BRPI0918215B1 - Método e sistema para controle de parâmetro de processo de uma composição líquida em um biorreator e uso de um sistema - Google Patents
Método e sistema para controle de parâmetro de processo de uma composição líquida em um biorreator e uso de um sistema Download PDFInfo
- Publication number
- BRPI0918215B1 BRPI0918215B1 BRPI0918215-2A BRPI0918215A BRPI0918215B1 BR PI0918215 B1 BRPI0918215 B1 BR PI0918215B1 BR PI0918215 A BRPI0918215 A BR PI0918215A BR PI0918215 B1 BRPI0918215 B1 BR PI0918215B1
- Authority
- BR
- Brazil
- Prior art keywords
- reed
- membrane
- cell
- fact
- electric field
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 98
- 230000008569 process Effects 0.000 title claims abstract description 68
- 239000000203 mixture Substances 0.000 title claims abstract description 32
- 239000012528 membrane Substances 0.000 claims abstract description 96
- 239000007788 liquid Substances 0.000 claims abstract description 48
- 230000005684 electric field Effects 0.000 claims abstract description 33
- 238000000909 electrodialysis Methods 0.000 claims abstract description 22
- 230000002441 reversible effect Effects 0.000 claims abstract description 17
- 210000004027 cell Anatomy 0.000 claims description 82
- 150000002500 ions Chemical class 0.000 claims description 38
- -1 organic acid ions Chemical class 0.000 claims description 17
- 238000000855 fermentation Methods 0.000 claims description 16
- 230000004151 fermentation Effects 0.000 claims description 16
- 239000003014 ion exchange membrane Substances 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 239000003112 inhibitor Substances 0.000 claims description 8
- 239000002207 metabolite Substances 0.000 claims description 8
- 238000005341 cation exchange Methods 0.000 claims description 6
- 238000005349 anion exchange Methods 0.000 claims description 5
- 241000894006 Bacteria Species 0.000 claims description 4
- 230000010261 cell growth Effects 0.000 claims description 4
- 238000009629 microbiological culture Methods 0.000 claims description 4
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 241000233866 Fungi Species 0.000 claims description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 2
- 210000004962 mammalian cell Anatomy 0.000 claims description 2
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- 230000000284 resting effect Effects 0.000 claims description 2
- 235000014676 Phragmites communis Nutrition 0.000 abstract 2
- 239000000243 solution Substances 0.000 description 15
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 12
- 239000012527 feed solution Substances 0.000 description 10
- 239000002253 acid Substances 0.000 description 9
- 238000000926 separation method Methods 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 238000005342 ion exchange Methods 0.000 description 8
- 230000001105 regulatory effect Effects 0.000 description 8
- 230000033228 biological regulation Effects 0.000 description 7
- 239000003011 anion exchange membrane Substances 0.000 description 6
- 230000001276 controlling effect Effects 0.000 description 6
- 239000006185 dispersion Substances 0.000 description 6
- 239000004310 lactic acid Substances 0.000 description 6
- 235000014655 lactic acid Nutrition 0.000 description 6
- 125000006850 spacer group Chemical group 0.000 description 6
- 238000009825 accumulation Methods 0.000 description 5
- 238000009792 diffusion process Methods 0.000 description 5
- 229910052739 hydrogen Inorganic materials 0.000 description 5
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- 238000005259 measurement Methods 0.000 description 5
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- 238000000108 ultra-filtration Methods 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 150000001768 cations Chemical class 0.000 description 3
- 238000000502 dialysis Methods 0.000 description 3
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- 230000012010 growth Effects 0.000 description 3
- 238000001471 micro-filtration Methods 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 2
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- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 238000012369 In process control Methods 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
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- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 238000010965 in-process control Methods 0.000 description 1
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- 239000003999 initiator Substances 0.000 description 1
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- 239000002184 metal Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
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- 230000005012 migration Effects 0.000 description 1
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- 239000000047 product Substances 0.000 description 1
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- 230000029219 regulation of pH Effects 0.000 description 1
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/42—Electrodialysis; Electro-osmosis ; Electro-ultrafiltration; Membrane capacitive deionization
- B01D61/44—Ion-selective electrodialysis
- B01D61/46—Apparatus therefor
- B01D61/50—Stacks of the plate-and-frame type
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/42—Electrodialysis; Electro-osmosis ; Electro-ultrafiltration; Membrane capacitive deionization
- B01D61/422—Electrodialysis
- B01D61/423—Electrodialysis comprising multiple electrodialysis steps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/42—Electrodialysis; Electro-osmosis ; Electro-ultrafiltration; Membrane capacitive deionization
- B01D61/44—Ion-selective electrodialysis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/42—Electrodialysis; Electro-osmosis ; Electro-ultrafiltration; Membrane capacitive deionization
- B01D61/44—Ion-selective electrodialysis
- B01D61/52—Accessories; Auxiliary operation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/42—Electrodialysis; Electro-osmosis ; Electro-ultrafiltration; Membrane capacitive deionization
- B01D61/44—Ion-selective electrodialysis
- B01D61/54—Controlling or regulating
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/26—Further operations combined with membrane separation processes
- B01D2311/2688—Biological processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2317/00—Membrane module arrangements within a plant or an apparatus
- B01D2317/02—Elements in series
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2317/00—Membrane module arrangements within a plant or an apparatus
- B01D2317/04—Elements in parallel
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2317/00—Membrane module arrangements within a plant or an apparatus
- B01D2317/06—Use of membrane modules of the same kind
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2317/00—Membrane module arrangements within a plant or an apparatus
- B01D2317/08—Use of membrane modules of different kinds
Landscapes
- Engineering & Computer Science (AREA)
- Water Supply & Treatment (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Botany (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Water Treatment By Electricity Or Magnetism (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9512308P | 2008-09-08 | 2008-09-08 | |
| EP08163856.1 | 2008-09-08 | ||
| EP08163856 | 2008-09-08 | ||
| US61/095,123 | 2008-09-08 | ||
| PCT/EP2009/006438 WO2010025933A1 (en) | 2008-09-08 | 2009-09-04 | Method and system for improved process parameter control of a liquid composition in a reverse electro-enhanced dialysis (reed) system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0918215A2 BRPI0918215A2 (pt) | 2015-12-08 |
| BRPI0918215B1 true BRPI0918215B1 (pt) | 2020-03-24 |
Family
ID=41202717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0918215-2A BRPI0918215B1 (pt) | 2008-09-08 | 2009-09-04 | Método e sistema para controle de parâmetro de processo de uma composição líquida em um biorreator e uso de um sistema |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8961769B2 (enExample) |
| EP (1) | EP2349540A1 (enExample) |
| JP (1) | JP5647610B2 (enExample) |
| CN (2) | CN102149448B (enExample) |
| AU (1) | AU2009289735B2 (enExample) |
| BR (1) | BRPI0918215B1 (enExample) |
| CA (1) | CA2735907A1 (enExample) |
| MX (1) | MX2011002511A (enExample) |
| NZ (1) | NZ591780A (enExample) |
| WO (1) | WO2010025933A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2349541B1 (en) | 2008-09-08 | 2021-11-24 | Carlsberg A/S | Process for controlling the ph and level of target ions of a liquid composition |
| US8961769B2 (en) * | 2008-09-08 | 2015-02-24 | Carlsberg A/S | Method and system for improved process parameter control of a liquid composition in a reverse electro-enhanced dialysis (REED) system |
| EP3434113B1 (en) | 2012-06-29 | 2020-10-28 | Carlsberg Breweries A/S | Method for producing beverages by acid removal |
| CN106062168A (zh) * | 2014-01-02 | 2016-10-26 | 嘉士伯酿酒有限公司 | 风味稳定的饮料 |
| EP3365653A4 (en) | 2015-10-23 | 2019-06-26 | Hewlett-Packard Development Company, L.P. | analyte extraction |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1037725A (en) * | 1963-12-31 | 1966-08-03 | American Mach & Foundry | Fluid treatment |
| DE3128564A1 (de) | 1981-07-18 | 1983-02-03 | Trützschler GmbH & Co KG, 4050 Mönchengladbach | Vorrichtung zum abliefern eines faserflockenvlieses, insbesondere zum beschicken einer textilmaschine, z. b. einer karde |
| US4381232A (en) * | 1981-08-24 | 1983-04-26 | Ionics, Incorporated | Multi-stage electrodialysis stack electrode reversal system and method of operation |
| JPS62146595A (ja) | 1985-12-20 | 1987-06-30 | Daicel Chem Ind Ltd | 醗酵による有機酸の連続製造方法 |
| DE3740785A1 (de) | 1987-12-02 | 1989-06-15 | Basf Ag | Verfahren zum entfernen von saeure aus kathodischen elektrotauchlackier-baedern mittels elektrodialyse |
| US6229046B1 (en) * | 1997-10-14 | 2001-05-08 | Cargill, Incorported | Lactic acid processing methods arrangements and products |
| CN1374932A (zh) | 1999-09-17 | 2002-10-16 | 康宁股份有限公司 | 在光波导中形成光栅的方法 |
| JP4230223B2 (ja) * | 2000-12-12 | 2009-02-25 | ユラク セパレーション アクティーゼルスカブ | イオン種を液体から単離するための方法及び装置 |
| WO2005044427A1 (en) * | 2003-10-27 | 2005-05-19 | Ionics, Incorporated | Improved electrodialysis system and process |
| EP2349541B1 (en) * | 2008-09-08 | 2021-11-24 | Carlsberg A/S | Process for controlling the ph and level of target ions of a liquid composition |
| US8961769B2 (en) * | 2008-09-08 | 2015-02-24 | Carlsberg A/S | Method and system for improved process parameter control of a liquid composition in a reverse electro-enhanced dialysis (REED) system |
-
2009
- 2009-09-04 US US13/062,806 patent/US8961769B2/en not_active Expired - Fee Related
- 2009-09-04 CN CN200980134817.5A patent/CN102149448B/zh not_active Expired - Fee Related
- 2009-09-04 BR BRPI0918215-2A patent/BRPI0918215B1/pt not_active IP Right Cessation
- 2009-09-04 AU AU2009289735A patent/AU2009289735B2/en not_active Ceased
- 2009-09-04 JP JP2011525466A patent/JP5647610B2/ja not_active Expired - Fee Related
- 2009-09-04 NZ NZ591780A patent/NZ591780A/xx not_active IP Right Cessation
- 2009-09-04 CN CN201410342397.2A patent/CN104084045B/zh not_active Expired - Fee Related
- 2009-09-04 CA CA2735907A patent/CA2735907A1/en not_active Abandoned
- 2009-09-04 MX MX2011002511A patent/MX2011002511A/es active IP Right Grant
- 2009-09-04 WO PCT/EP2009/006438 patent/WO2010025933A1/en not_active Ceased
- 2009-09-04 EP EP09778343A patent/EP2349540A1/en not_active Withdrawn
-
2015
- 2015-01-14 US US14/596,958 patent/US9216387B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2349540A1 (en) | 2011-08-03 |
| BRPI0918215A2 (pt) | 2015-12-08 |
| AU2009289735A1 (en) | 2010-03-11 |
| AU2009289735B2 (en) | 2015-10-01 |
| MX2011002511A (es) | 2011-06-22 |
| JP2012501632A (ja) | 2012-01-26 |
| CN104084045A (zh) | 2014-10-08 |
| US9216387B2 (en) | 2015-12-22 |
| WO2010025933A1 (en) | 2010-03-11 |
| CA2735907A1 (en) | 2010-03-11 |
| CN102149448B (zh) | 2014-08-13 |
| US8961769B2 (en) | 2015-02-24 |
| NZ591780A (en) | 2013-01-25 |
| CN102149448A (zh) | 2011-08-10 |
| CN104084045B (zh) | 2017-04-05 |
| JP5647610B2 (ja) | 2015-01-07 |
| US20110278171A1 (en) | 2011-11-17 |
| US20150182915A1 (en) | 2015-07-02 |
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Owner name: CARLSBERG A/S (DK) |
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| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
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