BRPI0907903B1 - Composto derivado de diazepan-2-ona e composição farmacêutica - Google Patents

Info

Publication number

BRPI0907903B1

BRPI0907903B1 BRPI0907903-3A BRPI0907903A BRPI0907903B1 BR PI0907903 B1 BRPI0907903 B1 BR PI0907903B1 BR PI0907903 A BRPI0907903 A BR PI0907903A BR PI0907903 B1 BRPI0907903 B1 BR PI0907903B1

Authority

BR

Brazil

Prior art keywords

methyl

diazepan

oxo

ethyl

naphthamide

Prior art date

2008-02-29

Links

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• 150000001875 compounds Chemical class 0.000 title claims abstract description 205
• 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 11
• -1 substituted Chemical class 0.000 claims description 198
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 74
• 125000003118 aryl group Chemical group 0.000 claims description 73
• 125000000217 alkyl group Chemical group 0.000 claims description 64
• 125000001072 heteroaryl group Chemical group 0.000 claims description 61
• 229910052739 hydrogen Inorganic materials 0.000 claims description 52
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 33
• KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims description 30
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 29
• 150000003839 salts Chemical class 0.000 claims description 29
• 229910052757 nitrogen Inorganic materials 0.000 claims description 28
• 125000006710 (C2-C12) alkenyl group Chemical group 0.000 claims description 25
• HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 25
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 24
• 125000001424 substituent group Chemical group 0.000 claims description 24
• SHGAZHPCJJPHSC-NUEINMDLSA-N Isotretinoin Chemical compound OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NUEINMDLSA-N 0.000 claims description 23
• 125000004404 heteroalkyl group Chemical group 0.000 claims description 22
• 229960005280 isotretinoin Drugs 0.000 claims description 22
• 229910052799 carbon Inorganic materials 0.000 claims description 21
• 125000000623 heterocyclic group Chemical group 0.000 claims description 21
• 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims description 20
• 125000004429 atom Chemical group 0.000 claims description 20
• 239000002253 acid Substances 0.000 claims description 17
• 229910052736 halogen Inorganic materials 0.000 claims description 15
• 150000002367 halogens Chemical class 0.000 claims description 15
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 15
• 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims description 14
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 14
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 14
• 229910052801 chlorine Inorganic materials 0.000 claims description 13
• 229910052731 fluorine Inorganic materials 0.000 claims description 13
• 229910052717 sulfur Inorganic materials 0.000 claims description 13
• DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims description 12
• 229910052794 bromium Inorganic materials 0.000 claims description 12
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 12
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 12
• 125000003545 alkoxy group Chemical group 0.000 claims description 11
• 229910052740 iodine Inorganic materials 0.000 claims description 11
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 11
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 10
• APEJMQOBVMLION-UHFFFAOYSA-N cinnamamide Chemical compound NC(=O)C=CC1=CC=CC=C1 APEJMQOBVMLION-UHFFFAOYSA-N 0.000 claims description 10
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 10
• 150000001721 carbon Chemical group 0.000 claims description 9
• 125000005842 heteroatom Chemical group 0.000 claims description 9
• 125000001624 naphthyl group Chemical group 0.000 claims description 9
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 8
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 8
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 8
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 8
• 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 8
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 8
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 8
• NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 8
• 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims description 7
• 125000006176 2-ethylbutyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(C([H])([H])*)C([H])([H])C([H])([H])[H] 0.000 claims description 7
• 125000005916 2-methylpentyl group Chemical group 0.000 claims description 7
• MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 claims description 7
• 239000003242 anti bacterial agent Substances 0.000 claims description 7
• 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 7
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 7
• 239000003085 diluting agent Substances 0.000 claims description 7
• 239000003937 drug carrier Substances 0.000 claims description 7
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
• 229910052760 oxygen Inorganic materials 0.000 claims description 7
• 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims description 7
• 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 7
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 6
• ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims description 6
• 229940088710 antibiotic agent Drugs 0.000 claims description 6
• 125000005605 benzo group Chemical group 0.000 claims description 6
• 239000004305 biphenyl Substances 0.000 claims description 6
• ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims description 6
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 6
• 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 6
• 125000004641 (C1-C12) haloalkyl group Chemical group 0.000 claims description 5
• 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 5
• 125000004493 2-methylbut-1-yl group Chemical group CC(C*)CC 0.000 claims description 4
• PLXBZRBLWZSFDH-LNMMVMNESA-N 6-chloro-n-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H]1N[C@H](CNC(=O)C=2C=C3C=CC(Cl)=CC3=CC=2)CCN(C1=O)C[C@@H](CC)C=1C=CC=CC=1)CN1CCCCC1 PLXBZRBLWZSFDH-LNMMVMNESA-N 0.000 claims description 4
• 239000004342 Benzoyl peroxide Substances 0.000 claims description 4
• OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims description 4
• JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims description 4
• 239000013543 active substance Substances 0.000 claims description 4
• 235000019400 benzoyl peroxide Nutrition 0.000 claims description 4
• 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
• 238000001794 hormone therapy Methods 0.000 claims description 4
• 125000000555 isopropenyl group Chemical group [H]\C([H])=C(\*)C([H])([H])[H] 0.000 claims description 4
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 4
• KBNVEJCZPFDCIH-LRHLLKFHSA-N n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-[3-(propan-2-ylamino)propyl]-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCNC(C)C)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 KBNVEJCZPFDCIH-LRHLLKFHSA-N 0.000 claims description 4
• WUFPAWGDVHSNQX-WEZIJMHWSA-N n-[[(3s,5s)-1-(2,2-diphenylethyl)-3-[3-[(n'-methylcarbamimidoyl)amino]propyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCNC(=N)NC)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 WUFPAWGDVHSNQX-WEZIJMHWSA-N 0.000 claims description 4
• OGICFAGGMUMKDU-LRHLLKFHSA-N n-[[(3s,5s)-3-[2-(diethylamino)ethyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-6-fluoronaphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC(F)=CC2=CC=1)N[C@H](C1=O)CCN(CC)CC)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 OGICFAGGMUMKDU-LRHLLKFHSA-N 0.000 claims description 4
• HFJKZDDMHRPINP-WNJJXGMVSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-1h-indole-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1NC2=CC=CC=C2C=1)N[C@H](C1=O)CCCNC(=N)N)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 HFJKZDDMHRPINP-WNJJXGMVSA-N 0.000 claims description 4
• WBKKFYBGSRVUDI-XCZPVHLTSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)C1=CC=CC=C1 WBKKFYBGSRVUDI-XCZPVHLTSA-N 0.000 claims description 4
• 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
• 125000003386 piperidinyl group Chemical group 0.000 claims description 4
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
• 125000005750 substituted cyclic group Chemical group 0.000 claims description 4
• KHQRZLTVFGBWSN-YKKXUYLKSA-N (2s)-2-acetamido-n-[(1s)-1-[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]-2-naphthalen-2-ylethyl]-3-(1h-imidazol-5-yl)propanamide Chemical compound C([C@H](NC(=O)C)C(=O)N[C@@H](CC=1C=C2C=CC=CC2=CC=1)[C@H]1N[C@@H](CCCNC(N)=N)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)C1=CN=CN1 KHQRZLTVFGBWSN-YKKXUYLKSA-N 0.000 claims description 3
• JOSSSQYONSYDQE-LJIABBGYSA-N (e)-3-(4-chlorophenyl)-n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]prop-2-enamide Chemical compound C1=CC(Cl)=CC=C1\C=C\C(=O)NC[C@H]1N[C@@H](CCN2CCCCC2)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 JOSSSQYONSYDQE-LJIABBGYSA-N 0.000 claims description 3
• NAOPCNXRXLBSFV-NYDCQLBNSA-N 2-[3-[(2s,7s)-4-(2,2-diphenylethyl)-7-[(naphthalen-2-ylsulfonylamino)methyl]-3-oxo-1,4-diazepan-2-yl]propyl]guanidine Chemical compound C([C@@H](CNS(=O)(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCNC(=N)N)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 NAOPCNXRXLBSFV-NYDCQLBNSA-N 0.000 claims description 3
• 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims description 3
• 239000004098 Tetracycline Substances 0.000 claims description 3
• OGQICQVSFDPSEI-UHFFFAOYSA-N Zorac Chemical compound N1=CC(C(=O)OCC)=CC=C1C#CC1=CC=C(SCCC2(C)C)C2=C1 OGQICQVSFDPSEI-UHFFFAOYSA-N 0.000 claims description 3
• 229960002916 adapalene Drugs 0.000 claims description 3
• LZCDAPDGXCYOEH-UHFFFAOYSA-N adapalene Chemical compound C1=C(C(O)=O)C=CC2=CC(C3=CC=C(C(=C3)C34CC5CC(CC(C5)C3)C4)OC)=CC=C21 LZCDAPDGXCYOEH-UHFFFAOYSA-N 0.000 claims description 3
• 229960003328 benzoyl peroxide Drugs 0.000 claims description 3
• 235000010290 biphenyl Nutrition 0.000 claims description 3
• KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims description 3
• 229960002227 clindamycin Drugs 0.000 claims description 3
• 229960003276 erythromycin Drugs 0.000 claims description 3
• FNOCAHWAWWALQQ-MALMBIFMSA-N n-[[(3s,5s)-2-oxo-1-[(2r)-2-phenylbutyl]-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H]1N[C@H](CNC(=O)C=2C=C3C=CC=CC3=CC=2)CCN(C1=O)C[C@H](CC)C=1C=CC=CC=1)CN1CCCCC1 FNOCAHWAWWALQQ-MALMBIFMSA-N 0.000 claims description 3
• FNOCAHWAWWALQQ-GWTOPCPNSA-N n-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H]1N[C@H](CNC(=O)C=2C=C3C=CC=CC3=CC=2)CCN(C1=O)C[C@@H](CC)C=1C=CC=CC=1)CN1CCCCC1 FNOCAHWAWWALQQ-GWTOPCPNSA-N 0.000 claims description 3
• IVQZHFPXELZMDW-SMCANUKXSA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-6-fluoronaphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC(F)=CC2=CC=1)N[C@H](C1=O)CCN)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 IVQZHFPXELZMDW-SMCANUKXSA-N 0.000 claims description 3
• MPNJIEHJLOQRCL-KFTXQHHCSA-N n-[[(3s,5s)-3-(2-aminoethyl)-2-oxo-1-(2-phenylbutyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound O=C([C@H](CCN)N[C@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)CC1)N1CC(CC)C1=CC=CC=C1 MPNJIEHJLOQRCL-KFTXQHHCSA-N 0.000 claims description 3
• KIYXBNPDQRSXPO-PHXCCWLDSA-N n-[[(3s,5s)-3-(2-aminoethyl)-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]-6-chloronaphthalene-2-carboxamide Chemical compound C1([C@@H](CN2C([C@H](CCN)N[C@H](CNC(=O)C=3C=C4C=CC(Cl)=CC4=CC=3)CC2)=O)CC)=CC=CC=C1 KIYXBNPDQRSXPO-PHXCCWLDSA-N 0.000 claims description 3
• WPCLPNAHZOHTIW-WEZIJMHWSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-6-bromo-n-methylnaphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CCCN)C1=O)CN(C)C(=O)C=2C=C3C=CC(Br)=CC3=CC=2)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 WPCLPNAHZOHTIW-WEZIJMHWSA-N 0.000 claims description 3
• GJDBJWUKDCFAPT-WEZIJMHWSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-4-methyl-2-oxo-1,4-diazepan-5-yl]methyl]-6-bromonaphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC(Br)=CC2=CC=1)N([C@H](C1=O)CCCN)C)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 GJDBJWUKDCFAPT-WEZIJMHWSA-N 0.000 claims description 3
• DKFQXTHTGAKMJQ-CDZUIXILSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCNC(=N)N)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 DKFQXTHTGAKMJQ-CDZUIXILSA-N 0.000 claims description 3
• 229960000565 tazarotene Drugs 0.000 claims description 3
• 229960002180 tetracycline Drugs 0.000 claims description 3
• 229930101283 tetracycline Natural products 0.000 claims description 3
• 235000019364 tetracycline Nutrition 0.000 claims description 3
• 150000003522 tetracyclines Chemical class 0.000 claims description 3
• KHQRZLTVFGBWSN-YOEXWAKESA-N (2s)-2-acetamido-n-[(1r)-1-[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]-2-naphthalen-2-ylethyl]-3-(1h-imidazol-5-yl)propanamide Chemical compound C([C@H](NC(=O)C)C(=O)N[C@H](CC=1C=C2C=CC=CC2=CC=1)[C@H]1N[C@@H](CCCNC(N)=N)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)C1=CNC=N1 KHQRZLTVFGBWSN-YOEXWAKESA-N 0.000 claims description 2
• VHRJTLUSJYUVEM-RUHGTMQNSA-N (3r)-n-[[(3s,5s)-3-(4-aminobutyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide Chemical compound C([C@@H](CNC(=O)[C@@H]1NCC2=CC=CC=C2C1)N[C@H](C1=O)CCCCN)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 VHRJTLUSJYUVEM-RUHGTMQNSA-N 0.000 claims description 2
• SELTWCXBYXUAHF-ASVWTAOFSA-N (3s)-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide Chemical compound C([C@@H](CNC(=O)[C@H]1NCC2=CC=CC=C2C1)N[C@H](C1=O)CCCNC(=N)N)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 SELTWCXBYXUAHF-ASVWTAOFSA-N 0.000 claims description 2
• QHDPVOTZDXQHFB-XXJPWZBZSA-N (3s)-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-2,3-dihydro-1,4-benzodioxine-3-carboxamide Chemical compound C([C@@H](CNC(=O)[C@H]1OC2=CC=CC=C2OC1)N[C@H](C1=O)CCCNC(=N)N)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 QHDPVOTZDXQHFB-XXJPWZBZSA-N 0.000 claims description 2
• DXEIOFDUNMIKQD-ZQAZVOLISA-N (3s,5s)-5-[[(3,4-dichlorophenyl)methylamino]methyl]-1-(2,2-diphenylethyl)-3-(2-piperidin-1-ylethyl)-1,4-diazepan-2-one Chemical compound C1=C(Cl)C(Cl)=CC=C1CNC[C@H]1N[C@@H](CCN2CCCCC2)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 DXEIOFDUNMIKQD-ZQAZVOLISA-N 0.000 claims description 2
• FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 claims description 2
• KPJHEZHHHSBCQP-LUGJTCGGSA-N (e)-3-(2,4-difluorophenyl)-n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]prop-2-enamide Chemical compound FC1=CC(F)=CC=C1\C=C\C(=O)NC[C@H]1N[C@@H](CCN2CCCCC2)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 KPJHEZHHHSBCQP-LUGJTCGGSA-N 0.000 claims description 2
• KUURASAEDVJBMF-CEUOVJQRSA-N (e)-3-(2,4-dimethylphenyl)-n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]prop-2-enamide Chemical compound CC1=CC(C)=CC=C1\C=C\C(=O)NC[C@H]1N[C@@H](CCN2CCCCC2)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 KUURASAEDVJBMF-CEUOVJQRSA-N 0.000 claims description 2
• NVVGQTPMRUUCRE-GNGQUEJKSA-N (e)-3-(2-chloro-6-fluorophenyl)-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)\C=C\C1=C(F)C=CC=C1Cl NVVGQTPMRUUCRE-GNGQUEJKSA-N 0.000 claims description 2
• ZENRZOUEURYXBY-MBSOTRTCSA-N (e)-3-(2-chlorophenyl)-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)\C=C\C1=CC=CC=C1Cl ZENRZOUEURYXBY-MBSOTRTCSA-N 0.000 claims description 2
• AXIUEUSYSMXVQP-AVYIKKKCSA-N (e)-3-(3-chlorophenyl)-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)\C=C\C1=CC=CC(Cl)=C1 AXIUEUSYSMXVQP-AVYIKKKCSA-N 0.000 claims description 2
• SIOMVAOKCFAIBG-DMIICRCOSA-N (e)-3-(4-bromophenyl)-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)\C=C\C1=CC=C(Br)C=C1 SIOMVAOKCFAIBG-DMIICRCOSA-N 0.000 claims description 2
• JXEPMPIBEAFAKR-RSPMAXTDSA-N (e)-3-(4-chlorophenyl)-n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(piperidin-1-ylmethyl)-1,4-diazepan-5-yl]methyl]prop-2-enamide Chemical compound C1=CC(Cl)=CC=C1\C=C\C(=O)NC[C@H]1N[C@@H](CN2CCCCC2)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 JXEPMPIBEAFAKR-RSPMAXTDSA-N 0.000 claims description 2
• XTGBCZCGZQOWFG-DEEASJLESA-N (e)-3-(4-chlorophenyl)-n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-[2-(propan-2-ylamino)ethyl]-1,4-diazepan-5-yl]methyl]prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCNC(C)C)NC(=O)\C=C\C1=CC=C(Cl)C=C1 XTGBCZCGZQOWFG-DEEASJLESA-N 0.000 claims description 2
• IFIMILOLJZBROZ-KYKXIQHDSA-N (e)-3-(4-chlorophenyl)-n-[[(3s,5s)-1-(2-ethylbutyl)-2-oxo-3-(piperidin-1-ylmethyl)-1,4-diazepan-5-yl]methyl]prop-2-enamide Chemical compound C([C@@H]1CCN(C([C@H](CN2CCCCC2)N1)=O)CC(CC)CC)NC(=O)\C=C\C1=CC=C(Cl)C=C1 IFIMILOLJZBROZ-KYKXIQHDSA-N 0.000 claims description 2
• DUBAUGQBIPHGAX-ASHVHYHESA-N (e)-3-(4-chlorophenyl)-n-[[(3s,5s)-1-[(3,5-dichlorophenyl)methyl]-2-oxo-3-(piperidin-1-ylmethyl)-1,4-diazepan-5-yl]methyl]prop-2-enamide Chemical compound C1=CC(Cl)=CC=C1\C=C\C(=O)NC[C@H]1N[C@@H](CN2CCCCC2)C(=O)N(CC=2C=C(Cl)C=C(Cl)C=2)CC1 DUBAUGQBIPHGAX-ASHVHYHESA-N 0.000 claims description 2
• OHDNJKGTZNVWRS-DRSMKOQMSA-N (e)-3-(4-chlorophenyl)-n-[[(3s,5s)-2-oxo-1-[(2r)-2-phenylbutyl]-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]prop-2-enamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCCCC2)N1)=O)C[C@H](CC)C=1C=CC=CC=1)NC(=O)\C=C\C1=CC=C(Cl)C=C1 OHDNJKGTZNVWRS-DRSMKOQMSA-N 0.000 claims description 2
• OHDNJKGTZNVWRS-MDJFSFQJSA-N (e)-3-(4-chlorophenyl)-n-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]prop-2-enamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCCCC2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)\C=C\C1=CC=C(Cl)C=C1 OHDNJKGTZNVWRS-MDJFSFQJSA-N 0.000 claims description 2
• HDKVRKCSKRSKEK-BXQFOXJWSA-N (e)-3-(4-chlorophenyl)-n-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-(2-pyrrolidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]prop-2-enamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCCC2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)\C=C\C1=CC=C(Cl)C=C1 HDKVRKCSKRSKEK-BXQFOXJWSA-N 0.000 claims description 2
• VMDTXDFHRODCRS-IENKDKBASA-N (e)-3-(4-chlorophenyl)-n-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-[2-(propan-2-ylamino)ethyl]-1,4-diazepan-5-yl]methyl]prop-2-enamide Chemical compound C([C@@H]1CCN(C([C@H](CCNC(C)C)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)\C=C\C1=CC=C(Cl)C=C1 VMDTXDFHRODCRS-IENKDKBASA-N 0.000 claims description 2
• ZQCYESXVTJNWQR-GPKXIUBGSA-N (e)-3-(4-chlorophenyl)-n-[[(3s,5s)-3-[2-(2,5-dimethylpyrrolidin-1-yl)ethyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]prop-2-enamide Chemical compound CC1CCC(C)N1CC[C@H]1C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC[C@@H](CNC(=O)\C=C\C=2C=CC(Cl)=CC=2)N1 ZQCYESXVTJNWQR-GPKXIUBGSA-N 0.000 claims description 2
• BWOGHILKJXWDHT-HAYNCCBLSA-N (e)-n-[2-[(3s,5s)-3-(2-aminoethyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]propan-2-yl]-3-(4-chlorophenyl)prop-2-enamide Chemical compound CC(C)([C@H]1N[C@@H](CCN)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)NC(=O)\C=C\C1=CC=C(Cl)C=C1 BWOGHILKJXWDHT-HAYNCCBLSA-N 0.000 claims description 2
• XMFOUGDSVPPWSV-FPTDTOSQSA-N (e)-n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]-3-(4-methylphenyl)prop-2-enamide Chemical compound C1=CC(C)=CC=C1\C=C\C(=O)NC[C@H]1N[C@@H](CCN2CCCCC2)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 XMFOUGDSVPPWSV-FPTDTOSQSA-N 0.000 claims description 2
• BYFLOOJPDOOQSY-KZVPQLAASA-N (e)-n-[[(3s,5s)-3-(2-aminoethyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(2,4-difluorophenyl)prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCN)NC(=O)\C=C\C1=CC=C(F)C=C1F BYFLOOJPDOOQSY-KZVPQLAASA-N 0.000 claims description 2
• SGWSXQNNJDWEEJ-CJMMIAHCSA-N (e)-n-[[(3s,5s)-3-(2-aminoethyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(2,4-dimethylphenyl)prop-2-enamide Chemical compound CC1=CC(C)=CC=C1\C=C\C(=O)NC[C@H]1N[C@@H](CCN)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 SGWSXQNNJDWEEJ-CJMMIAHCSA-N 0.000 claims description 2
• ZLCBVBPPYWCDIH-UKYGHKPSSA-N (e)-n-[[(3s,5s)-3-(2-aminoethyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(4-chlorophenyl)prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCN)NC(=O)\C=C\C1=CC=C(Cl)C=C1 ZLCBVBPPYWCDIH-UKYGHKPSSA-N 0.000 claims description 2
• FTDGEHKTTIZMPJ-UKYGHKPSSA-N (e)-n-[[(3s,5s)-3-(2-aminoethyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(4-fluorophenyl)prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCN)NC(=O)\C=C\C1=CC=C(F)C=C1 FTDGEHKTTIZMPJ-UKYGHKPSSA-N 0.000 claims description 2
• YCHYRKVWMWFCLG-AVYIKKKCSA-N (e)-n-[[(3s,5s)-3-(2-aminoethyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(4-methylphenyl)prop-2-enamide Chemical compound C1=CC(C)=CC=C1\C=C\C(=O)NC[C@H]1N[C@@H](CCN)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 YCHYRKVWMWFCLG-AVYIKKKCSA-N 0.000 claims description 2
• XKWKQGYXKCNJME-OYIMBBQMSA-N (e)-n-[[(3s,5s)-3-(2-aminoethyl)-1-(2-ethylbutyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(4-chlorophenyl)prop-2-enamide Chemical compound N1[C@@H](CCN)C(=O)N(CC(CC)CC)CC[C@H]1CNC(=O)\C=C\C1=CC=C(Cl)C=C1 XKWKQGYXKCNJME-OYIMBBQMSA-N 0.000 claims description 2
• SLXHJGCSDDGJGK-DZMZDYGNSA-N (e)-n-[[(3s,5s)-3-(2-aminoethyl)-1-[(3,5-dimethylcyclohexyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]-3-(4-chlorophenyl)prop-2-enamide Chemical compound C1C(C)CC(C)CC1CN1C(=O)[C@H](CCN)N[C@H](CNC(=O)\C=C\C=2C=CC(Cl)=CC=2)CC1 SLXHJGCSDDGJGK-DZMZDYGNSA-N 0.000 claims description 2
• FNLUWKMGVZNSBE-JCVVKITGSA-N (e)-n-[[(3s,5s)-3-(2-aminoethyl)-2-oxo-1-(2-phenylbutyl)-1,4-diazepan-5-yl]methyl]-3-(4-chlorophenyl)prop-2-enamide Chemical compound C([C@@H]1CCN(C([C@H](CCN)N1)=O)CC(CC)C=1C=CC=CC=1)NC(=O)\C=C\C1=CC=C(Cl)C=C1 FNLUWKMGVZNSBE-JCVVKITGSA-N 0.000 claims description 2
• UDSITAAHNQKBGQ-UXOMDGLISA-N (e)-n-[[(3s,5s)-3-(3-acetamidopropyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(4-methylphenyl)prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=O)C)NC(=O)\C=C\C1=CC=C(C)C=C1 UDSITAAHNQKBGQ-UXOMDGLISA-N 0.000 claims description 2
• HSMIYJGCJMTPNG-FMDWORLUSA-N (e)-n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(2,4-difluorophenyl)prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCN)NC(=O)\C=C\C1=CC=C(F)C=C1F HSMIYJGCJMTPNG-FMDWORLUSA-N 0.000 claims description 2
• JLNRCMUUXPWGOB-DMIICRCOSA-N (e)-n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(4-bromophenyl)prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCN)NC(=O)\C=C\C1=CC=C(Br)C=C1 JLNRCMUUXPWGOB-DMIICRCOSA-N 0.000 claims description 2
• MAPZAXOZABBDQU-DMIICRCOSA-N (e)-n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(4-chlorophenyl)prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCN)NC(=O)\C=C\C1=CC=C(Cl)C=C1 MAPZAXOZABBDQU-DMIICRCOSA-N 0.000 claims description 2
• LBTDUEULEZELRT-WIFSBWKTSA-N (e)-n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(4-cyanophenyl)prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCN)NC(=O)\C=C\C1=CC=C(C#N)C=C1 LBTDUEULEZELRT-WIFSBWKTSA-N 0.000 claims description 2
• ZCVUMSAODQOJOW-BGMRFITDSA-N (e)-n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(4-fluorophenyl)-n-methylprop-2-enamide Chemical compound C([C@H](N[C@@H](CCCN)C1=O)CN(C)C(=O)\C=C\C=2C=CC(F)=CC=2)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 ZCVUMSAODQOJOW-BGMRFITDSA-N 0.000 claims description 2
• RNJAIHODMDSNFG-KKLGXJKSSA-N (e)-n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(4-methylphenyl)prop-2-enamide Chemical compound C1=CC(C)=CC=C1\C=C\C(=O)NC[C@H]1N[C@@H](CCCN)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RNJAIHODMDSNFG-KKLGXJKSSA-N 0.000 claims description 2
• CULOJDFFTHFSJK-IOJNIJIISA-N (e)-n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(5-methylthiophen-2-yl)prop-2-enamide Chemical compound S1C(C)=CC=C1\C=C\C(=O)NC[C@H]1N[C@@H](CCCN)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 CULOJDFFTHFSJK-IOJNIJIISA-N 0.000 claims description 2
• IXXHJKVYYFJWMX-CIPWJDNOSA-N (e)-n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-naphthalen-2-ylprop-2-enamide Chemical compound C([C@@H](CNC(=O)\C=C\C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCN)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 IXXHJKVYYFJWMX-CIPWJDNOSA-N 0.000 claims description 2
• MZEBSJMWAQPJBX-BGMRFITDSA-N (e)-n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-4-methyl-2-oxo-1,4-diazepan-5-yl]methyl]-3-(4-fluorophenyl)prop-2-enamide Chemical compound C([C@H]1N([C@H](C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)CCCN)C)NC(=O)\C=C\C1=CC=C(F)C=C1 MZEBSJMWAQPJBX-BGMRFITDSA-N 0.000 claims description 2
• RULUGWUPNQLSDL-ZFTYBGOMSA-N (e)-n-[[(3s,5s)-3-(aminomethyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(4-chlorophenyl)prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CN)NC(=O)\C=C\C1=CC=C(Cl)C=C1 RULUGWUPNQLSDL-ZFTYBGOMSA-N 0.000 claims description 2
• ZTYQAEHHZPRNRH-TWTZQDPRSA-N (e)-n-[[(3s,5s)-3-(aminomethyl)-1-[(3,5-dichlorophenyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]-3-(4-chlorophenyl)prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC=2C=C(Cl)C=C(Cl)C=2)CC1)=O)CN)NC(=O)\C=C\C1=CC=C(Cl)C=C1 ZTYQAEHHZPRNRH-TWTZQDPRSA-N 0.000 claims description 2
• LNDVFZQEVZYSGF-CIQLSFSJSA-N (e)-n-[[(3s,5s)-3-[3-(cyclohexylamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(4-fluorophenyl)prop-2-enamide Chemical compound C1=CC(F)=CC=C1\C=C\C(=O)NC[C@H]1N[C@@H](CCCNC2CCCCC2)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 LNDVFZQEVZYSGF-CIQLSFSJSA-N 0.000 claims description 2
• PDMNGEJGQQMGAS-VQSCXVRDSA-N (e)-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-2-methyl-3-phenylprop-2-enamide Chemical compound C([C@H]1N[C@@H](CCCNC(N)=N)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)NC(=O)C(/C)=C/C1=CC=CC=C1 PDMNGEJGQQMGAS-VQSCXVRDSA-N 0.000 claims description 2
• UAVHJQMNCRUZRE-MBSOTRTCSA-N (e)-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(2-fluorophenyl)prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)\C=C\C1=CC=CC=C1F UAVHJQMNCRUZRE-MBSOTRTCSA-N 0.000 claims description 2
• ZUWYFRUXGNJKKL-JRTMWMOUSA-N (e)-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(2-hydroxyphenyl)prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)\C=C\C1=CC=CC=C1O ZUWYFRUXGNJKKL-JRTMWMOUSA-N 0.000 claims description 2
• SPWOFEDAAPORKI-HHFVMFDSSA-N (e)-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(2-methoxyphenyl)prop-2-enamide Chemical compound COC1=CC=CC=C1\C=C\C(=O)NC[C@H]1N[C@@H](CCCNC(N)=N)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 SPWOFEDAAPORKI-HHFVMFDSSA-N 0.000 claims description 2
• RDDLSTIRVULBOT-KKLGXJKSSA-N (e)-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(2-methylphenyl)prop-2-enamide Chemical compound CC1=CC=CC=C1\C=C\C(=O)NC[C@H]1N[C@@H](CCCNC(N)=N)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RDDLSTIRVULBOT-KKLGXJKSSA-N 0.000 claims description 2
• OJRZJJIVURUHSC-AVYIKKKCSA-N (e)-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(3-fluorophenyl)prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)\C=C\C1=CC=CC(F)=C1 OJRZJJIVURUHSC-AVYIKKKCSA-N 0.000 claims description 2
• VOZVXQUBUKUKRW-MDPFPKOOSA-N (e)-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(3-methoxyphenyl)prop-2-enamide Chemical compound COC1=CC=CC(\C=C\C(=O)NC[C@H]2N[C@@H](CCCNC(N)=N)C(=O)N(CC(C=3C=CC=CC=3)C=3C=CC=CC=3)CC2)=C1 VOZVXQUBUKUKRW-MDPFPKOOSA-N 0.000 claims description 2
• HFWBFLLAOGWUHZ-WIFSBWKTSA-N (e)-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(3-methylphenyl)prop-2-enamide Chemical compound CC1=CC=CC(\C=C\C(=O)NC[C@H]2N[C@@H](CCCNC(N)=N)C(=O)N(CC(C=3C=CC=CC=3)C=3C=CC=CC=3)CC2)=C1 HFWBFLLAOGWUHZ-WIFSBWKTSA-N 0.000 claims description 2
• LFIYZCPCCVFWBX-JXWBENGISA-N (e)-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(4-ethoxyphenyl)prop-2-enamide Chemical compound C1=CC(OCC)=CC=C1\C=C\C(=O)NC[C@H]1N[C@@H](CCCNC(N)=N)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 LFIYZCPCCVFWBX-JXWBENGISA-N 0.000 claims description 2
• PRNBKQZSIIFPHP-IMMITOCLSA-N (e)-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(4-methoxyphenyl)prop-2-enamide Chemical compound C1=CC(OC)=CC=C1\C=C\C(=O)NC[C@H]1N[C@@H](CCCNC(N)=N)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 PRNBKQZSIIFPHP-IMMITOCLSA-N 0.000 claims description 2
• ZPOBQHPMCOKSJS-AVYIKKKCSA-N (e)-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-[3-(trifluoromethyl)phenyl]prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)\C=C\C1=CC=CC(C(F)(F)F)=C1 ZPOBQHPMCOKSJS-AVYIKKKCSA-N 0.000 claims description 2
• SHJAPVBZCNIVDI-UOTZPRLLSA-N (e)-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-thiophen-2-ylprop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)\C=C\C1=CC=CS1 SHJAPVBZCNIVDI-UOTZPRLLSA-N 0.000 claims description 2
• YPJAUCSTGBVYRA-JZBGBCCGSA-N (e)-n-[[(3s,5s)-3-butyl-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(4-chlorophenyl)prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCC)NC(=O)\C=C\C1=CC=C(Cl)C=C1 YPJAUCSTGBVYRA-JZBGBCCGSA-N 0.000 claims description 2
• HDDGFPOMMDMKBV-HCRUOQKOSA-N (z)-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-2-fluoro-3-phenylprop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)C(\F)=C\C1=CC=CC=C1 HDDGFPOMMDMKBV-HCRUOQKOSA-N 0.000 claims description 2
• WPHBEGTZYVDRQF-NUAIVLOPSA-N 1-methoxy-n-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H]1N[C@H](CNC(=O)C=2C(=C3C=CC=CC3=CC=2)OC)CCN(C1=O)C[C@@H](CC)C=1C=CC=CC=1)CN1CCCCC1 WPHBEGTZYVDRQF-NUAIVLOPSA-N 0.000 claims description 2
• FKRMMEAHCSDUMA-ATILKMQGSA-N 2,4-dichloro-n-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCCCC2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C=C1Cl FKRMMEAHCSDUMA-ATILKMQGSA-N 0.000 claims description 2
• UNKOCJCWQNZANJ-CUBQBAPOSA-N 2,4-dichloro-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)C1=CC=C(Cl)C=C1Cl UNKOCJCWQNZANJ-CUBQBAPOSA-N 0.000 claims description 2
• RCIYABNHSMHNLS-CUBQBAPOSA-N 2,5-dichloro-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)C1=CC(Cl)=CC=C1Cl RCIYABNHSMHNLS-CUBQBAPOSA-N 0.000 claims description 2
• WUVYWNYGEKWEAN-CHWDOVFKSA-N 2-(4-chlorophenyl)-n-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCCCC2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=CC=C1C1=CC=C(Cl)C=C1 WUVYWNYGEKWEAN-CHWDOVFKSA-N 0.000 claims description 2
• GMBJCABNSIOVPX-YTMVLYRLSA-N 2-cyclohexyl-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]acetamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)CC1CCCCC1 GMBJCABNSIOVPX-YTMVLYRLSA-N 0.000 claims description 2
• 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims description 2
• PMOCXGYYNAHDHR-CPBHLAHYSA-N 3,4-dichloro-n-[2-[(3s,5r)-1-(2,2-diphenylethyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]ethyl]benzamide Chemical compound C1=C(Cl)C(Cl)=CC=C1C(=O)NCC[C@H]1N[C@@H](CCN2CCCCC2)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 PMOCXGYYNAHDHR-CPBHLAHYSA-N 0.000 claims description 2
• KXPBFUAPURTDIF-JOMNFKBKSA-N 3,4-dichloro-n-[2-[(3s,5r)-1-(2,2-diphenylethyl)-2-oxo-3-[2-(propan-2-ylamino)ethyl]-1,4-diazepan-5-yl]ethyl]benzamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCNC(C)C)CNC(=O)C1=CC=C(Cl)C(Cl)=C1 KXPBFUAPURTDIF-JOMNFKBKSA-N 0.000 claims description 2
• SLXSGWMJTDMEFD-HKFHRXRESA-N 3,4-dichloro-n-[2-[(3s,5r)-1-(2,2-diphenylethyl)-3-[2-[di(propan-2-yl)amino]ethyl]-2-oxo-1,4-diazepan-5-yl]ethyl]benzamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCN(C(C)C)C(C)C)CNC(=O)C1=CC=C(Cl)C(Cl)=C1 SLXSGWMJTDMEFD-HKFHRXRESA-N 0.000 claims description 2
• LNVJJEVSOJBSKY-IUDBTDONSA-N 3,4-dichloro-n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C1=C(Cl)C(Cl)=CC=C1C(=O)NC[C@H]1N[C@@H](CCN2CCCCC2)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 LNVJJEVSOJBSKY-IUDBTDONSA-N 0.000 claims description 2
• LEXSRDKHQMXVSD-ZQAZVOLISA-N 3,4-dichloro-n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(3-piperidin-1-ylpropyl)-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C1=C(Cl)C(Cl)=CC=C1C(=O)NC[C@H]1N[C@@H](CCCN2CCCCC2)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 LEXSRDKHQMXVSD-ZQAZVOLISA-N 0.000 claims description 2
• WFSJMDUAHLZHNM-YZNIXAGQSA-N 3,4-dichloro-n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-[2-(propan-2-ylamino)ethyl]-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCNC(C)C)NC(=O)C1=CC=C(Cl)C(Cl)=C1 WFSJMDUAHLZHNM-YZNIXAGQSA-N 0.000 claims description 2
• FGLWZBIXZABXNE-URXFXBBRSA-N 3,4-dichloro-n-[[(3s,5s)-1-(2-ethyl-2-methylbutyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCCCC2)N1)=O)CC(C)(CC)CC)NC(=O)C1=CC=C(Cl)C(Cl)=C1 FGLWZBIXZABXNE-URXFXBBRSA-N 0.000 claims description 2
• DQAAOLRIZLETQM-URXFXBBRSA-N 3,4-dichloro-n-[[(3s,5s)-1-(2-ethylbutyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCCCC2)N1)=O)CC(CC)CC)NC(=O)C1=CC=C(Cl)C(Cl)=C1 DQAAOLRIZLETQM-URXFXBBRSA-N 0.000 claims description 2
• KCSSEGHYQZNCCP-OFVILXPXSA-N 3,4-dichloro-n-[[(3s,5s)-1-[(2,4-dichlorophenyl)methyl]-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]benzamide Chemical compound ClC1=CC(Cl)=CC=C1CN1C(=O)[C@H](CCN2CCCCC2)N[C@H](CNC(=O)C=2C=C(Cl)C(Cl)=CC=2)CC1 KCSSEGHYQZNCCP-OFVILXPXSA-N 0.000 claims description 2
• QLNYGNOFHZPYHS-UWJYYQICSA-N 3,4-dichloro-n-[[(3s,5s)-1-[(2,4-dichlorophenyl)methyl]-3-[2-(methanesulfonamido)ethyl]-2-oxo-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@H]1N[C@H](C(N(CC=2C(=CC(Cl)=CC=2)Cl)CC1)=O)CCNS(=O)(=O)C)NC(=O)C1=CC=C(Cl)C(Cl)=C1 QLNYGNOFHZPYHS-UWJYYQICSA-N 0.000 claims description 2
• RJYFXWJXCJSLIE-REWPJTCUSA-N 3,4-dichloro-n-[[(3s,5s)-1-[(3,5-dichlorophenyl)methyl]-2-oxo-3-(pyrrolidin-1-ylmethyl)-1,4-diazepan-5-yl]methyl]benzamide Chemical compound ClC1=CC(Cl)=CC(CN2C([C@H](CN3CCCC3)N[C@H](CNC(=O)C=3C=C(Cl)C(Cl)=CC=3)CC2)=O)=C1 RJYFXWJXCJSLIE-REWPJTCUSA-N 0.000 claims description 2
• XTIZUBQPXVUJGO-URXFXBBRSA-N 3,4-dichloro-n-[[(3s,5s)-1-[(3,5-dichlorophenyl)methyl]-3-(2-morpholin-4-ylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]benzamide Chemical compound ClC1=CC(Cl)=CC(CN2C([C@H](CCN3CCOCC3)N[C@H](CNC(=O)C=3C=C(Cl)C(Cl)=CC=3)CC2)=O)=C1 XTIZUBQPXVUJGO-URXFXBBRSA-N 0.000 claims description 2
• VIKUYJSJMTVEHZ-ULNCZQIZSA-N 3,4-dichloro-n-[[(3s,5s)-2-oxo-1-[(2r)-2-phenylbutyl]-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCCCC2)N1)=O)C[C@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 VIKUYJSJMTVEHZ-ULNCZQIZSA-N 0.000 claims description 2
• YAKVKZKUPCCDBC-QURRFSBHSA-N 3,4-dichloro-n-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-(2-piperazin-1-ylethyl)-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCNCC2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 YAKVKZKUPCCDBC-QURRFSBHSA-N 0.000 claims description 2
• VIKUYJSJMTVEHZ-ATILKMQGSA-N 3,4-dichloro-n-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCCCC2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 VIKUYJSJMTVEHZ-ATILKMQGSA-N 0.000 claims description 2
• DVPKDLPZDYLBCA-QURRFSBHSA-N 3,4-dichloro-n-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-(2-pyrrolidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCCC2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 DVPKDLPZDYLBCA-QURRFSBHSA-N 0.000 claims description 2
• IODZISHAPUZLFB-IXLXJOPFSA-N 3,4-dichloro-n-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-(3-piperidin-1-ylpropyl)-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCCN2CCCCC2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 IODZISHAPUZLFB-IXLXJOPFSA-N 0.000 claims description 2
• BRSDRELKGQZAJO-QURRFSBHSA-N 3,4-dichloro-n-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-(piperidin-1-ylmethyl)-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CN2CCCCC2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 BRSDRELKGQZAJO-QURRFSBHSA-N 0.000 claims description 2
• LDBSCGRZNAGOPA-SEIBCYHCSA-N 3,4-dichloro-n-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-[2-(propan-2-ylamino)ethyl]-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCNC(C)C)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 LDBSCGRZNAGOPA-SEIBCYHCSA-N 0.000 claims description 2
• RJCVBFWPPCHXIN-WPWBMXPQSA-N 3,4-dichloro-n-[[(3s,5s)-3-[2-(2,5-dioxopyrrolidin-1-yl)ethyl]-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2C(CCC2=O)=O)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 RJCVBFWPPCHXIN-WPWBMXPQSA-N 0.000 claims description 2
• GEVMYKVUQGAFIN-QURRFSBHSA-N 3,4-dichloro-n-[[(3s,5s)-3-[2-(3,3-difluoropiperidin-1-yl)ethyl]-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CC(F)(F)CCC2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 GEVMYKVUQGAFIN-QURRFSBHSA-N 0.000 claims description 2
• CQHUSGLEUJPXHV-SEIBCYHCSA-N 3,4-dichloro-n-[[(3s,5s)-3-[2-(3,3-dimethyl-2,5-dioxopyrrolidin-1-yl)ethyl]-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2C(C(C)(C)CC2=O)=O)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 CQHUSGLEUJPXHV-SEIBCYHCSA-N 0.000 claims description 2
• OIDVFBXYRBOJBP-NHTPJNFVSA-N 3,4-dichloro-n-[[(3s,5s)-3-[2-(3,5-dimethylpiperidin-1-yl)ethyl]-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CC(C)CC(C)C2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 OIDVFBXYRBOJBP-NHTPJNFVSA-N 0.000 claims description 2
• CKAQUUWNFJIBHA-QURRFSBHSA-N 3,4-dichloro-n-[[(3s,5s)-3-[2-(4,4-difluoropiperidin-1-yl)ethyl]-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCC(F)(F)CC2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 CKAQUUWNFJIBHA-QURRFSBHSA-N 0.000 claims description 2
• ZQKLVIRSSQUDNX-NZRVCZAQSA-N 3,4-dichloro-n-[[(3s,5s)-3-[2-(4-hydroxypiperidin-1-yl)ethyl]-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCC(O)CC2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 ZQKLVIRSSQUDNX-NZRVCZAQSA-N 0.000 claims description 2
• QBGAEGKIHRSUOD-ATILKMQGSA-N 3,4-dichloro-n-[[(3s,5s)-3-[2-(4-methylpiperazin-1-yl)ethyl]-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCN(C)CC2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 QBGAEGKIHRSUOD-ATILKMQGSA-N 0.000 claims description 2
• AJBIWUGKBUEHLS-IXLXJOPFSA-N 3,4-dichloro-n-[[(3s,5s)-3-[2-(4-methylpiperidin-1-yl)ethyl]-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCC(C)CC2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 AJBIWUGKBUEHLS-IXLXJOPFSA-N 0.000 claims description 2
• OCJDGMQUGOBDQZ-QURRFSBHSA-N 3,4-dichloro-n-[[(3s,5s)-3-[2-(diethylamino)ethyl]-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN(CC)CC)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 OCJDGMQUGOBDQZ-QURRFSBHSA-N 0.000 claims description 2
• AMRWKBNCRRQGMN-ORZRXYGASA-N 3,4-dichloro-n-[[(3s,5s)-3-[2-(n-methylanilino)ethyl]-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN(C)C=2C=CC=CC=2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 AMRWKBNCRRQGMN-ORZRXYGASA-N 0.000 claims description 2
• AGILIWXVJIFSMA-XZQSQWLPSA-N 3,4-dichloro-n-[[(3s,5s)-3-[2-[(2s)-2-methylpiperidin-1-yl]ethyl]-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2[C@H](CCCC2)C)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 AGILIWXVJIFSMA-XZQSQWLPSA-N 0.000 claims description 2
• GDONOAOEWMFOBI-IXLXJOPFSA-N 3,4-dichloro-n-[[(3s,5s)-3-[2-[di(propan-2-yl)amino]ethyl]-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN(C(C)C)C(C)C)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 GDONOAOEWMFOBI-IXLXJOPFSA-N 0.000 claims description 2
• AOBVCTOCMJRLRQ-IXLXJOPFSA-N 3,4-dichloro-n-[[(3s,5s)-3-[2-[methyl(pentyl)amino]ethyl]-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@H]1N[C@H](C(N(C[C@@H](CC)C=2C=CC=CC=2)CC1)=O)CCN(C)CCCCC)NC(=O)C1=CC=C(Cl)C(Cl)=C1 AOBVCTOCMJRLRQ-IXLXJOPFSA-N 0.000 claims description 2
• FWFYNKUKZFQPHP-CUBQBAPOSA-N 3,4-dichloro-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)C1=CC=C(Cl)C(Cl)=C1 FWFYNKUKZFQPHP-CUBQBAPOSA-N 0.000 claims description 2
• ZWYAWFPAAPDRAD-XCZPVHLTSA-N 4-bromo-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)C1=CC=C(Br)C=C1 ZWYAWFPAAPDRAD-XCZPVHLTSA-N 0.000 claims description 2
• RYPWXPUSACPXFY-SMCANUKXSA-N 4-tert-butyl-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C1=CC(C(C)(C)C)=CC=C1C(=O)NC[C@H]1N[C@@H](CCCNC(N)=N)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RYPWXPUSACPXFY-SMCANUKXSA-N 0.000 claims description 2
• NIIWETPFMGGCNJ-CPJSRVTESA-N 5,6-dichloro-2-[[(3s,5s)-1-[(3,5-dichlorophenyl)methyl]-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]isoindole-1,3-dione Chemical compound ClC1=CC(Cl)=CC(CN2C([C@H](CCN3CCCCC3)N[C@H](CN3C(C4=CC(Cl)=C(Cl)C=C4C3=O)=O)CC2)=O)=C1 NIIWETPFMGGCNJ-CPJSRVTESA-N 0.000 claims description 2
• 125000004539 5-benzimidazolyl group Chemical group N1=CNC2=C1C=CC(=C2)* 0.000 claims description 2
• AHZLHBIQAMKSTD-CDZUIXILSA-N 6-amino-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC(N)=CC2=CC=1)N[C@H](C1=O)CCCNC(=N)N)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 AHZLHBIQAMKSTD-CDZUIXILSA-N 0.000 claims description 2
• PZZIFLZQVKUXJX-NSOVKSMOSA-N 6-bromo-n-[[(3s,5s)-1-(2-ethylbutyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H]1N[C@H](CNC(=O)C=2C=C3C=CC(Br)=CC3=CC=2)CCN(C1=O)CC(CC)CC)CN1CCCCC1 PZZIFLZQVKUXJX-NSOVKSMOSA-N 0.000 claims description 2
• JPDQABHVCKKMON-HTXOAEFJSA-N 6-chloro-n-[[(3s)-2-oxo-1-(2-phenylbutyl)-3-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C1([C@@H]2NC(CNC(=O)C=3C=C4C=CC(Cl)=CC4=CC=3)CCN(C2=O)CC(CC)C=2C=CC=CC=2)CCN(C(C)C)CC1 JPDQABHVCKKMON-HTXOAEFJSA-N 0.000 claims description 2
• CSDABATXCTVYHB-NGDHARACSA-N 6-chloro-n-[[(3s)-2-oxo-1-(2-phenylbutyl)-3-piperidin-4-yl-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C1([C@@H]2NC(CNC(=O)C=3C=C4C=CC(Cl)=CC4=CC=3)CCN(C2=O)CC(CC)C=2C=CC=CC=2)CCNCC1 CSDABATXCTVYHB-NGDHARACSA-N 0.000 claims description 2
• RAYWGUBSGQJFLB-GIWKVKTRSA-N 6-chloro-n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CCN1CCCCC1)C1=O)CNC(=O)C2=CC3=CC=C(C=C3C=C2)Cl)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 RAYWGUBSGQJFLB-GIWKVKTRSA-N 0.000 claims description 2
• KTMMPQNVEBKYCG-LRHLLKFHSA-N 6-chloro-n-[[(3s,5s)-1-(2,2-diphenylethyl)-3-(2-morpholin-4-ylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CCN1CCOCC1)C1=O)CNC(=O)C2=CC3=CC=C(C=C3C=C2)Cl)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 KTMMPQNVEBKYCG-LRHLLKFHSA-N 0.000 claims description 2
• IMOMRTFCBNFYET-OEJBOCFZSA-N 6-chloro-n-[[(3s,5s)-1-(2-cyclopropylbutyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H]1N[C@H](CNC(=O)C=2C=C3C=CC(Cl)=CC3=CC=2)CCN(C1=O)CC(CC)C1CC1)CN1CCCCC1 IMOMRTFCBNFYET-OEJBOCFZSA-N 0.000 claims description 2
• CGGIHAUITVPBSD-NSOVKSMOSA-N 6-chloro-n-[[(3s,5s)-1-(2-ethyl-2-methylbutyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H]1N[C@H](CNC(=O)C=2C=C3C=CC(Cl)=CC3=CC=2)CCN(C1=O)CC(C)(CC)CC)CN1CCCCC1 CGGIHAUITVPBSD-NSOVKSMOSA-N 0.000 claims description 2
• AZCPWHXJCFLILD-NSOVKSMOSA-N 6-chloro-n-[[(3s,5s)-1-(2-ethylbutyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H]1N[C@H](CNC(=O)C=2C=C3C=CC(Cl)=CC3=CC=2)CCN(C1=O)CC(CC)CC)CN1CCCCC1 AZCPWHXJCFLILD-NSOVKSMOSA-N 0.000 claims description 2
• XITCVVZMRPNABW-YTMVLYRLSA-N 6-chloro-n-[[(3s,5s)-1-[(2,4-dichlorophenyl)methyl]-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound ClC1=CC(Cl)=CC=C1CN1C(=O)[C@H](CCN2CCCCC2)N[C@H](CNC(=O)C=2C=C3C=CC(Cl)=CC3=CC=2)CC1 XITCVVZMRPNABW-YTMVLYRLSA-N 0.000 claims description 2
• DEPCHJKRPDKDGR-VMPREFPWSA-N 6-chloro-n-[[(3s,5s)-1-[(3,5-dichlorophenyl)methyl]-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CCN1CCCCC1)C1=O)CNC(=O)C2=CC3=CC=C(C=C3C=C2)Cl)CN1CC1=CC(Cl)=CC(Cl)=C1 DEPCHJKRPDKDGR-VMPREFPWSA-N 0.000 claims description 2
• OOGFMEDSHZOHOC-SVBPBHIXSA-N 6-chloro-n-[[(3s,5s)-1-[(3,5-dichlorophenyl)methyl]-2-oxo-3-[2-(propan-2-ylamino)ethyl]-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC(Cl)=CC2=CC=1)N[C@H](C1=O)CCNC(C)C)CN1CC1=CC(Cl)=CC(Cl)=C1 OOGFMEDSHZOHOC-SVBPBHIXSA-N 0.000 claims description 2
• KXPZUJMIXREJSZ-NSOVKSMOSA-N 6-chloro-n-[[(3s,5s)-1-[(3,5-dichlorophenyl)methyl]-3-(2-morpholin-4-ylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CCN1CCOCC1)C1=O)CNC(=O)C2=CC3=CC=C(C=C3C=C2)Cl)CN1CC1=CC(Cl)=CC(Cl)=C1 KXPZUJMIXREJSZ-NSOVKSMOSA-N 0.000 claims description 2
• QLTRQRZCYZZHLF-GTTXMTDLSA-N 6-chloro-n-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-(2-pyrrolidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H]1N[C@H](CNC(=O)C=2C=C3C=CC(Cl)=CC3=CC=2)CCN(C1=O)C[C@@H](CC)C=1C=CC=CC=1)CN1CCCC1 QLTRQRZCYZZHLF-GTTXMTDLSA-N 0.000 claims description 2
• MKEKXEBBUBZRGU-GTTXMTDLSA-N 6-chloro-n-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-(piperidin-1-ylmethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H]1N[C@H](CNC(=O)C=2C=C3C=CC(Cl)=CC3=CC=2)CCN(C1=O)C[C@@H](CC)C=1C=CC=CC=1)N1CCCCC1 MKEKXEBBUBZRGU-GTTXMTDLSA-N 0.000 claims description 2
• BUUJROZZGVHDFI-STQWGSIPSA-N 6-chloro-n-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-[2-(propan-2-ylamino)ethyl]-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C1([C@@H](CN2C([C@H](CCNC(C)C)N[C@H](CNC(=O)C=3C=C4C=CC(Cl)=CC4=CC=3)CC2)=O)CC)=CC=CC=C1 BUUJROZZGVHDFI-STQWGSIPSA-N 0.000 claims description 2
• YEFKIQMFPUSTSU-STQWGSIPSA-N 6-chloro-n-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-[2-(propan-2-ylcarbamoylamino)ethyl]-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C1([C@@H](CN2C([C@H](CCNC(=O)NC(C)C)N[C@H](CNC(=O)C=3C=C4C=CC(Cl)=CC4=CC=3)CC2)=O)CC)=CC=CC=C1 YEFKIQMFPUSTSU-STQWGSIPSA-N 0.000 claims description 2
• IXZQVROIFOTPNN-STQWGSIPSA-N 6-chloro-n-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-[2-(propan-2-ylsulfonylamino)ethyl]-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C1([C@@H](CN2C([C@H](CCNS(=O)(=O)C(C)C)N[C@H](CNC(=O)C=3C=C4C=CC(Cl)=CC4=CC=3)CC2)=O)CC)=CC=CC=C1 IXZQVROIFOTPNN-STQWGSIPSA-N 0.000 claims description 2
• WQWHNZFYYOCLPK-XCZPVHLTSA-N 6-chloro-n-[[(3s,5s)-2-oxo-3-(2-piperidin-1-ylethyl)-1-[(2,3,5-trichlorophenyl)methyl]-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CCN1CCCCC1)C1=O)CNC(=O)C2=CC3=CC=C(C=C3C=C2)Cl)CN1CC1=CC(Cl)=CC(Cl)=C1Cl WQWHNZFYYOCLPK-XCZPVHLTSA-N 0.000 claims description 2
• UNIUHTXBGLCPAQ-DJDPXSJISA-N 6-chloro-n-[[(3s,5s)-3-(2-methyl-2-piperidin-1-ylpropyl)-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H]1N[C@H](CNC(=O)C=2C=C3C=CC(Cl)=CC3=CC=2)CCN(C1=O)C[C@@H](CC)C=1C=CC=CC=1)C(C)(C)N1CCCCC1 UNIUHTXBGLCPAQ-DJDPXSJISA-N 0.000 claims description 2
• ZQSBKBHQNPDVKJ-MHWRTBLVSA-N 6-chloro-n-[[(3s,5s)-3-[2-[(n'-methylcarbamimidoyl)amino]ethyl]-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C1([C@@H](CN2C([C@H](CCNC(=N)NC)N[C@H](CNC(=O)C=3C=C4C=CC(Cl)=CC4=CC=3)CC2)=O)CC)=CC=CC=C1 ZQSBKBHQNPDVKJ-MHWRTBLVSA-N 0.000 claims description 2
• ILSJFQAVPNGFPA-COWIPBKQSA-N 6-chloro-n-[[3-(1-ethylpiperidin-4-yl)-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CC)C=1C=CC=CC=1)N(C1=O)CCC(CNC(=O)C=2C=C3C=CC(Cl)=CC3=CC=2)NC1C1CCN(CC)CC1 ILSJFQAVPNGFPA-COWIPBKQSA-N 0.000 claims description 2
• VMIUFLHAHCMJKL-WJHQPOGDSA-N 6-methoxy-n-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H]1N[C@H](CNC(=O)C=2C=C3C=CC(OC)=CC3=CC=2)CCN(C1=O)C[C@@H](CC)C=1C=CC=CC=1)CN1CCCCC1 VMIUFLHAHCMJKL-WJHQPOGDSA-N 0.000 claims description 2
• MSTAOBRZXXUMJU-TXIPYEPDSA-N N-[[(3S,5S)-3-[3-(diaminomethylideneamino)propyl]-1-(2-oxo-1-phenylethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound N(C(=N)N)CCC[C@H]1CN(CC[C@H](N1)CNC(=O)C1=CC2=CC=CC=C2C=C1)C(C=O)C1=CC=CC=C1 MSTAOBRZXXUMJU-TXIPYEPDSA-N 0.000 claims description 2
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• 125000002393 azetidinyl group Chemical group 0.000 claims description 2
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• 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 2
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• DUJLXNMGMRSYKZ-OCDQQJRCSA-N n-[2-[(2s,7s)-7-[[[(e)-3-(4-chlorophenyl)prop-2-enoyl]amino]methyl]-4-(2,2-diphenylethyl)-3-oxo-1,4-diazepan-2-yl]ethyl]cyclohexanecarboxamide Chemical compound C1=CC(Cl)=CC=C1\C=C\C(=O)NC[C@H]1N[C@@H](CCNC(=O)C2CCCCC2)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 DUJLXNMGMRSYKZ-OCDQQJRCSA-N 0.000 claims description 2
• WZZVZPAJKVCJKH-VTIYRKAUSA-N n-[2-[(3s,5r)-1-(2,2-diphenylethyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]ethyl]benzamide Chemical compound C([C@H](N[C@@H](CCN1CCCCC1)C1=O)CCNC(=O)C=2C=CC=CC=2)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 WZZVZPAJKVCJKH-VTIYRKAUSA-N 0.000 claims description 2
• TXZSDUWGCSMZLE-BZFILIQBSA-N n-[2-[(3s,5r)-1-(2,2-diphenylethyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]ethyl]naphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CCN1CCCCC1)C1=O)CCNC(=O)C=2C=C3C=CC=CC3=CC=2)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 TXZSDUWGCSMZLE-BZFILIQBSA-N 0.000 claims description 2
• FJJQFRFHGDPGKD-VHFKIGOXSA-N n-[2-[(3s,5r)-1-(2,2-diphenylethyl)-2-oxo-3-(2-pyrrolidin-1-ylethyl)-1,4-diazepan-5-yl]ethyl]naphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CCN1CCCC1)C1=O)CCNC(=O)C=2C=C3C=CC=CC3=CC=2)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 FJJQFRFHGDPGKD-VHFKIGOXSA-N 0.000 claims description 2
• DAZFBUPSURRZJX-IAPPQJPRSA-N n-[2-[(3s,5r)-3-(2-aminoethyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]ethyl]benzamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCN)CNC(=O)C1=CC=CC=C1 DAZFBUPSURRZJX-IAPPQJPRSA-N 0.000 claims description 2
• MZAGAXLYDIZEAQ-FSQVGHHWSA-N n-[[(2s,7s)-7-[[[(e)-3-(4-chlorophenyl)prop-2-enoyl]amino]methyl]-4-(2,2-diphenylethyl)-3-oxo-1,4-diazepan-2-yl]methyl]cyclohexanecarboxamide Chemical compound C1=CC(Cl)=CC=C1\C=C\C(=O)NC[C@H]1N[C@@H](CNC(=O)C2CCCCC2)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 MZAGAXLYDIZEAQ-FSQVGHHWSA-N 0.000 claims description 2
• MRYCUSLQWJOOEP-LBXWICMISA-N n-[[(2s,7s)-7-[[[(e)-3-(4-chlorophenyl)prop-2-enoyl]amino]methyl]-4-(2,2-diphenylethyl)-3-oxo-1,4-diazepan-2-yl]methyl]pyridine-2-carboxamide Chemical compound C1=CC(Cl)=CC=C1\C=C\C(=O)NC[C@H]1N[C@@H](CNC(=O)C=2N=CC=CC=2)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 MRYCUSLQWJOOEP-LBXWICMISA-N 0.000 claims description 2
• QOIYHTMMIORSMO-PJJRWXIWSA-N n-[[(3s,5s)-1-(1-adamantylmethyl)-3-[3-(diaminomethylideneamino)propyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C1CN(CC23CC4CC(CC(C4)C2)C3)C(=O)[C@H](CCCNC(=N)N)N[C@@H]1CNC(=O)C1=CC=C(C=CC=C2)C2=C1 QOIYHTMMIORSMO-PJJRWXIWSA-N 0.000 claims description 2
• VOPMGSQMQQNMQC-TWJUONSBSA-N n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]-3,4-dimethylbenzamide Chemical compound C1=C(C)C(C)=CC=C1C(=O)NC[C@H]1N[C@@H](CCN2CCCCC2)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 VOPMGSQMQQNMQC-TWJUONSBSA-N 0.000 claims description 2
• OWPKBLQWFBWNKD-CDZUIXILSA-N n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]-3-(trifluoromethyl)benzamide Chemical compound FC(F)(F)C1=CC=CC(C(=O)NC[C@H]2N[C@@H](CCN3CCCCC3)C(=O)N(CC(C=3C=CC=CC=3)C=3C=CC=CC=3)CC2)=C1 OWPKBLQWFBWNKD-CDZUIXILSA-N 0.000 claims description 2
• QJPNYLFEMHBJJE-TWJUONSBSA-N n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]-3-phenylprop-2-enamide Chemical compound C([C@H](N[C@@H](CCN1CCCCC1)C1=O)CNC(=O)C=CC=2C=CC=CC=2)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 QJPNYLFEMHBJJE-TWJUONSBSA-N 0.000 claims description 2
• ISICZEWTBMCGDK-CDZUIXILSA-N n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]-4-(trifluoromethyl)benzamide Chemical compound C1=CC(C(F)(F)F)=CC=C1C(=O)NC[C@H]1N[C@@H](CCN2CCCCC2)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 ISICZEWTBMCGDK-CDZUIXILSA-N 0.000 claims description 2
• LSVPMPZPLBNKJM-GIWKVKTRSA-N n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]-6-fluoronaphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CCN1CCCCC1)C1=O)CNC(=O)C2=CC3=CC=C(C=C3C=C2)F)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 LSVPMPZPLBNKJM-GIWKVKTRSA-N 0.000 claims description 2
• JPADPRBRCWWLNJ-GIWKVKTRSA-N n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CCN1CCCCC1)C1=O)CNC(=O)C=2C=C3C=CC=CC3=CC=2)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 JPADPRBRCWWLNJ-GIWKVKTRSA-N 0.000 claims description 2
• VEXDNIWRKHFDTI-LRHLLKFHSA-N n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(2-pyrrolidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CCN1CCCC1)C1=O)CNC(=O)C=2C=C3C=CC=CC3=CC=2)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 VEXDNIWRKHFDTI-LRHLLKFHSA-N 0.000 claims description 2
• ZOEXTJUHQXENMX-LRHLLKFHSA-N n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(3-piperidin-1-ylpropyl)-1,4-diazepan-5-yl]methyl]-3,4-dimethylbenzamide Chemical compound C1=C(C)C(C)=CC=C1C(=O)NC[C@H]1N[C@@H](CCCN2CCCCC2)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 ZOEXTJUHQXENMX-LRHLLKFHSA-N 0.000 claims description 2
• OFSDUHSZAHOEBR-LRHLLKFHSA-N n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(3-piperidin-1-ylpropyl)-1,4-diazepan-5-yl]methyl]-3-phenylprop-2-enamide Chemical compound C([C@H](N[C@@H](CCCN1CCCCC1)C1=O)CNC(=O)C=CC=2C=CC=CC=2)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 OFSDUHSZAHOEBR-LRHLLKFHSA-N 0.000 claims description 2
• WXTJVBJGZBPGMH-JSXFGMRASA-N n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(3-piperidin-1-ylpropyl)-1,4-diazepan-5-yl]methyl]-6-fluoronaphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CCCN1CCCCC1)C1=O)CNC(=O)C2=CC3=CC=C(C=C3C=C2)F)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 WXTJVBJGZBPGMH-JSXFGMRASA-N 0.000 claims description 2
• FGCNJHYOEJHYES-GIWKVKTRSA-N n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(3-pyrrolidin-1-ylpropyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CCCN1CCCC1)C1=O)CNC(=O)C=2C=C3C=CC=CC3=CC=2)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 FGCNJHYOEJHYES-GIWKVKTRSA-N 0.000 claims description 2
• ANTSJPZYEYUKQW-LRHLLKFHSA-N n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(piperidin-1-ylmethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CN1CCCCC1)C1=O)CNC(=O)C=2C=C3C=CC=CC3=CC=2)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 ANTSJPZYEYUKQW-LRHLLKFHSA-N 0.000 claims description 2
• VLSQOCSIELJZCT-GIWKVKTRSA-N n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-[4-(propan-2-ylamino)butyl]-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCCNC(C)C)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 VLSQOCSIELJZCT-GIWKVKTRSA-N 0.000 claims description 2
• KHSZVGIVMCAAEX-UIOOFZCWSA-N n-[[(3s,5s)-1-(2-cyclohexylethyl)-3-[3-(diaminomethylideneamino)propyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCNC(=N)N)CN1CCC1CCCCC1 KHSZVGIVMCAAEX-UIOOFZCWSA-N 0.000 claims description 2
• BDLQPOKUIAQPOP-NSOVKSMOSA-N n-[[(3s,5s)-1-(2-ethylbutyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]-6-fluoronaphthalene-2-carboxamide Chemical compound C([C@@H]1N[C@H](CNC(=O)C=2C=C3C=CC(F)=CC3=CC=2)CCN(C1=O)CC(CC)CC)CN1CCCCC1 BDLQPOKUIAQPOP-NSOVKSMOSA-N 0.000 claims description 2
• DTOOUBDUVXWTKR-NSOVKSMOSA-N n-[[(3s,5s)-1-(2-ethylbutyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H]1N[C@H](CNC(=O)C=2C=C3C=CC=CC3=CC=2)CCN(C1=O)CC(CC)CC)CN1CCCCC1 DTOOUBDUVXWTKR-NSOVKSMOSA-N 0.000 claims description 2
• QLKOVWMYGSDFMS-GFMLHKOCSA-N n-[[(3s,5s)-1-(3-anilino-3-oxo-2-phenylpropyl)-3-[3-(diaminomethylideneamino)propyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCNC(=N)N)CN1CC(C=1C=CC=CC=1)C(=O)NC1=CC=CC=C1 QLKOVWMYGSDFMS-GFMLHKOCSA-N 0.000 claims description 2
• IAQSNFZRQDKISL-URXFXBBRSA-N n-[[(3s,5s)-1-(cyclohexylmethyl)-3-[3-(diaminomethylideneamino)propyl]-2-oxo-1,4-diazepan-5-yl]methyl]-2-(1h-indol-3-yl)acetamide Chemical compound C([C@@H](CNC(=O)CC=1C2=CC=CC=C2NC=1)N[C@H](C1=O)CCCNC(=N)N)CN1CC1CCCCC1 IAQSNFZRQDKISL-URXFXBBRSA-N 0.000 claims description 2
• LXVAANGAZWTPKK-SVBPBHIXSA-N n-[[(3s,5s)-1-(cyclohexylmethyl)-3-[3-(diaminomethylideneamino)propyl]-2-oxo-1,4-diazepan-5-yl]methyl]-4-phenylbenzamide Chemical compound C([C@H]1N[C@H](C(N(CC2CCCCC2)CC1)=O)CCCNC(=N)N)NC(=O)C(C=C1)=CC=C1C1=CC=CC=C1 LXVAANGAZWTPKK-SVBPBHIXSA-N 0.000 claims description 2
• ADKVQJADKHYOED-UPVQGACJSA-N n-[[(3s,5s)-1-(cyclohexylmethyl)-3-[3-(diaminomethylideneamino)propyl]-2-oxo-1,4-diazepan-5-yl]methyl]quinoline-3-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=NC=1)N[C@H](C1=O)CCCNC(=N)N)CN1CC1CCCCC1 ADKVQJADKHYOED-UPVQGACJSA-N 0.000 claims description 2
• XPBDPPLRPHGTCD-AHCWXFLVSA-N n-[[(3s,5s)-1-[(2r)-2-(4-chlorophenyl)propyl]-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H]1N[C@H](CNC(=O)C=2C=C3C=CC=CC3=CC=2)CCN(C1=O)C[C@H](C)C=1C=CC(Cl)=CC=1)CN1CCCCC1 XPBDPPLRPHGTCD-AHCWXFLVSA-N 0.000 claims description 2
• MMMCEMRIDNKRNN-CPCREDONSA-N n-[[(3s,5s)-1-[(2r)-2-benzamido-2-phenylethyl]-3-[3-(diaminomethylideneamino)propyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound N([C@@H](CN1CC[C@@H](CNC(=O)C=2C=C3C=CC=CC3=CC=2)N[C@H](C1=O)CCCNC(=N)N)C=1C=CC=CC=1)C(=O)C1=CC=CC=C1 MMMCEMRIDNKRNN-CPCREDONSA-N 0.000 claims description 2
• CCWKJKIMXUBDRW-DSPMFFIESA-N n-[[(3s,5s)-1-[(2r)-3-methyl-2-phenylbutyl]-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H]1N[C@H](CNC(=O)C=2C=C3C=CC=CC3=CC=2)CCN(C1=O)C[C@H](C(C)C)C=1C=CC=CC=1)CN1CCCCC1 CCWKJKIMXUBDRW-DSPMFFIESA-N 0.000 claims description 2
• RDSQVPFVJVICFC-OIFRRMEBSA-N n-[[(3s,5s)-1-[(2s)-2-(cyclobutanecarbonylamino)-2-phenylethyl]-3-[3-(diaminomethylideneamino)propyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound N([C@H](CN1CC[C@@H](CNC(=O)C=2C=C3C=CC=CC3=CC=2)N[C@H](C1=O)CCCNC(=N)N)C=1C=CC=CC=1)C(=O)C1CCC1 RDSQVPFVJVICFC-OIFRRMEBSA-N 0.000 claims description 2
• OXLHHWIDPQHMOC-OWHBQTKESA-N n-[[(3s,5s)-1-[(2s)-2-(cyclohexanecarbonylamino)-2-phenylethyl]-3-[3-(diaminomethylideneamino)propyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound N([C@H](CN1CC[C@@H](CNC(=O)C=2C=C3C=CC=CC3=CC=2)N[C@H](C1=O)CCCNC(=N)N)C=1C=CC=CC=1)C(=O)C1CCCCC1 OXLHHWIDPQHMOC-OWHBQTKESA-N 0.000 claims description 2
• ITFIOTBKZZKPDD-HZFUHODCSA-N n-[[(3s,5s)-1-[(2s)-2-acetamido-2-phenylethyl]-3-[3-(diaminomethylideneamino)propyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C1([C@@H](CN2C([C@H](CCCNC(N)=N)N[C@H](CNC(=O)C=3C=C4C=CC=CC4=CC=3)CC2)=O)NC(=O)C)=CC=CC=C1 ITFIOTBKZZKPDD-HZFUHODCSA-N 0.000 claims description 2
• MMMCEMRIDNKRNN-OWHBQTKESA-N n-[[(3s,5s)-1-[(2s)-2-benzamido-2-phenylethyl]-3-[3-(diaminomethylideneamino)propyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound N([C@H](CN1CC[C@@H](CNC(=O)C=2C=C3C=CC=CC3=CC=2)N[C@H](C1=O)CCCNC(=N)N)C=1C=CC=CC=1)C(=O)C1=CC=CC=C1 MMMCEMRIDNKRNN-OWHBQTKESA-N 0.000 claims description 2
• CCWKJKIMXUBDRW-ZDCRTTOTSA-N n-[[(3s,5s)-1-[(2s)-3-methyl-2-phenylbutyl]-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H]1N[C@H](CNC(=O)C=2C=C3C=CC=CC3=CC=2)CCN(C1=O)C[C@@H](C(C)C)C=1C=CC=CC=1)CN1CCCCC1 CCWKJKIMXUBDRW-ZDCRTTOTSA-N 0.000 claims description 2
• KIPZSVAQDGHKGO-WNJJXGMVSA-N n-[[(3s,5s)-1-[(3,5-dichlorophenyl)methyl]-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]-1-methoxynaphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CCN1CCCCC1)C1=O)CNC(=O)C2=C(C3=CC=CC=C3C=C2)OC)CN1CC1=CC(Cl)=CC(Cl)=C1 KIPZSVAQDGHKGO-WNJJXGMVSA-N 0.000 claims description 2
• HXXBMEZXUSWFQJ-JDXGNMNLSA-N n-[[(3s,5s)-1-[(3,5-dichlorophenyl)methyl]-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]-6-methoxynaphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CCN1CCCCC1)C1=O)CNC(=O)C2=CC3=CC=C(C=C3C=C2)OC)CN1CC1=CC(Cl)=CC(Cl)=C1 HXXBMEZXUSWFQJ-JDXGNMNLSA-N 0.000 claims description 2
• PGBXMGDIUPDMAU-VMPREFPWSA-N n-[[(3s,5s)-1-[(3,5-dichlorophenyl)methyl]-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound ClC1=CC(Cl)=CC(CN2C([C@H](CCN3CCCCC3)N[C@H](CNC(=O)C=3C=C4C=CC=CC4=CC=3)CC2)=O)=C1 PGBXMGDIUPDMAU-VMPREFPWSA-N 0.000 claims description 2
• IZBHZOBLFBQQPY-SVBPBHIXSA-N n-[[(3s,5s)-1-[(3,5-dichlorophenyl)methyl]-2-oxo-3-(pyrrolidin-1-ylmethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound ClC1=CC(Cl)=CC(CN2C([C@H](CN3CCCC3)N[C@H](CNC(=O)C=3C=C4C=CC=CC4=CC=3)CC2)=O)=C1 IZBHZOBLFBQQPY-SVBPBHIXSA-N 0.000 claims description 2
• VHKRXIDKQSHFJJ-DQEYMECFSA-N n-[[(3s,5s)-1-[(3-chloro-5-fluorophenyl)methyl]-3-[3-(diaminomethylideneamino)propyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCNC(=N)N)CN1CC1=CC(F)=CC(Cl)=C1 VHKRXIDKQSHFJJ-DQEYMECFSA-N 0.000 claims description 2
• WPCJZOUXSQEEEF-DQEYMECFSA-N n-[[(3s,5s)-1-benzyl-3-[3-(diaminomethylideneamino)propyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCNC(=N)N)CN1CC1=CC=CC=C1 WPCJZOUXSQEEEF-DQEYMECFSA-N 0.000 claims description 2
• RQAUICUAVHREBS-UPVQGACJSA-N n-[[(3s,5s)-1-cyclohexyl-3-[3-(diaminomethylideneamino)propyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCNC(=N)N)CN1C1CCCCC1 RQAUICUAVHREBS-UPVQGACJSA-N 0.000 claims description 2
• LPJIFZVWSJVIJR-IGBKUBFESA-N n-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]-2-phenyl-1,3-thiazole-4-carboxamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCCCC2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C(N=1)=CSC=1C1=CC=CC=C1 LPJIFZVWSJVIJR-IGBKUBFESA-N 0.000 claims description 2
• GRJDLJXFXZBQLM-AFAVSPFMSA-N n-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]-4-phenylbenzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCCCC2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C(C=C1)=CC=C1C1=CC=CC=C1 GRJDLJXFXZBQLM-AFAVSPFMSA-N 0.000 claims description 2
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• BWKKOIFSAZINTN-HOFKKMOUSA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3,4-dichlorobenzamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCN)NC(=O)C1=CC=C(Cl)C(Cl)=C1 BWKKOIFSAZINTN-HOFKKMOUSA-N 0.000 claims description 2
• BTIWBRIJMDPPKC-YTMVLYRLSA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3,4-dimethylbenzamide Chemical compound C1=C(C)C(C)=CC=C1C(=O)NC[C@H]1N[C@@H](CCN)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 BTIWBRIJMDPPKC-YTMVLYRLSA-N 0.000 claims description 2
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• QJCVJUHQSMDVKK-JUQRWGLSSA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-(2-ethyl-3-methylbut-3-enyl)-2-oxo-1,4-diazepan-5-yl]methyl]-6-chloronaphthalene-2-carboxamide Chemical compound N1[C@@H](CCN)C(=O)N(CC(CC)C(C)=C)CC[C@H]1CNC(=O)C1=CC=C(C=C(Cl)C=C2)C2=C1 QJCVJUHQSMDVKK-JUQRWGLSSA-N 0.000 claims description 2
• IWXFBIJRILMYKC-LPHOPBHVSA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-(2-ethylbutyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-chloro-4-fluorobenzamide Chemical compound N1[C@@H](CCN)C(=O)N(CC(CC)CC)CC[C@H]1CNC(=O)C1=CC=C(F)C(Cl)=C1 IWXFBIJRILMYKC-LPHOPBHVSA-N 0.000 claims description 2
• SFWBAROKYIEQQK-ICSRJNTNSA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-(2-ethylbutyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-chloro-4-methylbenzamide Chemical compound N1[C@@H](CCN)C(=O)N(CC(CC)CC)CC[C@H]1CNC(=O)C1=CC=C(C)C(Cl)=C1 SFWBAROKYIEQQK-ICSRJNTNSA-N 0.000 claims description 2
• ZCQARZDWEORZBP-LPHOPBHVSA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-(2-ethylbutyl)-2-oxo-1,4-diazepan-5-yl]methyl]-4-chloro-3-fluorobenzamide Chemical compound N1[C@@H](CCN)C(=O)N(CC(CC)CC)CC[C@H]1CNC(=O)C1=CC=C(Cl)C(F)=C1 ZCQARZDWEORZBP-LPHOPBHVSA-N 0.000 claims description 2
• IZLQANWXAURBRV-ICSRJNTNSA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-(2-ethylbutyl)-2-oxo-1,4-diazepan-5-yl]methyl]-4-chloro-3-methylbenzamide Chemical compound N1[C@@H](CCN)C(=O)N(CC(CC)CC)CC[C@H]1CNC(=O)C1=CC=C(Cl)C(C)=C1 IZLQANWXAURBRV-ICSRJNTNSA-N 0.000 claims description 2
• CUXGFAFNHPUFBW-GOTSBHOMSA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-(2-ethylbutyl)-2-oxo-1,4-diazepan-5-yl]methyl]-6-chloronaphthalene-2-carboxamide Chemical compound N1[C@@H](CCN)C(=O)N(CC(CC)CC)CC[C@H]1CNC(=O)C1=CC=C(C=C(Cl)C=C2)C2=C1 CUXGFAFNHPUFBW-GOTSBHOMSA-N 0.000 claims description 2
• VRPPVWOIMJSSEJ-GOTSBHOMSA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-(2-ethylbutyl)-2-oxo-1,4-diazepan-5-yl]methyl]-6-fluoronaphthalene-2-carboxamide Chemical compound N1[C@@H](CCN)C(=O)N(CC(CC)CC)CC[C@H]1CNC(=O)C1=CC=C(C=C(F)C=C2)C2=C1 VRPPVWOIMJSSEJ-GOTSBHOMSA-N 0.000 claims description 2
• JCDGDLIWBJJHQP-GOTSBHOMSA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-(2-ethylbutyl)-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound N1[C@@H](CCN)C(=O)N(CC(CC)CC)CC[C@H]1CNC(=O)C1=CC=C(C=CC=C2)C2=C1 JCDGDLIWBJJHQP-GOTSBHOMSA-N 0.000 claims description 2
• HBKPZZFNAMXAOE-HSJPWVCISA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-(3-methyl-2-phenylbutyl)-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound O=C([C@H](CCN)N[C@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)CC1)N1CC(C(C)C)C1=CC=CC=C1 HBKPZZFNAMXAOE-HSJPWVCISA-N 0.000 claims description 2
• ZLMMRMFQYXKUTG-JXFKEZNVSA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-[(2,4-dichlorophenyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]-3,4-dichlorobenzamide Chemical compound C([C@H]1N[C@H](C(N(CC=2C(=CC(Cl)=CC=2)Cl)CC1)=O)CCN)NC(=O)C1=CC=C(Cl)C(Cl)=C1 ZLMMRMFQYXKUTG-JXFKEZNVSA-N 0.000 claims description 2
• VXNONGPPOZEGEO-UPVQGACJSA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-[(2,4-dichlorophenyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]-6-chloronaphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC(Cl)=CC2=CC=1)N[C@H](C1=O)CCN)CN1CC1=CC=C(Cl)C=C1Cl VXNONGPPOZEGEO-UPVQGACJSA-N 0.000 claims description 2
• HKNGQTNXBWWWPO-CNVLFFCLSA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-[(2r)-2-(4-chlorophenyl)propyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C1([C@H](CN2C([C@H](CCN)N[C@H](CNC(=O)C=3C=C4C=CC=CC4=CC=3)CC2)=O)C)=CC=C(Cl)C=C1 HKNGQTNXBWWWPO-CNVLFFCLSA-N 0.000 claims description 2
• SSKMMZGAMAHEJL-KNBMTAEXSA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-[(2r)-2-ethyl-3-methylbutyl]-2-oxo-1,4-diazepan-5-yl]methyl]-3,4-dichlorobenzamide Chemical compound N1[C@@H](CCN)C(=O)N(C[C@H](CC)C(C)C)CC[C@H]1CNC(=O)C1=CC=C(Cl)C(Cl)=C1 SSKMMZGAMAHEJL-KNBMTAEXSA-N 0.000 claims description 2
• YNDUUKABKHQMSJ-NWVWQQAFSA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-[(2r)-2-ethyl-3-methylbutyl]-2-oxo-1,4-diazepan-5-yl]methyl]-6-chloronaphthalene-2-carboxamide Chemical compound N1[C@@H](CCN)C(=O)N(C[C@H](CC)C(C)C)CC[C@H]1CNC(=O)C1=CC=C(C=C(Cl)C=C2)C2=C1 YNDUUKABKHQMSJ-NWVWQQAFSA-N 0.000 claims description 2
• SSKMMZGAMAHEJL-SYNHAJSKSA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-[(2s)-2-ethyl-3-methylbutyl]-2-oxo-1,4-diazepan-5-yl]methyl]-3,4-dichlorobenzamide Chemical compound N1[C@@H](CCN)C(=O)N(C[C@@H](CC)C(C)C)CC[C@H]1CNC(=O)C1=CC=C(Cl)C(Cl)=C1 SSKMMZGAMAHEJL-SYNHAJSKSA-N 0.000 claims description 2
• YNDUUKABKHQMSJ-DKLXNKCPSA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-[(2s)-2-ethyl-3-methylbutyl]-2-oxo-1,4-diazepan-5-yl]methyl]-6-chloronaphthalene-2-carboxamide Chemical compound N1[C@@H](CCN)C(=O)N(C[C@@H](CC)C(C)C)CC[C@H]1CNC(=O)C1=CC=C(C=C(Cl)C=C2)C2=C1 YNDUUKABKHQMSJ-DKLXNKCPSA-N 0.000 claims description 2
• LAOYIESGAAPHNK-PXNSSMCTSA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-[(3,5-dichlorophenyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]-3,4-dichlorobenzamide Chemical compound C([C@H]1N[C@H](C(N(CC=2C=C(Cl)C=C(Cl)C=2)CC1)=O)CCN)NC(=O)C1=CC=C(Cl)C(Cl)=C1 LAOYIESGAAPHNK-PXNSSMCTSA-N 0.000 claims description 2
• SAZDPTSZGYBNIO-ZEQRLZLVSA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-[(3,5-dichlorophenyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]-6-chloronaphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC(Cl)=CC2=CC=1)N[C@H](C1=O)CCN)CN1CC1=CC(Cl)=CC(Cl)=C1 SAZDPTSZGYBNIO-ZEQRLZLVSA-N 0.000 claims description 2
• QHOCHQYTGSIOPC-ZEQRLZLVSA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-[(3,5-dichlorophenyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCN)CN1CC1=CC(Cl)=CC(Cl)=C1 QHOCHQYTGSIOPC-ZEQRLZLVSA-N 0.000 claims description 2
• NKYAUCIDYPAKAP-ADNZQJBKSA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-[(3,5-dimethylcyclohexyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]-3,4-dichlorobenzamide Chemical compound C1C(C)CC(C)CC1CN1C(=O)[C@H](CCN)N[C@H](CNC(=O)C=2C=C(Cl)C(Cl)=CC=2)CC1 NKYAUCIDYPAKAP-ADNZQJBKSA-N 0.000 claims description 2
• GHTFXPGMMCNCPQ-OSTLVTSRSA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-[(3,5-dimethylcyclohexyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C1C(C)CC(C)CC1CN1C(=O)[C@H](CCN)N[C@H](CNC(=O)C=2C=C3C=CC=CC3=CC=2)CC1 GHTFXPGMMCNCPQ-OSTLVTSRSA-N 0.000 claims description 2
• HKNGQTNXBWWWPO-AIKKUKTPSA-N n-[[(3s,5s)-3-(2-aminoethyl)-1-[2-(4-chlorophenyl)propyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound O=C([C@H](CCN)N[C@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)CC1)N1CC(C)C1=CC=C(Cl)C=C1 HKNGQTNXBWWWPO-AIKKUKTPSA-N 0.000 claims description 2
• WICUPIKXMHXENI-FOLYQGEWSA-N n-[[(3s,5s)-3-(2-aminoethyl)-2-oxo-1-(2-phenylbutyl)-1,4-diazepan-5-yl]methyl]-3,4-dichlorobenzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN)N1)=O)CC(CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 WICUPIKXMHXENI-FOLYQGEWSA-N 0.000 claims description 2
• FGZDTSSBZOVZFL-MQTLACETSA-N n-[[(3s,5s)-3-(2-aminoethyl)-2-oxo-1-(2-thiophen-3-ylbutyl)-1,4-diazepan-5-yl]methyl]-6-chloronaphthalene-2-carboxamide Chemical compound O=C([C@H](CCN)N[C@H](CNC(=O)C=1C=C2C=CC(Cl)=CC2=CC=1)CC1)N1CC(CC)C=1C=CSC=1 FGZDTSSBZOVZFL-MQTLACETSA-N 0.000 claims description 2
• WICUPIKXMHXENI-MONBJTKQSA-N n-[[(3s,5s)-3-(2-aminoethyl)-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]-3,4-dichlorobenzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 WICUPIKXMHXENI-MONBJTKQSA-N 0.000 claims description 2
• MGXWYVJAKUDFJO-DVTKYRPYSA-N n-[[(3s,5s)-3-(2-anilinoethyl)-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]-3,4-dichlorobenzamide Chemical compound C([C@@H]1CCN(C([C@H](CCNC=2C=CC=CC=2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 MGXWYVJAKUDFJO-DVTKYRPYSA-N 0.000 claims description 2
• ZOJZPJKDVGKPAL-WNJJXGMVSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-1h-indole-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1NC2=CC=CC=C2C=1)N[C@H](C1=O)CCCN)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 ZOJZPJKDVGKPAL-WNJJXGMVSA-N 0.000 claims description 2
• FYYVLUVZEXACBD-WNJJXGMVSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-2-(4-fluorophenoxy)acetamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCN)NC(=O)COC1=CC=C(F)C=C1 FYYVLUVZEXACBD-WNJJXGMVSA-N 0.000 claims description 2
• QCBUQTAEJQXPDH-TXJYOHDVSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-2-ethylhexanamide Chemical compound O=C1[C@H](CCCN)N[C@H](CNC(=O)C(CC)CCCC)CCN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 QCBUQTAEJQXPDH-TXJYOHDVSA-N 0.000 claims description 2
• XSOVPZBZTYQPSS-XTBGFXFQSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-2-oxo-1-phenylpyrrolidine-3-carboxamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCN)NC(=O)C(C1=O)CCN1C1=CC=CC=C1 XSOVPZBZTYQPSS-XTBGFXFQSA-N 0.000 claims description 2
• WZRHDCPARKBLRT-YTMVLYRLSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-2-phenyl-1,3-thiazole-4-carboxamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCN)NC(=O)C(N=1)=CSC=1C1=CC=CC=C1 WZRHDCPARKBLRT-YTMVLYRLSA-N 0.000 claims description 2
• XAHFMULGPKQPNU-CUBQBAPOSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3,4-dichlorobenzamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCN)NC(=O)C1=CC=C(Cl)C(Cl)=C1 XAHFMULGPKQPNU-CUBQBAPOSA-N 0.000 claims description 2
• YRIJEWGEWVSBMX-JDXGNMNLSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3,4-dimethylbenzamide Chemical compound C1=C(C)C(C)=CC=C1C(=O)NC[C@H]1N[C@@H](CCCN)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 YRIJEWGEWVSBMX-JDXGNMNLSA-N 0.000 claims description 2
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• XOOWKJIZISVMFZ-DITALETJSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-4-(3,5-dimethylpyrazol-1-yl)benzamide Chemical compound N1=C(C)C=C(C)N1C1=CC=C(C(=O)NC[C@H]2N[C@@H](CCCN)C(=O)N(CC(C=3C=CC=CC=3)C=3C=CC=CC=3)CC2)C=C1 XOOWKJIZISVMFZ-DITALETJSA-N 0.000 claims description 2
• QIYHHMWGJGOPBJ-IZEXYCQBSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-4-(3-methyl-5-oxo-4h-pyrazol-1-yl)benzamide Chemical compound O=C1CC(C)=NN1C1=CC=C(C(=O)NC[C@H]2N[C@@H](CCCN)C(=O)N(CC(C=3C=CC=CC=3)C=3C=CC=CC=3)CC2)C=C1 QIYHHMWGJGOPBJ-IZEXYCQBSA-N 0.000 claims description 2
• RUDKYWWUECNFKN-TWJUONSBSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-4-phenylbenzamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCN)NC(=O)C(C=C1)=CC=C1C1=CC=CC=C1 RUDKYWWUECNFKN-TWJUONSBSA-N 0.000 claims description 2
• JUNSYZPRBPCSND-NYDCQLBNSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-4-pyrrol-1-ylbenzamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCN)NC(=O)C(C=C1)=CC=C1N1C=CC=C1 JUNSYZPRBPCSND-NYDCQLBNSA-N 0.000 claims description 2
• CLQPXYACEJHHPT-YTMVLYRLSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-5-(4-chlorophenyl)-1,2-oxazole-3-carboxamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCN)NC(=O)C(=NO1)C=C1C1=CC=C(Cl)C=C1 CLQPXYACEJHHPT-YTMVLYRLSA-N 0.000 claims description 2
• LRHDGJCOTTVMKL-JDXGNMNLSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-5-(4-chlorophenyl)furan-2-carboxamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCN)NC(=O)C(O1)=CC=C1C1=CC=C(Cl)C=C1 LRHDGJCOTTVMKL-JDXGNMNLSA-N 0.000 claims description 2
• ZUIVKBAJDLMMDS-CDZUIXILSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-6-bromonaphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC(Br)=CC2=CC=1)N[C@H](C1=O)CCCN)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 ZUIVKBAJDLMMDS-CDZUIXILSA-N 0.000 claims description 2
• XRTIRNHZVUVWOJ-UPVQGACJSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-[(2,3-dichlorophenyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCN)CN1CC1=CC=CC(Cl)=C1Cl XRTIRNHZVUVWOJ-UPVQGACJSA-N 0.000 claims description 2
• XTKNLEWVDDEEIW-ZCYQVOJMSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-[(2,4-dichlorophenyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCN)CN1CC1=CC=C(Cl)C=C1Cl XTKNLEWVDDEEIW-ZCYQVOJMSA-N 0.000 claims description 2
• GNYPKRMHSTUXSC-ZCYQVOJMSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-[(2,5-dichlorophenyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCN)CN1CC1=CC(Cl)=CC=C1Cl GNYPKRMHSTUXSC-ZCYQVOJMSA-N 0.000 claims description 2
• PJUVKKCZPWFZRM-OFVILXPXSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-[(2,6-dichlorophenyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCN)CN1CC1=C(Cl)C=CC=C1Cl PJUVKKCZPWFZRM-OFVILXPXSA-N 0.000 claims description 2
• GXINBEVXEUIFAY-ZCYQVOJMSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-[(2-chlorophenyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCN)CN1CC1=CC=CC=C1Cl GXINBEVXEUIFAY-ZCYQVOJMSA-N 0.000 claims description 2
• JKAROZVYTRWXET-DHLKQENFSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-[(3,4-dichlorophenyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCN)CN1CC1=CC=C(Cl)C(Cl)=C1 JKAROZVYTRWXET-DHLKQENFSA-N 0.000 claims description 2
• SDKHRVBEXCSFAH-DQEYMECFSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-[(3,5-difluorophenyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCN)CN1CC1=CC(F)=CC(F)=C1 SDKHRVBEXCSFAH-DQEYMECFSA-N 0.000 claims description 2
• CAVYLZGSZWGITF-IGKIAQTJSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-[(3,5-dimethoxyphenyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound COC1=CC(OC)=CC(CN2C([C@H](CCCN)N[C@H](CNC(=O)C=3C=C4C=CC=CC4=CC=3)CC2)=O)=C1 CAVYLZGSZWGITF-IGKIAQTJSA-N 0.000 claims description 2
• CZZGONADCVJPNV-DQEYMECFSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-[(3-chloro-5-fluorophenyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCN)CN1CC1=CC(F)=CC(Cl)=C1 CZZGONADCVJPNV-DQEYMECFSA-N 0.000 claims description 2
• YFYIVHIAEHXMCH-DQEYMECFSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-[(3-chlorophenyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCN)CN1CC1=CC=CC(Cl)=C1 YFYIVHIAEHXMCH-DQEYMECFSA-N 0.000 claims description 2
• PXFWVGFTDAQGCB-UIOOFZCWSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-[(3-fluoro-5-methylphenyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound CC1=CC(F)=CC(CN2C([C@H](CCCN)N[C@H](CNC(=O)C=3C=C4C=CC=CC4=CC=3)CC2)=O)=C1 PXFWVGFTDAQGCB-UIOOFZCWSA-N 0.000 claims description 2
• FYYRJGXJJZHVBW-DQEYMECFSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-[(4-chlorophenyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCN)CN1CC1=CC=C(Cl)C=C1 FYYRJGXJJZHVBW-DQEYMECFSA-N 0.000 claims description 2
• NHAPQTWPUKDQDZ-DQEYMECFSA-N n-[[(3s,5s)-3-(3-aminopropyl)-1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCN)CN1CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 NHAPQTWPUKDQDZ-DQEYMECFSA-N 0.000 claims description 2
• BAKDCQAYDVMYLF-KYJUHHDHSA-N n-[[(3s,5s)-3-(3-aminopropyl)-2-oxo-1-[(1-phenylcyclohexyl)methyl]-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCN)CN1CC1(C=2C=CC=CC=2)CCCCC1 BAKDCQAYDVMYLF-KYJUHHDHSA-N 0.000 claims description 2
• BQPYVCCPIGAKCW-PUUVEUEGSA-N n-[[(3s,5s)-3-(3-aminopropyl)-2-oxo-1-[(2r)-2-phenylpropyl]-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C1([C@H](CN2C([C@H](CCCN)N[C@H](CNC(=O)C=3C=C4C=CC=CC4=CC=3)CC2)=O)C)=CC=CC=C1 BQPYVCCPIGAKCW-PUUVEUEGSA-N 0.000 claims description 2
• HIXSQRVONZIWDI-WWEDSPNTSA-N n-[[(3s,5s)-3-(3-aminopropyl)-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C1([C@@H](CN2C([C@H](CCCN)N[C@H](CNC(=O)C=3C=C4C=CC=CC4=CC=3)CC2)=O)CC)=CC=CC=C1 HIXSQRVONZIWDI-WWEDSPNTSA-N 0.000 claims description 2
• BQPYVCCPIGAKCW-AIGMYPEUSA-N n-[[(3s,5s)-3-(3-aminopropyl)-2-oxo-1-[(2s)-2-phenylpropyl]-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C1([C@@H](CN2C([C@H](CCCN)N[C@H](CNC(=O)C=3C=C4C=CC=CC4=CC=3)CC2)=O)C)=CC=CC=C1 BQPYVCCPIGAKCW-AIGMYPEUSA-N 0.000 claims description 2
• NMLHHLNZWBDJJX-YTMVLYRLSA-N n-[[(3s,5s)-3-(4-aminobutyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-1-benzofuran-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1OC2=CC=CC=C2C=1)N[C@H](C1=O)CCCCN)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 NMLHHLNZWBDJJX-YTMVLYRLSA-N 0.000 claims description 2
• ZEMZLZWYFQYUMY-WEZIJMHWSA-N n-[[(3s,5s)-3-(4-aminobutyl)-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCCN)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 ZEMZLZWYFQYUMY-WEZIJMHWSA-N 0.000 claims description 2
• YISLVKWGIZADMO-SVEHJYQDSA-N n-[[(3s,5s)-3-(4-aminobutyl)-1-(naphthalen-1-ylmethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-2-(1h-indol-3-yl)acetamide Chemical compound C1CN(CC=2C3=CC=CC=C3C=CC=2)C(=O)[C@H](CCCCN)N[C@@H]1CNC(=O)CC1=CNC2=CC=CC=C12 YISLVKWGIZADMO-SVEHJYQDSA-N 0.000 claims description 2
• PDOBGZCNSXLOEM-YZNIXAGQSA-N n-[[(3s,5s)-3-(4-aminobutyl)-1-(naphthalen-1-ylmethyl)-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-1-carboxamide Chemical compound C1CN(CC=2C3=CC=CC=C3C=CC=2)C(=O)[C@H](CCCCN)N[C@@H]1CNC(=O)C1=CC=CC2=CC=CC=C12 PDOBGZCNSXLOEM-YZNIXAGQSA-N 0.000 claims description 2
• MVRXLHCLTQPYTR-JDXGNMNLSA-N n-[[(3s,5s)-3-(4-aminobutyl)-1-(naphthalen-1-ylmethyl)-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C1CN(CC=2C3=CC=CC=C3C=CC=2)C(=O)[C@H](CCCCN)N[C@@H]1CNC(=O)C1=CC=C(C=CC=C2)C2=C1 MVRXLHCLTQPYTR-JDXGNMNLSA-N 0.000 claims description 2
• MGRQBYLBMYEQPU-LQJZCPKCSA-N n-[[(3s,5s)-3-(4-aminobutyl)-1-(naphthalen-2-ylmethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-2-(4-phenylphenyl)acetamide Chemical compound C([C@H]1N[C@H](C(N(CC=2C=C3C=CC=CC3=CC=2)CC1)=O)CCCCN)NC(=O)CC(C=C1)=CC=C1C1=CC=CC=C1 MGRQBYLBMYEQPU-LQJZCPKCSA-N 0.000 claims description 2
• NJZJQPFTLCHGPS-SMCANUKXSA-N n-[[(3s,5s)-3-(4-aminobutyl)-1-(naphthalen-2-ylmethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-2-naphthalen-1-ylacetamide Chemical compound C1CN(CC=2C=C3C=CC=CC3=CC=2)C(=O)[C@H](CCCCN)N[C@@H]1CNC(=O)CC1=CC=CC2=CC=CC=C12 NJZJQPFTLCHGPS-SMCANUKXSA-N 0.000 claims description 2
• VCMTYQKPHKCMBO-KYJUHHDHSA-N n-[[(3s,5s)-3-(4-aminobutyl)-1-(naphthalen-2-ylmethyl)-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C1CN(CC=2C=C3C=CC=CC3=CC=2)C(=O)[C@H](CCCCN)N[C@@H]1CNC(=O)C1=CC=C(C=CC=C2)C2=C1 VCMTYQKPHKCMBO-KYJUHHDHSA-N 0.000 claims description 2
• PCFLAUAVIGOSHR-LPHOPBHVSA-N n-[[(3s,5s)-3-(aminomethyl)-1-[(3,5-dichlorophenyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]-3,4-dichlorobenzamide Chemical compound C([C@H]1N[C@H](C(N(CC=2C=C(Cl)C=C(Cl)C=2)CC1)=O)CN)NC(=O)C1=CC=C(Cl)C(Cl)=C1 PCFLAUAVIGOSHR-LPHOPBHVSA-N 0.000 claims description 2
• JOKUOPPJNZPFEZ-GOTSBHOMSA-N n-[[(3s,5s)-3-(aminomethyl)-1-[(3,5-dichlorophenyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CN)CN1CC1=CC(Cl)=CC(Cl)=C1 JOKUOPPJNZPFEZ-GOTSBHOMSA-N 0.000 claims description 2
• PEDUKYVFLGCZSG-IXLXJOPFSA-N n-[[(3s,5s)-3-[2-(azepan-1-yl)ethyl]-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]-3,4-dichlorobenzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCCCCC2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 PEDUKYVFLGCZSG-IXLXJOPFSA-N 0.000 claims description 2
• LEXIOIJEBBDYFC-DJDPXSJISA-N n-[[(3s,5s)-3-[2-(azepan-1-yl)ethyl]-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]-6-chloronaphthalene-2-carboxamide Chemical compound C([C@@H]1N[C@H](CNC(=O)C=2C=C3C=CC(Cl)=CC3=CC=2)CCN(C1=O)C[C@@H](CC)C=1C=CC=CC=1)CN1CCCCCC1 LEXIOIJEBBDYFC-DJDPXSJISA-N 0.000 claims description 2
• DHCFNRRGYVCRJE-XWJWOQKWSA-N n-[[(3s,5s)-3-[2-(benzylamino)ethyl]-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]-3,4-dichlorobenzamide Chemical compound C([C@@H]1CCN(C([C@H](CCNCC=2C=CC=CC=2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 DHCFNRRGYVCRJE-XWJWOQKWSA-N 0.000 claims description 2
• UWQQSOAJJGLAJJ-LRHLLKFHSA-N n-[[(3s,5s)-3-[2-(diethylamino)ethyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCN(CC)CC)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 UWQQSOAJJGLAJJ-LRHLLKFHSA-N 0.000 claims description 2
• YPNMORAXLMELEL-SEIBCYHCSA-N n-[[(3s,5s)-3-[2-(tert-butylamino)ethyl]-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]-3,4-dichlorobenzamide Chemical compound C([C@@H]1CCN(C([C@H](CCNC(C)(C)C)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 YPNMORAXLMELEL-SEIBCYHCSA-N 0.000 claims description 2
• YGGNBVSOSLCEBK-STQWGSIPSA-N n-[[(3s,5s)-3-[2-[[amino-(propan-2-ylamino)methylidene]amino]ethyl]-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]-6-chloronaphthalene-2-carboxamide Chemical compound C1([C@@H](CN2C([C@H](CCNC(=N)NC(C)C)N[C@H](CNC(=O)C=3C=C4C=CC(Cl)=CC4=CC=3)CC2)=O)CC)=CC=CC=C1 YGGNBVSOSLCEBK-STQWGSIPSA-N 0.000 claims description 2
• HFTHSMXFEPZROM-LNMMVMNESA-N n-[[(3s,5s)-3-[2-[acetyl(propan-2-yl)amino]ethyl]-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]-6-chloronaphthalene-2-carboxamide Chemical compound C1([C@@H](CN2C([C@H](CCN(C(C)C)C(C)=O)N[C@H](CNC(=O)C=3C=C4C=CC(Cl)=CC4=CC=3)CC2)=O)CC)=CC=CC=C1 HFTHSMXFEPZROM-LNMMVMNESA-N 0.000 claims description 2
• ZJQSFIJDEHYCSI-VUAYVDPTSA-N n-[[(3s,5s)-3-[2-[benzyl(methyl)amino]ethyl]-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]-3,4-dichlorobenzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN(C)CC=2C=CC=CC=2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 ZJQSFIJDEHYCSI-VUAYVDPTSA-N 0.000 claims description 2
• LARCUJCRWYFCOJ-QURRFSBHSA-N n-[[(3s,5s)-3-[2-[tert-butyl(methyl)amino]ethyl]-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]-3,4-dichlorobenzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN(C)C(C)(C)C)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 LARCUJCRWYFCOJ-QURRFSBHSA-N 0.000 claims description 2
• JGMYRBOXTPCJCO-LRHLLKFHSA-N n-[[(3s,5s)-3-[3-(azetidin-1-yl)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CCCN1CCC1)C1=O)CNC(=O)C=2C=C3C=CC=CC3=CC=2)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 JGMYRBOXTPCJCO-LRHLLKFHSA-N 0.000 claims description 2
• FVFAEOHHVAXJJV-QARUCVQPSA-N n-[[(3s,5s)-3-[3-(benzylamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CCCNCC=1C=CC=CC=1)C1=O)CNC(=O)C=2C=C3C=CC=CC3=CC=2)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 FVFAEOHHVAXJJV-QARUCVQPSA-N 0.000 claims description 2
• KDAXISWMONEIMN-MHWRTBLVSA-N n-[[(3s,5s)-3-[3-(carbamoylamino)propyl]-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]-6-chloronaphthalene-2-carboxamide Chemical compound C1([C@@H](CN2C([C@H](CCCNC(N)=O)N[C@H](CNC(=O)C=3C=C4C=CC(Cl)=CC4=CC=3)CC2)=O)CC)=CC=CC=C1 KDAXISWMONEIMN-MHWRTBLVSA-N 0.000 claims description 2
• WBJLUKAHTWVGIC-GIWKVKTRSA-N n-[[(3s,5s)-3-[3-(cyclobutylamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CCCNC1CCC1)C1=O)CNC(=O)C=2C=C3C=CC=CC3=CC=2)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 WBJLUKAHTWVGIC-GIWKVKTRSA-N 0.000 claims description 2
• DOKVYAMBTPOVNF-JSXFGMRASA-N n-[[(3s,5s)-3-[3-(cyclopentylamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CCCNC1CCCC1)C1=O)CNC(=O)C=2C=C3C=CC=CC3=CC=2)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 DOKVYAMBTPOVNF-JSXFGMRASA-N 0.000 claims description 2
• VPHOQWUKPMTLBC-UCGGBYDDSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-1,4-dimethoxynaphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CCCNC(N)=N)C1=O)CNC(=O)C=2C=C(C3=CC=CC=C3C=2OC)OC)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 VPHOQWUKPMTLBC-UCGGBYDDSA-N 0.000 claims description 2
• RJGLNXBOEGFWTK-XCZPVHLTSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-1-benzofuran-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1OC2=CC=CC=C2C=1)N[C@H](C1=O)CCCNC(=N)N)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 RJGLNXBOEGFWTK-XCZPVHLTSA-N 0.000 claims description 2
• QATWEZXRMWFGTE-XCZPVHLTSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-1-benzothiophene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1SC2=CC=CC=C2C=1)N[C@H](C1=O)CCCNC(=N)N)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 QATWEZXRMWFGTE-XCZPVHLTSA-N 0.000 claims description 2
• HDAGSQJWWKSPBM-IUDBTDONSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-1-methoxynaphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CCCNC(N)=N)C1=O)CNC(=O)C2=C(C3=CC=CC=C3C=C2)OC)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 HDAGSQJWWKSPBM-IUDBTDONSA-N 0.000 claims description 2
• OJOHMJHTJUYUDU-SVEHJYQDSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-2,4-dimethoxybenzamide Chemical compound COC1=CC(OC)=CC=C1C(=O)NC[C@H]1N[C@@H](CCCNC(N)=N)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 OJOHMJHTJUYUDU-SVEHJYQDSA-N 0.000 claims description 2
• XIWRUXIAEMMLHN-LSYYVWMOSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-2-(2,4-dichlorophenoxy)acetamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)COC1=CC=C(Cl)C=C1Cl XIWRUXIAEMMLHN-LSYYVWMOSA-N 0.000 claims description 2
• PPAIBAMUTBNIST-SVEHJYQDSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-2-(3,4-dichlorophenyl)acetamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)CC1=CC=C(Cl)C(Cl)=C1 PPAIBAMUTBNIST-SVEHJYQDSA-N 0.000 claims description 2
• UFCYHRZLFHTIGL-TXJYOHDVSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-2-ethylhexanamide Chemical compound O=C1[C@H](CCCNC(N)=N)N[C@H](CNC(=O)C(CC)CCCC)CCN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 UFCYHRZLFHTIGL-TXJYOHDVSA-N 0.000 claims description 2
• ICTHKJGARPGKGX-WNJJXGMVSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-2-phenoxyacetamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)COC1=CC=CC=C1 ICTHKJGARPGKGX-WNJJXGMVSA-N 0.000 claims description 2
• JPYWMTFCLCNPPY-RSNGWFSUSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-2-phenylcyclopropane-1-carboxamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)C1CC1C1=CC=CC=C1 JPYWMTFCLCNPPY-RSNGWFSUSA-N 0.000 claims description 2
• UYYDDRYFTZEDCZ-JDXGNMNLSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3,4-dimethylbenzamide Chemical compound C1=C(C)C(C)=CC=C1C(=O)NC[C@H]1N[C@@H](CCCNC(N)=N)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 UYYDDRYFTZEDCZ-JDXGNMNLSA-N 0.000 claims description 2
• PKRYJKIJRNTLIG-NYDCQLBNSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-methoxynaphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CCCNC(N)=N)C1=O)CNC(=O)C2=CC3=CC=CC=C3C=C2OC)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 PKRYJKIJRNTLIG-NYDCQLBNSA-N 0.000 claims description 2
• BGYBDRQRKARBIH-NHZFLZHXSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-phenoxybenzamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)C(C=1)=CC=CC=1OC1=CC=CC=C1 BGYBDRQRKARBIH-NHZFLZHXSA-N 0.000 claims description 2
• HSWYIFVAUMCGPT-JDXGNMNLSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-phenylpropanamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)CCC1=CC=CC=C1 HSWYIFVAUMCGPT-JDXGNMNLSA-N 0.000 claims description 2
• MGALBVBSAKGKNO-LSYYVWMOSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3h-benzimidazole-5-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2N=CNC2=CC=1)N[C@H](C1=O)CCCNC(=N)N)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 MGALBVBSAKGKNO-LSYYVWMOSA-N 0.000 claims description 2
• JOPRNKCJFWPMKD-NHZFLZHXSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-4-phenoxybenzamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)C(C=C1)=CC=C1OC1=CC=CC=C1 JOPRNKCJFWPMKD-NHZFLZHXSA-N 0.000 claims description 2
• SEHSYULGJIALHX-TWJUONSBSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-4-phenylbenzamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)C(C=C1)=CC=C1C1=CC=CC=C1 SEHSYULGJIALHX-TWJUONSBSA-N 0.000 claims description 2
• ZOFQWNXCEGKDES-IUDBTDONSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-5-methyl-1-phenylpyrazole-4-carboxamide Chemical compound CC1=C(C(=O)NC[C@H]2N[C@@H](CCCNC(N)=N)C(=O)N(CC(C=3C=CC=CC=3)C=3C=CC=CC=3)CC2)C=NN1C1=CC=CC=C1 ZOFQWNXCEGKDES-IUDBTDONSA-N 0.000 claims description 2
• LHQIFXQXKCPIAN-JDXGNMNLSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-5-phenylfuran-2-carboxamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)C(O1)=CC=C1C1=CC=CC=C1 LHQIFXQXKCPIAN-JDXGNMNLSA-N 0.000 claims description 2
• LUHXUGOQYLKEAQ-CDZUIXILSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-6-fluoronaphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC(F)=CC2=CC=1)N[C@H](C1=O)CCCNC(=N)N)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 LUHXUGOQYLKEAQ-CDZUIXILSA-N 0.000 claims description 2
• FFXCJBHZYBVAQZ-NYDCQLBNSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-6-hydroxynaphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC(O)=CC2=CC=1)N[C@H](C1=O)CCCNC(=N)N)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 FFXCJBHZYBVAQZ-NYDCQLBNSA-N 0.000 claims description 2
• QWZOMDZWJNKNEN-DITALETJSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-6-methoxynaphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CCCNC(N)=N)C1=O)CNC(=O)C2=CC3=CC=C(C=C3C=C2)OC)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 QWZOMDZWJNKNEN-DITALETJSA-N 0.000 claims description 2
• LVLRCGQAMVAAFS-QPQPGPPRSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]adamantane-1-carboxamide Chemical compound C([C@@H](CNC(=O)C12CC3CC(CC(C3)C1)C2)N[C@H](C1=O)CCCNC(=N)N)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 LVLRCGQAMVAAFS-QPQPGPPRSA-N 0.000 claims description 2
• SZIKENIAXDBLSZ-XCZPVHLTSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]cyclohexanecarboxamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)C1CCCCC1 SZIKENIAXDBLSZ-XCZPVHLTSA-N 0.000 claims description 2
• IAFLAYKZFOVGIP-BDYUSTAISA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]cyclopentanecarboxamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)C1CCCC1 IAFLAYKZFOVGIP-BDYUSTAISA-N 0.000 claims description 2
• XBQSFLUOEFLRMW-JDXGNMNLSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]isoquinoline-3-carboxamide Chemical compound C([C@@H](CNC(=O)C=1N=CC2=CC=CC=C2C=1)N[C@H](C1=O)CCCNC(=N)N)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 XBQSFLUOEFLRMW-JDXGNMNLSA-N 0.000 claims description 2
• JHNKBSKIHRSONS-DHIFEGFHSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]quinoline-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1N=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCNC(=N)N)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 JHNKBSKIHRSONS-DHIFEGFHSA-N 0.000 claims description 2
• DGSLZNRWLKTSPO-IZEXYCQBSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]quinoline-3-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=NC=1)N[C@H](C1=O)CCCNC(=N)N)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 DGSLZNRWLKTSPO-IZEXYCQBSA-N 0.000 claims description 2
• ORGUBOVABKKYFO-ACHIHNKUSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylpropyl)-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound O=C([C@H](CCCNC(N)=N)N[C@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)CC1)N1CC(C)(C=1C=CC=CC=1)C1=CC=CC=C1 ORGUBOVABKKYFO-ACHIHNKUSA-N 0.000 claims description 2
• MVQZRJYURGRTIW-ZEQRLZLVSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2-ethylbutyl)-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound N1[C@@H](CCCNC(N)=N)C(=O)N(CC(CC)CC)CC[C@H]1CNC(=O)C1=CC=C(C=CC=C2)C2=C1 MVQZRJYURGRTIW-ZEQRLZLVSA-N 0.000 claims description 2
• CBJRTXOFLNIBPS-TXIPYEPDSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2-methoxy-2-phenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound O=C([C@H](CCCNC(N)=N)N[C@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)CC1)N1CC(OC)C1=CC=CC=C1 CBJRTXOFLNIBPS-TXIPYEPDSA-N 0.000 claims description 2
• WKXADWDUHHIJAQ-KYJUHHDHSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2-naphthalen-2-ylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C1CN(CCC=2C=C3C=CC=CC3=CC=2)C(=O)[C@H](CCCNC(=N)N)N[C@@H]1CNC(=O)C1=CC=C(C=CC=C2)C2=C1 WKXADWDUHHIJAQ-KYJUHHDHSA-N 0.000 claims description 2
• JKHAMWNJJHWPQL-IEWVHIKDSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(9h-fluoren-9-ylmethyl)-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C1CN(CC2C3=CC=CC=C3C3=CC=CC=C32)C(=O)[C@H](CCCNC(=N)N)N[C@@H]1CNC(=O)C1=CC=C(C=CC=C2)C2=C1 JKHAMWNJJHWPQL-IEWVHIKDSA-N 0.000 claims description 2
• RUAUGPCLNGSTAG-YTMVLYRLSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(naphthalen-1-ylmethyl)-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C1CN(CC=2C3=CC=CC=C3C=CC=2)C(=O)[C@H](CCCNC(=N)N)N[C@@H]1CNC(=O)C1=CC=C(C=CC=C2)C2=C1 RUAUGPCLNGSTAG-YTMVLYRLSA-N 0.000 claims description 2
• YUDDAXQRMZKAPF-VMPREFPWSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(naphthalen-2-ylmethyl)-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C1CN(CC=2C=C3C=CC=CC3=CC=2)C(=O)[C@H](CCCNC(=N)N)N[C@@H]1CNC(=O)C1=CC=C(C=CC=C2)C2=C1 YUDDAXQRMZKAPF-VMPREFPWSA-N 0.000 claims description 2
• RADDCXSUXMLAEQ-LNMMVMNESA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-[(2r)-1,1-diphenylpropan-2-yl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C=1C=CC=CC=1C([C@@H](C)N1C([C@H](CCCNC(N)=N)N[C@H](CNC(=O)C=2C=C3C=CC=CC3=CC=2)CC1)=O)C1=CC=CC=C1 RADDCXSUXMLAEQ-LNMMVMNESA-N 0.000 claims description 2
• OSNCOMUVMKIOFM-LNMMVMNESA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-[(2r)-1-fluoro-1,1-diphenylpropan-2-yl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C=1C=CC=CC=1C(F)([C@H](N1C([C@H](CCCNC(N)=N)N[C@H](CNC(=O)C=2C=C3C=CC=CC3=CC=2)CC1)=O)C)C1=CC=CC=C1 OSNCOMUVMKIOFM-LNMMVMNESA-N 0.000 claims description 2
• RADDCXSUXMLAEQ-OATBXSGESA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-[(2s)-1,1-diphenylpropan-2-yl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C=1C=CC=CC=1C([C@H](C)N1C([C@H](CCCNC(N)=N)N[C@H](CNC(=O)C=2C=C3C=CC=CC3=CC=2)CC1)=O)C1=CC=CC=C1 RADDCXSUXMLAEQ-OATBXSGESA-N 0.000 claims description 2
• VCQJMRSDQYAODK-HDYFOKATSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-[(3,5-dimethylcyclohexyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C1C(C)CC(C)CC1CN1C(=O)[C@H](CCCNC(N)=N)N[C@H](CNC(=O)C=2C=C3C=CC=CC3=CC=2)CC1 VCQJMRSDQYAODK-HDYFOKATSA-N 0.000 claims description 2
• QUXFTJDVAXLSOB-SVBPBHIXSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-[(3,5-dimethylphenyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound CC1=CC(C)=CC(CN2C([C@H](CCCNC(N)=N)N[C@H](CNC(=O)C=3C=C4C=CC=CC4=CC=3)CC2)=O)=C1 QUXFTJDVAXLSOB-SVBPBHIXSA-N 0.000 claims description 2
• XEECERRNBOAODP-OZXSUGGESA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-[2-(3,4-dichlorophenyl)ethyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCNC(=N)N)CN1CCC1=CC=C(Cl)C(Cl)=C1 XEECERRNBOAODP-OZXSUGGESA-N 0.000 claims description 2
• GQLFUOIDZYRUBH-HSJPWVCISA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-[3-(dimethylamino)-3-oxo-2-phenylpropyl]-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound O=C([C@H](CCCNC(N)=N)N[C@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)CC1)N1CC(C(=O)N(C)C)C1=CC=CC=C1 GQLFUOIDZYRUBH-HSJPWVCISA-N 0.000 claims description 2
• OGFAWJRTQSHKDV-XCZPVHLTSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-naphthalen-2-yl-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C1CN(C=2C=C3C=CC=CC3=CC=2)C(=O)[C@H](CCCNC(=N)N)N[C@@H]1CNC(=O)C1=CC=C(C=CC=C2)C2=C1 OGFAWJRTQSHKDV-XCZPVHLTSA-N 0.000 claims description 2
• FQJPIRCJJADUTL-AQBAIUPUSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-2-oxo-1-(2-phenoxy-2-phenylethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCNC(=N)N)CN1CC(C=1C=CC=CC=1)OC1=CC=CC=C1 FQJPIRCJJADUTL-AQBAIUPUSA-N 0.000 claims description 2
• QSTKPYSOOVYKHW-KOPQTXDBSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-2-oxo-1-(2-phenyl-2-phenylmethoxyethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCNC(=N)N)CN1CC(C=1C=CC=CC=1)OCC1=CC=CC=C1 QSTKPYSOOVYKHW-KOPQTXDBSA-N 0.000 claims description 2
• ZZGHTUOZQOCZOF-GAVYTZHXSA-N n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-2-oxo-1-(3-oxo-2-phenyl-3-piperidin-1-ylpropyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCNC(=N)N)CN1CC(C=1C=CC=CC=1)C(=O)N1CCCCC1 ZZGHTUOZQOCZOF-GAVYTZHXSA-N 0.000 claims description 2
• WUHIICRVHPJKFZ-TWJUONSBSA-N n-[[(3s,5s)-3-[3-[[amino(dimethylamino)methylidene]amino]propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCCNC(=N)N(C)C)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 WUHIICRVHPJKFZ-TWJUONSBSA-N 0.000 claims description 2
• XHLLZJNFKOIUFF-PUAPYOPTSA-N n-[[(3s,5s)-3-[3-[di(cyclobutyl)amino]propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@H](N[C@@H](CCCN(C1CCC1)C1CCC1)C1=O)CNC(=O)C=2C=C3C=CC=CC3=CC=2)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 XHLLZJNFKOIUFF-PUAPYOPTSA-N 0.000 claims description 2
• PNITVXIZXUWQET-UHFFFAOYSA-N n-[[1-(2,2-diphenylethyl)-2-oxo-3-(piperidin-4-ylmethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C=1C=C2C=CC=CC2=CC=1C(=O)NCC(NC(CC1CCNCC1)C1=O)CCN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 PNITVXIZXUWQET-UHFFFAOYSA-N 0.000 claims description 2
• YTNMWQMBKAZCMS-UHFFFAOYSA-N n-[[1-(2,2-diphenylethyl)-2-oxo-3-piperidin-4-yl-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C=1C=C2C=CC=CC2=CC=1C(=O)NCC(NC(C1=O)C2CCNCC2)CCN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 YTNMWQMBKAZCMS-UHFFFAOYSA-N 0.000 claims description 2
• 125000004193 piperazinyl group Chemical group 0.000 claims description 2
• 125000004353 pyrazol-1-yl group Chemical group [H]C1=NN(*)C([H])=C1[H] 0.000 claims description 2
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 2
• 125000004159 quinolin-2-yl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C([H])C(*)=NC2=C1[H] 0.000 claims description 2
• 125000004548 quinolin-3-yl group Chemical group N1=CC(=CC2=CC=CC=C12)* 0.000 claims description 2
• 125000000446 sulfanediyl group Chemical group *S* 0.000 claims description 2
• 125000004495 thiazol-4-yl group Chemical group S1C=NC(=C1)* 0.000 claims description 2
• 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
• 125000004566 azetidin-1-yl group Chemical group N1(CCC1)* 0.000 claims 2
• 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 2
• 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 2
• 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
• AOIVVCOHGHEUTB-AZIXZEHSSA-N (3s,5s)-5-[[(3,4-dichlorophenyl)methylamino]methyl]-1-[(2s)-2-phenylbutyl]-3-(2-piperidin-1-ylethyl)-1,4-diazepan-2-one Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCCCC2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NCC1=CC=C(Cl)C(Cl)=C1 AOIVVCOHGHEUTB-AZIXZEHSSA-N 0.000 claims 1
• CZXCIQORTIBWEM-LJIABBGYSA-N (e)-3-(4-bromophenyl)-n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]prop-2-enamide Chemical compound C1=CC(Br)=CC=C1\C=C\C(=O)NC[C@H]1N[C@@H](CCN2CCCCC2)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 CZXCIQORTIBWEM-LJIABBGYSA-N 0.000 claims 1
• GAQRLIMNOZLZDZ-OCDQQJRCSA-N (e)-3-(4-chlorophenyl)-n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(3-piperidin-1-ylpropyl)-1,4-diazepan-5-yl]methyl]prop-2-enamide Chemical compound C1=CC(Cl)=CC=C1\C=C\C(=O)NC[C@H]1N[C@@H](CCCN2CCCCC2)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GAQRLIMNOZLZDZ-OCDQQJRCSA-N 0.000 claims 1
• JKNVWNAMFUEANF-OMIZDKLOSA-N (e)-3-(4-chlorophenyl)-n-[[(3s,5s)-1-(2-ethylbutyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]prop-2-enamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCCCC2)N1)=O)CC(CC)CC)NC(=O)\C=C\C1=CC=C(Cl)C=C1 JKNVWNAMFUEANF-OMIZDKLOSA-N 0.000 claims 1
• HYVIXZUCJRMWQX-SORORRETSA-N (e)-3-(4-chlorophenyl)-n-[[(3s,5s)-1-[(3,5-dichlorophenyl)methyl]-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]prop-2-enamide Chemical compound C1=CC(Cl)=CC=C1\C=C\C(=O)NC[C@H]1N[C@@H](CCN2CCCCC2)C(=O)N(CC=2C=C(Cl)C=C(Cl)C=2)CC1 HYVIXZUCJRMWQX-SORORRETSA-N 0.000 claims 1
• UTRNFXWRAARSOK-DDCPTMJBSA-N (e)-3-(4-chlorophenyl)-n-[[(3s,5s)-3-[2-(diethylamino)ethyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCN(CC)CC)NC(=O)\C=C\C1=CC=C(Cl)C=C1 UTRNFXWRAARSOK-DDCPTMJBSA-N 0.000 claims 1
• OCUXIUVTDRGAJB-FURQHFQBSA-N (e)-n-[[(3s,5s)-1-[(3,5-dichlorophenyl)methyl]-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide Chemical compound C1=CC(OC(F)(F)F)=CC=C1\C=C\C(=O)NC[C@H]1N[C@@H](CCN2CCCCC2)C(=O)N(CC=2C=C(Cl)C=C(Cl)C=2)CC1 OCUXIUVTDRGAJB-FURQHFQBSA-N 0.000 claims 1
• HKHYCIVOBIBWKQ-KEENAYDUSA-N (e)-n-[[(3s,5s)-3-(2-aminoethyl)-1-[(3,5-dichlorophenyl)methyl]-2-oxo-1,4-diazepan-5-yl]methyl]-3-(4-chlorophenyl)prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC=2C=C(Cl)C=C(Cl)C=2)CC1)=O)CCN)NC(=O)\C=C\C1=CC=C(Cl)C=C1 HKHYCIVOBIBWKQ-KEENAYDUSA-N 0.000 claims 1
• ZZPYJOPHCYOACQ-GNGQUEJKSA-N (e)-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(2,6-difluorophenyl)prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)\C=C\C1=C(F)C=CC=C1F ZZPYJOPHCYOACQ-GNGQUEJKSA-N 0.000 claims 1
• AMORVAMTZWXWQL-ILCJSEBQSA-N (e)-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-(4-hydroxyphenyl)prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)\C=C\C1=CC=C(O)C=C1 AMORVAMTZWXWQL-ILCJSEBQSA-N 0.000 claims 1
• XBBQPGZJOHOLGT-MBSOTRTCSA-N (e)-n-[[(3s,5s)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-[2-(trifluoromethyl)phenyl]prop-2-enamide Chemical compound C([C@H]1N[C@H](C(N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1)=O)CCCNC(=N)N)NC(=O)\C=C\C1=CC=CC=C1C(F)(F)F XBBQPGZJOHOLGT-MBSOTRTCSA-N 0.000 claims 1
• WHOZDLQKWBNXOC-UHFFFAOYSA-N 1,4-dioxine-2-carboxamide Chemical compound NC(=O)C1=COC=CO1 WHOZDLQKWBNXOC-UHFFFAOYSA-N 0.000 claims 1
• KGVCCWDMPOPTEX-IGBKUBFESA-N 1-[(4-chlorophenyl)methyl]-3-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]urea Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCCCC2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)NCC1=CC=C(Cl)C=C1 KGVCCWDMPOPTEX-IGBKUBFESA-N 0.000 claims 1
• LBTPHRXHXMLVPM-ZNFSXRAMSA-N 1-[2-[(2s,7s)-7-[[(3,4-dichlorobenzoyl)amino]methyl]-3-oxo-4-[(2s)-2-phenylbutyl]-1,4-diazepan-2-yl]ethyl]piperidine-4-carboxylic acid Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCC(CC2)C(O)=O)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 LBTPHRXHXMLVPM-ZNFSXRAMSA-N 0.000 claims 1
• SWLXXUVUBCIWHL-UHFFFAOYSA-N 1-benzothiophene-5-carboxamide Chemical compound NC(=O)C1=CC=C2SC=CC2=C1 SWLXXUVUBCIWHL-UHFFFAOYSA-N 0.000 claims 1
• BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims 1
• MVUCRYIIHIPBSJ-OVTKCHPXSA-N 2-(2,4-dichlorophenyl)-n-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]acetamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCCCC2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)CC1=CC=C(Cl)C=C1Cl MVUCRYIIHIPBSJ-OVTKCHPXSA-N 0.000 claims 1
• ZEQPGUYIMWCIOD-ZJSQPSORSA-N 3,4-dichloro-n-[[(3s,5s)-1-(2-cyclopropylbutyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCCCC2)N1)=O)CC(CC)C1CC1)NC(=O)C1=CC=C(Cl)C(Cl)=C1 ZEQPGUYIMWCIOD-ZJSQPSORSA-N 0.000 claims 1
• BXWSMRFYPHIAKJ-SWHSWYIVSA-N 3,4-dichloro-n-[[(3s,5s)-1-(2-ethyl-3-methylbut-3-enyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCCCC2)N1)=O)CC(CC)C(C)=C)NC(=O)C1=CC=C(Cl)C(Cl)=C1 BXWSMRFYPHIAKJ-SWHSWYIVSA-N 0.000 claims 1
• PBOXUPFPJGHUAV-XTJBDQBJSA-N 3,4-dichloro-n-[[(3s,5s)-1-[(2r)-2-ethyl-3-methylbutyl]-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCCCC2)N1)=O)C[C@H](CC)C(C)C)NC(=O)C1=CC=C(Cl)C(Cl)=C1 PBOXUPFPJGHUAV-XTJBDQBJSA-N 0.000 claims 1
• JHFWVCSWKAZHNG-WLIUQRSMSA-N 3,4-dichloro-n-[[(3s,5s)-1-[(3,5-dimethylcyclohexyl)methyl]-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C1C(C)CC(C)CC1CN1C(=O)[C@H](CCN2CCCCC2)N[C@H](CNC(=O)C=2C=C(Cl)C(Cl)=CC=2)CC1 JHFWVCSWKAZHNG-WLIUQRSMSA-N 0.000 claims 1
• ANCNDIIDLUJRTQ-ZAGALENVSA-N 3,4-dichloro-n-[[(3s,5s)-1-[(3,5-dimethylcyclohexyl)methyl]-2-oxo-3-[2-(propan-2-ylamino)ethyl]-1,4-diazepan-5-yl]methyl]benzamide Chemical compound C([C@H]1N[C@H](C(N(CC2CC(C)CC(C)C2)CC1)=O)CCNC(C)C)NC(=O)C1=CC=C(Cl)C(Cl)=C1 ANCNDIIDLUJRTQ-ZAGALENVSA-N 0.000 claims 1
• PFYBQPHXKAUXBU-TWJUONSBSA-N 3-(4-chlorophenyl)-n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]propanamide Chemical compound C1=CC(Cl)=CC=C1CCC(=O)NC[C@H]1N[C@@H](CCN2CCCCC2)C(=O)N(CC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 PFYBQPHXKAUXBU-TWJUONSBSA-N 0.000 claims 1
• VUWULNQKIIDOAC-WEZIJMHWSA-N 5-(4-chlorophenyl)-n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]-1,2-oxazole-3-carboxamide Chemical compound C1=CC(Cl)=CC=C1C1=CC(C(=O)NC[C@H]2N[C@@H](CCN3CCCCC3)C(=O)N(CC(C=3C=CC=CC=3)C=3C=CC=CC=3)CC2)=NO1 VUWULNQKIIDOAC-WEZIJMHWSA-N 0.000 claims 1
• WEXORUUHZATMPJ-UIOOFZCWSA-N 5-(4-chlorophenyl)-n-[[(3s,5s)-1-[(3,5-dichlorophenyl)methyl]-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]-1,2-oxazole-3-carboxamide Chemical compound C1=CC(Cl)=CC=C1C1=CC(C(=O)NC[C@H]2N[C@@H](CCN3CCCCC3)C(=O)N(CC=3C=C(Cl)C=C(Cl)C=3)CC2)=NO1 WEXORUUHZATMPJ-UIOOFZCWSA-N 0.000 claims 1
• IDERYEQWEHJVCJ-MHZHKKNFSA-N 5-(4-chlorophenyl)-n-[[(3s,5s)-2-oxo-1-[(2s)-2-phenylbutyl]-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]-1,2-oxazole-3-carboxamide Chemical compound C([C@@H]1CCN(C([C@H](CCN2CCCCC2)N1)=O)C[C@@H](CC)C=1C=CC=CC=1)NC(=O)C(=NO1)C=C1C1=CC=C(Cl)C=C1 IDERYEQWEHJVCJ-MHZHKKNFSA-N 0.000 claims 1
• VECSQBGFYNJZBA-MGONOCMRSA-N 6-chloro-n-[[(3s,5s)-1-[(2s)-2-ethyl-3-methylbutyl]-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H]1N[C@H](CNC(=O)C=2C=C3C=CC(Cl)=CC3=CC=2)CCN(C1=O)C[C@@H](CC)C(C)C)CN1CCCCC1 VECSQBGFYNJZBA-MGONOCMRSA-N 0.000 claims 1
• XKIDWGAOZSALDO-STQWGSIPSA-N 6-chloro-n-[[(3s,5s)-2-oxo-3-(2-piperidin-1-ylethyl)-1-[(2s)-2-thiophen-3-ylbutyl]-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H]1N[C@H](CNC(=O)C=2C=C3C=CC(Cl)=CC3=CC=2)CCN(C1=O)C[C@@H](CC)C1=CSC=C1)CN1CCCCC1 XKIDWGAOZSALDO-STQWGSIPSA-N 0.000 claims 1
• GZBRXEXEFIIBOK-PHXCCWLDSA-N 6-chloro-n-[[(3s,5s)-3-[2-(diaminomethylideneamino)ethyl]-2-oxo-1-[(2s)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C1([C@@H](CN2C([C@H](CCNC(N)=N)N[C@H](CNC(=O)C=3C=C4C=CC(Cl)=CC4=CC=3)CC2)=O)CC)=CC=CC=C1 GZBRXEXEFIIBOK-PHXCCWLDSA-N 0.000 claims 1
• NHHFALOIHDVYCS-WEZIJMHWSA-N benzyl n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-(2-piperidin-1-ylethyl)-1,4-diazepan-5-yl]methyl]carbamate Chemical compound C([C@H](N[C@@H](CCN1CCCCC1)C1=O)CNC(=O)OCC=2C=CC=CC=2)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 NHHFALOIHDVYCS-WEZIJMHWSA-N 0.000 claims 1
• RHJVIGLEIFVHIJ-UHFFFAOYSA-N cyclohexanecarboxamide Chemical compound NC(=O)C1[CH]CCCC1 RHJVIGLEIFVHIJ-UHFFFAOYSA-N 0.000 claims 1
• CSVKOBXXZWQJFH-TWJUONSBSA-N n-[[(3s,5s)-1-(2,2-diphenylethyl)-2-oxo-3-[2-(propan-2-ylamino)ethyl]-1,4-diazepan-5-yl]methyl]naphthalene-2-carboxamide Chemical compound C([C@@H](CNC(=O)C=1C=C2C=CC=CC2=CC=1)N[C@H](C1=O)CCNC(C)C)CN1CC(C=1C=CC=CC=1)C1=CC=CC=C1 CSVKOBXXZWQJFH-TWJUONSBSA-N 0.000 claims 1
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