CA1015662A - ANTIHYPERTENSIVE COMPOSITION OF HYDRALAZINE AND .beta.-ADRENERGIC BLOCKING AGENT - Google Patents

ANTIHYPERTENSIVE COMPOSITION OF HYDRALAZINE AND .beta.-ADRENERGIC BLOCKING AGENT

Info

Publication number
CA1015662A
CA1015662A CA164,752A CA164752A CA1015662A CA 1015662 A CA1015662 A CA 1015662A CA 164752 A CA164752 A CA 164752A CA 1015662 A CA1015662 A CA 1015662A
Authority
CA
Canada
Prior art keywords
hydralazine
beta
blocking agent
adrenergic blocking
antihypertensive composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA164,752A
Other languages
English (en)
Other versions
CA164752S (en
Inventor
Carl E. Nelson
Alexander Scriabine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of CA1015662A publication Critical patent/CA1015662A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01Five-membered rings
    • C07D285/02Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/101,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA164,752A 1972-03-06 1973-02-27 ANTIHYPERTENSIVE COMPOSITION OF HYDRALAZINE AND .beta.-ADRENERGIC BLOCKING AGENT Expired CA1015662A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00232294A US3833727A (en) 1972-03-06 1972-03-06 Hydralazine and beta-adrenergic blocking agent compositions for treating hypertension

Publications (1)

Publication Number Publication Date
CA1015662A true CA1015662A (en) 1977-08-16

Family

ID=22872572

Family Applications (1)

Application Number Title Priority Date Filing Date
CA164,752A Expired CA1015662A (en) 1972-03-06 1973-02-27 ANTIHYPERTENSIVE COMPOSITION OF HYDRALAZINE AND .beta.-ADRENERGIC BLOCKING AGENT

Country Status (19)

Country Link
US (1) US3833727A (xx)
AT (1) AT331966B (xx)
BE (1) BE796288A (xx)
CA (1) CA1015662A (xx)
CY (1) CY951A (xx)
DD (1) DD103559A5 (xx)
FR (1) FR2181786B1 (xx)
GB (1) GB1385648A (xx)
HK (1) HK23378A (xx)
HU (1) HU165714B (xx)
IE (1) IE37326B1 (xx)
IL (1) IL41610A (xx)
KE (1) KE2839A (xx)
LU (1) LU67144A1 (xx)
MY (1) MY7800295A (xx)
NL (1) NL176746C (xx)
PH (1) PH18901A (xx)
SE (1) SE400472B (xx)
ZA (1) ZA731505B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001421A (en) * 1971-10-27 1977-01-04 Syntex (U.S.A.) Inc. Thiazole cardiovascular agents
AU540656B2 (en) * 1980-02-19 1984-11-29 Merck & Co., Inc. S-(-)-1-(tert-butylamino-3((4-morpholino-1,2,5-thiadiazol-3- yl)-oxy)-2-propanol pamoate
US4521414A (en) * 1981-06-18 1985-06-04 The Texas A&M University System Ophthalmic compositions and their use for treating elevated intraocular pressure and glaucoma
US20110092507A1 (en) * 2009-10-20 2011-04-21 Chin-Tsai Fan Process for preparing R-(+)-3-morpholino-4-(3- tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazole

Also Published As

Publication number Publication date
HK23378A (en) 1978-05-12
AU5266273A (en) 1974-08-29
IL41610A (en) 1975-08-31
IL41610A0 (en) 1973-04-30
NL176746B (nl) 1985-01-02
DD103559A5 (xx) 1974-02-05
ATA195873A (de) 1975-12-15
PH18901A (en) 1985-10-30
BE796288A (fr) 1973-09-05
SE400472B (sv) 1978-04-03
MY7800295A (en) 1978-12-31
IE37326B1 (en) 1977-06-22
IE37326L (en) 1973-09-06
CY951A (en) 1978-12-22
LU67144A1 (xx) 1973-09-06
AT331966B (de) 1976-09-10
NL176746C (nl) 1985-06-03
DE2310836B2 (de) 1976-11-04
FR2181786B1 (xx) 1976-05-14
US3833727A (en) 1974-09-03
ZA731505B (en) 1974-10-30
DE2310836A1 (de) 1973-09-20
FR2181786A1 (xx) 1973-12-07
NL7302728A (xx) 1973-09-10
HU165714B (xx) 1974-10-28
KE2839A (en) 1978-05-26
GB1385648A (en) 1975-02-26

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