BRPI0607059A2 - uso de tiopeptolìdeos para determinar a atividade de protease adam-ts - Google Patents

uso de tiopeptolìdeos para determinar a atividade de protease adam-ts

Info

Publication number
BRPI0607059A2
BRPI0607059A2 BRPI0607059-0A BRPI0607059A BRPI0607059A2 BR PI0607059 A2 BRPI0607059 A2 BR PI0607059A2 BR PI0607059 A BRPI0607059 A BR PI0607059A BR PI0607059 A2 BRPI0607059 A2 BR PI0607059A2
Authority
BR
Brazil
Prior art keywords
adam
protease
activity
substrate
xaa
Prior art date
Application number
BRPI0607059-0A
Other languages
English (en)
Inventor
Klaus-Ulrich Weithmann
Volker Jeske
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of BRPI0607059A2 publication Critical patent/BRPI0607059A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/105—Osteoarthritis, e.g. cartilage alteration, hypertrophy of bone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Rheumatology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

USO DE TIOPEPTOLìDEOS PARA DETERMINAR A ATIVIDADE DE PROTEASES ADAM-TS. A presente invenção refere-se ao uso de tiopeptolídeos da fórmula R-(Xaa)2 n2-Pro-X-GIy-S-Y-Z-GIy-(Xaa)2 m2-R2 12 (1) como substrato para determinar a atividade de proteases ADAMTS, e um método para encontrar um modulador de protease ADAMTS, mais particularmente, um inibidor.
BRPI0607059-0A 2005-02-09 2006-02-10 uso de tiopeptolìdeos para determinar a atividade de protease adam-ts BRPI0607059A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005005972A DE102005005972A1 (de) 2005-02-09 2005-02-09 Verwendung von Thiopeptoliden zur Aktivitätsbestimmung von ADAM-T8 Proteasen
PCT/EP2006/001184 WO2006092203A1 (de) 2005-02-09 2006-02-10 Verwendung von thiopeptoliden zur aktivitätsbestimmung von adam-ts proteasen

Publications (1)

Publication Number Publication Date
BRPI0607059A2 true BRPI0607059A2 (pt) 2009-08-04

Family

ID=36169124

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0607059-0A BRPI0607059A2 (pt) 2005-02-09 2006-02-10 uso de tiopeptolìdeos para determinar a atividade de protease adam-ts

Country Status (13)

Country Link
US (1) US20090149332A1 (pt)
EP (1) EP1851542B1 (pt)
JP (1) JP2008543273A (pt)
KR (1) KR20070120091A (pt)
CN (1) CN101115993A (pt)
AT (1) ATE464563T1 (pt)
AU (1) AU2006220096A1 (pt)
BR (1) BRPI0607059A2 (pt)
CA (1) CA2597862A1 (pt)
DE (2) DE102005005972A1 (pt)
IL (1) IL184769A0 (pt)
MX (1) MX2007009380A (pt)
WO (1) WO2006092203A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012522977A (ja) * 2009-04-01 2012-09-27 ガラパゴス・ナムローゼ・フェンノートシャップ 変形性関節症の治療のための方法及び手段
EP2471945A1 (de) * 2010-12-30 2012-07-04 Siemens Healthcare Diagnostics Products GmbH Verfahren zur Bestimmung von Inhibitoren der Gerinnung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4569907A (en) 1984-01-16 1986-02-11 Monsanto Company Thiopeptolide substrates for vertebrate collagenase
ATE196652T1 (de) 1996-01-18 2000-10-15 Aventis Pharma Gmbh In kunstlisches rekombinantes substrat ragg-1 und nativem aggrecan zum studium der proteolytischen wirkung von 'aggrecanase' in zellkultursystemen
US20020142362A1 (en) 2000-05-23 2002-10-03 Flick Rosemarie Beth Colorimetric assay system using thiopeptolide substrate for detection of membrane-type matrix metalloproteinase

Also Published As

Publication number Publication date
IL184769A0 (en) 2007-12-03
EP1851542A1 (de) 2007-11-07
DE102005005972A1 (de) 2006-08-17
CN101115993A (zh) 2008-01-30
WO2006092203A1 (de) 2006-09-08
DE502006006695D1 (de) 2010-05-27
CA2597862A1 (en) 2006-09-08
AU2006220096A1 (en) 2006-09-08
EP1851542B1 (de) 2010-04-14
KR20070120091A (ko) 2007-12-21
ATE464563T1 (de) 2010-04-15
US20090149332A1 (en) 2009-06-11
JP2008543273A (ja) 2008-12-04
MX2007009380A (es) 2007-08-16

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012.