CA1002528A - Preparation of 5-aroyl-pyrroles and intermediates therefor - Google Patents

Preparation of 5-aroyl-pyrroles and intermediates therefor

Info

Publication number
CA1002528A
CA1002528A CA177,635A CA177635A CA1002528A CA 1002528 A CA1002528 A CA 1002528A CA 177635 A CA177635 A CA 177635A CA 1002528 A CA1002528 A CA 1002528A
Authority
CA
Canada
Prior art keywords
aroyl
pyrroles
preparation
intermediates therefor
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA177,635A
Other languages
English (en)
Other versions
CA177635S (en
Inventor
John R. Carson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
McNeil Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by McNeil Laboratories Inc filed Critical McNeil Laboratories Inc
Priority to CA237,049A priority Critical patent/CA1002054A/en
Application granted granted Critical
Publication of CA1002528A publication Critical patent/CA1002528A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA177,635A 1972-08-03 1973-07-30 Preparation of 5-aroyl-pyrroles and intermediates therefor Expired CA1002528A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA237,049A CA1002054A (en) 1972-08-03 1975-10-06 Preparation of 5-aroyl-pyrroles and intermediates therefor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00277845A US3846447A (en) 1972-08-03 1972-08-03 Preparation of 5-aroyl-pyrroles and intermediates therefor

Publications (1)

Publication Number Publication Date
CA1002528A true CA1002528A (en) 1976-12-28

Family

ID=23062597

Family Applications (1)

Application Number Title Priority Date Filing Date
CA177,635A Expired CA1002528A (en) 1972-08-03 1973-07-30 Preparation of 5-aroyl-pyrroles and intermediates therefor

Country Status (9)

Country Link
US (1) US3846447A (sv)
JP (1) JPS4955659A (sv)
AT (1) AT325602B (sv)
CA (1) CA1002528A (sv)
DE (1) DE2339140A1 (sv)
FR (1) FR2239246B1 (sv)
GB (1) GB1428272A (sv)
NL (1) NL7310359A (sv)
SE (2) SE389671B (sv)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4140696A (en) * 1973-08-22 1979-02-20 Gruppo Lepetit S.P.A. Aminopyrrole derivatives
US4187230A (en) * 1975-05-27 1980-02-05 Ethyl Corporation Preparation of 5-aroyl-pyrrole compounds
US3998844A (en) * 1975-06-02 1976-12-27 Mcneil Laboratories, Incorporated Uncatalyzed aroylation of 1-alkylpyrrole-2-acetic acid derivatives
US4048191A (en) * 1975-06-27 1977-09-13 Mcneil Laboratories, Incorporated Halo-substituted 1-loweralkyl-5-aroylpyrrole-2-acetic acid compounds
US4125537A (en) * 1977-02-07 1978-11-14 Mcneil Laboratories, Incorporated Preparation of pyrrole-2-acetates
US4097579A (en) * 1977-03-31 1978-06-27 Syntex (U.S.A.) Inc. 5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4200645A (en) * 1977-05-10 1980-04-29 Beecham Group Limited Pyrrole derivatives
US4119639A (en) * 1977-06-27 1978-10-10 Mcneil Laboratories, Incorporated Preparation of 5-aroylpyrrole-2-acetic acid derivatives
JPS5481264A (en) * 1977-12-08 1979-06-28 Sagami Chem Res Center Preparation of 1-methyl-5-aroylpryrrole-2-acetic acid
EP0010553B1 (en) * 1978-10-27 1983-05-18 McNeilab, Inc. Process of reducing a loweralkyl 1-loweralkyl-pyrrole-2-glyoxylate to a loweralkyl 1-loweralkyl-pyrrole-2-acetate
US4246176A (en) * 1979-07-05 1981-01-20 Ethyl Corporation Synthesis of 5-aroyl-1-hydrocarbylpyrrole-2-acetic acid
WO2009072139A1 (en) * 2007-12-07 2009-06-11 Matrix Laboratories Limited Process for producing 2-[1-methyl-5-(4-methylbenzoyl)- pyrrol-2- yl]acetic acid or salt thereof
CN103435527B (zh) * 2013-09-03 2015-09-23 张家港市信谊化工有限公司 一种非甾体抗炎药托美汀的制备方法

Also Published As

Publication number Publication date
GB1428272A (en) 1976-03-17
SE389671B (sv) 1976-11-15
NL7310359A (sv) 1974-02-05
SE7602534L (sv) 1976-02-26
JPS4955659A (sv) 1974-05-30
DE2339140A1 (de) 1974-02-14
ATA678373A (de) 1975-01-15
US3846447A (en) 1974-11-05
AT325602B (de) 1975-10-27
FR2239246A1 (sv) 1975-02-28
FR2239246B1 (sv) 1977-04-15

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