BRPI0519330A2 - Ácido nuclÉico isolado; vetor; cÉlula hospedeira; mÉtodo para expressar uma proteÍna; polipeptÍdeo isolado; cromoproteÍna isolada; oligonucleotÍdeo; mÉtodo para identificar um Ácido nuclÉico que codifica uma apoproteÍna de um enediina de nove membros contendo cromoproteÍna; cultura biologicamente pura de actinomadura sp. 21g792 (nrrl 30778); mÉtodo para preparar uma cromoproteÍna; mÉtodo para preparar uma cromoproteÍna modificada; mÉtodo para inibir a progressço de uma doenÇa neoplÁsica em um mamÍfero; composiÇço farmacÊutica; e composto - Google Patents

Ácido nuclÉico isolado; vetor; cÉlula hospedeira; mÉtodo para expressar uma proteÍna; polipeptÍdeo isolado; cromoproteÍna isolada; oligonucleotÍdeo; mÉtodo para identificar um Ácido nuclÉico que codifica uma apoproteÍna de um enediina de nove membros contendo cromoproteÍna; cultura biologicamente pura de actinomadura sp. 21g792 (nrrl 30778); mÉtodo para preparar uma cromoproteÍna; mÉtodo para preparar uma cromoproteÍna modificada; mÉtodo para inibir a progressço de uma doenÇa neoplÁsica em um mamÍfero; composiÇço farmacÊutica; e composto

Info

Publication number
BRPI0519330A2
BRPI0519330A2 BRPI0519330-3A BRPI0519330A BRPI0519330A2 BR PI0519330 A2 BRPI0519330 A2 BR PI0519330A2 BR PI0519330 A BRPI0519330 A BR PI0519330A BR PI0519330 A2 BRPI0519330 A2 BR PI0519330A2
Authority
BR
Brazil
Prior art keywords
chromoprotein
isolated
nucleic acid
preparing
actinomadura
Prior art date
Application number
BRPI0519330-3A
Other languages
English (en)
Inventor
Bradley Haltli
Haiyin He
Ying Huang
Sridhar Krishna Rabindran
Jiang Wu
Min He
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0519330A2 publication Critical patent/BRPI0519330A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

ACIDO NUCLÉICO ISOLADO; VETOR; CÉLULA HOSPEDEIRA; MÉTODO PARA EXPRESSAR UMA PROTEÍNA; POLIPEPTÍDEO ISOLADO; CROMOPROTEÍNA ISOLADA; OLIGONUCLEOTÍDEO; MÉTODO PARA IDENTIFICAR UM ÁCIDO NUCLÉICO QUE CODIFICA UMA APOPROTEÍNA DE UM ENEDIINA DE NOVE MEMBROS CONTENDO CROMOPROTEÍNA; CULTURA BIOLOGICAMENTE PURA DE ACTINOMADURA SP. 21G792 (NRRL 30778); MÉTODO PARA PREPARAR UMA CROMOPROTEÍNA; MÉTODO PARA PREPARAR UMA CROMOPROTEÍNA MODIFICADA; MÉTODO PARA INIBIR A PROGRESSçO DE UMA DOENÇA NEOPLÁSICA EM UM MAMÍFERO; COMPOSIÇAO FARMACÊUTICA; E COMPOSTO. A presente invenção refere-se a uma cromoproteina produzida por Actinomadura sp. 21G792, bem como seqúências de aminoácidos e de ácidos nucléicos do componente de apoproteina da cromoproteina e de componentes da via biossintética para o cromáforo. A presente invenção é útil para desenvolver composições farmacêuticas e tratar doenças tais como câncer ou infecções bacterianas.
BRPI0519330-3A 2004-12-17 2005-12-16 Ácido nuclÉico isolado; vetor; cÉlula hospedeira; mÉtodo para expressar uma proteÍna; polipeptÍdeo isolado; cromoproteÍna isolada; oligonucleotÍdeo; mÉtodo para identificar um Ácido nuclÉico que codifica uma apoproteÍna de um enediina de nove membros contendo cromoproteÍna; cultura biologicamente pura de actinomadura sp. 21g792 (nrrl 30778); mÉtodo para preparar uma cromoproteÍna; mÉtodo para preparar uma cromoproteÍna modificada; mÉtodo para inibir a progressço de uma doenÇa neoplÁsica em um mamÍfero; composiÇço farmacÊutica; e composto BRPI0519330A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63739104P 2004-12-17 2004-12-17
PCT/US2005/045818 WO2006066153A2 (en) 2004-12-17 2005-12-16 Actinomadura chromoprotein, apoprotein, and gene cluster

Publications (1)

Publication Number Publication Date
BRPI0519330A2 true BRPI0519330A2 (pt) 2009-01-20

Family

ID=36588624

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0519330-3A BRPI0519330A2 (pt) 2004-12-17 2005-12-16 Ácido nuclÉico isolado; vetor; cÉlula hospedeira; mÉtodo para expressar uma proteÍna; polipeptÍdeo isolado; cromoproteÍna isolada; oligonucleotÍdeo; mÉtodo para identificar um Ácido nuclÉico que codifica uma apoproteÍna de um enediina de nove membros contendo cromoproteÍna; cultura biologicamente pura de actinomadura sp. 21g792 (nrrl 30778); mÉtodo para preparar uma cromoproteÍna; mÉtodo para preparar uma cromoproteÍna modificada; mÉtodo para inibir a progressço de uma doenÇa neoplÁsica em um mamÍfero; composiÇço farmacÊutica; e composto

Country Status (8)

Country Link
US (1) US20080274959A1 (pt)
EP (1) EP1836219A2 (pt)
JP (1) JP2008523817A (pt)
CN (1) CN101175767A (pt)
AU (1) AU2005316379A1 (pt)
BR (1) BRPI0519330A2 (pt)
CA (1) CA2587285A1 (pt)
WO (1) WO2006066153A2 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2008016269A (es) * 2006-06-21 2009-06-08 Wyeth Corp Fermentacion y purificacion de cromoproteinas actinomadura y especies relacionadas.
JP5387313B2 (ja) * 2009-10-08 2014-01-15 住友ベークライト株式会社 成形体の製造方法、成形体、眼鏡および防護製品
CN106916835B (zh) * 2015-12-24 2022-08-12 武汉合生科技有限公司 化合物的生物合成基因簇及其应用
CN106916834B (zh) * 2015-12-24 2022-08-05 武汉合生科技有限公司 化合物的生物合成基因簇及其应用
US20190127411A1 (en) 2016-04-06 2019-05-02 Croda International Plc Glycolipopeptide biosurfactants
US10975403B2 (en) 2017-08-09 2021-04-13 Conagen Inc. Biosynthesis of eriodictyol from engineered microbes
CN112359048B (zh) * 2020-08-27 2021-12-28 浙江大学 一种吕宋肽菌素c的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5053394A (en) * 1988-09-21 1991-10-01 American Cyanamid Company Targeted forms of methyltrithio antitumor agents
US6583266B1 (en) * 1993-08-19 2003-06-24 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to mycobacterium tuberculosis and leprae for diagnostics and therapeutics
US6599707B1 (en) * 1998-09-11 2003-07-29 Exsar Corporation Methods for identifying hot-spot residues of binding proteins and small compounds that bind to the same
JP2002045185A (ja) * 2000-08-02 2002-02-12 Kyowa Hakko Kogyo Co Ltd Ｆ０Ｆ１−ＡＴＰａｓｅおよび該酵素をコードするＤＮＡ
US7314974B2 (en) * 2002-02-21 2008-01-01 Monsanto Technology, Llc Expression of microbial proteins in plants for production of plants with improved properties

Also Published As

Publication number Publication date
CN101175767A (zh) 2008-05-07
WO2006066153A2 (en) 2006-06-22
AU2005316379A1 (en) 2006-06-22
US20080274959A1 (en) 2008-11-06
CA2587285A1 (en) 2006-06-22
EP1836219A2 (en) 2007-09-26
WO2006066153A8 (en) 2008-10-23
WO2006066153A3 (en) 2007-12-13
JP2008523817A (ja) 2008-07-10

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BRPI0519330A2 (pt) Ácido nuclÉico isolado; vetor; cÉlula hospedeira; mÉtodo para expressar uma proteÍna; polipeptÍdeo isolado; cromoproteÍna isolada; oligonucleotÍdeo; mÉtodo para identificar um Ácido nuclÉico que codifica uma apoproteÍna de um enediina de nove membros contendo cromoproteÍna; cultura biologicamente pura de actinomadura sp. 21g792 (nrrl 30778); mÉtodo para preparar uma cromoproteÍna; mÉtodo para preparar uma cromoproteÍna modificada; mÉtodo para inibir a progressço de uma doenÇa neoplÁsica em um mamÍfero; composiÇço farmacÊutica; e composto
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