BRPI0801417A2 - process for obtaining pharmaceutical composition of retinoids, retinoid derived product and use - Google Patents

process for obtaining pharmaceutical composition of retinoids, retinoid derived product and use

Info

Publication number
BRPI0801417A2
BRPI0801417A2 BRPI0801417-5A BRPI0801417A BRPI0801417A2 BR PI0801417 A2 BRPI0801417 A2 BR PI0801417A2 BR PI0801417 A BRPI0801417 A BR PI0801417A BR PI0801417 A2 BRPI0801417 A2 BR PI0801417A2
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
retinoids
derived product
obtaining
obtaining pharmaceutical
Prior art date
Application number
BRPI0801417-5A
Other languages
Portuguese (pt)
Inventor
Ferreira Lucas Antonio Miranda
Goulart Gisele Assis Castro
Rodrigo Lambert Orefice
Buono Vicente Tadeu Lopes
Oliveira Cleida Aparecida De
Mahecha German Arturo Bohorque
Original Assignee
Univ Minas Gerais
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Minas Gerais filed Critical Univ Minas Gerais
Priority to BRPI0801417A priority Critical patent/BRPI0801417B8/en
Priority to PCT/BR2009/000072 priority patent/WO2009111852A2/en
Publication of BRPI0801417A2 publication Critical patent/BRPI0801417A2/en
Publication of BRPI0801417B1 publication Critical patent/BRPI0801417B1/en
Publication of BRPI0801417B8 publication Critical patent/BRPI0801417B8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11—Encapsulated compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROCESSO PARA OBTENçãO DE COMPOSIçãO FARMACêUTICA DE RETINóIDES, PRODUTO DERIVADO DE RETINOIDES E USO. A presente invenção descreve o desenvolvimento de uma composição farmacêutica de nanopartículas lipídicas sólidas contendo retinóldes e aminas lipofilicas com aplicação cosmética. A invenção relata também, o processo para obtenção da composição com elevadas taxas de encapsulação de ácido retinóico em nanopartículas lipídicas sólidas através da formação de par iónico entre o ácido retinóico e aminas lipofílicas bem como seu uso.PROCESS FOR OBTAINING PHARMACEUTICAL COMPOSITION OF RETINOIDS, RETINOID DERIVED PRODUCT AND USE. The present invention describes the development of a pharmaceutical composition of solid lipid nanoparticles containing retinoids and lipophilic amines with cosmetic application. The invention also relates to the process for obtaining the composition with high retinoic acid encapsulation rates in solid lipid nanoparticles through the formation of ionic pair between retinoic acid and lipophilic amines as well as their use.

BRPI0801417A 2008-03-13 2008-03-13 process for obtaining pharmaceutical composition of retinoids, retinoid-derived product and use BRPI0801417B8 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BRPI0801417A BRPI0801417B8 (en) 2008-03-13 2008-03-13 process for obtaining pharmaceutical composition of retinoids, retinoid-derived product and use
PCT/BR2009/000072 WO2009111852A2 (en) 2008-03-13 2009-03-13 Process to obtain a pharmaceutical composition of retinoids, derivative product of retinoids and its use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI0801417A BRPI0801417B8 (en) 2008-03-13 2008-03-13 process for obtaining pharmaceutical composition of retinoids, retinoid-derived product and use

Publications (3)

Publication Number Publication Date
BRPI0801417A2 true BRPI0801417A2 (en) 2009-11-10
BRPI0801417B1 BRPI0801417B1 (en) 2019-04-09
BRPI0801417B8 BRPI0801417B8 (en) 2021-05-25

Family

ID=41065588

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0801417A BRPI0801417B8 (en) 2008-03-13 2008-03-13 process for obtaining pharmaceutical composition of retinoids, retinoid-derived product and use

Country Status (2)

Country Link
BR (1) BRPI0801417B8 (en)
WO (1) WO2009111852A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113164368B (en) * 2018-12-04 2023-06-13 株式会社Lg生活健康 High-content and sustained-release retinoid capsule and wrinkle-improving composition containing same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816247A (en) * 1985-09-11 1989-03-28 American Cyanamid Company Emulsion compositions for administration of sparingly water soluble ionizable hydrophobic drugs
US6383471B1 (en) * 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents

Also Published As

Publication number Publication date
BRPI0801417B8 (en) 2021-05-25
WO2009111852A3 (en) 2009-11-12
WO2009111852A2 (en) 2009-09-17
BRPI0801417B1 (en) 2019-04-09

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Legal Events

Date Code Title Description
B03A Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06A Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/04/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/04/2019, OBSERVADAS AS CONDICOES LEGAIS

B16C Correction of notification of the grant

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 13/03/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF