BRPI1011822A2 - "compostos de 3-substituída-8-substituída-3h-imidazo[5,1-d][1,2,3,5-tetrazin-4-ona e sua aplicação" - Google Patents

"compostos de 3-substituída-8-substituída-3h-imidazo[5,1-d][1,2,3,5-tetrazin-4-ona e sua aplicação"

Info

Publication number
BRPI1011822A2
BRPI1011822A2 BRPI1011822A BRPI1011822A BRPI1011822A2 BR PI1011822 A2 BRPI1011822 A2 BR PI1011822A2 BR PI1011822 A BRPI1011822 A BR PI1011822A BR PI1011822 A BRPI1011822 A BR PI1011822A BR PI1011822 A2 BRPI1011822 A2 BR PI1011822A2
Authority
BR
Brazil
Prior art keywords
substituted
tetrazin
imidazo
compounds
application
Prior art date
Application number
BRPI1011822A
Other languages
English (en)
Portuguese (pt)
Inventor
David Cousin
Malcolm Francis Graham Stevens
Marc Geoffery Hummersone
Original Assignee
Pharminox Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharminox Ltd filed Critical Pharminox Ltd
Publication of BRPI1011822A2 publication Critical patent/BRPI1011822A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
BRPI1011822A 2009-06-23 2010-06-23 "compostos de 3-substituída-8-substituída-3h-imidazo[5,1-d][1,2,3,5-tetrazin-4-ona e sua aplicação" BRPI1011822A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21957509P 2009-06-23 2009-06-23
PCT/GB2010/001233 WO2010149968A1 (en) 2009-06-23 2010-06-23 3-substituted-8-substituted-3h imidazo[5,1-d][1,2,3,5-tetrazin-4-one compounds and their use

Publications (1)

Publication Number Publication Date
BRPI1011822A2 true BRPI1011822A2 (pt) 2016-03-29

Family

ID=42563083

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1011822A BRPI1011822A2 (pt) 2009-06-23 2010-06-23 "compostos de 3-substituída-8-substituída-3h-imidazo[5,1-d][1,2,3,5-tetrazin-4-ona e sua aplicação"

Country Status (13)

Country Link
US (1) US9024018B2 (zh)
EP (1) EP2445915B1 (zh)
JP (1) JP2012530775A (zh)
CN (1) CN102803264A (zh)
AU (1) AU2010264339A1 (zh)
BR (1) BRPI1011822A2 (zh)
CA (1) CA2763766A1 (zh)
ES (1) ES2583006T3 (zh)
HK (1) HK1172321A1 (zh)
IL (1) IL216794A0 (zh)
PL (1) PL2445915T3 (zh)
WO (1) WO2010149968A1 (zh)
ZA (1) ZA201108849B (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20091101A1 (es) * 2007-12-18 2009-07-26 Pharminox Ltd AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO
US9024018B2 (en) 2009-06-23 2015-05-05 Pharminox Limited 3-substituted-8-substituted-3H-imidazo[5,1-d][1,2,3,5]tetrazin-4-one compounds and their use
US20120261650A1 (en) 2010-10-22 2012-10-18 Commonwealth Scientific And Industrial Research Organisation Organic electroluminescent device
WO2012085501A1 (en) * 2010-12-20 2012-06-28 Pharminox Limited 8 - sulfo - imidazotetrazin- 4 - one compounds and their use as anticancer drug
US10562901B2 (en) 2016-09-22 2020-02-18 The University Of Massachusetts Temozolomide compounds, polymers prepared therefrom, and method of treating a disease
WO2020033880A1 (en) * 2018-08-09 2020-02-13 The Board Of Trustees Of The University Of Illinois Imidazotetrazine compounds
GB201907813D0 (en) 2019-05-31 2019-07-17 Univ Nottingham Therapeutic compounds
WO2023049806A1 (en) * 2021-09-23 2023-03-30 Yale University Compounds and methods for treating cancers that are mgmt deficient regardless of mmr status

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260291A (en) 1981-08-24 1993-11-09 Cancer Research Campaign Technology Limited Tetrazine derivatives
OA07174A (fr) 1981-08-24 1984-04-30 May & Baker Ltd Nouvelles imidazotétrazionones, leur préparation et les médicaments qui les contiennent.
GB2125402B (en) * 1982-08-17 1985-11-13 May & Baker Ltd New tetrazine derivatives
US4504475A (en) 1983-05-24 1985-03-12 Warner Lambert Company 3-(Haloethyl)-4-oxopyrazolo[5,1-D]-1,2,3,5-tetrazine-8-carboxamide compounds
GB8616125D0 (en) * 1986-07-02 1986-08-06 May & Baker Ltd Compositions of matter
GB9504361D0 (en) 1995-03-04 1995-04-26 Glaxo Spa Heterocyclic compounds
EP1353924A1 (en) 2001-01-18 2003-10-22 Schering Corporation Synthesis of temozolomide and analogs
CN1742723A (zh) 2004-09-02 2006-03-08 天津倍方科技发展有限公司 含有替莫唑胺－8－羧酸酯的药物组合物以及该类化合物用于制备抗肿瘤药物的用途
PE20091101A1 (es) 2007-12-18 2009-07-26 Pharminox Ltd AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO
GB0807103D0 (en) 2008-04-18 2008-05-21 Univ Bradford The Compounds
US9024018B2 (en) 2009-06-23 2015-05-05 Pharminox Limited 3-substituted-8-substituted-3H-imidazo[5,1-d][1,2,3,5]tetrazin-4-one compounds and their use
WO2011107726A1 (en) 2010-03-01 2011-09-09 Pharminox Ltd Methods and intermediates for the synthesis of 4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazines

Also Published As

Publication number Publication date
HK1172321A1 (zh) 2013-04-19
ES2583006T3 (es) 2016-09-16
AU2010264339A1 (en) 2011-12-22
JP2012530775A (ja) 2012-12-06
WO2010149968A1 (en) 2010-12-29
EP2445915A1 (en) 2012-05-02
US20120083513A1 (en) 2012-04-05
CA2763766A1 (en) 2010-12-29
US9024018B2 (en) 2015-05-05
CN102803264A (zh) 2012-11-28
EP2445915B1 (en) 2016-04-20
ZA201108849B (en) 2013-02-27
PL2445915T3 (pl) 2016-10-31
IL216794A0 (en) 2012-02-29

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]