BRPI0515811A - substituted indols, process for preparation and use thereof, medicament and pharmaceutical composition - Google Patents

substituted indols, process for preparation and use thereof, medicament and pharmaceutical composition

Info

Publication number
BRPI0515811A
BRPI0515811A BRPI0515811-7A BRPI0515811A BRPI0515811A BR PI0515811 A BRPI0515811 A BR PI0515811A BR PI0515811 A BRPI0515811 A BR PI0515811A BR PI0515811 A BRPI0515811 A BR PI0515811A
Authority
BR
Brazil
Prior art keywords
preparation
medicament
pharmaceutical composition
substituted
indols
Prior art date
Application number
BRPI0515811-7A
Other languages
Portuguese (pt)
Inventor
Frank Halley
Catherine Souaille
Michel Tabart
Eric Bacque
Fabrice Viviani
Jean-Philippe Letallec
Bruno Filoche-Romme
Baptiste Ronan
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0412966A external-priority patent/FR2878849B1/en
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of BRPI0515811A publication Critical patent/BRPI0515811A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B55/00—Racemisation; Complete or partial inversion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"INDóIS SUBSTITUìDOS, PROCESSO PARA PREPARAçãO, BEM COMO UTILIZAçãO DOS MESMOS, MEDICAMENTO E COMPOSIçãO FARMACêUTICA". A presente invenção refere-se notadamente ao preparo de indóis substituídos, das composições que os contêm, ao respectivo processo de preparo e à respectiva utilização como medicamento, em particular como agentes anticancerígenos."SUBSTITUTED INDOS, PROCESS FOR PREPARATION, AS WELL AS USE, MEDICINAL PRODUCT AND PHARMACEUTICAL COMPOSITION". The present invention relates notably to the preparation of substituted indoles, the compositions containing them, their preparation process and their use as a medicament, in particular as anticancer agents.

BRPI0515811-7A 2004-12-06 2005-12-02 substituted indols, process for preparation and use thereof, medicament and pharmaceutical composition BRPI0515811A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0412966A FR2878849B1 (en) 2004-12-06 2004-12-06 SUBSTITUTED INDOLES, COMPOSITIONS CONTAINING SAME, METHOD OF MANUFACTURE AND USE
US65046505P 2005-02-07 2005-02-07
PCT/FR2005/003003 WO2006061493A1 (en) 2004-12-06 2005-12-02 Substituted indoles, compositions containing them, method for the production thereof and their use

Publications (1)

Publication Number Publication Date
BRPI0515811A true BRPI0515811A (en) 2008-08-05

Family

ID=38792212

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515811-7A BRPI0515811A (en) 2004-12-06 2005-12-02 substituted indols, process for preparation and use thereof, medicament and pharmaceutical composition

Country Status (9)

Country Link
JP (1) JP2008532926A (en)
KR (1) KR20070100277A (en)
BR (1) BRPI0515811A (en)
CR (1) CR9115A (en)
EA (1) EA012613B1 (en)
IL (1) IL183438A0 (en)
MA (1) MA29026B1 (en)
MX (1) MX2007006764A (en)
NO (1) NO20073015L (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005037499A1 (en) * 2005-08-09 2007-02-15 Merck Patent Gmbh pyrazole
CN111574521A (en) * 2019-02-18 2020-08-25 深圳市塔吉瑞生物医药有限公司 Substituted aromatic fused ring derivatives, compositions and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6376529B1 (en) * 1995-06-07 2002-04-23 Peng Cho Tang Mono- and bis-indolylquinones and prophylactic and therapeutic uses thereof
WO1996040115A1 (en) * 1995-06-07 1996-12-19 Sugen, Inc. Method and compositions for inhibition of adaptor protein/tyrosine kinase interactions
CA2464214C (en) * 2001-10-22 2011-02-08 The Research Foundation Of State University Of New York Protein kinase and phosphatase inhibitors, methods for designing them, and methods of using them
CN100497334C (en) * 2002-06-24 2009-06-10 先灵公司 Indole derivatives useful as histamine h3 antagonists
FR2842526B1 (en) * 2002-07-16 2007-07-13 Aventis Pharma Sa PHARMACEUTICAL COMPOSITIONS COMPRISING A 3-GUANIDINOCARBONYL-1-HETEROARYL-INDOLE DERIVATIVE, PROCESS FOR THE PREPARATION AS MEDICAMENTS
JP2004149429A (en) * 2002-10-29 2004-05-27 Takeda Chem Ind Ltd Indole compound and application thereof

Also Published As

Publication number Publication date
JP2008532926A (en) 2008-08-21
MA29026B1 (en) 2007-11-01
NO20073015L (en) 2007-08-28
IL183438A0 (en) 2007-09-20
EA012613B1 (en) 2009-10-30
MX2007006764A (en) 2007-08-15
KR20070100277A (en) 2007-10-10
EA200701227A1 (en) 2007-10-26
CR9115A (en) 2007-10-23

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012.