CA1006159A - D-6-methyl 2,8-disubstituted ergolines - Google Patents

D-6-methyl 2,8-disubstituted ergolines

Info

Publication number
CA1006159A
CA1006159A CA177,021A CA177021A CA1006159A CA 1006159 A CA1006159 A CA 1006159A CA 177021 A CA177021 A CA 177021A CA 1006159 A CA1006159 A CA 1006159A
Authority
CA
Canada
Prior art keywords
methyl
ergolines
disubstituted
disubstituted ergolines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA177,021A
Other languages
English (en)
Other versions
CA177021S (en
Inventor
Nicholas J. Bach
James A. Clemens
Edmund C. Kornfeld
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of CA1006159A publication Critical patent/CA1006159A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA177,021A 1972-07-21 1973-07-20 D-6-methyl 2,8-disubstituted ergolines Expired CA1006159A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27390272A 1972-07-21 1972-07-21

Publications (1)

Publication Number Publication Date
CA1006159A true CA1006159A (en) 1977-03-01

Family

ID=23045910

Family Applications (1)

Application Number Title Priority Date Filing Date
CA177,021A Expired CA1006159A (en) 1972-07-21 1973-07-20 D-6-methyl 2,8-disubstituted ergolines

Country Status (24)

Country Link
JP (2) JPS576431B2 (ja)
AR (3) AR206772A1 (ja)
AT (1) AT331425B (ja)
BE (1) BE802531A (ja)
BG (3) BG22400A3 (ja)
CA (1) CA1006159A (ja)
CH (5) CH580625A5 (ja)
CS (1) CS208164B2 (ja)
DD (1) DD107690A5 (ja)
DE (2) DE2335750C3 (ja)
DK (1) DK140986B (ja)
ES (5) ES417078A1 (ja)
FR (1) FR2193606B1 (ja)
GB (1) GB1423065A (ja)
HU (1) HU167274B (ja)
IE (1) IE37936B1 (ja)
IL (3) IL42730A (ja)
NL (1) NL7309969A (ja)
PH (1) PH11229A (ja)
RO (2) RO71305A (ja)
SE (3) SE393111B (ja)
SU (3) SU645581A3 (ja)
YU (1) YU36953B (ja)
ZA (1) ZA734627B (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1517971A (en) * 1974-07-19 1978-07-19 Sandoz Ltd 8alpha-substituted ergoline i derivatives
US3968111A (en) * 1974-12-06 1976-07-06 Eli Lilly And Company 8,8-Disubstituted-6-methylergolines and related compounds
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
AU526764B2 (en) * 1978-09-08 1983-01-27 Farmitalia Carlo Erba S.P.A. Ergoline derivatives
DE3587860D1 (de) * 1984-04-09 1994-07-28 Schering Ag 2-substituierte Ergolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
HU196598B (en) * 1986-04-25 1988-12-28 Richter Gedeon Vegyeszet Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds
DE3620293A1 (de) * 1986-06-16 1987-12-17 Schering Ag 1-und/oder 2-substituierte ergolinderivate
JPH0596382U (ja) * 1992-05-28 1993-12-27 イビデン株式会社 ドアユニット

Also Published As

Publication number Publication date
SU645581A3 (ru) 1979-01-30
CS208164B2 (en) 1981-08-31
IL42730A (en) 1976-06-30
NL7309969A (ja) 1974-01-23
IL42730A0 (en) 1973-10-25
SU584780A3 (ru) 1977-12-15
GB1423065A (en) 1976-01-28
ES442885A1 (es) 1977-04-16
JPS5813541B2 (ja) 1983-03-14
JPS5781487A (en) 1982-05-21
CH580625A5 (ja) 1976-10-15
SE393111B (sv) 1977-05-02
DD107690A5 (ja) 1974-08-12
DK140986C (ja) 1980-07-21
BE802531A (fr) 1974-01-21
SE7611467L (sv) 1976-10-15
BG21410A3 (bg) 1976-05-20
FR2193606B1 (ja) 1977-07-15
AR206887A1 (es) 1976-08-31
AT331425B (de) 1976-08-25
CH580626A5 (ja) 1976-10-15
RO71305A (ro) 1982-03-24
SU575029A3 (ru) 1977-09-30
ATA643473A (de) 1975-11-15
IE37936L (en) 1974-01-21
ZA734627B (en) 1974-06-26
IL48288A0 (en) 1975-12-31
DE2365974A1 (de) 1977-03-24
YU194573A (en) 1982-06-18
HU167274B (ja) 1975-09-27
ES417078A1 (es) 1976-05-01
ES446789A1 (es) 1977-06-01
CH578563A5 (ja) 1976-08-13
CH581135A5 (ja) 1976-10-29
BG22400A3 (bg) 1977-02-20
AR206772A1 (es) 1976-08-23
FR2193606A1 (ja) 1974-02-22
AR210072A1 (es) 1977-06-30
IE37936B1 (en) 1977-11-23
BG21411A3 (ja) 1976-05-20
IL48288A (en) 1976-06-30
JPS4985099A (ja) 1974-08-15
CH578564A5 (ja) 1976-08-13
PH11229A (en) 1977-10-28
ES442887A1 (es) 1977-05-16
SE410459B (sv) 1979-10-15
JPS576431B2 (ja) 1982-02-04
ES442886A1 (es) 1977-04-16
AU5792673A (en) 1975-01-16
RO63792A (fr) 1978-12-15
YU36953B (en) 1984-08-31
DE2335750C3 (de) 1978-10-19
DE2335750B2 (de) 1978-02-23
DE2335750A1 (de) 1974-02-14
DK140986B (da) 1979-12-17
SE410603B (sv) 1979-10-22
SE7611466L (sv) 1976-10-15

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