BRPI0520563A2 - agonistas de receptores y4 seletivos para intervenções terapêuticas - Google Patents
agonistas de receptores y4 seletivos para intervenções terapêuticasInfo
- Publication number
- BRPI0520563A2 BRPI0520563A2 BRPI0520563-8A BRPI0520563A BRPI0520563A2 BR PI0520563 A2 BRPI0520563 A2 BR PI0520563A2 BR PI0520563 A BRPI0520563 A BR PI0520563A BR PI0520563 A2 BRPI0520563 A2 BR PI0520563A2
- Authority
- BR
- Brazil
- Prior art keywords
- selective
- receptor agonists
- therapeutic interventions
- receptor
- thr3o
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
AGONISTAS DE RECEPTORES Y4 SELETIVOS PARA INTERVENçõES TERAPêUTICAS. Peptídeo agonista de Y4 receptor selecionado entre o grupo consistindo de: [Ala3O]PP~ 2-36~, [Thr3O] PP~ 2-36~, Asn3O]PP~ 2-36~, [GIn3O]PP~ 2-36~, [Glul O]PP~ 2-36~, [Glu10, Leu17,Thr30]PP~ 2-36~, [Nle17,Nle3O]PP~ 2-36~, [GIu10,NIe17,NIe3O]PP~ 2-36~, seus PP~ 1-36~ equivalentes, e análogos e derivados dos mesmos conforme descrito na especificação, são agonistas seletivos do Y4 receptor em relação aos Y1 e Y2 receptores, e são úteis no tratamento, por exemplo, de obesidade e sobrepeso, e condições nas quais estes são considerados fatores contribuintes, e no tratamento da diarréia e de hipersecreção intestinal.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2005/010314 WO2007038942A1 (en) | 2005-09-21 | 2005-09-21 | Y4 selective receptor agonists for therapeutic interventions |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0520563A2 true BRPI0520563A2 (pt) | 2009-05-19 |
Family
ID=35976513
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0520563-8A BRPI0520563A2 (pt) | 2005-09-21 | 2005-09-21 | agonistas de receptores y4 seletivos para intervenções terapêuticas |
Country Status (11)
Country | Link |
---|---|
US (1) | US8022035B2 (pt) |
EP (1) | EP1934254A1 (pt) |
JP (1) | JP2009508885A (pt) |
CN (1) | CN101268099A (pt) |
AU (1) | AU2005337116A1 (pt) |
BR (1) | BRPI0520563A2 (pt) |
CA (1) | CA2623088A1 (pt) |
EA (1) | EA200800874A1 (pt) |
IL (1) | IL189938A0 (pt) |
NO (1) | NO20081908L (pt) |
WO (1) | WO2007038942A1 (pt) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100425282C (zh) * | 2004-03-17 | 2008-10-15 | 7Tm制药联合股份有限公司 | 用于治疗性干预的y2/y4选择性受体激动剂 |
JP2007531714A (ja) * | 2004-03-17 | 2007-11-08 | 7ティーエム ファーマ エイ/エス | 治療的介入のためのy2/y4選択性レセプターアゴニスト |
CA2623088A1 (en) | 2005-09-21 | 2007-04-12 | 7Tm Pharma A/S | Y4 selective receptor agonists for therapeutic interventions |
CN101268096A (zh) * | 2005-09-21 | 2008-09-17 | 7Tm制药联合股份有限公司 | 用于治疗性干预的y2选择性受体激动剂 |
BRPI0715160A2 (pt) | 2006-08-08 | 2013-06-11 | Sanofi Aventis | imidazolidina-2,4-dionas substituÍdas por arilamimoaril-alquil-, processo para preparÁ-las, medicamentos compeendendo estes compostos, e seu uso |
GB0708226D0 (en) * | 2007-04-27 | 2007-06-06 | 7Tm Pharma As | Y-receptor agonists |
CA2693392A1 (en) * | 2007-07-09 | 2009-01-15 | Imperial Innovations Limited | Novel compounds and their effects on feeding behaviour |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
EP2310372B1 (en) | 2008-07-09 | 2012-05-23 | Sanofi | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
GB0817067D0 (en) * | 2008-09-18 | 2008-10-22 | 7Tm Pharma As | Intestinal treatment |
WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
BR112012003973A2 (pt) | 2009-08-26 | 2015-09-08 | Sanofi Sa | hidratos de fluoroglicosídeo heteroaromático cristalinos, produtos farmacêuticos compreendendo estes compostos e seu uso |
WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US9278123B2 (en) | 2010-12-16 | 2016-03-08 | Novo Nordisk A/S | Solid compositions comprising a GLP-1 agonist and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid |
WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120053A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
HRP20231060T1 (hr) | 2012-03-22 | 2023-12-22 | Novo Nordisk A/S | Pripravci peptida glp-1 i njihova priprava |
CA2929672A1 (en) | 2013-11-15 | 2015-05-21 | Novo Nordisk A/S | Selective pyy compounds and uses thereof |
CN105764919B (zh) * | 2013-11-15 | 2021-04-27 | 诺和诺德股份有限公司 | 在位置35具有β-高精氨酸置换的hPYY(1-36) |
AR104984A1 (es) | 2015-06-12 | 2017-08-30 | Novo Nordisk As | Compuestos selectivos para pyy y sus usos |
ES2960687T3 (es) | 2018-02-02 | 2024-03-06 | Novo Nordisk As | Composiciones sólidas que comprenden un agonista del GLP-1 y una sal del ácido n-(8-(2-hidroxibenzoil)amino)caprílico y un lubricante |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992007935A1 (en) | 1990-11-01 | 1992-05-14 | The Scripps Research Institute | Glycosaminoglycan-targeted fusion proteins, their design, construction and compositions |
EP0692971A4 (en) * | 1993-03-29 | 1997-11-12 | Univ Cincinnati | PEPTIDE YY ANALOGS AND USES THEREOF |
US5516653A (en) * | 1993-12-28 | 1996-05-14 | Synaptic Pharmaceutical Corporation | DNA encoding a human neuropeptide Y/peptide YY/pancreatic polypeptide receptor (Y4) and uses thereof |
DE19605175A1 (de) * | 1996-02-13 | 1997-08-14 | Sourovoi Andrej Dr | Lipidverbindungen und deren Verwendung |
JP2001505872A (ja) | 1996-09-09 | 2001-05-08 | ジーランド ファーマシューティカルズ アクティーゼルスカブ | α―ヒドロキシ酸リンカーを含むペプチドプロドラッグ |
US5830434A (en) * | 1997-02-26 | 1998-11-03 | Medical University Of South Carolina Foundation For Research Development | Methods of treating non-insulin dependent diabetes mellitus with pancreatic polypeptide |
WO1999046283A1 (en) * | 1998-03-09 | 1999-09-16 | Zealand Pharmaceuticals A/S | Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis |
DE60140693D1 (en) | 2000-12-14 | 2010-01-14 | Amylin Pharmaceuticals Inc | Ankheiten |
US6588708B2 (en) * | 2001-01-29 | 2003-07-08 | The Boeing Company | Spacecraft methods and structures for acquiring and determining power-safe attitudes |
BR0212985A (pt) | 2001-09-24 | 2005-08-30 | Imp College Innovations Ltd | Uso de pyy ou de um agonista do mesmo na preparação de medicamentos para tratamento de distúrbios associados com excesso de peso |
US7229966B2 (en) * | 2002-12-17 | 2007-06-12 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity |
EP1689421A4 (en) | 2003-11-25 | 2009-06-24 | Bayer Healthcare Ag | SELECTIVE AGONISTS OF NEUROPEPTIDE Y2 RECEPTOR |
US8603969B2 (en) * | 2004-02-11 | 2013-12-10 | Amylin Pharmaceuticals, Llc | Pancreatic polypeptide family motifs and polypeptides comprising the same |
JP2007531714A (ja) * | 2004-03-17 | 2007-11-08 | 7ティーエム ファーマ エイ/エス | 治療的介入のためのy2/y4選択性レセプターアゴニスト |
CN100425282C (zh) * | 2004-03-17 | 2008-10-15 | 7Tm制药联合股份有限公司 | 用于治疗性干预的y2/y4选择性受体激动剂 |
CA2559838A1 (en) | 2004-03-17 | 2005-09-29 | 7Tm Pharma A/S | Y2 selective receptor agonists for therapeutic interventions |
DE602005025199D1 (en) * | 2004-03-17 | 2011-01-20 | 7Tm Pharma As | Y4-selektive rezeptoragonist für therapeutische interventionen |
CA2623088A1 (en) | 2005-09-21 | 2007-04-12 | 7Tm Pharma A/S | Y4 selective receptor agonists for therapeutic interventions |
CN101268096A (zh) * | 2005-09-21 | 2008-09-17 | 7Tm制药联合股份有限公司 | 用于治疗性干预的y2选择性受体激动剂 |
GB0708226D0 (en) | 2007-04-27 | 2007-06-06 | 7Tm Pharma As | Y-receptor agonists |
GB0817067D0 (en) | 2008-09-18 | 2008-10-22 | 7Tm Pharma As | Intestinal treatment |
-
2005
- 2005-09-21 CA CA002623088A patent/CA2623088A1/en not_active Abandoned
- 2005-09-21 BR BRPI0520563-8A patent/BRPI0520563A2/pt not_active IP Right Cessation
- 2005-09-21 CN CNA200580051632XA patent/CN101268099A/zh active Pending
- 2005-09-21 EA EA200800874A patent/EA200800874A1/ru unknown
- 2005-09-21 AU AU2005337116A patent/AU2005337116A1/en not_active Abandoned
- 2005-09-21 EP EP05787295A patent/EP1934254A1/en not_active Withdrawn
- 2005-09-21 JP JP2008531540A patent/JP2009508885A/ja not_active Ceased
- 2005-09-21 US US12/067,392 patent/US8022035B2/en not_active Expired - Fee Related
- 2005-09-21 WO PCT/EP2005/010314 patent/WO2007038942A1/en active Application Filing
-
2008
- 2008-03-04 IL IL189938A patent/IL189938A0/en unknown
- 2008-04-21 NO NO20081908A patent/NO20081908L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN101268099A (zh) | 2008-09-17 |
EP1934254A1 (en) | 2008-06-25 |
US20090118178A1 (en) | 2009-05-07 |
JP2009508885A (ja) | 2009-03-05 |
CA2623088A1 (en) | 2007-04-12 |
NO20081908L (no) | 2008-06-20 |
WO2007038942A1 (en) | 2007-04-12 |
IL189938A0 (en) | 2008-08-07 |
US8022035B2 (en) | 2011-09-20 |
AU2005337116A1 (en) | 2007-04-12 |
EA200800874A1 (ru) | 2008-08-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2168 DE 24/07/2012. |