BRPI0711945A2 - derivado 36-des (3-metóxi-4-hidroxiciclo-exil)-36-(3-hidroxicicloeptil) de rapamicina; composto; composição farmacêutica; método para o tratamento de cáncer e/ou malignidades de células b, indução ou manutenção de imunossupressão, tratamento da rejeição de transplantes, doença de enxerto versus hospedeiro, transtornos autoimunes, doenças de inflamação, doença vascular e doenças fibróticas, estimulação da regeneração neuronal ou tratamento de infecções fúngicas; uso do composto; processo para a preparação do composto; e composição ou kit de partes - Google Patents

derivado 36-des (3-metóxi-4-hidroxiciclo-exil)-36-(3-hidroxicicloeptil) de rapamicina; composto; composição farmacêutica; método para o tratamento de cáncer e/ou malignidades de células b, indução ou manutenção de imunossupressão, tratamento da rejeição de transplantes, doença de enxerto versus hospedeiro, transtornos autoimunes, doenças de inflamação, doença vascular e doenças fibróticas, estimulação da regeneração neuronal ou tratamento de infecções fúngicas; uso do composto; processo para a preparação do composto; e composição ou kit de partes Download PDF

Info

Publication number
BRPI0711945A2
BRPI0711945A2 BRPI0711945-3A BRPI0711945A BRPI0711945A2 BR PI0711945 A2 BRPI0711945 A2 BR PI0711945A2 BR PI0711945 A BRPI0711945 A BR PI0711945A BR PI0711945 A2 BRPI0711945 A2 BR PI0711945A2
Authority
BR
Brazil
Prior art keywords
compound according
formula
compound
treatment
rapamycin
Prior art date
Application number
BRPI0711945-3A
Other languages
English (en)
Portuguese (pt)
Inventor
Barrie Wilkinson
Ming-Qiang Zhang
Rose Mary Sheridan
Christoph Beckmann
Original Assignee
Biotica Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotica Tech Ltd filed Critical Biotica Tech Ltd
Publication of BRPI0711945A2 publication Critical patent/BRPI0711945A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0711945-3A 2006-05-19 2007-05-18 derivado 36-des (3-metóxi-4-hidroxiciclo-exil)-36-(3-hidroxicicloeptil) de rapamicina; composto; composição farmacêutica; método para o tratamento de cáncer e/ou malignidades de células b, indução ou manutenção de imunossupressão, tratamento da rejeição de transplantes, doença de enxerto versus hospedeiro, transtornos autoimunes, doenças de inflamação, doença vascular e doenças fibróticas, estimulação da regeneração neuronal ou tratamento de infecções fúngicas; uso do composto; processo para a preparação do composto; e composição ou kit de partes BRPI0711945A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0609962.6 2006-05-19
GBGB0609962.6A GB0609962D0 (en) 2006-05-19 2006-05-19 Novel compounds
PCT/GB2007/001856 WO2007135397A1 (en) 2006-05-19 2007-05-18 36 -des (3 -methoxy-4 -hydroxycyclohexyl) 36 - (3 -hydroxycycloheptyl) derivatives of rapamycin for the treatment of cancer and other disorders

Publications (1)

Publication Number Publication Date
BRPI0711945A2 true BRPI0711945A2 (pt) 2011-12-13

Family

ID=36660469

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0711945-3A BRPI0711945A2 (pt) 2006-05-19 2007-05-18 derivado 36-des (3-metóxi-4-hidroxiciclo-exil)-36-(3-hidroxicicloeptil) de rapamicina; composto; composição farmacêutica; método para o tratamento de cáncer e/ou malignidades de células b, indução ou manutenção de imunossupressão, tratamento da rejeição de transplantes, doença de enxerto versus hospedeiro, transtornos autoimunes, doenças de inflamação, doença vascular e doenças fibróticas, estimulação da regeneração neuronal ou tratamento de infecções fúngicas; uso do composto; processo para a preparação do composto; e composição ou kit de partes

Country Status (10)

Country Link
US (1) US20090209572A1 (https=)
EP (1) EP2027130A1 (https=)
JP (1) JP2009537502A (https=)
CN (1) CN101443333A (https=)
AU (1) AU2007253118A1 (https=)
BR (1) BRPI0711945A2 (https=)
CA (1) CA2651405A1 (https=)
GB (1) GB0609962D0 (https=)
MX (1) MX2008014746A (https=)
WO (1) WO2007135397A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2601201B1 (en) 2010-08-04 2014-09-24 Meril Life Sciences Pvt. Ltd. Process for preparation of novel 42-0-(heteroalkoxyalkyl) rapamycin compounds with anti-proliferative properties"
EP2670756B1 (en) * 2011-02-04 2017-06-21 Synthon BV Process for making everolimus
CN102268015B (zh) * 2011-08-30 2013-08-28 成都摩尔生物医药有限公司 一种依维莫司的合成方法
CN102786534A (zh) * 2012-05-25 2012-11-21 上海现代制药股份有限公司 一种依维莫司的制备方法
CN113244399A (zh) 2015-01-26 2021-08-13 耶鲁大学 利用酪氨酸激酶抑制剂的组合物和方法
EP3109250A1 (en) 2015-06-23 2016-12-28 Synbias Pharma AG Method for the synthesis of rapamycin derivatives
CN106916835B (zh) * 2015-12-24 2022-08-12 武汉合生科技有限公司 化合物的生物合成基因簇及其应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA737247B (en) * 1972-09-29 1975-04-30 Ayerst Mckenna & Harrison Rapamycin and process of preparation
US5023262A (en) * 1990-08-14 1991-06-11 American Home Products Corporation Hydrogenated rapamycin derivatives
US5221670A (en) * 1990-09-19 1993-06-22 American Home Products Corporation Rapamycin esters
US5138051A (en) * 1991-08-07 1992-08-11 American Home Products Corporation Rapamycin analogs as immunosuppressants and antifungals
WO1992021341A1 (en) * 1991-05-31 1992-12-10 Pfizer Inc. Use of rapamycin prodrugs as immunosuppressant agents
ZA935112B (en) * 1992-07-17 1994-02-08 Smithkline Beecham Corp Rapamycin derivatives
GB9221220D0 (en) * 1992-10-09 1992-11-25 Sandoz Ag Organic componds
US5373014A (en) * 1993-10-08 1994-12-13 American Home Products Corporation Rapamycin oximes
US5378836A (en) * 1993-10-08 1995-01-03 American Home Products Corporation Rapamycin oximes and hydrazones
US5391730A (en) * 1993-10-08 1995-02-21 American Home Products Corporation Phosphorylcarbamates of rapamycin and oxime derivatives thereof
US5912253A (en) * 1993-12-17 1999-06-15 Novartis Ag Rapamycin derivatives
US5362718A (en) * 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US5563145A (en) * 1994-12-07 1996-10-08 American Home Products Corporation Rapamycin 42-oximes and hydroxylamines
US5780462A (en) * 1995-12-27 1998-07-14 American Home Products Corporation Water soluble rapamycin esters
US6015815A (en) * 1997-09-26 2000-01-18 Abbott Laboratories Tetrazole-containing rapamycin analogs with shortened half-lives
US6277983B1 (en) * 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives
CA2492153C (en) * 2002-07-16 2012-05-08 Biotica Technology Limited Production of polyketide fkbp-ligand analogues

Also Published As

Publication number Publication date
US20090209572A1 (en) 2009-08-20
EP2027130A1 (en) 2009-02-25
CA2651405A1 (en) 2007-11-29
WO2007135397A1 (en) 2007-11-29
CN101443333A (zh) 2009-05-27
JP2009537502A (ja) 2009-10-29
MX2008014746A (es) 2009-02-19
GB0609962D0 (en) 2006-06-28
AU2007253118A1 (en) 2007-11-29

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BRPI0711945A2 (pt) derivado 36-des (3-metóxi-4-hidroxiciclo-exil)-36-(3-hidroxicicloeptil) de rapamicina; composto; composição farmacêutica; método para o tratamento de cáncer e/ou malignidades de células b, indução ou manutenção de imunossupressão, tratamento da rejeição de transplantes, doença de enxerto versus hospedeiro, transtornos autoimunes, doenças de inflamação, doença vascular e doenças fibróticas, estimulação da regeneração neuronal ou tratamento de infecções fúngicas; uso do composto; processo para a preparação do composto; e composição ou kit de partes
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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE 6A. ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2226 DE 03/09/2013.