BRPI0910560B8 - Compostos de 2,6-diamino-pirimidin-5-il-carboxamidas como inibidores de syk ou jak quinases, composição, método para inibição de syk, jak quinase ou um sinal de via de transdução mediada ao menos por atividade de syk ou jak, e kit - Google Patents

Compostos de 2,6-diamino-pirimidin-5-il-carboxamidas como inibidores de syk ou jak quinases, composição, método para inibição de syk, jak quinase ou um sinal de via de transdução mediada ao menos por atividade de syk ou jak, e kit

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Publication number
BRPI0910560B8
BRPI0910560B8 BRPI0910560A BRPI0910560A BRPI0910560B8 BR PI0910560 B8 BRPI0910560 B8 BR PI0910560B8 BR PI0910560 A BRPI0910560 A BR PI0910560A BR PI0910560 A BRPI0910560 A BR PI0910560A BR PI0910560 B8 BRPI0910560 B8 BR PI0910560B8
Authority
BR
Brazil
Prior art keywords
syk
jak
compounds
inhibiting
jak kinase
Prior art date
Application number
BRPI0910560A
Other languages
English (en)
Inventor
M Bauer Shawn
Venkataramani Chandrasekar
Huang Wolin
W Rose Jack
J Jia Zhaozhong
Song Yonghong
Xu Qing
Mehrotra Mukund
Pandey Anjali
Original Assignee
Portola Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Portola Pharm Inc filed Critical Portola Pharm Inc
Priority claimed from PCT/US2009/002420 external-priority patent/WO2009145856A1/en
Publication of BRPI0910560A2 publication Critical patent/BRPI0910560A2/pt
Publication of BRPI0910560B1 publication Critical patent/BRPI0910560B1/pt
Publication of BRPI0910560B8 publication Critical patent/BRPI0910560B8/pt

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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
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  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
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  • Neurosurgery (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPOSTOS DE 2,6-DIAMINO-PIRIMIDIN-5-IL-CARBOXAMIDAS COMO INIBIDORES DE SYK OU JAK QUINASE, COMPOSIÇÃO, MÉTODO PARA INIBIÇÃO DE SYK, JAK QUINASE OU UM SINNAL DE VIA DE TRANSDUÇÃO MEDIADA AO MENOS POR ATIVIDADE DE SYK OU JAK, E KIT. A presente invenção refere-se a compostos de fórmula I-II e tautômeros, sais estereoisômeros dos mesmos farmaceuticamente aceitáveis que são inibidores de syk e/ou JAK quinase. A presente invenção é também dirigida para os intermediários usados na preparação de tais compostos, a preparação de tais compostos, composições farmacêuticas contendo tais compostos, métodos de inibição da atividade de syk e/ou JAK quinase, métodos de inibição de agregação de plaquetas, e métodos para prevenir ou tratar um número de condições mediadas, pelo menos em partes, pela atividade de syk e/ou JAK quinase, tais como doença cardiovascular, doença inflamatória, doença autoimune e doença de células proliferativas, trombose, alergia, asma, reumatoide, leucemia ou linfoma de Não Hodgkin.
BRPI0910560A 2008-04-16 2009-04-16 Compostos de 2,6-diamino-pirimidin-5-il-carboxamidas como inibidores de syk ou jak quinases, composição, método para inibição de syk, jak quinase ou um sinal de via de transdução mediada ao menos por atividade de syk ou jak, e kit BRPI0910560B8 (pt)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US4540608P 2008-04-16 2008-04-16
US4541708P 2008-04-16 2008-04-16
US4539908P 2008-04-16 2008-04-16
US61/045,406 2008-04-16
US61/045,399 2008-04-16
US61/045,417 2008-04-16
US12034108P 2008-12-05 2008-12-05
US12034408P 2008-12-05 2008-12-05
US12034808P 2008-12-05 2008-12-05
US61/120,344 2008-12-05
US61/120,341 2008-12-05
US61/120,348 2008-12-05
PCT/US2009/002420 WO2009145856A1 (en) 2008-04-16 2009-04-16 2, 6-diamino-pyrimidin- 5-yl-carboxamides as syk or jak kinases inhibitors

Publications (3)

Publication Number Publication Date
BRPI0910560A2 BRPI0910560A2 (pt) 2021-04-27
BRPI0910560B1 BRPI0910560B1 (pt) 2023-01-24
BRPI0910560B8 true BRPI0910560B8 (pt) 2023-03-21

Family

ID=43570275

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0910560A BRPI0910560B8 (pt) 2008-04-16 2009-04-16 Compostos de 2,6-diamino-pirimidin-5-il-carboxamidas como inibidores de syk ou jak quinases, composição, método para inibição de syk, jak quinase ou um sinal de via de transdução mediada ao menos por atividade de syk ou jak, e kit

Country Status (18)

Country Link
AU (1) AU2009251863B2 (pt)
BR (1) BRPI0910560B8 (pt)
CO (1) CO6331433A2 (pt)
CY (1) CY1118559T1 (pt)
DK (1) DK2321283T3 (pt)
ES (1) ES2597441T3 (pt)
GT (1) GT201000298A (pt)
HK (1) HK1158179A1 (pt)
HU (1) HUE031638T2 (pt)
IL (3) IL208637A (pt)
LT (1) LT2321283T (pt)
MX (1) MX353206B (pt)
NI (1) NI201000176A (pt)
NZ (1) NZ589314A (pt)
PL (1) PL2321283T3 (pt)
PT (1) PT2321283T (pt)
SI (1) SI2321283T1 (pt)
ZA (1) ZA201007045B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013202496B2 (en) * 2008-06-27 2016-08-04 Celgene Car Llc Heteroaryl compounds and uses thereof
US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
JP2011526299A (ja) 2008-06-27 2011-10-06 アビラ セラピューティクス， インコーポレイテッド ヘテロアリール化合物およびそれらの使用
AU2011289604C1 (en) 2010-08-10 2016-04-21 Celgene Avilomics Research, Inc. Besylate salt of a BTK inhibitor
MX2015009952A (es) 2013-02-08 2015-10-05 Celgene Avilomics Res Inc Inhibidores de cinasas reguladas por señales extracelulares (erk) y sus usos.
DK3179858T3 (da) 2014-08-13 2019-07-22 Celgene Car Llc Forme og sammensætninger af en ERK-inhibitor
CN114196651B (zh) * 2021-12-15 2023-06-30 中国林业科学研究院亚热带林业研究所 D6蛋白激酶d6pkl2的新用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999031073A1 (fr) * 1997-12-15 1999-06-24 Yamanouchi Pharmaceutical Co., Ltd. Nouveaux derives de pyrimidine-5-carboxamide
US7449456B2 (en) * 2002-06-28 2008-11-11 Astellas Pharma, Inc. Diaminopyrimidinecarboxamide derivative
MX2009000769A (es) * 2006-07-21 2009-01-28 Novartis Ag Compuestos de 2,4-di(arilaminio)-pirimidin-5-carboxamida como inhibidores de cinasas jak.

Also Published As

Publication number Publication date
HK1158179A1 (zh) 2012-07-13
PL2321283T3 (pl) 2017-01-31
BRPI0910560B1 (pt) 2023-01-24
AU2009251863A2 (en) 2011-06-09
MX353206B (es) 2018-01-08
NI201000176A (es) 2011-08-08
IL251655B (en) 2020-05-31
PT2321283T (pt) 2016-10-19
DK2321283T3 (en) 2016-10-31
IL208637A (en) 2017-04-30
LT2321283T (lt) 2016-12-12
HUE031638T2 (en) 2017-07-28
AU2009251863B2 (en) 2014-09-25
IL274522A (en) 2020-06-30
IL251655A0 (en) 2017-06-29
NZ589314A (en) 2012-10-26
ES2597441T3 (es) 2017-01-18
IL208637A0 (en) 2010-12-30
MX2010011464A (es) 2014-06-16
AU2009251863A1 (en) 2009-12-03
SI2321283T1 (sl) 2017-01-31
BRPI0910560A2 (pt) 2021-04-27
GT201000298A (es) 2014-05-07
ZA201007045B (en) 2012-08-29
CO6331433A2 (es) 2011-10-20
CY1118559T1 (el) 2017-07-12

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