BRPI0815768B1 - use of UV absorbers, and, cosmetic composition. - Google Patents

Description

“USE OF UV ABSORBERS, AND COSMETIC COMPOSITION” It is well known that ultraviolet (light) radiation is harmful to human skin. Depending on wavelength UV radiation causes different types of skin damage. UV-B radiation (about 290 nm to about 320 nm) is responsible for sunburn and can cause skin cancer. UV-A radiation (about 320 nm to about 400 nm) although it produces skin tanning, it also contributes to sunburn and the induction of skin cancers. In addition, the harmful effects of UV-B radiation can be aggravated by UV-A radiation.

Therefore, an effective sunscreen formulation preferably comprises at least one filter of both UV-A and UV-B covering the total range from about 290 nm to about 400 nm to prevent human skin from the harmful effects of sunlight.

The effects of UV-A are mainly mediated by free radicals, e.g. reactive oxygen species inducing different types of degradation of cellular proteins, lipids and DNA. Visible indications are often the result of long-term cumulative effects. This is why skin photoaging is associated with UV-A light. It is also known that normal external UV-A radiation can be sufficiently effective to cause degradation of collagen and elastin proteins leading to loss of skin firmness and resilience. Therefore the protection against UVA from daily skin care is of significant relevance.

Numerous UV-B filters are registered and their use in sunscreen preparations, which are mainly derived from 3-benzylidene camphor, ethylhexyl salicylates and cinnamic acid esters such as ethyl p-methoxy cinnamate. hexyl.

A new class of organic UV filters are micronized triazine derivatives which are commonly used in combination with cinnamic acid derivatives and / or dibenzoyl methane derivatives.

Unfortunately, this combination of UV filters used in sunscreen compositions suffer from relatively rapid photodegradation with the consequence that protection against sun damage is lost.

A challenge of this invention is therefore to improve the stability of these specific UV filter combinations.

Surprisingly, it has been found that the use of specific triazine diphenyl acrylates and derivatives will enhance the stability of cosmetic and dermatological formulations comprising the combination of specific micronized triazine derivatives and UV absorbers selected from cinnamic acid derivatives and dibenzoyl methane derivatives .

Therefore, the present invention relates to the use of UV absorbers selected from (α-diphenyl acrylates; (α 2) hydroxy-phenyl triazines of formula wherein R 1, R 2 and R 3 independently of each other are Cr Cigalkyl; (a3) benzotriazole derivatives of formula wherein R 4 is a random statistical mixture of at least three isomeric branched secondary alkyl groups having 8 to 30 carbon atoms and having the formula E 1 is a straight chain C 1 -C 4 alkyl; C4 -C15 straight chain alkyl wherein the total number of carbon atoms in E1 plus E2 is 7 to 29 and R5 is C1 -C5 alkyl and (a4) dialkyl naphthalate to stabilize cosmetic compositions comprising (b) derivatives Symmetric triazine compounds of formula (3), wherein A is a radical of formula R 1 and R 2 independently of one another are hydrogen, C 1 -C 12 alkyl, or C 6 -C 12 aryl; R 7, R 8 and R 9 independently of each other are hydrogen; of formula (3c) in which, in of formula (3a), at least one of the radicals R 7, R 8 and R 9 are a radical of formula (3 c);

Rn, R12, R13 and R14 independently of one another are hydrogen; hydroxyl; halogen; C1 -C8 alkyl; C 1 -C 18 alkoxy; C 1 -C 4 aryl; biphenylyl; C6 -C4 aryloxy; C1 -C8 alkylthio; carboxyl; -COOM; C1 -C8 alkylcarboxyl; amino carbonyl; mono- or di-C1 -C18 alkylamino; C1 -C10 acyl amino; or -COOH; M is an alkali metal ion; X is 1 or 2; and Y is a number from 2 to 10; and a UV absorber selected from (ci) cinnamic acid derivatives; and (C2) dibenzoyl methane derivatives.

C 1 -C 8 -alkyl as defined by the radicals of the compound of formula (1) are straight or branched chain alkyl radicals such as methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, tert-butyl, amyl, isoamyl or tert-amyl, hexyl, 2-ethylhexyl, heptyl, octyl, isooctyl, nonyl, decyl, undecyl, dodecyl, tetradecyl, pentadecyl, hexadecyl, hepta-decyl or octadecyl.

C 1 -C 18 alkyl according to the definition of the radicals of the compound of formula (1) may be substituted by methoxyethyl, ethoxypropyl, 2-ethylhexyl, hydroxyethyl, chloropropyl, N, N-diethylamino -propyl, cyano-ethyl, phenethyl, benzyl, p-tert-butyl-phenethyl, p-tert-octyl-phenoxy-ethyl, 3- (2,4-di-tert-amyl-phenoxy) -propyl, ethoxy-carbonyl -methyl-2- (2-hydroxy-ethoxy) -ethyl, or 2-furyl-ethyl.

C 1 -C 18 alkyl as defined by the radicals of the compound of formula (1) are for example methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, sec-butoxy, tert-butoxy, amyloxy, isoamyloxy or tert-amyloxy, hexyloxy, heptyloxy, octyloxy, isooctyloxy, nonyloxy, decyloxy, undecyloxy, dodecyloxy, tetradecyloxy, pentadecyloxy, hexadecyl oxyl, heptadecyl oxyl or octadecyl oxyl. C6 -C10 aryl as defined by the radicals of the compound of formula (1) is for example naphthyl and preferably phenyl.

Preferably the present invention relates to the use of UY absorbers selected from (ai) diphenyl acrylates; (a2) hydroxy phenyl triazines of the formula wherein R 1, R 2 and R 3 independently of each other are C 1 -C 5 alkyl; (a3) benzotriazole derivatives of the formula wherein R 4 is a random statistical mixture of at least three isomeric branched secondary alkyl groups having 8 to 30 carbon atoms and having the formula E 1 is a straight chain C 1-4 alkyl; E2 is a straight chain C4 -C15 alkyl; wherein the total number of carbon atoms in Ej plus E2 is from 7 to 29; and Rs is CpCsalkyl; and (a4) dialkyl naphthalate; for stabilizing cosmetic compositions comprising (b) symmetrical triazine derivatives of formula (3), wherein A is a radical of formula R6 and R10 independently of one another are hydrogen; C1 -C18 alkyl; or C6 -C12 aryl; R 7, R 8 and R 9 independently of each other are hydrogen; or a radical of formula wherein in formula (3a) at least one of the radicals R7, Rg and R9 are a radical of formula (3c);

R 11, R 12, R 13, R 14 and R 15 independently of each other are hydrogen; hydroxyl; halogen; Cj-Cigalkyl; C1 -C18 alkoxy; C6 -C12 aryl; biphenylyl; C6 -C12 aryloxy; C1 -C8 alkylthio; carboxyl; -COOM; C1 -C8 alkyl carboxyl; amino carbonyl; mono- or di-C1 -C8 alkylamino; C1 -C10 acyl amino; or -COOH; M is an alkali metal ion; X is 1 or 2; and Y is a number from 2 to 10; and (cj) cinnamic acid derivatives.

Preferably the present invention relates to the use of (ai) diphenyl acrylates; (a2) hydroxy-phenyl triazines of formula (1); (a3) benzotriazole derivatives of formula (2); (a4) dialkyl naphthalate; for stabilizing cosmetic compositions comprising (b) symmetrical triazine derivatives of formula (3) and a UV absorber selected from (c2) dibenzoyl methane derivatives.

Diphenyl acrylates (a) are preferably selected from 2-ethylhexyl 2-cyano-3,3-diphenyl acrylate, and 3- (benzofuranyl) 2-cyanoacrylate, and more preferably from 2- 2-ethylhexyl cyano-3,3-diphenyl acrylate.

Symmetric triazine derivatives (b) preferably correspond to the formula in which Rs, Rjo, Rn, R12 and R13 are defined as in formula (1).

More preferably, in formula (1) R1 and R10 are hydrogen and / or Ru and R13 are hydrogen.

In formula (3), preferably R 12 is hydrogen; hydroxyl; C1 -C5 alkyl; C1 -C5 alkoxy; -COOM; -COOH; or COOR15; M is an alkali metal ion; and - Ris is C1 -C5 alkyl.

Much more preferred symmetrical triazine derivatives (b) correspond to the compounds of formula R, R 7, R 8, Rh and R 15 are as defined in formula (1).

In formula (5) R d, R 7, R 8, R 14 and R 15 are preferably; or independently of one another C1 -Cigalkyl.

Much more preferred symmetrical triazine derivatives (b) correspond to the compounds of formula. Other examples of triazine derivatives which are preferably used in the present invention are the compounds of formula. The triazine derivatives (component (b)) according to formula ( 3) are preferably used in the micronized state.

Triazine derivatives of formula (3) which have no alkyl substituents or only lower alkyl substituents are characterized by unsatisfactory oil solubility and a high melting point. They are therefore particularly suitable as micronised UV absorbers.

They may be prepared by any known process suitable for the preparation of microparticles, for example wet milling, wet mixing, spray drying of a suitable solvent, by expansion according to the Rapid Expansion of Supercritical Solutions (RESS) process. Supercriticals)) of supercritical fluids (eg CO2, by reprecipitation in suitable solvents, including supercritical fluids (GASR = Gas Anti-Solvent Recrystallisation process / PCA = Precipitation with Çompressed Anti-solvents process) Anti-solvent Tablets]).

As a grinding apparatus for the preparation of sparingly soluble micronized organic compounds, for example, a jet mill, ball mill, vibratory mill or hammer mill, preferably a high speed mixing mill, may be used. Even more preferable mills are modern ball mills; Manufacturers of these types of mill are, for example, Netzsch (LMZ mill), Drais (DCP-Viscoflow or Cosmo), Bühler AG (centrifugal mills) or Bachhofer. Examples of mixing apparatus for the preparation of micronized organic UV absorbers are sigma-blade batch mixers but also serial batch mixers (IKA-Werke) or continuous mixers (Wemer and Pfleiderer Continues). The milling of the sparingly soluble organic compounds used in the present invention is preferably carried out with a milling aid. The dispersing agent is used as a low molecular weight milling aid for all of the above micronization processes.

Useful anionic, nonionic or amphoteric surfactants are disclosed below in the sections entitled "specific dispersing agents".

Preferred useful milling aids for an aqueous dispersion are anionic surfactants having an HLB (Hydrophile-Lipophile Balance) value greater than 8, more preferably greater than 10.

Any conventionally usable anionic, nonionic or amphoteric surfactants may be used as dispersing agents. Such surfactant systems may comprise for example: carboxylic acids and their salts: sodium, potassium and ammonium alkaline soap, soap | calcium or magnesium metal, organic based soap such as lauric acid, myristic acid, palmitic acid and oleic acid etc., alkyl phosphates or esters of phosphoric acid, acid phosphate, diethanol amine phosphate, potassium cetyl phosphate , ethoxylated or poly (ethylene glycol) -esters, PEG-acylates, esters or carboxylic acids. Fattyl polyglycol ether such as laureth-n, myreth-n, ceteareth-n, steareth-n, oleth-n. fatty acid polyglycol ether such as PEG-n stearate, PEG-n oleate, PEG-n cocoate, monoglycerides and polyol esters, C1-2 C22 fatty acid mono- and diesters of 1 to 100 mol addition products of ethylene oxide with polyols, fatty acid ester and polyglycol such as glycerol monostearate, diisostearoyl-1 polyglyceryl-3-diisostearates, polyglyceryl-3-diestearates, triglyceryl diestearates, polyglyceryl-2-sesquiisoestearates or dimerates. Mixtures of compounds of a plurality of those classes of substances are also suitable. Fatty acid polyglycol esters such as diethylene glycol monostearate, and poly (ethylene glycol) fatty acid esters, fatty acid and sucrose esters such as sugar esters, glycerol and sucrose esters such as sugar glycerides . Sorbitol and sorbitan, saturated and unsaturated fatty acid sorbitan mono- and di-esters having from 6 to 22 carbon atoms and ethylene oxide addition products, n-polysorbate series, sorbitan esters such as sorbitan sesquiisoestearate, Sorbitan PEG- (6) -isoestearate, PEG- (10) sorbitan laurate, PEG-17-sorbitan dioleate, glucose derivatives, C8-C22 alkyl mono and oliglycosides and glucose ethoxylated analogues being preferred as the sugar component, O / W emulsifiers such as gluceth-20 methyl sesquiestearate, sorbitan stearate / sucrose cocoate, methyl glucose sesquiestearate, cetearyl alcohol / cetearyl glycoside, W / O emulsifiers such as methyl glucose dioleate / methyl glucose isostearate. Sulphate and sulphonate derivatives, dialkyl sulpho succinates, dioctyl succinate, alkyl lauryl sulphonate, linear sulphonated paraffins, sulphonated tetrapropylene sulphonate, sodium lauryl sulphates, ammonium and ethanol amine lauryl sulphates ether sulfates, sodium laureth sulfates [Texapon N70] or sodium myreth sulfates [Texapon K14S], sulfosuccinates, acetyl isothionates, alkanol amide sulfates, taurines, methyl taurines, imidazole sulfates. Zuiterionic or amphoteric surfactants that carry at least one quaternary ammonium group and at least one carboxylate and / or sulfonate group in the molecule. Zuiterionic surfactants that are especially suitable are betaines, such as N-alkyl-N, N-dimethyl ammonium glycinates, cocoalkyl dimethyl ammonium glycinate, N-acyl amino-propyl-N glycinates, N-dimethyl ammonium , cocoacyl-amino-propyl-dimethyl-ammonium glycinate and 2-alkyl-3-carboxy-methyl-3-hydroxy-ethyl-midazolines each having from 8 to 18 carbon atoms in the alkyl or acyl group and also cocoacyl glycinate -amino-ethyl-hydroxy-ethyl-carboxy-methyl, N-alkyl betaine, N-alkylamino betines.

Examples of mild surfactants suitable as dispersing agents, i.e. especially skin-tolerated surfactants, include fatty alcohol polyglycol ether sulfates, monoglycerides sulfates, mono and / or dialkyl sulfosuccinates, fatty acid isethionates, fatty acid, fatty acid taurides, fatty acid glutamates, α-olefin sulfonates, ether carboxylic acids, alkyl oligoglycosides, fatty acid glycamides, alkyl starch betaines and / or fatty acid protein condensation products, the latter being preferably based on wheat proteins.

Nonionic surfactants such as PEG-6 beeswax (e) PEG-6 stearate (e) polyglyceryl -2-isostearate [Apifac], glyceryl stearate (e) PEG-100 stearate. [Arlacel 165], PEG-5 glyceryl stearate [arlatone 983 S], sorbitan (e) polyglyceryl-3 ricinoleate oleate [Arlacel 1689], sorbitan stearate and sucrose cocoate [arlatone 2121], glyceryl and laureth stearate -23 [Cerasynth 945], cetearyl alcohol and ceteth-20 [Cetomacrogol Wax], cetearyl alcohol and colissorbate 60 and PEG-150 and stearate-20 [Polawax GP 200, Polawax NF], cetearyl alcohol and cetearyl polyglycoside [ Emulgade PL 1618], cetearyl alcohol and ceteareth-20 [Emulgade 1000NI, Cosmowax], cetearyl alcohol and PEG-40 castor oil [Emulgade F Special], cetearyl alcohol and PEG-40 castor oil and cetearyl sulfate sodium [Emulgade F], stearyl alcohol and steareth-7 and steareth-10 [Emulgator E 2155], cetearyl alcohol and szeareth-7 and steareth-10 [Emulsifying wax USNF], glyceryl stearate and PEG-75 stearate [Gelot 64], propylene glycol ceteth-3 acetate [Hetester PCS], propylene glycol isoceth-3 acetate [Hetester PHA], cetearyl alcohol and ceteth-12 and oleth-12 [Lanbritol Wax N 21], PEG-6 stearate and PEG-32 stearate [Tefose 1500], PEG-6 stearate and ceteth-20 and steareth-20 [Tefose 2000], PEG-6 stearate and ceteth-20 and glyceryl stearate and steareth -20 [Tefose 2561], glyceryl stearate and ceteareth-20 [Teginacid H, C, X].

Anionic emulsifiers such as PEG-2 SE stearate, SE glyceryl stearate [Monelgine, Cutina KD], propylene glycol stearate [Tegin P], cetearyl alcohol and sodium cetearyl sulfate [Lanette N, Cutina LE, Crodacol GP], cetearyl alcohol and sodium lauryl sulfate [Lanette W], trilaneth-4 phosphate and glycol stearate and PEG-2 stearate [Sedefos 75], glyceryl stearate and sodium lauryl sulfate [Teginacid Special]. Cationic acid bases such as cetearyl alcohol and cetrimonium bromide.

More preferred dispersing agents are sodium alkyl sulfates or sodium alkyl ether sulfates, such as sodium laureth sulfate [Cognis Texapon N70] or sodium myreth sulfate [Cognis Texapon K14 S].

Specific dispersing agents may be used in an amount of, for example, from 1 to 30% by weight, especially from 2 to 20% by weight and preferably from 3 to 10% by weight, based on the total weight of the composition.

Useful solvents are water, brine, (poly) ethylene glycol, glycerol or cosmetically acceptable oils. Other useful solvents are disclosed below in the sections entitled "Fatty Acid Esters", "Natural and Synthetic Triglycerides, including Glyceryl Esters and Derivatives", "Perolescent Waxes", "Hydrocarbon Oils" and "Silicones or Siloxanes".

The moderately soluble micronized organic compounds thus obtained usually have an average particle size of from 0.02 to 2 micrometers, preferably from 0.03 to 1.5 micrometers and more especially from 0.05 to 1.0 micrometers.

Micronized UV absorbers according to component (b) of the present invention are used as aqueous dispersions comprising 30-60, preferably 35 to 55 parts of moderately soluble micronized organic substance according to component (b); 2-20, preferably 2 to 20 parts of dispersing agent; 0.1-1 part, preferably 0.1 to 0.5 part of a thickening agent (e.g. xanthan gum); and 20-68 parts water.

The compounds according to component (b) also have a stabilizing effect for UV absorbers selected from ethylhexyl triazine and dioctyl butamido triazone.

Cinnamic acid derivatives (cj) preferably correspond to formula (14), wherein R 16 and R 11 are independently from each other; are hydrogen; hydroxyl; or C1 -C5 alkyl; or C1 -C5 alkoxy; and Ris is Ci-Csalquila.

Most preferred cinnamic acid derivative (ci) is 2-ethylhexyl 4-methoxy cinnamate. The dibenzoyl methane derivative (C2) is preferably selected from 4- (tert-butyl) -4'-methoxy dibenzoyl methane. The present invention also relates to a cosmetic composition comprising 0.1 to 10% by weight of a diphenyl acrylate UV filter (a); 0.1 to 10.% by weight of a triazine UV filter (b); and 0.1 to 10% by weight of a cinnamic acid derivative (ci) UV filter and / or a dibenzoyl methane derivative (c2); wherein the UV filters (a), (b), (ci) and (c2) are defined in claim 1.

Preferably, the cosmetic composition comprises 0.1 to 10% by weight of a diphenyl acrylate UV filter (a); 0.1 to 10.% by weight of a triazine UV filter (b); and 0.1 to 10% by weight of a cinnamic acid derivative UV filter (4); wherein the UV filters (a), (b) and (cj) are defined in claim 1.

Preferably, the cosmetic composition comprises 0.1 to 10% by weight of a diphenyl acrylate UV filter (a); 0.1 to 10.% by weight of a triazine UV filter (b); and 0.1 to 10% by weight of a dibenzoyl methane derivative (c2); wherein the UV filters (a), (b) and (c2) are defined in claim 1.

Cosmetic formulations or pharmaceutical compositions according to the present invention may additionally contain one or more than one other UV filter as listed in Tables 1 and 2.

Cosmetic or pharmaceutical preparations may be prepared by physically mixing the UV absorbers (a), (b) and (c) and optionally other UV absorbers with the adjuvant using standard methods, for example by simply shaking the individual components together.

Cosmetic or pharmaceutical preparations contain from 0.05-40% by weight, based on the total weight of the UV absorber blend composition of the present invention. The blend of UV absorbers according to the present invention is useful for protecting skin, hair and / or natural or artificial hair color.

Cosmetic or pharmaceutical preparations may be, for example, creams, gels, lotions, alcoholic and aqueous / alcoholic solutions, emulsions, wax / fat compositions, stick preparations, powders or ointments. In addition to the above mentioned UV filters, the cosmetic or pharmaceutical preparations may contain other adjuvants as described below.

As emulsions containing water and oil (eg W / O, O / W, O / W / O and W / O / W or microemulsions or emulsions) the preparations contain, for example, from 0.1 to 30% by weight, preferably from 0.1 to 15% by weight and especially from 0.5 to 10% by weight, based on the total weight of the composition of one or more UV absorbers, from 1 to 60% by weight, especially from 5 to 50%. by weight and preferably from 10 to 35% by weight, based on the total weight of the composition of at least one oily component, from 0 to 30% by weight, especially from 1 to 30% by weight and preferably from 4 to 20% by weight. weight, based on the total weight of the composition, of at least one emulsifier, from 10 to 90% by weight, especially from 30 to 90% by weight, based on the total weight of the composition, water, and from 0 to 88.9% by weight, especially from 1 to 50% by weight, of other cosmetically acceptable adjuvants.

Cosmetic or pharmaceutical preparations / compositions according to the invention may also contain one or more additional compounds as described below.

Fatty alcohols Fatty alcohol-based Guerbet alcohols having from 6 to 18, preferably from 8 to 10 carbon atoms including cetyl alcohol, stearyl alcohol, cetearyl alcohol, oleyl alcohol, octyldodecanol, Cl 2 -C 15 benzoate alcohols , acetylated lanolin alcohol, etc.

Fatty acid esters Linear C6-C24 fatty acid esters with linear C3-C24 alcohols, linear C6-C13 carboxylic acid esters with linear Cs-C24 fatty alcohol, linear C6-C24 fatty acid esters, especially 2- ethylhexanol, linear or branched C6-C22 fatty alcohol esters of hydroxy carboxylic acids, especially dioctyl malates, linear and / or branched fatty acid esters with polyhydric alcohols (eg propylene glycol, diol dimer or trimer triol) and / or Guerbet alcohols, for example caproic acid, caprylic acid, 2-ethylhexanoic acid, capric acid, lauric acid, isotridecanoic acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, iso-stearic acid, oleic acid, elaidic acid, petroselinic acid, linoleic acid, linolenic acid, elaostearic acid, arachidic acid, gadoleic acid, behenic acid and and its technical grade mixtures (obtained, for example, by the removal under pressure of natural oils and fats, reduction of Roelen oxosynthesis aldehydes or dimerization of unsaturated fatty acids) with alcohols, for example isopropyl alcohol, alcohol caproic, capryl alcohol, 2-ethylhexyl alcohol, capric alcohol, lauryl alcohol, isotridecyl alcohol, myristyl alcohol, cetyl alcohol, palmoleyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, elaidyl -alcohol, petroselinyl-alcohol, linol-alcohol, linolenyl-alcohol, elastaryl-alcohol, arachidyl-alcohol, gadoleyl-alcohol, behenyl-alcohol, erucyl-alcohol and brassidyl-alcohol and mixtures thereof (obtained, for example, in high pressure hydrogenation of technical grade methyl esters based on Roelen oxyynthesis fats and oils or aldehydes and as monomeric fractions in the dimerization of unsaturated fatty alcohols).

Examples of such ester oils are isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl isostearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, isooctyl stearate , iso-nonyl stearate, isononyl isononate, 2-ethylhexyl palmitate, 2-hexyl laurate, 2-hexyl-decyl stearate, 2-octyldodecyl palmitate, oleyl oleate, oleyl erucate, oleate erucila, erucila erucate, cetearyl octanoate, cetyl palmitate, cetyl stearate, cetyl oleate, cetyl behenate, myristyl myristate, myristyl behenate, myristyl oleate, myristyl palmitate, myristyl , myristyl lactate, propylene glycol dicaprilate / caprate, stearyl heptanoate, diisoestearyl malate, octyl hydroxy stearate, etc.

Other Adjuvants Alpha-glycosyl rutin (CAS No. 130603-71-3), 2-Butyloctyl o-hydroxy benzoate (CAS No. 190085-41-7), Vitamin E (CAS No. 1406-18- 4), vitamin E acetate (CAS No. 58-95-7), diethylhexyl 2,6-naphthalate, di-N-butyl adipate, di (2-ethylhexyl) adipate, diethyl succinate (2-ethylhexyl) and diisotridecyl acetate, and also diol esters, such as ethylene glycol dioleate, ethylene glycol diisotridecanoate, propylene glycol di (2-ethylhexanoate), propylene glycol diisoestearate propylene glycol dipelargonate, butanediol diisostearate and neopentyl glycol dicaprylate. C6-C24 fatty alcohol esters and / or Guerbet alcohols with aromatic, saturated and / or unsaturated carboxylic acids, especially benzoic acid, C2-C12 dicarboxylic acid esters with linear or branched alcohols having from 1 to 22 carbon atoms or polyols having from 2 to 10 carbon atoms and from 2 to 6 hydroxyl groups, or imino-disuccinic acid and salts of imink-disuccinic acid [CAS 7408-20-0] or particles of latex, aloe vera, chamomile, ginko biloba, ginseng , coenzyme Q10, Laminaria ochroleuca extract, Magnolia oborata extract, Melalenca alternifolia leaf oil, Rubus idaeus seed oil, Vaccinium macrocarpon seed oil, pumpkin seed extract, vine seed extract, camosin, alpha -arbutine, madecassoside, terminolaside, tetrahydro-curcuminoids (THC), mycosporins, mycosporin-like amino acids from red algae Porphyra umbilicalis, mycosporin-like amino acids (as described in W02002039974), cis-9-octadecene dioic acid, lipoic acid, laurimine dipropionic acid tocopheryl phosphates (LDTP), microcrystalline cellulose (MCC), polycarbonates as described in WO 0341676, sterols (cholesterol, lanosterol, phytosterols), as described in WO0341675 and linear polyglycans as described in US6616935 Natural or synthetic triglycerides including glyceryl esters and Di- or triglyceride derivatives based on C6-C18 fatty acids modified by reaction with other alcohols (triglyceride caprylic / capric, wheat germ glycerides, etc.). Polyglycerin-fatty acid esters (polyglyceryl-n such as polyglyceryl-4 caprate, polyglyceryl-2 isostearate, etc. or castor oil, hydrogenated vegetable oil, sweet almond oil, wheat germ oil, sesame oil, hydrogenated cottonseed oil, coconut oil, avocado oil, corn oil, hydrogenated castor oil, shea butter, cocoa butter, soybean oil, mink oil, sunflower oil, safflower oil, macadamia nut oil, olive oil, hydrogenated tallow, apricot kernel oil, hazelnut oil, borrago oil, etc.

Wax including esters of alcohols and long chain fatty acids as well as compounds having wax-like properties, eg, carnauba wax, beeswax (white or yellow), lanolin wax, candellila wax, ozokerite, Japanese wax, paraffin wax, microcrystalline wax, ceresine, cetearyl ester wax, synthetic beeswax, etc. Also, hydrophilic waxes such as cetearyl alcohol or partial glycerides.

Adolescent waxes: Alkylene glycol esters, especially ethylene glycol distearate; fatty acid alkanol amides, especially coconut fatty acid diethanol amide; partial glycerides, especially stearic acid monoglycerides; polyvalent, unsubstituted or hydroxy-substituted fatty acid carboxylic acid esters having from 6 to 22 carbon atoms, especially long chain esters of tartaric acid; fatty substances, for example fatty alcohols, fatty ketones, fatty aldehydes, fatty esters and fatty carbonates, which in total have at least 24 carbon atoms, especially laurone and distearyl ether; fatty acids such as stearic acid, hydroxy stearic acid or behenic acid, olefin epoxide ring openers having from 12 to 22 carbon atoms with fatty alcohols having from 12 to 22 carbon atoms and / or polyols having from 2 to 15 carbon atoms and from 2 to 10 hydroxyl groups, and mixtures thereof. r Hydrocarbon oils: Mineral oil (light or heavy), petrolatum (yellow or white), microcrystalline wax, paraffinic and isoparaffin compounds, hydrogenated isoparaffin molecules such as polydecenes and polybutene, hydrogenated polyisobutene, squalane, isohexadecane, isododecane and other kingdoms animal and vegetable.

Silicones or siloxanes (organo-substituted polysiloxanes) Dimethyl polysiloxanes, methyl phenyl polysiloxanes, cyclic silicones, and also amino-, fatty acid-, alcohol-, polyether-, epoxy-, fluoro-, glycoside-e silicon compounds / or alkyl-modified, which at room temperature may be in either liquid or resinous form. Linear polysiloxanes, dimethicone (Dow Corning 200 fluid, Rhodia Mirasil DM), dimethiconol, cyclic silicone fluids, volatile cyclopentasiloxanes (Dow Corning 345 fluid), phenyl trimethicone (Dow Corning 556 fluid). Semiticones, which are mixtures of dimethicones having an average chain length of 200 to 300 units of dimethyl siloxane with hydrogenated silicates, are also suitable. A detailed study written by Todd et al. Suitable volatile silicones can in addition be found in "Cosm. Toil." 91.27 (1976). Fluorinated or perfluorinated oils Perfluorohexane, dimethylcyclohexane, ethylcyclopentane, poly (perfluoromethylisopropyl ether).

Emulsifiers Any conventionally usable emulsifier may be used in the compositions. Emulsifier systems may comprise for example: carboxylic acids and their salts: sodium, potassium and ammonium alkaline soap, calcium or magnesium metal soap, organic based soap such as lauric, palmitic, stearic and oleic acids etc. Alkyl phosphates or esters of phosphoric acid, acid phosphate, diethanol amine phosphate, potassium cetyl phosphate. Ethoxylated carboxylic acids or esters of poly (ethylene glycol), PEG-acylates. Linear fatty alcohols having from 8 to 22 carbon atoms, branched from 2 to 30 moles of ethylene oxide and / or 0 to 5 moles of propylene oxide with fatty acids having from 12 to 22 carbon atoms and with alkyl phenols having from 8 to 15 carbon atoms in the alkyl group. Fatty alcohol polyglycol ether such as laureth-n, ceteareth-n, steareth-n, oleth-n. Fatty acid polyglycol ether such as PEG-n stearate, PEG-n oleate, PEG-n cocoate. Monoglycerides and polyol esters. C12-C22 fatty acid mono- and di-esters of 1 to 30 mol of ethylene oxide additions products with polyols. Polyglycerol fatty acid ester such as glycerol monostearate, diisostearoyl polyglyceryl-3-diisostearates, polyglyceryl-3-diisoestearates, triglyceryl diisostearates, polyglyceryl-2-sesquiisoestearates or polyglyceryl dimerates. Mixtures of compounds of a plurality of those classes of substances are also suitable. Fatty acid polyglycol esters such as diethylene glycol monostearate, fatty acid and polyethylene glycol esters, sucrose fatty acid esters such as sucrose esters, glycerol esters and sucrose such as sugar glycerides. Sorbitol and sorbitan, sorbitan mono-and di-esters of saturated and unsaturated fatty acids having from 6 to 22 carbon atoms and ethylene oxide addition products. N-polysorbate series, sorbitan esters such as sorbitan sesquiisoestearate, PEG- (6) -sorbitan isostearate, PEG- (10) -sorbitan laurate, PEG-17-sorbitan dioleate. Glucose derivatives, C8 -C22 alkyl mono and oliglycosides and glucose ethoxylated analogs being preferred as the sugar component. O / W emulsifiers such as gluceth-20 methyl sesquiestearate, sorbitan stearate / sucrose cocoate, methyl glucose sesquiestearate, cetearyl alcohol / cetearyl glycoside. W / O emulsifiers such as methyl glucose dioleate / methyl glucose isostearate. Sulfonated sulphates and derivatives, dialkyl sulpho succinates, dioctyl succinate, alkyl lauryl sulphonates, linear sulphonated paraffins, sulphonated tetrapropylene sulphonates, sodium lauryl sulphates and amine lauryl sulphates, lauryl - ether sulphates, sodium laureth sulphates, sulpho succinates, acetyl isothionates, alkanolamide sulphates, taurines, methyl taurines, imidazol sulphates. Amine derivatives, amine salts, ethoxylated amines, amine oxide with chains containing a heterocycle such as alkyl imidazolines, pyridine derivatives, isoquinoteins, cetyl pyridinium chloride, cetyl pyridinium bromide such as cetyl bromide - trimethylbroide ammonium (CTBA); Amide derivatives, alkanol amides such as acyl amide DEA, ethoxylated amides such as PEG-n acyl amide, oxide amide. Polysiloxane / polyalkyl / polyether copolymers and derivatives, dimethicone, copolyols, poly (ethylene oxide) silicone copolymer, silicone glycol copolymer. Propoxylated ethers or POE-n ethers (Meroxapols), Polaxamers or poly (oxyethylene) m-block-poly (oxypropylene) n-block (oxyethylene). Zuiterionic surfactants that carry at least one quaternary ammonium group and at least one carboxylate and / or sulfonate group in the molecule. Zuiterionic surfactants that are especially suitable are betaines such as N-alkyl-N, N-dimethyl ammonium glycinates, coco-alkyl-dimethyl ammonium glycinate, N-acyl-amino-propyl-N, N-dimethyl glycinates -ammonium, cocoacylamino-propyl-dimethyl-ammonium glycinate and 2-alkyl-3-carboxy-methyl-3-hydroxy-ethyl-imidazolines each having from 8 to 18 carbon atoms in the alkyl or acyl group and also glycinate of cocoacylaminoethylhydroxyethylcarboxymethyl, N-alkyl betaine, N-alkylamino betaines. Alkyl imidazolines, alkyl peptides, lipoaminoacides, self-emulsifying bases and the compounds as described in K.F.DePolo, "A short textbook of cosmetology", Chapter 8, Table 8-7, p250-251.

Nonionic emulsifiers such as PEG-6 beeswax (e) PEG-6 stearate (e) polyglyceryl-2-isostearate [Apifac], glyceryl stearate (e) PEG-100 stearate. [Arlacel 165], PEG-5 glyceryl stearate [arlatone 983 S], sorbitan (e) polyglyceryl-3 ricinoleate oleate [Arlacel 1689], sorbitan stearate and sucrose cocoate [arlatone 2121], glyceryl and laureth stearate -23 [Cerasynth 945], cetearyl alcohol and ceteth-20 [Cetomacrogol Wax], cetearyl alcohol and colissorbate 60 and PEG-150 and stearate-20 [Polawax GP 200, Polawax NF], cetearyl alcohol and cetearyl polyglycoside [ Emulgade PL 1618], cetearyl alcohol and ceteareth-20 [Emulgade 1000NI, Cosmowax], cetearyl alcohol and PEG-40 castor oil [Emulgade F Special], cetearyl alcohol and PEG-40 castor oil and cetearyl sulfate sodium [Emulgade F], stearyl alcohol and steareth-7 and steareth-10 [Emulgator E 2155], cetearyl alcohol and steareth-7 and steareth-10 [Emulsifying wax USNF], glyceryl stearate and PEG-75 stearate [Gelot 64], ceteth-3 propylene glycol acetate [Hetester PCS], isoceth-3 propylene glycol acetate [Hetester PHA], 1 cetearyl alcohol and ceteth-12 and oleth-12 [L ambritol Wax N 21], PEG-6 stearate and PEG-32 stearate [Tefose 1500], PEG-6 stearate and ceteth-20 and steareth-20 [Tefose 2000], PEG-6 stearate and ceteth-20 and glyceryl stearate and steareth-20 [Tefose 2561], glyceryl stearate and ceteareth-20 [Teginacid H, C, X].

Anionic emulsifiers such as PEG-2 SE stearate, SE glyceryl stearate [Monelgine, Cutina KD], propylene glycol stearate [Tegin P], cetearyl alcohol and sodium cetearyl sulfate [Lanette N, Cutina LE, Crodacol GP] , cetearyl alcohol and sodium lauryl sulfate [Lanette W], trilaneth-4 phosphate and glycol stearate and PEG-2 stearate [Sedefos 75], glyceryl stearate and sodium lauryl sulfate [Teginacid Special], Acid Bases such as cetearyl alcohol and cetrimonium bromide.

Emulsifiers may be used in an amount of, for example, from 1 to 30% by weight, especially from 4 to 20% by weight and preferably from 5 to 10% by weight, based on the total weight of the composition.

When formulated in O / W emulsions, the preferred amount of such emulsifier system could represent 5% to 20% of the oil phase. Additives and additives Cosmetic / pharmaceutical preparations, for example creams, gels, lotions, alcoholic and aqueous / alcoholic solutions, emulsions, wax / fat compositions, stick preparations, powders or ointments, may in addition contain, as other adjuvants and additives , mild surfactants, over-greasing agents, consistency regulators, thickeners, polymers, stabilizers, biogenic active ingredients, deodorant active ingredients, agents, anti-dandruff, film-forming agents, expanding agents, other UV light-protecting factors, antioxidants, hydrotropic agents, preservatives, insect repellents, self-tanning agents, solubilizing agents, perfume oils, colorants, bacterial inhibiting agents and the like.

Super-greasing agents Suitable substances for use as super-greasing agents are, for example, lanolin and lecithin as well as polyethoxylated and acrylated lanolin and lecithin derivatives, fatty acid polyol esters, monoglycerides and alkanol amides, the latter simultaneously acting as foam stabilizers.

Surfactants Examples of suitable mild surfactants, i.e. especially well-tolerated skin-surfactants, include fatty alcohol polyglycol ether sulfates, monoglyceride sulfates, mono- and / or di-sulfosuccinates, fatty acid isethionates, sarcosinates fatty acids, fatty acid taurides, fatty acid glutamates, α-olefin sulfonates, ether carboxylic acids, alkyl oligoglycosides, fatty acid glycamides, alkyl starch betaines and / or fatty acid protein condensation products , the latter preferably being based on wheat proteins.

Consistency Regulators / Thickeners and Rheology Modifiers Silicon dioxide, magnesium silicates, aluminum silicates, polysaccharides or derivatives thereof for example hyaluronic acid, xanthan gum, guar-guar, agar, alginates, carrageenan, gelan, pectins, or modified celluloses such as hydroxy cellulose, hydroxy propyl methyl cellulose. In addition polyacrylates or homopolymer of cross-linked acrylic acids and polyacrylamides, carbomer (carbopol types 980, 981, 1382, ETD 2001, ETD2020, Ultrez 10) or Salcare varieties such as Salcare SC80 (steareth-10 allyl ether / acrylates copolymer) , Salcare SC81 (acrylate copolymer), Salcare SC91 and Salcare AST (sodium acrylate copolymer / -PPG-1 trideceth-6), sepigel 305 (polyacrylamide / laureth-7), Simulgel NS and Simulgel EG (acrylic copolymer of sodium hydroxyethyl / acryloyl dimethyl taurate), Stabilen 30 (acrylate cross-polymer / vinyl isodecanoate), Pemulen TR-1 (acrylate cross-polymer / Cl0-30 alkyl acrylate), Luvigel EM (acrylate copolymer) Aculyn 28 (acrylate / beheneth-25 methacrylate copolymer), etc.

Polymers Suitable cationic polymers are, for example, cationic cellulose derivatives, for example quantified hydroxy methyl cellulose obtainable under the name Amerchol Polymer JR 400, cationic starches, diallylammonium salt and acrylamide copolymers, vinyl polymers. quaternized pyrrolidone / vinyl imizadol, for example Luviquat® (BASF), polyglycol and amine condensation products, quaternized collagen, quaternized polypeptides, for example hydrolyzed lauryl dimonhoxypropyl collagen (Lamequat®L / Grünau), polypeptides wheat seeds, polyethyleneimine, silicone cationic polymers, for example starch methicones, adipic acid and dimethyl amino hydroxy propyl diethylene triamine copolymers (Cartaretin / Sandoz), acrylic acid copolymers with dimethyl diallyl chloride. ammonium (Merquat 550 / Chemviron), polyamino polyamides, as described, for example, in FR-A-2,252,840, and their water-soluble cross-linked polymers, cationic chitin derivatives, for example of quatemized chitosan, optionally distributed as microcrystals; dihaloalkyl condensation products, for example dibromo-butane, with bisdialkyl amines, for example bisdimethyl-amino-1,3-propane, cationic guar gum, for example Jaguar C-17, Jaguar 6 of Celanese, quaternized ammonium salt polymers, for example Mirapol A-15, Mirapol AD-1, Mirapol AZ-1 from Miranol. As anionic, zuiterionic, amphoteric and nonionic polymers can be considered, for example vinyl acetate / crotonic acid copolymers, vinyl pyrrolidone / vinyl acetate copolymers, vinyl pyrrolidone / vinyl acrylate copolymers, vinyl / butyl maleate / isobomyl acrylate, methyl vinyl ether / maleic anhydride copolymers and their esters, non-crosslinked poly (acrylic acids) and polyol cross-linked poly (acrylic acids), acrylamido-propyl trimethyl chloride copolymers -ammonium / acrylate, octyl acrylamide / methyl methacrylate / tert-butyl amino ethyl methacrylate / 2-hydroxypropyl methacrylate, poly (vinyl pyrrolidone), vinyl pyrrolidone / vinyl acetate copolymers, vinyl pyrrolidone / dimethyl amino ethyl methacrylate / vinyl caprolactam terpolymers and also optionally derived silicones and cellulose ethers. In addition the polymers as described in EP 1093796 (pages 3-8, paragraphs 17-68) may be used.

Biogenic Active Ingredients Biogenic Active Ingredients are to be understood as meaning, for example tocopherol, tocopherol acetate, tocopherol palmitate, ascorbic acid, deoxyribonucleic acid, retinol, bisabolol, allantoin, phyanthiol, panthenol, AHA acids, amino acids, ceramides, pseudoceramides, essential oils, plant extracts and vitamin complexes.

Deodorant Active Ingredients As deodorant active ingredients come into consideration, for example antiperspirants, for example aluminum hydrochlorides (see J. Soc. Cosm. Chem. 24, 281 (1973)). Under the tradename Locron® of Hoechst AG, Frankfurt (FRG), for example, an aluminum hydrochloride corresponding to the formula Al 2 (OH) 5 Cl x 2.5 H2 O is commercially available (see J. Pharm. Pharmacol 26, 531 (1975)). In addition to hydrochlorides, it is also possible to use aluminum hydroxyacetates and acid aluminum / zirconium salts. Esterase inhibitors may be added as other deodorant active ingredients. Such inhibitors are preferably trialkyl citrates, such as trimethyl citrate, tripropyl citrate, triisopropyl citrate, tributyl citrate and especially triethyl citrate (Hydagen CAT, Henkel), which inhibit enzymatic activity and consequently reduce odor formation. Other substances that are considered as esterase inhibitors are sterol phosphates or sulphates, for example lanosterol sulphate or phosphate, cholesterol, campesterol, stigmasterol and sitosterol, dicarboxylic acids and their esters, for example glutaric acid monoethyl ester, diethyl glutaric acid ester, adipic acid, adipic acid monoethyl ester, adipic acid diethyl ester, malonic acid and malonic acid diethyl ester and hydroxy carboxylic acids and their esters, for example citric acid, malic acid, tartaric acid or tartaric acid diester. Antibacterial active ingredients that influence germ flora and kill or inhibit the growth of sweat-decomposing bacteria may also be present in preparations (especially in stick preparations).

Examples include chitosan, phenoxyethanol, chlorhexidine glyconate. 5-Chloro-2- (2,4-dichloro-phenoxy) -phenol (Triclosan, Irgasan, Ciba Specialty Chemicals Inc.) has also been shown to be especially effective.

Anti-Dandruff Agents As anti-dandruff agents, for example, climbazole, octopirox and zinc pyrithione may be used. Usual film formers include, chitosan, microcrystalline chitosan, chitated chitosan, vinyl pyrrolidone / vinyl acetate copolymers, quaternary cellulose derivative polymers containing a high proportion of acrylic acid, collagen, hyaluronic acid and its salts and similar compounds.

Antioxidants In addition to the primary light shielding substances, it is also possible to use antioxidant-type secondary light shielding substances that interrupt the chain of photochemical reactions triggered when UV radiation penetrates the skin or hair. Typical examples of such antioxidants are amino acids (eg glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (eg urocanic acid) and their derivatives, peptides such as D, L-camosine, D-camosine, L-camosine and their derivatives. derivatives (eg anserine), carotenoids, carotenes, lycopene and its derivatives, chlorogenic acid and its derivatives, lipoic acid and its derivatives (eg dihydro-lipoic acid), aurothioglycosis, propylthiouracil and other thiols (eg thioredoxin, glutathione, cysteine, cystine, cystamine and its glycosyl-, N-acetyl-, methyl-, ethyl-, propyl-, amyl-, butyl-, lauryl-, palmitoyl-, oleyl-, linoleyl-, cholesteryl- and glyceryl esters) and also their salts, dilauryl thiodipropionate, isostearyl thiodipropionate, thiodipropionic acid and its derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and also sulfoximine compounds (eg butionine sulfoximines, homocysteine sulfoximine, butionine sulfones, pen ta-, hexa-, hepta-thionine sulfoximine), also (metal) chelating agents (e.g. hydroxyl fatty acids, palmitic acid, phytic acid, lactoferrin), hydroxyl acids (eg citric acid, lactic acid, malic acid), humic acid, bile acid, bile extracts, bilirubin, biliverdin, EDTA, EDDS, EGTA and their derivatives, unsaturated fatty acids and their derivatives (eg linolenic acid, linoleic acid, oleic acid), folic acid and its derivatives, ubiquinone and ubiquinol and their derivatives, vitamin C and derivatives (eg ascorbyl palmitate, magnesium ascorbyl phosphate, acetate ascorbyl), tocopherols and derivatives (eg vitamin E acetate), vitamin A and derivatives (eg vitamin A palmitate) and also benzoin resin coniferyl benzoate, rutinic acid and its derivatives, glycosyl rutin, ferulic acid, furfurylidene- glucitol, camosine, butylhydroxy toluene, butylhydroxy anisole, nordihydroic acid, trihydroxybutyrophenone, uric acid and its derivatives, mannose and its derivatives, superoxide dismutase, acid N- [3- (3,5-di-tert-Butyl-4-hydroxy-phenyl) -propionyl] -sulfanyl (and its salts, for example disodium salts), zinc and their derivatives (e.g. ZnO, ZnSO4), selenium and its derivatives (eg selenium methionine), stilbene and its derivatives (eg stilbene oxide, trans-stilbene oxide) and suitable derivatives according to the invention (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids) of those active ingredients mentioned. HALS (-'Hindered Amine Light Stabilizers ") compounds may also be mentioned.

Other natural and synthetic antioxidants are listed e.g. in WO 0025731: Structures 1-3 (page 2), structure 4 (page 6), structures 5-6 (page 7) and compounds 7-33 (page 8-14). The amount of antioxidants present is usually from 0.001 to 30 wt%, preferably from 0.01 to 3 wt%, based on the weight of UV absorber of formula (1).

Hydrotropic agents To improve flow behavior hydrotropic agents may also be used, for example low ethoxylated or non-ethoxylated mono-alcohols, diols or polyols or their ethers (eg ethanol, isopropanol, 1,2- dipropanediol, propylene glycol, glycerine, ethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether and the like). Polyols which are considered for this purpose preferably have from 2 to 15 carbon atoms and at least two hydroxyl groups. The polyols may also contain other functional groups, especially amino groups, and / or may be modified with nitrogen. Typical examples are as follows: glycerol, alkylene glycols, for example ethylene glycol, diethylene glycol, propylene glycol, butylene glycol, hexylene glycol and also poly (ethylene glycols) having an average molecular weight of 100 to 1,000. Dalton; technical mixtures of oligoglycerol having an intrinsic degree of condensation of 1.5 to 10, for example technical mixtures of diglycerol having a content of 40 to 50% by weight; methylol compounds such as especially trimethylol ethane, trimethylol propane, trimethylol butane, pentaerythritol and dipentaerythritol; lower alkyl glycosides, especially those having from 1 to 8 carbon atoms in the alkyl radical, for example methyl and butyl glycosides; sugar alcohols having from 5 to 12 carbon atoms, for example sorbitol or mannitol; sugars having from 5 to 12 carbon atoms, for example glucose or sucrose; amino sugars, for example glycamine; dialcohol amines, such as diethanol amine or 2-amino-1,3-propane diol. Preservatives Suitable preservatives include, for example, Methyl-, Ethyl-, Propyl-, Butyl-Parabens, Benzalkonium Chloride, 2-Bromo-2-nitro-propane-1,3-diol, Dehydroacetic Acid, Diazolidinyl Urea, 2-Dichloro-benzyl alcohol, DMDM hydantoin, Formaldehyde solution, Methyl dibromo-glutanitrile, Phenoxyethanol, Sodium hydroxymethyl glycinate, Imidazolidinyl-Urea, Triclosan and other classes of substances listed in the following reference: KFDePolo - "A short textbook of cosmetology", Chapter 7, Table 7-2, 7-3, 7-4 and 7-5, p210-219.

Bacterial Inhibiting Agents Typical examples of bacterial inhibiting agents are preservatives that have a specific action against gram-positive bacteria, such as 2,4,4'-trichloro-2'-hydroxy-diphenyl ether, chlorhexidine (1,6- di (4-chloro-phenyl-biguanido) -hexane) or TCC (3,4,4'-trichloro-carbanilide). A large number of aromatic substances and ethereal oils also have antimicrobial properties. Typical examples are the active ingredients eugenol, menthol and thymol in clove oil, mint oil and thyme oil. A natural deodorant agent of interest is famesol terpene alcohol (3,7,11-trimethyl-2,6,10-dodecatrien-1-ol), which is present in the oil of the lemon blossom. Glycerol monolaurate has also been shown to be a bacteriostatic agent. The amount of additional bacterial inhibiting agents present is usually from 0.1 to 2% by weight based on the solids content of the preparations. r Perfume oils Mixtures of natural and / or synthetic aromatic substances may be mentioned as perfume oils. Natural aromatic substances are, for example, flower extracts (lilies, lavender, roses, jasmine, n eroli, ilang-ilang), stems and leaves (geranium, patchuli, petitgrain), fruit (anise seed, coriander, caraway). , juniper), peeled (bergamot, lemons, oranges), rooted (nutmeg, angelica, celery, cardamom, costus, iris, calmus), wood (pine wood, sandalwood wood, guava wood , cedarwood, rosewood), herbs and grasses (tarragon, lemongrass, sage, thyme), thin branches and pine leaves (spruce, pine, Scots pine, mountain pine), resins and balsams (galbanum, elemi, benzoin, myrrh, olibanum, opopanace). Animal raw materials are also taken into consideration, for example algal and castoreum. Typical synthetic aromatic substances are, for example, ester, ether, aldehyde, ketone, alcohol or hydrocarbon products. Compounds of aromatic ester type are, for example benzyl acetate, phenoxy ethyl isobutyrate, p-tert-butyl cyclohexyl acetate, linalyl acetate, dimethyl benzyl carbinyl acetate, phenyl ethyl acetate , linalyl benzoate, benzyl formate, ethyl methylphenyl glycinate, allyl cyclohexyl propionate, styryl propionate and benzyl salicylate. Ethers include, for example, benzyl ethyl ether; aldehydes include, for example, linear alkanes of 8 to 18 carbon atoms, citral, citronellal, citronellyl oxyacetaldehyde, cyclamene aldehyde, hydroxycitronellal, lilial and bourgeonal; ketones include, for example, ionones, isometilionone and methyl cedril ketone; alcohols include, for example, anethole, citronellol, eugenol, isoeugenol, geraniol, linalool, phenylethyl alcohol and terpinol; and hydrocarbons include mainly terpenes and balms. It is preferable, however, to use mixing of various aromatic substances which together produce an attractive aroma. Relatively low volatile ethereal oils, which are mainly used as aroma components, are also suitable as perfume oils, eg sage oil, chamomile oil, clove oil, melissa oil, cinnamon leaf oil , lime-galician flower oil, juniper berry oil, vetiver oil, oliban oil, galbanum oil, labolanum oil and lavandin oil. Preference is given to the use of bergamot oil, dihydro-mircenol, lilial, liral, citronellol, phenylethyl alcohol, hexyl cinnamaldehyde, geraniol, benzyl acetone, cyclamene aldehyde, linalool, boisambrene forte, ambroxane, indole. , hedione, sandelice, lemon oil, tangerine oil, orange oil, allylamine glycolate, cyclovertal, lavandin oil, sage muscatel oil, apricot, bourbon geranium oil, cyclohexyl salicylate, vertofix coeur , iso-E-Super, Fixolide NP, evemila, iraldein gamma, phenyl acetic acid, geranyl acetate, benzyl acetate, rose oxide, romillat, irotil and floramat alone or mixed together.

Colorants Substances which are suitable and permitted for cosmetic purposes as compiled may be used as colorants, for example in the Farbstoffkommission der Deutschen Forschungsgemeinschaft publication, Verlag Chemie, Weinheim, 1984, pages 81 to 106. used at concentrations of 0.001 to 0.1% by weight based on the total mixture.

Other adjuvants It is furthermore possible that cosmetic preparations contain, as adjuvants, defoamers such as silicones, builders such as maleic acid, solubilising agents such as ethylene glycol, propylene glycol, glycerol or diethylene glycol, opacifiers such as such as latex, styrene / PVP or styrene / acrylamide copolymers, complexing agents such as EDTA, NTA, alanine diacetic acid or phosphonic acids, propellants such as propane / butane mixtures, N20, dimethyl ether, CO2, N2 or connective and developer components as oxidation dye precursors, reducing agents such as thioglycolic acid and its derivatives, thiolatic acid, cysteamine, thiomic acid or mercapto-ethanesulfonic acid, or oxidizing agents such as hydrogen peroxide, potassium bromate or sodium bromate.

Suitable insect repellents are, for example, N, N-diethyl-m-toluamide, 1,2-pentanediol or insect repellent 3535; Suitable self-tanning agents are, for example, dihydroxy acetone and / or erythrulose or dihydroxyl acetone and / or dihydroxyl acetone precursors as described in WO 01/85124 and / or erythrulose.

Polymeric globules or hollow spheres as SPF enhancers The combination of UV absorbers and UV absorber combinations, listed above, with SPF enhancers, such as non-active ingredients such as styrene / acrylate copolymer, silica globules, magnesium silicate spheroidal, cross-linked poly (methyl methacrylates) (PMMA; Micopearl M305 Seppic), can best maximize the UV protection of solar products. Holosphere additives (Sunspheres® ISP, Silica Shells Kobo.) Deflect radiation and the effective photon path length is therefore increased (EP0893119). Some blood cells, as mentioned earlier, provide a soft sensation during spreading. In addition, the optical activity of such globules, e.g. Micropearl M305, can modulate skin brightness by eliminating reflection phenomena and indirectly can scatter UV light.

Cosmetic or Pharmaceutical Preparations Cosmetic or pharmaceutical formulations are contained in a wide variety of cosmetic preparations. For example, the following preparations are especially taken into consideration: -skin care preparations, eg preparations for cleaning and washing the skin in the form of tablets or liquid soaps, soap-free detergents or washing pastes, bath, eg liquid bath preparations (bath foams, milks, shower preparations) or solid bath preparations, eg bath salts and bath cubes; skin care preparations, e.g. emulsions, multi-emulsions for skin or oils for skin; cosmetic preparations for personal care, eg facial make-up in the form of daily use creams or creams, face powder (loose or pressed), rouge or cream make-up, eye care preparation, eg eye shadow preparations eye mask, eyeliner, eye cream or eye cream; lip care preparations, e.g., sticks, clear liquid lipstick, lip contour pencil, nail care preparations, such as nail polish, nail polish removers, nail hardeners or cuticle removers; p-care preparations, e.g. p-baths, p-powder, p-cream or p-balms, special deodorants and antiperspirants or callus removal preparations; light-protective preparations, such as milks, lotions, sun creams or oils, sunscreen or tropical blockers, pre-tanning preparations or sunbathing preparations; -skinning preparations, e.g. self-tanning creams; depigmenting preparations, e.g. skin whitening preparations or skin lightening preparations; insect repellents, e.g. insect repellent oils, lotions, sprays or sticks; deodorants, such as deodorant sprays, pump-driven sprays, deodorant gels, deodorant sticks, or roller ball deodorant bottles; antiperspirants, e.g. rods, creams or bottles with antiperspirant rolling beads; -preparations for the cleaning and care of blemished skin, e.g. synthetic detergents (solid or liquid), scrubbing or peeling preparations or peeling masks; -chemical hair removal preparations (depilation), e.g. hair-removing powders, hair-removing liquid preparations, hair-removing cream or paste preparations, hair-removing gel or aerosol preparations; -shaving preparations, e.g. shaving soap, sparkling shaving creams, non-foaming shaving creams, foams and gels, dry-shave before-shave preparations, aftershave lotions; - fragrance preparations, eg fragrances (cologne, toilet water, perfume water, toilet perfume, perfume, perfume oils or perfume creams; - cosmetic hair care preparations, eg hair wash preparations in the form of shampoos and conditioners, hair care preparations, eg pre-treatment preparations, hair tonics, styling creams, styling gels, ointments, hair rinses, treatment packages, intensive hair treatments, structuring hair preparations, eg preparations permanent wave hair curlers (hot wave, soft wave, cold wave), hair straightening preparations, liquid hair preparation preparations, hair foams, hair sprays, bleach preparations, eg hydrogen peroxide solutions, shampoos bleaches, bleaching powders, bleaching oils or pastes, temporary hair coloring, semi-perm permanent or permanent preparations containing self-oxidizing dyes or natural hair dyes such as henna or chamomile.

Presentation forms The final formulations listed may exist in a wide variety of presentation forms, for example: -in the form of liquid preparations such as a W / O, O / W, O / W / O, W / O / W emulsion or PIT and all types of microemulsions, in the form of a gel, in the form of an oil, cream, milk or lotion, in the form of a powder, a lacquer, a tablet or a make-up, of a stick, in the form of a spray (propellant spray or pump spray) or an aerosol, in the form of a foam, or in the form of a paste.

Of particular importance as cosmetic skin preparations are light-protective preparations such as milks, lotions, creams, solar oils, sunscreen or tropical blockers, pre-tanning preparations or sunbathing preparations, also tanning preparations. skin, for example self-tanning creams. Of particular interest are sunscreen creams, sunscreen lotions, sunscreen milk and sunscreen preparations in the form of a spray.

Of particular importance as cosmetic hair preparations are the aforementioned hair care preparations, especially shampooing hair preparations, hair conditioners, hair care preparations, eg pretreatment preparations, toners hair care, styling creams, styling gels, ointments, hair rinses, treatment packages, intensive hair treatments, hair straightening preparations, liquid hair straightening preparations, hair foams and hair sprays. Of particular interest are hair shampoo preparations.

A shampoo has, for example, the following composition: from 0.01 to 5 wt% aqueous dispersion as defined in claim 1, 12.0 wt% sodium laureth-2-sulfate, 4.0 wt% of cocamido-propyl betaine, 3.0% by weight of sodium chloride, and 100% ad water.

For example, especially the following cosmetic hair formulations may be used: ai) spontaneously emulsifying stock formulation consisting of UV absorber according to the invention, PEG-6-CIOOXO-alcohol and sorbitan sesquioleate, in which water is added and any desired quaternary ammonium compound, for example 4% minkamido-propyl-dimethyl-2-hydroxy-ethyl-ammonium chloride or Quaternium 80; a2) Spontaneously emulsifying stock formulation consisting of the UV absorber according to the invention, tributyl citrate and PEG-20 sorbitan monooleate, in which water and any desired quaternary ammonium compound, for example 4% of minkamido-propyl-dimethyl-2-hydroxy-ethyl-ammonium chloride or Quaternium 80; b) quat-doped solutions of UV absorber according to the invention in butyl triglycol citrate and tributyl citrate; c) mixtures or solutions of the UV absorber according to the invention with n-alkyl pyrrolidone.

Other typical ingredients in such formulations are preservatives, bactericides and bacteriostatic agents, perfumes, dyes, pigments, thickening agents, moisturizing agents, moisturizers, greases, oils, waxes or other typical ingredients of cosmetic and personal care formulations such as alcohols, polystyrene. -alcohols, polymers, electrolytes, organic solvents, silicon derivatives, emollients, emulsifiers or surfactants emulsifiers, surfactants, dispersing agents, antioxidants, anti-irritants and anti-inflammatory agents etc.

Examples of cosmetic and pharmaceutical preparations (X = preferred combinations) The cosmetic preparation according to the invention is distinguished by excellent protection of human skin against the harmful effect of sunlight.

The following examples illustrate the invention.

Example 1: Formulations F1 -F3 _____________________________________ Example 2: Photodegradation of IJV Absorber Combinations

For the determination of photodegradation the so-called "plaque test" is used: 2 pL / cm2 of the Formulations are spread over quartz plates (sand blasted 2.8 cm2 surface), and removed from the plates after 0, 5, and 10 UV irradiation MED using an Atlas CPS + solar simulator.

Tested formulation comprising components (a), (b) and (c): Results Results are listed in Table 3.

Substances marked with an asterisk (*) are those to which recovery percentages refer. The experimental error in terms of standard deviation is within ± 3%. 1,2,5-Triazine, 2,4,6-tris ([1,1'-biphenyl] -4-yl) (TBT) (component (b)) shows in itself no degradation within the experimental error range under all conditions. The same is observed with Octocrylene (OCR).

The results further show that in the combination of Ethylhexyl Methoxy cinnamate (OCR) and 1,3,5-Triazine, 2,4,6-tris ([1,1'-biphenyl] -4-yl) (TBT) Ethylhexyl methoxy cinnamate can be stabilized by the addition of Octocrylene.

Example 3; The so-called "plaque test" is used: 2 pL / cm2 of the Formulations are spread over quartz plates (sand blasted 2.8 cm2 surface), and removed by washing the plates after 0, 5, and 10 MED of irradiation. using an Atlas CPS + solar simulator.

BMDBM (Butyl-Methoxyl-Dibenzoyl-Methane) Formulations Alone, BMDBM in Combination with OCR (Octocrylene), and BMDBM Formulations with Tris-Biphenyl-Triazine (TBT) in Combination with either BEMT (Bis-Ethyl-Hexyl-Oxide) Methoxy-phenyl-Triazine) or Benzotriazolyl-Dodecyl-p-Cresol (BDC) are investigated. The concentration of 1 Tris-Biphenyl-Triazine (TBT) is maintained at 14%, corresponding to 2% active agent.

Results Results are listed in Table 4.

The percentages refer to BMDBM recovery. The experimental error in terms of the 95% significance level confidence interval is within + 2% of the original amount of BMDBM (with each condition four plates were investigated). Tris-Biphenyl-Triazine (TBT) active agent itself did not show degradation within the experimental error range under all conditions. The same is observed with BEMT, BDC and OCR.

Conclusion The data show that the presence of TBT leads to the accelerated photodegradation of BMDBM. This effect can be almost completely reversed by the addition of Octocrylene and also by BEMT or BDC when realistic concentrations are used.

Claims (13)

1. Use of UV absorbers selected from (ai) diphenyl acrylates; characterized in that it is for stabilizing cosmetic compositions against photodegradation comprising (b) symmetrical triazine derivatives of formula f wherein A is a radical of formula R 1 and R 2 independently of each other are hydrogen; Cysalkyl; or Ce-aryl; R ', Rs and Rc> independently of each other are hydrogen; or a radical of formula wherein in formula (3a) at least one of the radicals R 7, R 5 and R 9 are a radical of formula (3 c); Rn, R12, R13 and Rh independently of each other are hydrogen; hydroxyl; halogen; C 1 -C 7 Kalquila; CrCysalcoxyl; C1 -C4 aryl; biphenylyl; Co-Carnyloxy; C1 -Cysalkylthio; carboxyl; -COOM; C1 -C6 alkylcarboxyl; amino-earbonyl; or mono- or di-C 1 -C 5 -alkylamino; C1 -C1 -acyl amino; or -COOH; M is an alkali metal ion; X is 1 or 2; and Y is a number from 2 to 10; and a UV absorber selected from (ci) cinnamic acid derivatives. Use according to claim 1, characterized in that it comprises UV absorbers selected from (ai) diphenyl acrylates; characterized in that it is for stabilizing cosmetic compositions comprising (b) symmetrical triazine derivatives of formula, wherein A is a radical of formula Rf, and Rio independently of each other are hydrogen; Cyclinalkyl; or C1 -C4 aryl; R ?, R? And R? Independently of each other are hydrogen; or a radical of formula wherein, in formula (3a), at least one of the radicals R 7, R s and R 1) are a radical of formula (3c); Rh, R 12, R 13, R 14 and R 17 independently of each other hydrogen; hydroxyl; halogen; CpCysalkyl; C1 -C4 alkoxy; Ce-Cijarila; biphenylyl; C 1 -C 4 aryloxy; C 1 -C 6 -alkylthio; carboxyl; -COOM; C1 -C6 alkylcarboxyl; amino carbonyl; or mono- or di-C 1 -C 1 -alkyl 1-amino; C1 -C10 acyl amino; -COOH; M is an alkali metal ion; X is 1 or 2; and Y is a number from 2 to 10; and (Ci) cinnamic acid derivatives. Use according to claim 1 or 2, characterized in that the diphenyl acrylates (a) are selected from 2-ethylhextla 2-cyano-3,3-diphenyl acrylate and 2-cyano acrylate of 3- (benzo-furanyl). Use according to claim 3, characterized in that the diphenyl acrylates (a) are selected from 2-ethylhexyl 2-cyano-3,3-diphenyl acrylate. Use according to any one of claims 1 to 4, characterized in that the symmetrical triazine derivatives (b) correspond to the formula (4), wherein Rft, R10, Ru, R12 and R13 are defined in claim. 1. Use according to any one of claims 1 to 5, characterized in that Rf> and Rio are hydrogen. Use according to one of Claims 1 to 6, characterized in that Rn and R13 are hydrogen. Use according to one of claims 1 to 7, characterized in that R 12 is hydrogen; hydroxyl; C1 -C6 alkyl; C1 -C6 alkoxy; -COOM; -COOH; or COOR15; M is an alkali metal ion; and Ris is Ci-Cgalquila. Smooth according to any one of claims 1 to 8, characterized in that the symmetrical triazine derivatives (b) correspond to the compounds of formula: Use according to any one of claims 1 to 9, characterized in that the symmetrical triazine derivatives (b) are used in micronized form. Use according to any one of claims 1 to 10, characterized in that the cinnamic acid derivatives (ci) correspond to the formula: R 16 and R 7 independently of each other; are hydrogen; hydroxyl; C1 -C6 alkyl; or C1 -C6 alkoxy; and Rm is C1 -C6 alkyl. Use according to any one of claims 1 to 11, characterized in that the cinnamic acid derivative (ei) is 2-ethylhexyl 4-methoxy cinnamate. A cosmetic composition comprising: 0.1 to 10% by weight of a diphenyl acrylate UV filter (a); 0.1 to 10% by weight of a triazine UV filter (b); and 0.1 to 10% by weight of a cinnamic acid derivative UV filter (ci); wherein the UV filters (a), (b) and (ei) are defined in claim 1.