BRPI0512256A - método para caracterizar o estágio de desenvolvimento ou patologia de uma amostra de tecido; método de identificação de uma célula de interesse ou de sincìcios multe-nuclear de interesse; método para diagnóstico de pré-neoplasia ou neoplasia; métodos de identificação de um ou mais agentes anti-tumorìgenos e método de preparação de uma amostra de tecido de mamìfero adequada para a identificação de células - Google Patents

método para caracterizar o estágio de desenvolvimento ou patologia de uma amostra de tecido; método de identificação de uma célula de interesse ou de sincìcios multe-nuclear de interesse; método para diagnóstico de pré-neoplasia ou neoplasia; métodos de identificação de um ou mais agentes anti-tumorìgenos e método de preparação de uma amostra de tecido de mamìfero adequada para a identificação de células

Info

Publication number
BRPI0512256A
BRPI0512256A BRPI0512256-2A BRPI0512256A BRPI0512256A BR PI0512256 A BRPI0512256 A BR PI0512256A BR PI0512256 A BRPI0512256 A BR PI0512256A BR PI0512256 A BRPI0512256 A BR PI0512256A
Authority
BR
Brazil
Prior art keywords
interest
neoplasia
identifying
tissue sample
cell
Prior art date
Application number
BRPI0512256-2A
Other languages
English (en)
Inventor
Elena V Gostjeva
William G Thilly
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Publication of BRPI0512256A publication Critical patent/BRPI0512256A/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G01N33/5017—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity for testing neoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5026—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell morphology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

MéTODO PARA CARACTERIZAR O ESTáGIO DE DESENVOLVIMENTO OU PATOLOGIA DE UMA AMOSTRA DE TECIDO; MéTODO DE IDENTIFICAçãO DE UMA CéLULA DE INTERESSE OU DE SINCìCIOS MULTE-NUCLEAR DE INTERESSE; MéTODO PARA DIAGNóSTICO DE PRé-NEOPLASIA OU NEOPLASIA MéTODOS DE IDENTIFICAçãO DE UM OU MAIS AGENTES ANTI-TUMORìGENOS E MéTODO DE PREPARAçãO DE UMA AMOSTRA DE TECIDO DE MAMìFERO ADEQUADA PARA A IDENTIFICAçãO DE CéLULAS Trata-se da descrição de métodos para identificação de células tronco e outras células específicas para embriogênese e carcinogênese, classificando amostras de tecido, diagnosticando lesões pré-cancerosas e cancerosas ou arteriosclerose, testando o valor de agentes contra o câncer, descobrindo macromoléculas especificamente expressas em tipos de célula específicos, usando células tronco na terapia restauradora de tecido, bem como métodos para preparação de amostras de tecidos de modo que os tipos morfológicos nucleares heteromórficos permaneçam intactos.
BRPI0512256-2A 2004-06-17 2005-06-17 método para caracterizar o estágio de desenvolvimento ou patologia de uma amostra de tecido; método de identificação de uma célula de interesse ou de sincìcios multe-nuclear de interesse; método para diagnóstico de pré-neoplasia ou neoplasia; métodos de identificação de um ou mais agentes anti-tumorìgenos e método de preparação de uma amostra de tecido de mamìfero adequada para a identificação de células BRPI0512256A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58057504P 2004-06-17 2004-06-17
PCT/US2005/021504 WO2006009860A2 (en) 2004-06-17 2005-06-17 Methods for identifying stem cells based on nuclear morphotypes

Publications (1)

Publication Number Publication Date
BRPI0512256A true BRPI0512256A (pt) 2008-02-19

Family

ID=35735073

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512256-2A BRPI0512256A (pt) 2004-06-17 2005-06-17 método para caracterizar o estágio de desenvolvimento ou patologia de uma amostra de tecido; método de identificação de uma célula de interesse ou de sincìcios multe-nuclear de interesse; método para diagnóstico de pré-neoplasia ou neoplasia; métodos de identificação de um ou mais agentes anti-tumorìgenos e método de preparação de uma amostra de tecido de mamìfero adequada para a identificação de células

Country Status (12)

Country Link
US (5) US7427502B2 (pt)
EP (1) EP1774325B1 (pt)
JP (1) JP5130042B2 (pt)
KR (1) KR101209833B1 (pt)
CN (1) CN101006342B (pt)
AU (1) AU2005265122A1 (pt)
BR (1) BRPI0512256A (pt)
CA (1) CA2570422A1 (pt)
IL (1) IL179972A (pt)
RU (1) RU2007101496A (pt)
WO (1) WO2006009860A2 (pt)
ZA (1) ZA200610596B (pt)

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* Cited by examiner, † Cited by third party
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CA2570422A1 (en) 2004-06-17 2006-01-26 Massachusetts Institute Of Technology Methods for identifying stem cells based on nuclear morphotypes
US8070312B2 (en) * 2004-08-02 2011-12-06 Orion Energy Systems, Inc. Fluorescent light fixture with lamp catcher
EP1963490A2 (en) * 2005-12-09 2008-09-03 Massachussets Institute of Technology Methods for identifying and targeting tumor stem cells based on nuclear morphology
WO2008115517A2 (en) * 2007-03-19 2008-09-25 Massachusetts Institute Of Technology Methods for identifying stem cells by detecting autofluorescence of cells and syncytia
US20100284905A1 (en) * 2007-06-13 2010-11-11 Massachusetts Institute of Tehnology Methods and Agents for Inhibiting Tumor Growth by Targeting the SSDNA Replication Intermediate of Tumor Stem Cells
US8940500B2 (en) 2008-09-24 2015-01-27 Massachusetts Institute Of Technology Methods for identifying stem cells by detecting fluorescence of cells and syncytia
EP2423661A1 (de) * 2010-08-30 2012-02-29 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH Vorrichtung und Verfahren zum automatisierten Isolieren und Transferieren mindestens einer mikroskopischen Probe von einem Probenträger zu einem Auffangsystem
EP2633323A1 (en) 2010-10-25 2013-09-04 Massachusetts Institute Of Technology Wound healing metakaryotic stem cells and methods of use thereof
CN103688175B (zh) * 2011-03-24 2015-09-09 罗戈辛研究院 用于筛选选择性降低癌干细胞数量的化合物的测定法
CA2837546A1 (en) 2011-06-02 2012-12-06 Tufts University Dsrna/dna hybrid genome replication intermediate of metakaryotic stem cells
US9006515B2 (en) 2012-01-06 2015-04-14 Pioneer Hi Bred International Inc Pollen preferred promoters and methods of use
CN102589943B (zh) * 2012-02-08 2013-09-11 河南省农业科学院 花生根尖细胞染色体有丝分裂中期的制片方法
WO2015142865A2 (en) 2014-03-17 2015-09-24 Massachusetts Institute Of Technology Metakaryocidal treatments
US20170081698A1 (en) 2014-03-17 2017-03-23 Massachusetts Institute Of Technology Survival assays for metakaryotic stem cells
CN107072716A (zh) 2014-05-30 2017-08-18 托德.F.奥沃凯蒂斯 用于产生和使用活化的干细胞的方法和系统
US10202598B2 (en) 2014-05-30 2019-02-12 Todd Frank Ovokaitys Methods and systems for generation, use, and delivery of activated stem cells
US10040728B2 (en) 2014-06-06 2018-08-07 Todd Frank Ovokaitys Methods and compositions for increasing the bioactivity of nutrients
US10384985B2 (en) 2014-06-06 2019-08-20 B.K. Consultants, Inc. Methods and compositions for increasing the yield of, and beneficial chemical composition of, certain plants
CN112434554B (zh) * 2020-10-16 2023-08-04 中科院成都信息技术股份有限公司 一种基于异质化缩减的云状图像识别方法及系统
CN113865951A (zh) * 2021-08-19 2021-12-31 贵州大学 一种马尾松愈伤组织染色体制片方法

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US5784162A (en) * 1993-08-18 1998-07-21 Applied Spectral Imaging Ltd. Spectral bio-imaging methods for biological research, medical diagnostics and therapy
CA2093037A1 (en) * 1992-04-01 1993-10-02 Masaru Fukuda Method of detecting injured nuclear dna
US7361336B1 (en) * 1997-09-18 2008-04-22 Ivan Bergstein Methods of cancer therapy targeted against a cancer stem line
US6091984A (en) * 1997-10-10 2000-07-18 Massachusetts Institute Of Technology Measuring tissue morphology
US6984522B2 (en) * 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
WO2004018648A2 (en) * 2002-08-26 2004-03-04 Case Western Reserve University Methods for treating patients and identifying therapeutics
WO2005097147A1 (en) 2004-03-30 2005-10-20 Boston Scientific Limited (Incorporated In Ireland) Restenosis therapy using mesenchymal stem cells
CA2570422A1 (en) * 2004-06-17 2006-01-26 Massachusetts Institute Of Technology Methods for identifying stem cells based on nuclear morphotypes
EP1963490A2 (en) 2005-12-09 2008-09-03 Massachussets Institute of Technology Methods for identifying and targeting tumor stem cells based on nuclear morphology
WO2008115517A2 (en) 2007-03-19 2008-09-25 Massachusetts Institute Of Technology Methods for identifying stem cells by detecting autofluorescence of cells and syncytia
US20100284905A1 (en) * 2007-06-13 2010-11-11 Massachusetts Institute of Tehnology Methods and Agents for Inhibiting Tumor Growth by Targeting the SSDNA Replication Intermediate of Tumor Stem Cells
US8940500B2 (en) * 2008-09-24 2015-01-27 Massachusetts Institute Of Technology Methods for identifying stem cells by detecting fluorescence of cells and syncytia

Also Published As

Publication number Publication date
US20140154672A1 (en) 2014-06-05
EP1774325B1 (en) 2016-02-24
IL179972A0 (en) 2007-05-15
AU2005265122A1 (en) 2006-01-26
US7427502B2 (en) 2008-09-23
US20090098562A1 (en) 2009-04-16
WO2006009860A3 (en) 2006-08-10
KR101209833B1 (ko) 2012-12-07
JP5130042B2 (ja) 2013-01-30
WO2006009860A2 (en) 2006-01-26
JP2008503726A (ja) 2008-02-07
ZA200610596B (en) 2009-04-29
US20090081720A1 (en) 2009-03-26
CA2570422A1 (en) 2006-01-26
IL179972A (en) 2011-09-27
CN101006342B (zh) 2014-10-29
KR20070040372A (ko) 2007-04-16
US20160024577A1 (en) 2016-01-28
US7977092B2 (en) 2011-07-12
US20060063144A1 (en) 2006-03-23
CN101006342A (zh) 2007-07-25
RU2007101496A (ru) 2008-07-27
EP1774325A2 (en) 2007-04-18
US8465943B2 (en) 2013-06-18

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