CA1001161A - 5-(3-substituted amino-2-hydroxypropoxy)1,3-disubstituted pyrazoles and method of preparation - Google Patents

5-(3-substituted amino-2-hydroxypropoxy)1,3-disubstituted pyrazoles and method of preparation

Info

Publication number
CA1001161A
CA1001161A CA141470A CA141470A CA1001161A CA 1001161 A CA1001161 A CA 1001161A CA 141470 A CA141470 A CA 141470A CA 141470 A CA141470 A CA 141470A CA 1001161 A CA1001161 A CA 1001161A
Authority
CA
Canada
Prior art keywords
hydroxypropoxy
preparation
substituted amino
disubstituted pyrazoles
pyrazoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA141470A
Other languages
English (en)
Inventor
Burton K. Wasson
Clarence S. Rooney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme IA Corp
Original Assignee
Merck Sharp and Dohme IA Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme IA Corp filed Critical Merck Sharp and Dohme IA Corp
Priority to CA141470A priority Critical patent/CA1001161A/en
Priority to SE7305383A priority patent/SE400076B/xx
Priority to NL7305477A priority patent/NL7305477A/xx
Priority to AU54937/73A priority patent/AU474793B2/en
Priority to GB2047573A priority patent/GB1390485A/en
Priority to JP48047644A priority patent/JPS4947367A/ja
Priority to FR7315861A priority patent/FR2183751B1/fr
Priority to ES414320A priority patent/ES414320A1/es
Priority to DE2322313A priority patent/DE2322313A1/de
Priority to BE130745A priority patent/BE799098A/xx
Priority to HUME1624A priority patent/HU165583B/hu
Priority to CH636973A priority patent/CH582677A5/xx
Priority to ZA733049A priority patent/ZA733049B/xx
Priority to US521416A priority patent/US3920691A/en
Application granted granted Critical
Publication of CA1001161A publication Critical patent/CA1001161A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/28—Two oxygen or sulfur atoms
    • C07D231/30—Two oxygen or sulfur atoms attached in positions 3 and 5
    • C07D231/32—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA141470A 1972-05-05 1972-05-05 5-(3-substituted amino-2-hydroxypropoxy)1,3-disubstituted pyrazoles and method of preparation Expired CA1001161A (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
CA141470A CA1001161A (en) 1972-05-05 1972-05-05 5-(3-substituted amino-2-hydroxypropoxy)1,3-disubstituted pyrazoles and method of preparation
SE7305383A SE400076B (sv) 1972-05-05 1973-04-16 Forfarande for framstellning av 5-(3-substituerade amino-2-hydroxipropoxi)-1,3-disubstituerade pyrazolforeningar vilka uppvisar beta-adrenergiskt blockerande egenskaper
NL7305477A NL7305477A (hu) 1972-05-05 1973-04-18
AU54937/73A AU474793B2 (en) 1972-05-05 1973-04-27 5-(3-SUBSTITUTED AMINO-2-HYDROXYPROPOXY)-l, 3 DISUBSTITUTED PYRAZOLES
GB2047573A GB1390485A (en) 1972-05-05 1973-04-30 Pyrazoles
JP48047644A JPS4947367A (hu) 1972-05-05 1973-05-01
FR7315861A FR2183751B1 (hu) 1972-05-05 1973-05-03
ES414320A ES414320A1 (es) 1972-05-05 1973-05-03 Un procedimiento para la preparacion de un pirazol.
DE2322313A DE2322313A1 (de) 1972-05-05 1973-05-03 Pyrazolderivate und verfahren zu ihrer herstellung
BE130745A BE799098A (fr) 1972-05-05 1973-05-04 Derives de pyrazole et procede pour les preparer
HUME1624A HU165583B (hu) 1972-05-05 1973-05-04
CH636973A CH582677A5 (hu) 1972-05-05 1973-05-04
ZA733049A ZA733049B (en) 1972-05-05 1973-05-04 Pyrazole derivatives and process for preparing
US521416A US3920691A (en) 1972-05-05 1974-11-06 5-(3-substituted amino-2-hydroxypropoxy)-1,3-disubstituted pyrazoles and method of preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA141470A CA1001161A (en) 1972-05-05 1972-05-05 5-(3-substituted amino-2-hydroxypropoxy)1,3-disubstituted pyrazoles and method of preparation

Publications (1)

Publication Number Publication Date
CA1001161A true CA1001161A (en) 1976-12-07

Family

ID=4093188

Family Applications (1)

Application Number Title Priority Date Filing Date
CA141470A Expired CA1001161A (en) 1972-05-05 1972-05-05 5-(3-substituted amino-2-hydroxypropoxy)1,3-disubstituted pyrazoles and method of preparation

Country Status (14)

Country Link
US (1) US3920691A (hu)
JP (1) JPS4947367A (hu)
AU (1) AU474793B2 (hu)
BE (1) BE799098A (hu)
CA (1) CA1001161A (hu)
CH (1) CH582677A5 (hu)
DE (1) DE2322313A1 (hu)
ES (1) ES414320A1 (hu)
FR (1) FR2183751B1 (hu)
GB (1) GB1390485A (hu)
HU (1) HU165583B (hu)
NL (1) NL7305477A (hu)
SE (1) SE400076B (hu)
ZA (1) ZA733049B (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2619164C2 (de) * 1976-04-30 1985-07-11 Boehringer Mannheim Gmbh, 6800 Mannheim Indazolyl-(4)-oxy-propanolamine, Verfahren zu ihrer Herstellung und deren Verwendung
FI57617C (fi) * 1979-01-18 1980-09-10 Viljanmaa Antti Spaennanordning foer skinn
DE2926517A1 (de) * 1979-06-30 1981-01-15 Beiersdorf Ag Substituierte 3-aryl-pyrazole und 5-aryl-isoxazole und verfahren zu ihrer herstellung
DE4341749A1 (de) * 1993-12-08 1995-06-14 Kali Chemie Pharma Gmbh 3-(Phenylalkylaminoalkyloxy)-5-phenylpyrazol- Verbindungen sowie Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5547967A (en) * 1993-12-08 1996-08-20 Kali-Chemie Pharma Gmbh (Phenylalkylaminoalkyloxy)-heteroaryl-compounds, processes and intermediates for their production and pharmaceutical compositions containing them
CO5011072A1 (es) 1997-12-05 2001-02-28 Lilly Co Eli Etanolaminas pirazinil substituidas como agfonistas de los receptores
WO1999029672A1 (en) * 1997-12-05 1999-06-17 Eli Lilly And Company SELECTIVE β3 ADRENERGIC AGONISTS

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1201061A (en) * 1966-08-26 1970-08-05 Endo Lab Oxo pyrroles and process for preparing same
US3629433A (en) * 1968-09-16 1971-12-21 Ciba Geigy Corp Antidepressant compositions of cycloalkano(c)pyrazole ethers
US3637738A (en) * 1969-02-12 1972-01-25 Ciba Geigy Corp Cycloalkano(c)pyrazole ethers
US3726896A (en) * 1970-05-06 1973-04-10 Szabo Hnos Kessler & Cia 1-benzyl-3(2,3-dihydroxypropoxy)indazole

Also Published As

Publication number Publication date
FR2183751B1 (hu) 1976-10-22
SE400076B (sv) 1978-03-13
CH582677A5 (hu) 1976-12-15
FR2183751A1 (hu) 1973-12-21
GB1390485A (en) 1975-04-16
ZA733049B (en) 1974-12-24
DE2322313A1 (de) 1973-11-22
AU5493773A (en) 1974-10-31
AU474793B2 (en) 1976-08-05
NL7305477A (hu) 1973-11-07
HU165583B (hu) 1974-09-28
US3920691A (en) 1975-11-18
BE799098A (fr) 1973-11-05
JPS4947367A (hu) 1974-05-08
ES414320A1 (es) 1976-02-01

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