BRPI0813115A2 - plasmídeo isolado, e, métodos para obter uma neurotoxina de botulina codificada por plasmídeo, e para produzir neurotoxinas de botulina e complexos de neurotoxinas de botulina - Google Patents

plasmídeo isolado, e, métodos para obter uma neurotoxina de botulina codificada por plasmídeo, e para produzir neurotoxinas de botulina e complexos de neurotoxinas de botulina

Info

Publication number
BRPI0813115A2
BRPI0813115A2 BRPI0813115A BRPI0813115A BRPI0813115A2 BR PI0813115 A2 BRPI0813115 A2 BR PI0813115A2 BR PI0813115 A BRPI0813115 A BR PI0813115A BR PI0813115 A BRPI0813115 A BR PI0813115A BR PI0813115 A2 BRPI0813115 A2 BR PI0813115A2
Authority
BR
Brazil
Prior art keywords
plasmid
botulinum
botulinum neurotoxin
obtaining
methods
Prior art date
Application number
BRPI0813115A
Other languages
English (en)
Inventor
A Johnson Eric
Marshall Kristin
Bradshaw Marite
Pellett Sabine
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of BRPI0813115A2 publication Critical patent/BRPI0813115A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
BRPI0813115A 2007-06-29 2008-06-27 plasmídeo isolado, e, métodos para obter uma neurotoxina de botulina codificada por plasmídeo, e para produzir neurotoxinas de botulina e complexos de neurotoxinas de botulina BRPI0813115A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94709007P 2007-06-29 2007-06-29
PCT/US2008/068532 WO2009006281A1 (en) 2007-06-29 2008-06-27 Plasmid-encoded neurotoxin genes in clostridium botulinum serotype a subtypes

Publications (1)

Publication Number Publication Date
BRPI0813115A2 true BRPI0813115A2 (pt) 2017-05-23

Family

ID=40226483

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0813115A BRPI0813115A2 (pt) 2007-06-29 2008-06-27 plasmídeo isolado, e, métodos para obter uma neurotoxina de botulina codificada por plasmídeo, e para produzir neurotoxinas de botulina e complexos de neurotoxinas de botulina

Country Status (8)

Country Link
US (3) US8435759B2 (pt)
EP (1) EP2167532A4 (pt)
CN (1) CN101848930A (pt)
AU (1) AU2008270020B2 (pt)
BR (1) BRPI0813115A2 (pt)
CA (1) CA2691825C (pt)
NZ (1) NZ582087A (pt)
WO (1) WO2009006281A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2167532A4 (en) 2007-06-29 2010-07-14 Wisconsin Alumni Res Found NEUROTOXIN GENES CODED BY PLASMID IN A SEROTYPE OF CLOSTRIDIUM BOTULINUM SUBTYPES A
WO2011047274A1 (en) 2009-10-15 2011-04-21 Wisconsin Alumni Research Foundation Conjugative plasmids from clostridium botulinum and methods of use thereof
WO2013049139A1 (en) * 2011-09-28 2013-04-04 Wisconsin Alumni Research Foundation Purification, characterization, and use of clostridium botulinum neurotoxin bont/a3
CN103107859B (zh) * 2011-11-15 2015-08-19 中国科学院大学 基于ccsds idc和sms4的联合信源与信息安全编译码方法
US10751394B2 (en) * 2016-10-25 2020-08-25 Cellsnap Llc Neurotoxins and uses thereof
US10688162B2 (en) * 2017-01-10 2020-06-23 Cellsnap Llc Hybrid neurotoxins and uses thereof
IL273435B2 (en) * 2017-10-13 2024-05-01 Wisconsin Alumni Res Found Botulinum neurotoxin A subtype 6 and methods of pharmacological use
CN109022603A (zh) * 2018-07-09 2018-12-18 中国疾病预防控制中心传染病预防控制所 检测b型肉毒梭菌的实时荧光定量pcr核酸序列以及试剂盒

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955368A (en) 1998-04-06 1999-09-21 Wisconsin Alumni Research Foundation Expression system for clostridium species
EP2167532A4 (en) 2007-06-29 2010-07-14 Wisconsin Alumni Res Found NEUROTOXIN GENES CODED BY PLASMID IN A SEROTYPE OF CLOSTRIDIUM BOTULINUM SUBTYPES A

Also Published As

Publication number Publication date
EP2167532A4 (en) 2010-07-14
US20160362671A1 (en) 2016-12-15
NZ582087A (en) 2012-06-29
AU2008270020A1 (en) 2009-01-08
WO2009006281A1 (en) 2009-01-08
US20100311118A1 (en) 2010-12-09
US9453057B2 (en) 2016-09-27
CA2691825A1 (en) 2009-01-08
EP2167532A1 (en) 2010-03-31
CN101848930A (zh) 2010-09-29
US8435759B2 (en) 2013-05-07
AU2008270020B2 (en) 2013-05-16
US20140065668A1 (en) 2014-03-06
CA2691825C (en) 2016-05-17

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]