BRPI0821894A2 - Pharmaceutically acceptable phosphorylation state modulator of at least one enzyme and / or enzyme complex, or subunits thereof, in mitochondria of diseased cells of warm-blooded animals, including humans, method of modulating at least one enzyme or enzyme complex , or a subunit thereof, in a patient having a disease, condition, or syndrome including a change in the phosphorylation state of at least one enzyme and / or an enzyme complex, or a subunit thereof, and method to diagnose and predict benefit in a patient who has symptoms of a disease, condition, or syndrome that includes a change in the phosphorylation state of at least one enzyme and / or enzyme complex, or a subunit thereof - Google Patents
Pharmaceutically acceptable phosphorylation state modulator of at least one enzyme and / or enzyme complex, or subunits thereof, in mitochondria of diseased cells of warm-blooded animals, including humans, method of modulating at least one enzyme or enzyme complex , or a subunit thereof, in a patient having a disease, condition, or syndrome including a change in the phosphorylation state of at least one enzyme and / or an enzyme complex, or a subunit thereof, and method to diagnose and predict benefit in a patient who has symptoms of a disease, condition, or syndrome that includes a change in the phosphorylation state of at least one enzyme and / or enzyme complex, or a subunit thereofInfo
- Publication number
- BRPI0821894A2 BRPI0821894A2 BRPI0821894-3A BRPI0821894A BRPI0821894A2 BR PI0821894 A2 BRPI0821894 A2 BR PI0821894A2 BR PI0821894 A BRPI0821894 A BR PI0821894A BR PI0821894 A2 BRPI0821894 A2 BR PI0821894A2
- Authority
- BR
- Brazil
- Prior art keywords
- enzyme
- subunit
- phosphorylation state
- enzyme complex
- complex
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2008/004410 WO2009123597A1 (en) | 2008-04-04 | 2008-04-04 | Pharmaceutical composition |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0821894A2 true BRPI0821894A2 (en) | 2015-07-21 |
Family
ID=41135840
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0821894-3A BRPI0821894A2 (en) | 2008-04-04 | 2008-04-04 | Pharmaceutically acceptable phosphorylation state modulator of at least one enzyme and / or enzyme complex, or subunits thereof, in mitochondria of diseased cells of warm-blooded animals, including humans, method of modulating at least one enzyme or enzyme complex , or a subunit thereof, in a patient having a disease, condition, or syndrome including a change in the phosphorylation state of at least one enzyme and / or an enzyme complex, or a subunit thereof, and method to diagnose and predict benefit in a patient who has symptoms of a disease, condition, or syndrome that includes a change in the phosphorylation state of at least one enzyme and / or enzyme complex, or a subunit thereof |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP2268278A4 (en) |
JP (1) | JP2011516473A (en) |
KR (1) | KR20110025168A (en) |
CN (1) | CN102056605A (en) |
AU (1) | AU2008354009A1 (en) |
BR (1) | BRPI0821894A2 (en) |
CA (1) | CA2720396A1 (en) |
IL (1) | IL208387A0 (en) |
MX (1) | MX2010010867A (en) |
WO (1) | WO2009123597A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX343847B (en) | 2010-07-08 | 2016-11-24 | Wrigley W M Jun Co | Chewing gum containing a cross-linked gelatin matrix gum base. |
US9421234B2 (en) * | 2011-05-20 | 2016-08-23 | Nutramax Laboratories, Inc. | Orally administrable compositions comprising avocado/soybean unsaponifiables and lipoic acid and methods of administration |
JP6253596B2 (en) * | 2012-02-16 | 2017-12-27 | ザ ペン ステイト リサーチ ファンデーション | Acyl coenzyme A: a method for identifying an inhibitor of expression, function or activity of lysocardiolipin acyltransferase 1 (ALCAT1) |
US20150322103A1 (en) * | 2012-12-19 | 2015-11-12 | Cornerstone Pharmaceuticals, Inc. | Pharmaceutical compounds |
AU2014398232B2 (en) | 2014-06-19 | 2019-11-28 | Rafael Pharmaceuticals, Inc. | Pharmaceutical compounds |
WO2015195071A1 (en) | 2014-06-19 | 2015-12-23 | Robert Shorr | Pharmaceutical compounds |
CN110590624B (en) * | 2019-09-26 | 2021-02-26 | 苏州富士莱医药股份有限公司 | Preparation method of lipoic acid derivative 8- (ethyl disulfide) -6- (phenyl disulfide) caprylic acid |
WO2023012305A1 (en) * | 2021-08-04 | 2023-02-09 | Cytacoat Ab | Disulfide compounds as medicaments |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2853497A (en) * | 1953-12-04 | 1958-09-23 | Merck & Co Inc | 6, 8-bis (hydrocarbon substituted mercapto) 5-hydroxycaprylic acids and delta-lactones thereof |
US2789991A (en) * | 1954-05-20 | 1957-04-23 | American Cyanamid Co | Substituted disulfones |
JPS61198148A (en) * | 1985-01-29 | 1986-09-02 | Fuji Photo Film Co Ltd | Silver halide photographic sensitive material |
GB9618934D0 (en) * | 1996-09-11 | 1996-10-23 | Univ London | Inositol phosphoglycans for therapeutic use in the treatment of diabetes and obesity |
KR101085210B1 (en) * | 1998-03-20 | 2011-11-21 | 커먼웰쓰 사이언티픽 앤드 인더스트리얼 리서치 오가니제이션 | Control of gene expression |
FR2777001B1 (en) * | 1998-04-01 | 2000-06-09 | Cird Galderma | 6,8-DIMERCAPTOOCTANOIC ACID DERIVATIVES SUBSTITUTED IN 6-S AND / OR 8-S BY RADICAL (3-METHYLTHIOPROPANOYL) AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CANCER TUMORS |
WO2000024734A1 (en) * | 1998-10-26 | 2000-05-04 | The Research Foundation Of State University Of New York | Lipoic acid derivatives and their use in treatment of disease |
DE19904794A1 (en) * | 1999-02-05 | 2000-08-10 | Biotechnolog Forschung Gmbh | Methods for improving the primary metabolism of mammalian cell lines |
US6284786B1 (en) * | 1999-02-16 | 2001-09-04 | The Center For The Improvement Of Human Functioning, Int'l., Inc. | Treatment of cancer using lipoic acid in combination with ascorbic acid |
AR042572A1 (en) * | 1999-04-02 | 2005-06-29 | Sod Conseils Rech Applic | DERIVATIVES OF LIPOIC ACID, PROCEDURE FOR THE PREPARATION, MEDICINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE OF SUCH DERIVATIVES FOR THE PREPARATION OF THE REFERRED MEDICATIONS |
IT1312060B1 (en) * | 1999-04-09 | 2002-04-04 | Antibioticos Spa | USE OF ALPHA LIPOIC ACID IN ANTIMETASTATIC TREATMENT. |
AU2001260309A1 (en) * | 2000-05-19 | 2001-12-03 | F.Hoffmann-La Roche Ag | A process for determining the tumoricidal potential of a sample by the use of a nucleic acid which is downregulated in human tumor cells |
WO2006119355A2 (en) * | 2005-05-03 | 2006-11-09 | Albert Einstein College Of Medicine Of Yeshiva University | Mammalian hypothalamic nutrient modulation of glucose metabolism |
WO2007072219A2 (en) * | 2005-09-21 | 2007-06-28 | Aurelium Biopharma Inc. | Alpha enolase-directed diagnostics and therapeutics for cancer and chemotherapeutic drug resistance |
US20070212360A1 (en) * | 2006-01-17 | 2007-09-13 | Denko Nicholas C | Modulation of mitochondrial oxygen consumption for therapeutic purposes |
NZ580973A (en) * | 2007-04-18 | 2011-10-28 | Cornerstone Pharmaceuticals Inc | Pharmaceutical formulations containing lipoic acid derivatives |
EP2139321B1 (en) * | 2007-04-18 | 2013-11-06 | Cornerstone Pharmaceuticals, Inc. | Lipoic acid derivatives |
AU2008352076A1 (en) * | 2008-03-04 | 2009-09-11 | Robert Rodriguez | Modulation of enzymatic structure, activity, and/or expression level |
-
2008
- 2008-04-04 EP EP08742562A patent/EP2268278A4/en not_active Withdrawn
- 2008-04-04 CN CN2008801296335A patent/CN102056605A/en active Pending
- 2008-04-04 CA CA2720396A patent/CA2720396A1/en not_active Abandoned
- 2008-04-04 AU AU2008354009A patent/AU2008354009A1/en not_active Abandoned
- 2008-04-04 JP JP2011502908A patent/JP2011516473A/en active Pending
- 2008-04-04 MX MX2010010867A patent/MX2010010867A/en not_active Application Discontinuation
- 2008-04-04 WO PCT/US2008/004410 patent/WO2009123597A1/en active Application Filing
- 2008-04-04 KR KR1020107024775A patent/KR20110025168A/en not_active Application Discontinuation
- 2008-04-04 BR BRPI0821894-3A patent/BRPI0821894A2/en not_active IP Right Cessation
-
2010
- 2010-10-03 IL IL208387A patent/IL208387A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2009123597A1 (en) | 2009-10-08 |
MX2010010867A (en) | 2011-05-25 |
IL208387A0 (en) | 2010-12-30 |
KR20110025168A (en) | 2011-03-09 |
EP2268278A4 (en) | 2011-11-09 |
AU2008354009A1 (en) | 2009-10-08 |
CN102056605A (en) | 2011-05-11 |
EP2268278A1 (en) | 2011-01-05 |
JP2011516473A (en) | 2011-05-26 |
CA2720396A1 (en) | 2009-10-08 |
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Legal Events
Date | Code | Title | Description |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |