CA1031355A - C10-c20 alkyl furoylacetic acid derivatives as hypolipidemic agents - Google Patents

C10-c20 alkyl furoylacetic acid derivatives as hypolipidemic agents

Info

Publication number
CA1031355A
CA1031355A CA194,209A CA194209A CA1031355A CA 1031355 A CA1031355 A CA 1031355A CA 194209 A CA194209 A CA 194209A CA 1031355 A CA1031355 A CA 1031355A
Authority
CA
Canada
Prior art keywords
furoylacetic
alkyl
acid derivatives
hypolipidemic agents
hypolipidemic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA194,209A
Other languages
English (en)
French (fr)
Other versions
CA194209S (en
Inventor
Roger A. Parker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richardson Vicks Ltd Canada
Original Assignee
Richardson Merrell Canada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richardson Merrell Canada Ltd filed Critical Richardson Merrell Canada Ltd
Application granted granted Critical
Publication of CA1031355A publication Critical patent/CA1031355A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/64—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
CA194,209A 1973-04-02 1974-03-06 C10-c20 alkyl furoylacetic acid derivatives as hypolipidemic agents Expired CA1031355A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/347,232 US4000164A (en) 1973-04-02 1973-04-02 Hypolipidemic agents

Publications (1)

Publication Number Publication Date
CA1031355A true CA1031355A (en) 1978-05-16

Family

ID=23362868

Family Applications (1)

Application Number Title Priority Date Filing Date
CA194,209A Expired CA1031355A (en) 1973-04-02 1974-03-06 C10-c20 alkyl furoylacetic acid derivatives as hypolipidemic agents

Country Status (13)

Country Link
US (1) US4000164A (xx)
JP (1) JPS5844663B2 (xx)
AU (1) AU473144B2 (xx)
BE (1) BE813041A (xx)
CA (1) CA1031355A (xx)
CH (1) CH603615A5 (xx)
DE (1) DE2414252A1 (xx)
FR (1) FR2223031B1 (xx)
GB (1) GB1417103A (xx)
NL (1) NL7404218A (xx)
PH (1) PH24978A (xx)
SE (1) SE415255B (xx)
ZA (1) ZA741421B (xx)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4032647A (en) * 1975-06-16 1977-06-28 Richardson-Merrell Inc. Substituted thenoylacetic acid and esters
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
GB1540917A (en) * 1976-08-06 1979-02-21 Wassermann Spa A Furan derivatives for use as pharmaceutical products particularly for the treatment of rheumatic illnesses and a method for their preparation
CA1104574A (en) * 1976-12-20 1981-07-07 Roger A. Parker Antirhinovirus agents
US4169202A (en) * 1978-06-05 1979-09-25 American Home Products Corporation Process for preparing 4,5-dihydro-4-oxofuran-2-carboxylic acid derivatives
US4980371A (en) * 1988-12-21 1990-12-25 Merrell Dow Pharmaceuticals Antiretroviral furan ketones
US4977185A (en) * 1988-12-21 1990-12-11 Merrell Dow Pharmaceuticals Antiretroviral aryloxy substituted furan ketones
US5759837A (en) * 1989-01-17 1998-06-02 John Hopkins University Chemotherapy for cancer by inhibiting the fatty acid biosynthetic pathway
US5759791A (en) * 1989-01-17 1998-06-02 The Johns Hopkins University Cancer related antigen
US5665874A (en) * 1989-01-17 1997-09-09 John Hopkins University Cancer related antigen
US5614551A (en) * 1994-01-24 1997-03-25 The Johns Hopkins University Inhibitors of fatty acid synthesis as antimicrobial agents
US5981575A (en) * 1996-11-15 1999-11-09 Johns Hopkins University, The Inhibition of fatty acid synthase as a means to reduce adipocyte mass

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2834789A (en) * 1955-02-15 1958-05-13 Sadolin & Holmblad As Process of preparing lower lakyl 2, 3, 6-trihydroxybenzoate, and intermediates therefor

Also Published As

Publication number Publication date
SE415255B (sv) 1980-09-22
JPS49127964A (xx) 1974-12-07
JPS5844663B2 (ja) 1983-10-04
DE2414252C2 (xx) 1988-02-18
DE2414252A1 (de) 1974-10-17
AU6649674A (en) 1975-09-11
NL7404218A (xx) 1974-10-04
GB1417103A (en) 1975-12-10
PH24978A (en) 1990-12-26
FR2223031B1 (xx) 1977-01-21
CH603615A5 (xx) 1978-08-31
FR2223031A1 (xx) 1974-10-25
BE813041A (fr) 1974-07-15
US4000164A (en) 1976-12-28
AU473144B2 (en) 1976-06-17
ZA741421B (en) 1975-01-29

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