BRPI1014874A2 - piperazinyl azetidinyl heteroaromatic and aromatic amides as monoacylglycerol lipase inhibitors - Google Patents
piperazinyl azetidinyl heteroaromatic and aromatic amides as monoacylglycerol lipase inhibitorsInfo
- Publication number
- BRPI1014874A2 BRPI1014874A2 BRPI1014874A BRPI1014874A BRPI1014874A2 BR PI1014874 A2 BRPI1014874 A2 BR PI1014874A2 BR PI1014874 A BRPI1014874 A BR PI1014874A BR PI1014874 A BRPI1014874 A BR PI1014874A BR PI1014874 A2 BRPI1014874 A2 BR PI1014874A2
- Authority
- BR
- Brazil
- Prior art keywords
- heteroaromatic
- lipase inhibitors
- aromatic amides
- monoacylglycerol lipase
- azetidinyl
- Prior art date
Links
- 229940127470 Lipase Inhibitors Drugs 0.000 title 1
- 102000005398 Monoacylglycerol Lipase Human genes 0.000 title 1
- 108020002334 Monoacylglycerol lipase Proteins 0.000 title 1
- 150000008430 aromatic amides Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17166109P | 2009-04-22 | 2009-04-22 | |
PCT/US2010/032100 WO2010124122A1 (en) | 2009-04-22 | 2010-04-22 | Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI1014874A2 true BRPI1014874A2 (en) | 2016-04-12 |
Family
ID=42226535
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI1014874A BRPI1014874A2 (en) | 2009-04-22 | 2010-04-22 | piperazinyl azetidinyl heteroaromatic and aromatic amides as monoacylglycerol lipase inhibitors |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP2421535A1 (en) |
JP (1) | JP2012524810A (en) |
KR (1) | KR20120005517A (en) |
CN (1) | CN102458407B (en) |
AU (1) | AU2010238746B2 (en) |
BR (1) | BRPI1014874A2 (en) |
CA (1) | CA2759706A1 (en) |
IL (1) | IL215797A0 (en) |
RU (1) | RU2011147201A (en) |
TW (1) | TW201103914A (en) |
WO (1) | WO2010124122A1 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20140068243A (en) * | 2011-09-30 | 2014-06-05 | 얀센 파마슈티카 엔.브이. | Monoacylglycerol lipase inhibitors for the treatment of metabolic diseases and related disorders |
WO2014100834A1 (en) * | 2012-12-21 | 2014-06-26 | The Regents Of The University Of California | Methods and compositions for treatment of cyanide and hydrogen sulfide toxicity |
WO2015099196A1 (en) | 2013-12-26 | 2015-07-02 | Takeda Pharmaceutical Company Limited | 4-(piperrazin-1-yl)-pyrrolidin-2-one compounds as monoacylglycerol lipase (magl) inhibitors |
US10106556B2 (en) | 2015-03-30 | 2018-10-23 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
WO2017143283A1 (en) | 2016-02-19 | 2017-08-24 | Abide Therapeutics, Inc. | Radiolabeled monoacylglycerol lipase occupancy probe |
CN109715613B (en) | 2016-03-31 | 2021-07-30 | 武田药品工业株式会社 | Heterocyclic compounds |
WO2017170830A1 (en) | 2016-03-31 | 2017-10-05 | 武田薬品工業株式会社 | Heterocyclic compound |
WO2019065791A1 (en) | 2017-09-29 | 2019-04-04 | 武田薬品工業株式会社 | Heterocyclic compound |
EP3717477B1 (en) | 2017-11-28 | 2022-07-20 | F. Hoffmann-La Roche AG | New heterocyclic compounds |
TW201930300A (en) * | 2017-12-15 | 2019-08-01 | 瑞士商赫孚孟拉羅股份公司 | New heterocyclic compounds |
JOP20210058A1 (en) * | 2018-09-28 | 2021-03-24 | Janssen Pharmaceutica Nv | Monoacylglycerol lipase modulators |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2915199B1 (en) * | 2007-04-18 | 2010-01-22 | Sanofi Aventis | TRIAZOLOPYRIDINE-CARBOXAMIDE AND TRIAZOLOPYRIMIDINE-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE. |
EP2180048B1 (en) * | 2008-10-09 | 2014-12-17 | Janssen Pharmaceutica N.V. | Alternative crystal form of monoacylglycerol lipase (MGLL) |
-
2010
- 2010-04-22 CN CN201080028761.8A patent/CN102458407B/en not_active Expired - Fee Related
- 2010-04-22 KR KR1020117027431A patent/KR20120005517A/en not_active Application Discontinuation
- 2010-04-22 JP JP2012507395A patent/JP2012524810A/en active Pending
- 2010-04-22 BR BRPI1014874A patent/BRPI1014874A2/en active Search and Examination
- 2010-04-22 RU RU2011147201/15A patent/RU2011147201A/en not_active Application Discontinuation
- 2010-04-22 CA CA2759706A patent/CA2759706A1/en not_active Abandoned
- 2010-04-22 TW TW099112745A patent/TW201103914A/en unknown
- 2010-04-22 AU AU2010238746A patent/AU2010238746B2/en not_active Ceased
- 2010-04-22 EP EP10714829A patent/EP2421535A1/en not_active Withdrawn
- 2010-04-22 WO PCT/US2010/032100 patent/WO2010124122A1/en active Application Filing
-
2011
- 2011-10-23 IL IL215797A patent/IL215797A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2010238746B2 (en) | 2015-02-19 |
TW201103914A (en) | 2011-02-01 |
CN102458407A (en) | 2012-05-16 |
CA2759706A1 (en) | 2010-10-28 |
AU2010238746A1 (en) | 2011-11-10 |
RU2011147201A (en) | 2013-05-27 |
JP2012524810A (en) | 2012-10-18 |
CN102458407B (en) | 2014-03-05 |
KR20120005517A (en) | 2012-01-16 |
EP2421535A1 (en) | 2012-02-29 |
IL215797A0 (en) | 2012-01-31 |
WO2010124122A1 (en) | 2010-10-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |