BRPI0802368A2 - medicinal, veterinary and cosmetic formulations using the extract obtained from the fermented juice of one or more types of fruit, containing various natural bioactive compounds, whether or not supplemented with other vegetable extracts - Google Patents

Abstract

MEDICAL, VETERINARY AND COSMETIC FORMULATIONS USING THE EXTRACT OBTAINED FROM THE FERMENTED BROTH OF ONE OR MORE TYPES OF FRUIT, CONTAINING VARIOUS NATURAL BIOACTIVE COMPOUNDS, COMPLEMENTED OR NOT WITH OTHER VEGETABLE EXTRACTS. Medicinal, veterinary and cosmetic formulations containing extracts obtained from the fermented juice of one or more types of fruit containing various natural bioactive compounds, whether or not supplemented with other topical plant extracts, suitable for the recovery of lesions caused by dermabrasion (tattooing); genetic (ichthyosis), congenital (atopic dermatitis, keratinization, dry skin) or psychosomatic (psoriasis) diseases; superficial inflammatory processes (acnes, abscesses); deep burns and wounds; use in physiotherapy and traumatology; veterinary use in the healing of skin and surgical lesions, trauma, insecticide and repellent; Use in cosmetics for hygiene (deodorant, solid and liquid soaps, shampoos, conditioners and toothpaste for gingivitis treatment) and body hydration, wrinkle treatment, stretch marks, permanent makeup.

Description

"MEDICAL, VETERINARY ECOSMETIC FORMULATIONS USING THE EXTRACT OBTAINED FROM ONE OR MORE TYPES OF FRUIT, CONTAINING VARIOUS NATURAL BIOACTIVE COMPOUNDS, WHETHER COMPLEMENTED OR NOT WITH OTHER EXTRACTOSVEGETALS".

TECHNICAL FIELD - This invention deals with medicinal, veterinary and cosmetic formulations with extract obtained from the fermented broth of one or more types of fruit containing various natural bioactive compounds supplemented or not with other topical vegetable extracts, indicated for:

-recovery of lesions caused by dermabrasion (tattooing);

- genetic (ichthyosis), congenital (dermatiteatopic, keratinization, dry skin) or psychosomatic (psoriasis) diseases;

superficial inflammatory processes (acne, abscesses);

- burns and deep wounds;

- use in physiotherapy and traumatology;

- veterinary use, healing of cutaneous and surgical lesions, trauma, and repellent insecticide;

- Use in cosmetics for hygiene (deodorant, solid and liquid soaps, shampoos, conditioners and toothpaste for degingivitis treatment) and body hydration, wrinkle treatment, stretch marks, permanent makeup.

The broth extract obtained by mixed fermentation from one or more types of fruit, fermentation is composed of various microorganisms, yeasts and bacteria, presenting mainly Gram-negative bacteria, Acetobacter, Agrobacteria, Rhizobium Zoogloea, Sarcine, Gluconacetobacter, and Leuconostoc, contains several bioactive molecules. as short chain carbon acids with alpha or beta substituted carbon, such as lactic, acetic, pyruvic, glucuronic acid (30%), which confers them pharmacological activity on dermatological diseases, accelerating the healing and healing process after treatment. by topical application (Van Scott et al., PI 394269, Philadelphia, USA), natural exopolymers such as proteins and polysaccharides, sugars, mainly sucrose, glucose and fructose, and polar and polar lipids. In addition to the aforementioned organic compounds, as a natural product of plant origin, it also contains other phytomomolecules with phytotherapeutic activity, such as: tannins, phytosteroids, chlorophyll, flavonoids, resins, lignins. Some of these phytomolecules present healing and antioxidant activity, acting in synergism with other bioactive molecules.

In this same aspect, it was found that the use of fermented juice extract of one or more types of fruit supplemented with other plant extracts, herbs and plants, admittedly of medicinal properties, could help the pharmacological activity accelerating the healing process of some diseases mentioned above, bringing huge benefits when applied to skin tissue, repairing the most diverse problems of dermatological origin, toning and regenerating the skin, in many other applications.

Accordingly, the patent application in question seeks to prepare medicinal, veterinary and cosmetic formulations using broth extract obtained by mixed fermentation of one or more types of fruit, whether or not supplemented with certain plants, herbs or plant extracts, some of which will be mentioned below:

- Copaifera sp. - Terpene rich essential oil, hyrtiosal, successfully tested on nine types of cancer;

- Garapa guianensis Aubl. - The oil is used as an insect repellent and for the treatment of arthritis, muscle strains and skin tissue changes. Peel tea is used to combat bacterial infection and meat tea as a fungicide.

- Cymbopogon winterianus - rich in geraniol and crironellal, responsible for the action of repellant and squamous repellent due to the characteristic aroma of these compounds.

- Azadiradite indica (Neem) - used in India and Africa for the treatment of malaria, dermatological / inflammatory and rheumatic diseases and for the treatment of wrinkles. It is also used in veterinary as a tick and fungicide.

The extracts obtained from the fermented broth of one or more types of fruits and medicinal plants used in this invention are processed to prepare pharmacological formulations for use in human medicine, veterinary medicine and the cosmetic industry, having as main characteristics the possibility of a rapid decrease of painful symptoms, fast healing process, dermis regeneration in rejuvenation treatments, deodorant function, moisturizer and sunscreen, adjuvant in dental treatment (gingivitis, thrush), insecticide (tick), fungicide and repellent properties.

BACKGROUND OF THE TECHNIQUE - As is well known to those skilled in the medical or veterinary field, measured is the consequence of a mechanical aggression that produces a loss of tissue continuity. It can occur only in the epidermis, caused by abrasion or abrasion, or deeper structures (muscles, tendons, etc.). Deferred healing happens through regeneration, decicatrization or both.

The healing process is defined as the restoration of the continuity of living tissue and is an integrated response to various types of cells involved in the injured tissue. So healing involves platelet aggregation and blood coagulation, fibrin formation, an inflammatory response, change in granular substance. , endothelial proliferation and surface coverage and capillarity, regeneration of certain cell types, variable remodeling and contraction (Ching-Hua et al., 1999).

Application of formulations rich in glycoaminoglycan proteins resulted in a reduction in protein and energy requirements by the injured tissue during structural protein synthesis for healing.

In atopic dermatitis, in which predisposition is determined by genetic factors, exposure to environmental factors influences the clinical severity of the disease.

The bacterium Staphylococcus aureus, which releases various stoxins and enzymes, and a microflora imbalance have been detected not only in severe skin conditions, but also in the dry skin of patients with atopic dermatitis. Such patients have recently used cosmetic skin moisturizing products, which have been shown to be insufficient to normalize microflora balance. Antibiotics and bactericides are not generally used for dry skin because of the problem of bacterial resistance and skin irritation. When a bacteria attacks the surface of the skin, it always forms a biofilm that facilitates bacterial growth. Thus, Masako et al. (2005) investigates substances that do not affect the normal microflora of the skin, such as Staphylococcus epiderrnidis, but that eliminate only pathogenic bacteria (Staphylococcus aureus) for daily moisturizing use by people with atopic dry skin or sensitive skin. They found that a combination of farnesol exilitol in XF cream synergistically inhibited the formation of biofilmepela Staphylococcus aureus, dissolving it in vitro.

The formulations of said invention described herein, gels, ointments, creams, liquids, shampoos, have been successfully tested for the dermatological disorders mentioned above and for ichthyosis epsoriasis, showing regeneration of the injured tissue and recovery of normal skin coloration in various patients.

Regarding veterinary formulations, they have been tested on various animals for pharmacological action, wound healing and reduction of infectious and traumatic processes, as well as for use as an insecticide and fungicide.

Cosmetic formulations showed satisfactory results as wrinkle reducer, permanent makeup, deodorant, moisturizer and sunscreen action, as well as repellent. Cosmetic formulations were also successfully used for the tattooing and healing process without pain due to local inflammation (door organism reaction) and itching (reaction to healing). The endowed recovery injured occurred rapidly within two days, always pigment loss. Given the demand for the use of bioformulations that can stimulate, effective orderly reconstruction of the cutaneous tissue architecture is increasingly necessary.

BRIEF DESCRIPTION OF THE INVENTION The use of microformulations in skin repair is a treatment aimed at improving wound healing and the structural quality endowed with the scar. In recent years and due to the possibility of developing studies that verify a "guided" healing through the use of natural phytotherapeutic bioformulations applied to the injured tissue, it was noted that the object in question is capable of promoting a biological repair of the cutis through processes of the type regenerative repair instead of healing healing, in order to present human or animal medicines or cosmetics in the form of liquid, gel, cream, ointment and cosmetic formulations, to treat wrinkles and other skin problems, hygiene and hydration of the body based on the bioactive compounds contained. in the extract obtained from the defermentation of one or more types of fruit and in the extracts of medicinal and aromatic plants, applied to the skin recovery especially epithelial lesions caused by abrasion such as tattooing, burns, deep wounds, dermatological diseases such as psoriasis and dermatiteatopic, or used for hygienic body product formulations such as shampoos, conditioners, solid eliquid soaps, toothpaste and body moisturizing and cosmetic formulations.

The applicant has developed medical, veterinary and cosmetic formulations with extract obtained from the fermentation of one or more types of fruit containing various natural bioactive compounds, whether or not supplemented with plant extracts, for topical use:

recovery from lesions caused by dermabrasion (tattooing);

- genetic (ichthyosis), congenital (dermatiteatopic, keratinization, dry skin) or psychosomatic (psoriasis) diseases, superficial inflammatory processes (acnes, abscesses);

- burns and deep wounds;

- use in physiotherapy and traumatology;

- veterinary use, healing of cutaneous and surgical lesions, trauma, and repellent insecticide;

- Use in cosmetics for hygiene (deodorant, solid and liquid soaps, shampoos, conditioners and toothpaste for degingivitis treatment) and body hydration, wrinkle treatment, stretch marks, permanent makeup.

With regard to the quantitative equalizing compositions of the said formulations, the same basically comprises the components and proportions below:

- fermented extract of papaya or other fruit, by approximately 4 to 6%;

- andiroba oily extract by approximately 3 to 10%;

- oily aloe vera extract, approximately 3 to 10%;

- preservatives and essences;

- base for cosmetic formulation;

- shampoo base - glycolic extract of aloe eandiroba;

- base for creams - is the above;

- base for hair lotion - in the capillary is used extratoglycolic, aloe and andiroba - carbopol 940;

emphasizing that they all take about 4 to 6% of extract extract.

The extract obtained from the fermented broth from one or more types of fruit, used in the eco-pharmacological formulations, contains the soluble exopolysaccharides rich in hexuronic acid glycosides and other active biomolecules such as proteins, amino acids and short chain organic acids (acetate, pyruvate, lactate, glycolate), tannins, chlorophyll, flavonoids and vitamins, which are proven to be important natural bioactive compounds for cell regeneration in the treatment of the above-mentioned skin disorders.

The formulations described herein as objects of this invention are products used for skin repair which have peculiar structural and functional requirements, ie, no antigenicity, do not cause inflammatory reaction and facilitate rapid healing, fully recovering tissue tissue, favor migration and differentiation of epithelial cells. In addition, they are biodegradable and give rise to non-toxic ametabolites, modulating scar formation.

There are some characteristics of extreme secondary importance, such as preventing or hindering bacterial contamination, maintaining the microenvironment in conditions of correct humidity and oxygenation, and in the case of gels, creams and ointments for superficial lesions, the formation of a film on the surface. injured area, reducing the volume of transududates and exudates.

Biohydrogels, for example, formed by blending exopolysaccharides, short-chain organic acids and active phytomolecules from the extract obtained from the fermented broth of one or more types of fruits, plant extracts and essential oils, have been successfully used for wounds and burns, as well as skin diseases and dermatological diseases. psoriasis, dermatiteatopic and ichthyosis.

Cosmetic formulations for body hygiene and moisturizing composed of a mixture of this extract obtained from the fermented broth of one or more types of fruit, other vegetable extracts and incipient moisturizing and deodorant creams, solid and liquid soaps and shampoos have excellent results. smoother, healthier skin and finer, more hydrated hair.

Finally, there is the moderate cost, an element that, today, has extreme relevance to the final consumer, because in addition to all the advantages over the process of normal healing, medicinal formulations (for humans and animals) must represent affordable cost to the public. in general, allowing access to new recovery and body care aids, and in the case of veterinary use, beauty, pet health or competition, adding important cost / benefit factors.

Claims (6)

1. - "MEDICAL FORMULATIONS, COSMETIC VETERINARIES AND COSMETIC USES USING THE EXTRACT OBTAINED FROM ONE OR MORE TYPES OF FRUIT, CONTAINING VARIOUS NATURAL BIOACTIVE COMPOUNDS, COMPLEMENTED OR NOT WITH OTHER EXTRACTOSVEGETINAL FORMULATIONS COMPOSED BY COMPETERATED WITH VEGETABLES Copaiferasp., Garapa guianensis Aubl., Cymbopogon winterianus, Azadiradita indica (Neem), among other plants, herbs or plant extracts. 2. - "MEDICAL FORMULATIONS, COSMETIC VETERINARIES AND COSMETIC USES USING THE EXTRACT OBTAINED FROM ONE OR MORE TYPES OF FRUIT, CONTAINING VARIOUS NATURAL BIOACTIVE COMPOUNDS, COMPLEMENTED OR NOT WITH THE OTHER EXTRACTOSCHARACTERIZED BY THE FOREGOING" basically, the following components and their proportions: - fermented extract of papaya or other fruit, approximately 4 to 6%; - deandiroba oily extract by approximately 3 to 10%; oily extract of aloevera by approximately 3 to 10%; - preservatives and essences; -basis for cosmetic formulation; - shampoo base - aloe and andiroba extratoglycolic; - base for creams - is the above; - basepair for hair lotion - in the capillary is used glycolic extract, aloe eandiroba - carbopol 940; stressing that everyone takes about 4 to 6% of fermented extract. 3. - "MEDICAL FORMULATIONS, USING THE EXTRACT OBTAINED FROM THE FERMENTED BROTH OF ONE OR MORE FRUITS, CONTAINING VARIOUS COMPOSITE OR EXTRACT VEGETABLES" - In accordance with claims 1 and 2, characterized by the fact of pharmacology , in liquid form, gels, creams or ointments for generic, congenital and psychosomatic dermatological diseases, such as ichthyosis, atopic dermatosis, psoriasis, dry skin and dermatoses in general. These formulations are based on bioactive compounds contained in the extract obtained from Fermented juice of one or more types of fruit may or may not be supplemented with other vegetable extracts and essential oils which act in synergy with the active ingredient of the described extract, improving absorption and amplifying pharmacological action. 4. - "MEDICAL FORMULATIONS, USING THE EXTRACT OBTAINED FROM THE FERMENTED BROTH OF ONE OR MORE FRUITS, CONTAINING VARIOUS COMPOSITE OR EXTRACT OTHER VEGETABLES" - in accordance with claims 1 and 2, as set out in g, and rheumatic problem creams containing the extract obtained from the fermented broth of one or more types of fruit and herbal extracts; pharmacological formulations in gels, ointments and creams based on the extract obtained from the fermented broth of one or more types of fruits and extracts of medicinal plants with essential anti-inflammatory and healing properties for regeneration of damaged tissue and injuries such as superficial and deep burns, tattoos, boils, superficial abscesses , acne and infectious processes in general; formulations in gels, ointments and creams antimicotic comming, based on extract obtained from the fermented broth of one or more types of fruits, extracts of medicinal plants and essential oils; formulations in gels, ointments, creams and liquids for application in physiotherapy and traumatology containing sweetened extract fermented from one or more types of fruits and other extracts of medicinal plants and essential oils, which facilitate the absorption of the active ingredient described; toothpaste formulation for dental use in gingivitis, thrush and other disorders of the oral region, containing the fermented broth extract obtained from one or more types of fruit and other herbal extracts to improve the absorption of the active ingredients described; formulations in gels, ointments and creams for rheumatic problems containing the extract obtained from the fermented broth from one or more types of fruit and extracts from other medicinal plants. 5. - "VETERINARY FORMULATIONS USING THE EXTRACT OBTAINED FROM THE FERMENTED BOTTLE OF ONE OR OTHER TYPE OF FRUIT, CONTAINING VARIOUS COMPOSITE OR EXTRACT OTHER VEGETABLES" - according to the veterinary claims for use in accordance with the claims 1 and 2 the form of deposits and creams for various dermatological lesions, such as myiasis, berne, abrunema and others, the fermented cald extract obtained from one or more types of fruits, containing the main active ingredient, and medicinal plant extracts that are used for drug preparation; formulations in gels, ointments and creams for healing of veterinary surgical interventions, containing the extract obtained from the fermented broth from one or more types of fruit and other medicinal plant extracts; formulations in gels, ointments and creams for trauma, the basis of the extract obtained from the fermented juice from one or more types of fruit, and other extracts of medicinal plants and essential oils; liquid formulations, shampoos with insecticidal activity against ticks, flies, fleas and other insects that cause discomfort and stress to the animal, maintaining the beauty of the coat, and the products are developed from the extract obtained from the fermented broth from one or more types of fruits and other medicinal plant extracts and essential oils; Liquid spray formulations used as a repellent, which ensures the animal's well-being, improving its performance in competitions, production of meat and milk, are also prepared using the extract obtained from fermented cald from one or more types of fruits, and other herbal extracts and oils. essentials. 6. - "COSMETIC FORMULATIONS USING THE EXTRACT OBTAINED FROM THE FERMENTED BROTH OF ONE OR MORE FRUITS, CONTAINING VARIOUS COMPOSITE OR EXTRACT OTHER VEGETABLES" - in accordance with claims 1 and 2, in accordance with the provisions of paragraphs 1 and 2 below, , creams, shampoos and moisturizers for the treatment of wrinkles, stretch marks, stains and also as deodorant, containing the extract obtained from the fermented broth from one or more types of fruits, and other herbal extracts, essential oils, in the respective commercial and specific bases for each formulation cited. ; screen gel formulations for healing and hydration in the definitive make-up process, preventing infection of the injured area and loss of pigments, where the products are prepared using mainly the extract obtained from the broth fermented from one or more types of fruits and other plant extracts mixed with bases. specific commercial solutions for each formulation.