BRPI0806902A2 - MÉTODOS E COMPOSIÇÕES PARA MODULAÇÃO DAS VIAS DE METILAÇÃO DE DNA DIRECIONADA POR sIRNA E RNA - Google Patents
MÉTODOS E COMPOSIÇÕES PARA MODULAÇÃO DAS VIAS DE METILAÇÃO DE DNA DIRECIONADA POR sIRNA E RNAInfo
- Publication number
- BRPI0806902A2 BRPI0806902A2 BRPI0806902-6A2A BRPI0806902A BRPI0806902A2 BR PI0806902 A2 BRPI0806902 A2 BR PI0806902A2 BR PI0806902 A BRPI0806902 A BR PI0806902A BR PI0806902 A2 BRPI0806902 A2 BR PI0806902A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- sirna
- rna
- compositions
- modulation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8281—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for bacterial resistance
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88141807P | 2007-01-19 | 2007-01-19 | |
PCT/IB2008/000954 WO2008087561A2 (en) | 2007-01-19 | 2008-01-18 | Methods and compositions for modulating the sirna and rna-directed-dna methylation pathways |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0806902A2 true BRPI0806902A2 (pt) | 2014-06-17 |
Family
ID=39636444
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0806902-6A2A BRPI0806902A2 (pt) | 2007-01-19 | 2008-01-18 | MÉTODOS E COMPOSIÇÕES PARA MODULAÇÃO DAS VIAS DE METILAÇÃO DE DNA DIRECIONADA POR sIRNA E RNA |
Country Status (6)
Country | Link |
---|---|
US (1) | US20100169996A1 (pt) |
EP (1) | EP2121939B1 (pt) |
BR (1) | BRPI0806902A2 (pt) |
CA (1) | CA2675946A1 (pt) |
ES (1) | ES2447840T3 (pt) |
WO (1) | WO2008087561A2 (pt) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101437933B (zh) | 2005-12-28 | 2013-11-06 | 斯克里普斯研究所 | 作为药物靶标的天然反义和非编码的rna转录物 |
JP5951924B2 (ja) * | 2006-12-21 | 2016-07-13 | ノボザイムス,インコーポレイティド | 二次的rna干渉による糸状菌株における遺伝子発現の低減又は除去方法 |
US8153606B2 (en) | 2008-10-03 | 2012-04-10 | Opko Curna, Llc | Treatment of apolipoprotein-A1 related diseases by inhibition of natural antisense transcript to apolipoprotein-A1 |
CA2746003C (en) | 2008-12-04 | 2020-03-31 | Opko Curna, Llc | Treatment of vascular endothelial growth factor (vegf) related diseases by inhibition of natural antisense transcript to vegf |
CA2745329C (en) | 2008-12-04 | 2022-07-12 | Opko Curna, Llc | Treatment of erythropoietin (epo) related diseases by inhibition of natural antisense transcript to epo |
RU2618688C2 (ru) | 2008-12-04 | 2017-05-10 | КьюРНА,Инк.,US | Лечение связанных с геном-супрессором опухолей заболеваний посредством ингибирования природного транскрипта в антисмысловой ориентации относительно этого гена |
WO2010093904A2 (en) | 2009-02-12 | 2010-08-19 | Curna, Inc. | Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf |
JP6116242B2 (ja) | 2009-03-16 | 2017-04-19 | クルナ・インコーポレーテッド | 核因子(赤血球由来2)様2(nrf2)に対する天然アンチセンス転写物の抑制によるnrf2関連疾患の治療 |
CN102549159B (zh) | 2009-03-17 | 2016-08-10 | 库尔纳公司 | 通过抑制针对δ样1同源物(DLK1)的天然反义转录物来治疗DLK1相关的疾病 |
WO2010129799A2 (en) | 2009-05-06 | 2010-11-11 | Curna, Inc. | Treatment of lipid transport and metabolism gene related diseases by inhibition of natural antisense transcript to a lipid transport and metabolism gene |
US20120046236A1 (en) | 2009-05-06 | 2012-02-23 | Opko Curna Llc | Treatment of tristetraproline (ttp) related diseases by inhibition of natural antisense transcript to ttp |
CA3185821A1 (en) | 2009-05-08 | 2010-11-11 | Curna, Inc. | Treatment of dystrophin family related diseases by inhibition of natural antisense transcript to dmd family |
ES2664590T3 (es) | 2009-05-18 | 2018-04-20 | Curna, Inc. | Tratamiento de enfermedades relacionadas con factores de reprogramación por inhibición del tránscrito antisentido natural a un factor de reprogramación |
WO2010135695A2 (en) | 2009-05-22 | 2010-11-25 | Curna, Inc. | TREATMENT OF TRANSCRIPTION FACTOR E3 (TFE3) and INSULIN RECEPTOR SUBSTRATE 2 (IRS2) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO TFE3 |
WO2010138806A2 (en) | 2009-05-28 | 2010-12-02 | Curna, Inc. | Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene |
CN102612560B (zh) | 2009-06-16 | 2017-10-17 | 库尔纳公司 | 通过抑制针对对氧磷酶1(pon1)的天然反义转录物来治疗pon1相关的疾病 |
EP2443237B1 (en) | 2009-06-16 | 2017-02-22 | CuRNA, Inc. | Treatment of collagen gene related diseases by inhibition of natural antisense transcript to a collagen gene |
CN102597238B (zh) | 2009-06-24 | 2016-06-29 | 库尔纳公司 | 通过抑制针对肿瘤坏死因子受体2(tnfr2)的天然反义转录物来治疗tnfr2相关的疾病 |
EP2446037B1 (en) | 2009-06-26 | 2016-04-20 | CuRNA, Inc. | Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene |
CN102712925B (zh) | 2009-07-24 | 2017-10-27 | 库尔纳公司 | 通过抑制sirtuin(sirt)的天然反义转录物来治疗sirtuin(sirt)相关性疾病 |
CN102762731B (zh) | 2009-08-05 | 2018-06-22 | 库尔纳公司 | 通过抑制针对胰岛素基因(ins)的天然反义转录物来治疗胰岛素基因(ins)相关的疾病 |
WO2011019815A2 (en) | 2009-08-11 | 2011-02-17 | Curna, Inc. | Treatment of adiponectin (adipoq) related diseases by inhibition of natural antisense transcript to an adiponectin (adipoq) |
KR101805213B1 (ko) | 2009-08-21 | 2017-12-06 | 큐알엔에이, 인크. | Chip에 대한 천연 안티센스 전사체의 억제에 의한 “hsp70-상호작용 단백질(chip)의 c-말단” 관련된 질환의 치료 |
JP5964232B2 (ja) | 2009-08-25 | 2016-08-03 | カッパーアールエヌエー,インコーポレイテッド | ‘iqモチーフ含有gtpアーゼ活性化タンパク質’(iqgap)に対する天然アンチセンス転写産物の阻害によるiqgap関連疾患の治療 |
KR101802540B1 (ko) | 2009-09-25 | 2017-11-28 | 큐알엔에이, 인크. | Flg의 발현 및 활성을 조절함으로써 필라그린(flg)에 관련된 질환의 치료 |
ES2661813T3 (es) | 2009-12-16 | 2018-04-04 | Curna, Inc. | Tratamiento de enfermedades relacionadas con la peptidasa del factor de transcripción de membrana, sitio 1 (mbtps1) mediante inhibición del transcrito antisentido natural al gen mbtps1 |
CA2782375C (en) | 2009-12-23 | 2023-10-31 | Opko Curna, Llc | Treatment of uncoupling protein 2 (ucp2) related diseases by inhibition of natural antisense transcript to ucp2 |
ES2661387T3 (es) | 2009-12-23 | 2018-03-28 | Curna, Inc. | Tratamiento de enfermedades relacionadas con el factor de crecimiento de hepatocitos (hgf) mediante inhibición del transcrito antisentido natural a hgf |
ES2585829T3 (es) | 2009-12-29 | 2016-10-10 | Curna, Inc. | Tratamiento de las enfermedades relacionadas con la proteína tumoral 63 (p63) por inhibición de transcripción antisentido natural a p63 |
RU2615450C2 (ru) | 2009-12-29 | 2017-04-04 | Курна, Инк. | Лечение заболеваний, связанных с ядерным респираторным фактором 1(nrf1), путем ингибирования природного антисмыслового транскрипта к nrf1 |
ES2677044T3 (es) | 2009-12-31 | 2018-07-27 | Curna, Inc. | Tratamiento de enfermedades relacionadas con el sustrato 2 del receptor de insulina (IRS2) mediante inhibición de transcrito antisentido natural para el IRS2 y factor de transcripción E3 (TFE3) |
JP5886757B2 (ja) | 2010-01-04 | 2016-03-16 | カッパーアールエヌエー,インコーポレイテッド | インターフェロン調節因子8(irf8)に対する天然アンチセンス転写物の阻害によるインターフェロン調節因子8(irf8)関連疾患の治療 |
US8912157B2 (en) | 2010-01-06 | 2014-12-16 | Curna, Inc. | Treatment of pancreatic developmental gene related diseases by inhibition of natural antisense transcript to a pancreatic developmental gene |
RU2611191C2 (ru) | 2010-01-11 | 2017-02-21 | Курна, Инк. | Лечение заболеваний, связанных со связывающим половые гормоны глобулином (гспг), путем ингибирования природного антисмыслового транскрипта к гспг |
WO2011091390A2 (en) | 2010-01-25 | 2011-07-28 | Opko Curna, Llc | Treatment of rnase h1 related diseases by inhibition of natural antisense transcript to rnase h1 |
EP2539452B1 (en) | 2010-02-22 | 2016-07-27 | CuRNA, Inc. | Treatment of pyrroline-5-carboxylate reductase 1 (pycr1) related diseases by inhibition of natural antisense transcript to pycr1 |
JP5973419B2 (ja) | 2010-04-02 | 2016-08-23 | カッパーアールエヌエー,インコーポレイテッド | コロニー刺激因子3(csf3)に対する天然アンチセンス転写物の阻害によるcsf3関連疾患の治療 |
CA2795281A1 (en) | 2010-04-09 | 2011-10-13 | Curna, Inc. | Treatment of fibroblast growth factor 21 (fgf21) related diseases by inhibition of natural antisense transcript to fgf21 |
RU2693462C2 (ru) | 2010-05-03 | 2019-07-03 | Курна, Инк. | Лечение заболеваний, связанных с сиртуином (sirt), путем ингибирования природного антисмыслового транскрипта к сиртуину (sirt) |
TWI531370B (zh) | 2010-05-14 | 2016-05-01 | 可娜公司 | 藉由抑制par4天然反股轉錄本治療par4相關疾病 |
CA2799596C (en) | 2010-05-26 | 2020-09-22 | Curna, Inc. | Treatment of methionine sulfoxide reductase a (msra) related diseases by inhibition of natural antisense transcript to msra |
KR101857090B1 (ko) | 2010-05-26 | 2018-06-26 | 큐알엔에이, 인크. | 무조(無調)의 동소체 1 (atoh1)에 대한 자연 안티센스 전사체의 저해에 의한 atoh1 관련된 질환의 치료 |
PL2585596T3 (pl) | 2010-06-23 | 2021-06-28 | Curna, Inc. | Leczenie chorób związanych z podjednostką alfa kanału sodowego bramkowanego napięciem (SCNA) poprzez hamowanie naturalnego transkryptu antysensownego SCNA |
NO2593547T3 (pt) | 2010-07-14 | 2018-04-14 | ||
JP5986998B2 (ja) | 2010-10-06 | 2016-09-06 | カッパーアールエヌエー,インコーポレイテッド | シアリダーゼ4(neu4)への天然アンチセンス転写物の阻害によるneu4関連疾患の治療 |
CN103180445B (zh) | 2010-10-22 | 2018-02-16 | 库尔纳公司 | 通过抑制α‑L‑艾杜糖醛酸酶(IDUA)的天然反义转录物而治疗IDUA相关疾病 |
EP2640738A1 (en) * | 2010-11-15 | 2013-09-25 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Anti-fungal agents |
US10000752B2 (en) | 2010-11-18 | 2018-06-19 | Curna, Inc. | Antagonat compositions and methods of use |
EP2643463B1 (en) | 2010-11-23 | 2017-09-27 | CuRNA, Inc. | Treatment of nanog related diseases by inhibition of natural antisense transcript to nanog |
TWI678375B (zh) | 2011-06-09 | 2019-12-01 | 可娜公司 | 藉由抑制共濟蛋白(frataxin,fxn)之天然反股轉錄本治療fxn相關疾病 |
BR112014005234A2 (pt) | 2011-09-06 | 2017-04-11 | Curna Inc | tratamento de doenças relacionadas com subunididades alfa dos canais de sódio dependentes de voltagem (scnxa) com pequenas moléculas |
HUE040179T2 (hu) | 2012-03-15 | 2019-02-28 | Curna Inc | Agyi eredetû neutrotróf faktorral (Brain-derived neurotrophic factor, BDNF) összefüggõ betegségek kezelése a BDNF-fel kapcsolatos természetes antiszensz transzkriptumok gátlása révén |
EP2885409A1 (en) * | 2012-08-17 | 2015-06-24 | Novozymes A/S | Methods for co-silencing expression of genes in filamentous fungal strains and uses thereof |
CN109554496A (zh) * | 2018-12-17 | 2019-04-02 | 北京林业大学 | 一种检测胁迫处理前后植物中转座子活性变化的方法 |
EP4294933A1 (en) * | 2021-02-19 | 2023-12-27 | Nuclear RNA Networks, Inc. | Compositions and methods for modulating gene transcription networks based on shared high identity transposable element remnant sequences and nonprocessive promoter and promoter-proximal transcripts |
CN116622739B (zh) * | 2023-06-25 | 2023-11-28 | 中国农业科学院植物保护研究所 | 番茄SlSUVH2或SlSUVH4基因在调控双生病毒中的应用及转基因植物培育方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4031758A1 (de) | 1990-10-06 | 1992-04-09 | Bayer Ag | Resistenz-gene |
US5629470A (en) * | 1995-01-20 | 1997-05-13 | Rutgers, The State University Of New Jersey | Transgenic plants and plant cells with enhanced pathogen resistance and related methods |
GB0021879D0 (en) | 2000-09-06 | 2000-10-18 | Univ Edinburgh | Plant resistance gene |
-
2008
- 2008-01-18 EP EP08737478.1A patent/EP2121939B1/en not_active Not-in-force
- 2008-01-18 ES ES08737478.1T patent/ES2447840T3/es active Active
- 2008-01-18 BR BRPI0806902-6A2A patent/BRPI0806902A2/pt not_active IP Right Cessation
- 2008-01-18 CA CA002675946A patent/CA2675946A1/en not_active Abandoned
- 2008-01-18 US US12/523,655 patent/US20100169996A1/en not_active Abandoned
- 2008-01-18 WO PCT/IB2008/000954 patent/WO2008087561A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2008087561A9 (en) | 2009-10-15 |
WO2008087561A3 (en) | 2009-04-09 |
ES2447840T3 (es) | 2014-03-13 |
EP2121939A2 (en) | 2009-11-25 |
EP2121939B1 (en) | 2013-12-04 |
WO2008087561A2 (en) | 2008-07-24 |
CA2675946A1 (en) | 2008-07-24 |
WO2008087561A8 (en) | 2008-10-09 |
US20100169996A1 (en) | 2010-07-01 |
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Legal Events
Date | Code | Title | Description |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2344 DE 08-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |