 A CA1051801 A CA 1051801A
Authority
CA
Canada
Prior art keywords
bestatin
methanol
aminopeptidase
bleomycin
soluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA230,530A
Other languages
English (en)
French (fr)
Other versions
CA230530S (en
Inventor
Hamao Umezawa
Takaaki Aoyagi
Tomio Takeuchi
Masa Hamada
Yoshiro Okami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Application granted granted Critical
Publication of CA1051801A publication Critical patent/CA1051801A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
CA230,530A 1974-07-01 1975-06-30 Bestatin, an enzyme inhibitor from streptomyces Expired CA1051801A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7509074A JPS5439477B2 (enrdf_load_stackoverflow) 1974-07-01 1974-07-01

Publications (1)

Publication Number Publication Date
CA1051801A true CA1051801A (en) 1979-04-03

Family

ID=13566108

Family Applications (1)

Application Number Title Priority Date Filing Date
CA230,530A Expired CA1051801A (en) 1974-07-01 1975-06-30 Bestatin, an enzyme inhibitor from streptomyces

Country Status (5)

Country Link
JP (1) JPS5439477B2 (enrdf_load_stackoverflow)
CA (1) CA1051801A (enrdf_load_stackoverflow)
DE (1) DE2528984C3 (enrdf_load_stackoverflow)
FR (1) FR2276818A1 (enrdf_load_stackoverflow)
GB (1) GB1510323A (enrdf_load_stackoverflow)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1510477A (en) * 1975-07-22 1978-05-10 Microbial Chem Res Found Peptides and to amino acid intermediates thereof
JPS52116435A (en) * 1976-03-26 1977-09-29 Microbial Chem Res Found Novel bio-active substance bestatin and its derivatives
JPS54153868A (en) * 1978-05-23 1979-12-04 Bridgestone Corp Mold for plastic foam
JPS5767516A (en) * 1980-09-24 1982-04-24 Microbial Chem Res Found Novel analgesic agent
JPS58110553A (ja) * 1981-12-24 1983-07-01 Microbial Chem Res Found ベスタチンのγ型結晶及びその製造法
JPS6083880U (ja) * 1983-11-15 1985-06-10 松下冷機株式会社 断熱扉
CN1098249C (zh) * 1995-06-21 2003-01-08 国家医药管理局四川抗菌素工业研究所 乌比美克及含乌比美克的药物组合物治疗病毒性肝炎的用途

Also Published As

Publication number Publication date
DE2528984A1 (de) 1976-01-29
DE2528984B2 (de) 1978-10-26
FR2276818B1 (enrdf_load_stackoverflow) 1979-08-10
JPS517187A (enrdf_load_stackoverflow) 1976-01-21
DE2528984C3 (de) 1979-06-13
JPS5439477B2 (enrdf_load_stackoverflow) 1979-11-28
FR2276818A1 (fr) 1976-01-30
GB1510323A (en) 1978-05-10

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