CA1030154A - Polyene compounds - Google Patents

Polyene compounds

Info

Publication number
CA1030154A
CA1030154A CA207,490A CA207490A CA1030154A CA 1030154 A CA1030154 A CA 1030154A CA 207490 A CA207490 A CA 207490A CA 1030154 A CA1030154 A CA 1030154A
Authority
CA
Canada
Prior art keywords
polyene compounds
polyene
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA207,490A
Other languages
English (en)
French (fr)
Other versions
CA207490S (en
Inventor
Beverly A. Pawson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of CA1030154A publication Critical patent/CA1030154A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/14—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by doubly-bound oxygen atoms
    • C07C403/16—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by doubly-bound oxygen atoms not being part of —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
    • C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C07C45/676—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton by elimination of carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA207,490A 1973-08-24 1974-08-21 Polyene compounds Expired CA1030154A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1219673A CH585709A5 (no) 1973-08-24 1973-08-24
US05/495,367 US3931257A (en) 1973-08-24 1974-08-07 Polyene compounds

Publications (1)

Publication Number Publication Date
CA1030154A true CA1030154A (en) 1978-04-25

Family

ID=25709815

Family Applications (1)

Application Number Title Priority Date Filing Date
CA207,490A Expired CA1030154A (en) 1973-08-24 1974-08-21 Polyene compounds

Country Status (12)

Country Link
US (1) US3931257A (no)
JP (1) JPS5049243A (no)
BE (1) BE819116A (no)
CA (1) CA1030154A (no)
CH (1) CH585709A5 (no)
DE (1) DE2440606A1 (no)
DK (1) DK451874A (no)
FR (1) FR2241297B1 (no)
GB (1) GB1442107A (no)
NL (1) NL7411016A (no)
SE (1) SE422788B (no)
ZA (1) ZA744964B (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4107190A (en) * 1974-09-26 1978-08-15 Hoffmann-La Roche Inc. Novel compounds of 9-phenyl-3,7-dimethyl-2,4,6,8-nonatetraenamide
US4187247A (en) * 1974-09-26 1980-02-05 Hoffmann-La Roche Inc. 9-Substituted phenyl-3,7-dimethyl-nona 2,4,6,8-tetraene compounds
JPS51125234A (en) * 1974-09-26 1976-11-01 Hoffmann La Roche Preparation of polyene compounds
US4054589A (en) * 1974-09-26 1977-10-18 Hoffmann-La Roche Inc. Novel 9-substituted phenyl-3,7-dimethyl-nona-2,4,6,8-tetraene esters
US4190594A (en) * 1975-11-03 1980-02-26 Johnson & Johnson Retinoic acid derivatives
US4108880A (en) * 1975-11-03 1978-08-22 Johnson & Johnson Esters of retinoic acid
CA1111441A (en) * 1976-12-20 1981-10-27 Werner Bollag Polyene compounds
LU77254A1 (no) * 1977-05-04 1979-01-18
US4199587A (en) * 1977-08-10 1980-04-22 Eisai Co., Ltd. Method of treating hypertension with polyprenyl alcohol ester
JPS5640651A (en) * 1979-09-12 1981-04-16 Takeda Chem Ind Ltd Quinone compound and its preparation
US4533554A (en) * 1979-05-18 1985-08-06 Takeda Chemical Industries, Ltd. Quinone derivatives and use
US4439614A (en) * 1982-09-22 1984-03-27 Sri International 5,6-Methano-5,6-dihydroretinoids
US4642318A (en) * 1982-11-17 1987-02-10 Klaus Wolff Method for decreasing radiation load in PUVA therapy
US4523042A (en) * 1983-07-29 1985-06-11 Usv Pharmaceutical Derivatives of alpha-alkyl polyolefinic carboxylic acid useful in the treatment of psoriasis
US4722939A (en) * 1983-07-29 1988-02-02 Usv Pharmaceutical Corporation Derivatives of alpha-alkyl polyolefinic carboxylic acid useful in the treatment of psoriasis
US4648996A (en) * 1984-07-27 1987-03-10 Hoffmann-La Roche Inc. Phenyl substituted-2,4,6,8-nonatetraenoic acid
US4894480A (en) * 1984-07-27 1990-01-16 Hoffmann-La Roche Inc. Phenyl substituted-2,4,6,8-nonatetraenoic acid
US4843096A (en) * 1985-06-26 1989-06-27 Stiefel Laboratories, Inc. Treatment of acne
US4677120A (en) * 1985-07-31 1987-06-30 Molecular Design International Topical prodrugs for treatment of acne and skin diseases
US5070108A (en) * 1990-10-12 1991-12-03 Trustees Of The University Of Pennsylvania Methods of treating osteoporosis, increasing bone mineral content and preventing the occurrence of compression fractures in a mammal
US5786391A (en) * 1995-01-11 1998-07-28 Cornell Research Foundation, Inc. Regulating gene expression using retinoids with Ch2 OH or related groups at the side chain terminal position
US6150421A (en) * 1995-01-11 2000-11-21 Cornell Research Foundation, Inc. Treatment of estrogen-receptor positive breast cancer and estrogen-receptor negative breast cancer with retinoid with CH2 OH at the side chain terminal position

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2529498A (en) * 1946-04-12 1950-11-14 Hoffmann La Roche Process for the manufacture of pentaenes
DE1149353B (de) * 1960-08-03 1963-05-30 Bayer Ag Verfahren zur Herstellung von 6-[2', 6', 6'-Trimethylcyclohexen-(1')-yl]-4-methylhexadien-(3, 5)-in-(1) (íÀC-KohlenwasserstoffíÂ)
US3876673A (en) * 1970-08-05 1975-04-08 Rhone Poulenc Sa Intermediates useful in the synthesis of vitamin a
CA939369A (en) * 1970-10-13 1974-01-01 John A. Findlay Process for preparing hydrocarbon acid esters
US3781313A (en) * 1971-01-20 1973-12-25 Rhone Poulenc Sa Sulfone intermediates for the synthesis of vitamin a

Also Published As

Publication number Publication date
GB1442107A (no) 1976-07-07
US3931257A (en) 1976-01-06
BE819116A (fr) 1975-02-24
SE422788B (sv) 1982-03-29
DK451874A (no) 1975-04-28
NL7411016A (nl) 1975-02-26
JPS5049243A (no) 1975-05-01
FR2241297B1 (no) 1978-11-10
ZA744964B (en) 1975-08-27
DE2440606A1 (de) 1975-03-06
AU7214674A (en) 1976-02-12
CH585709A5 (no) 1977-03-15
FR2241297A1 (no) 1975-03-21
SE7410757L (no) 1975-02-25

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