BRPI0911973A2 - derivados de imidazoquinazolina como análogos de anagrelide para tratamento de doenças mieloproliferativas e doenças trombóticas. - Google Patents
derivados de imidazoquinazolina como análogos de anagrelide para tratamento de doenças mieloproliferativas e doenças trombóticas.Info
- Publication number
- BRPI0911973A2 BRPI0911973A2 BRPI0911973A BRPI0911973A BRPI0911973A2 BR PI0911973 A2 BRPI0911973 A2 BR PI0911973A2 BR PI0911973 A BRPI0911973 A BR PI0911973A BR PI0911973 A BRPI0911973 A BR PI0911973A BR PI0911973 A2 BRPI0911973 A2 BR PI0911973A2
- Authority
- BR
- Brazil
- Prior art keywords
- diseases
- treatment
- thrombotic
- myeloproliferative
- imidazoquinazoline derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0808944.3A GB0808944D0 (en) | 2008-05-16 | 2008-05-16 | Substituted quinazolines |
PCT/GB2009/050514 WO2009138794A1 (en) | 2008-05-16 | 2009-05-13 | Imidazoquinazoline derivatives as anagrelide analogues for the treatment of myeloprolific diseases and thrombotic diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0911973A2 true BRPI0911973A2 (pt) | 2015-10-13 |
Family
ID=39596024
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0911973A BRPI0911973A2 (pt) | 2008-05-16 | 2009-05-13 | derivados de imidazoquinazolina como análogos de anagrelide para tratamento de doenças mieloproliferativas e doenças trombóticas. |
Country Status (9)
Country | Link |
---|---|
US (1) | US20110071173A1 (pt) |
EP (1) | EP2313410A1 (pt) |
JP (1) | JP2011520864A (pt) |
CN (1) | CN102076695A (pt) |
AU (1) | AU2009247795A1 (pt) |
BR (1) | BRPI0911973A2 (pt) |
CA (1) | CA2724181A1 (pt) |
GB (1) | GB0808944D0 (pt) |
WO (1) | WO2009138794A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8304420B2 (en) * | 2006-11-28 | 2012-11-06 | Shire Llc | Substituted quinazolines for reducing platelet count |
US7910597B2 (en) * | 2006-11-28 | 2011-03-22 | Shire Llc | Substituted quinazolines |
GB201017783D0 (en) | 2010-10-21 | 2010-12-01 | Shire Llc | Process for the preparation of anagrelide and analogues thereof |
AU2015370666B2 (en) * | 2014-12-22 | 2020-09-03 | Arovella Therapeutics Limited | Prevention and treatment of metastatic disease in thrombocytotic cancer patients |
WO2022199627A1 (en) * | 2021-03-23 | 2022-09-29 | National Institute Of Biological Sciences, Beijing | Polycyclic compounds and uses thereof |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE31617E (en) * | 1972-02-04 | 1984-06-26 | Bristol-Myers Company | Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones |
US3932407A (en) * | 1973-11-19 | 1976-01-13 | Bristol-Myers Company | Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones |
US3974165A (en) * | 1974-02-21 | 1976-08-10 | Bristol-Myers Company | Hypotensive agents |
US3983119A (en) * | 1974-11-06 | 1976-09-28 | Bristol-Myers Company | Process for the preparation of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones |
NL7807507A (nl) * | 1977-07-25 | 1979-01-29 | Hoffmann La Roche | Tricyclische verbindingen. |
US4146718A (en) * | 1978-04-10 | 1979-03-27 | Bristol-Myers Company | Alkyl 5,6-dichloro-3,4-dihydro-2(1h)-iminoquinazoline-3-acetate hydrohalides |
ZA803535B (en) * | 1979-06-20 | 1981-06-24 | Hoffmann La Roche | Novel quinazoline derivatives and pharmaceutical preparations |
EP0029559A3 (en) * | 1979-11-24 | 1981-09-30 | Sandoz Ag | 5,10-dihydroimidazo(2,1-b)quinazolines, their production and pharmaceutical compositions containing them |
US4663320A (en) * | 1983-02-16 | 1987-05-05 | Syntex (U.S.A.) Inc. | (2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof |
US4490371A (en) * | 1983-02-16 | 1984-12-25 | Syntex (U.S.A.) Inc. | N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides |
JPS6028979A (ja) * | 1983-07-14 | 1985-02-14 | Dai Ichi Seiyaku Co Ltd | イミダゾキナゾリン類化合物 |
US4593029A (en) * | 1984-02-15 | 1986-06-03 | Syntex (U.S.A.) Inc. | Novel ω-(N-imidazolyl)alkyl ethers of 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones |
US4670434A (en) * | 1985-11-14 | 1987-06-02 | Syntex (U.S.A.) Inc. | (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors |
NZ234186A (en) * | 1989-07-07 | 1991-10-25 | Janssen Pharmaceutica Nv | Imidazo quinazolin-one derivatives and pharmaceutical compositions |
TW593317B (en) * | 1993-06-21 | 2004-06-21 | Janssen Pharmaceutica Nv | Positive cardiac inotropic and lusitropic pyrroloquinolinone derivatives |
US7700608B2 (en) * | 2004-08-04 | 2010-04-20 | Shire Holdings Ag | Quinazoline derivatives and their use in the treatment of thrombocythemia |
GB0623750D0 (en) * | 2006-11-28 | 2007-01-10 | Shire Llc | Substituted quinazolines |
US8304420B2 (en) * | 2006-11-28 | 2012-11-06 | Shire Llc | Substituted quinazolines for reducing platelet count |
-
2008
- 2008-05-16 GB GBGB0808944.3A patent/GB0808944D0/en not_active Ceased
-
2009
- 2009-05-13 US US12/993,054 patent/US20110071173A1/en not_active Abandoned
- 2009-05-13 WO PCT/GB2009/050514 patent/WO2009138794A1/en active Application Filing
- 2009-05-13 AU AU2009247795A patent/AU2009247795A1/en not_active Abandoned
- 2009-05-13 BR BRPI0911973A patent/BRPI0911973A2/pt not_active IP Right Cessation
- 2009-05-13 CA CA2724181A patent/CA2724181A1/en not_active Abandoned
- 2009-05-13 JP JP2011509018A patent/JP2011520864A/ja active Pending
- 2009-05-13 EP EP09746111A patent/EP2313410A1/en not_active Withdrawn
- 2009-05-13 CN CN2009801251589A patent/CN102076695A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
EP2313410A1 (en) | 2011-04-27 |
AU2009247795A1 (en) | 2009-11-19 |
GB0808944D0 (en) | 2008-06-25 |
JP2011520864A (ja) | 2011-07-21 |
US20110071173A1 (en) | 2011-03-24 |
CA2724181A1 (en) | 2009-11-19 |
WO2009138794A1 (en) | 2009-11-19 |
CN102076695A (zh) | 2011-05-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2344 DE 08-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |