BRPI0511624A - antibodies and related molecules that bind to psca proteins - Google Patents
antibodies and related molecules that bind to psca proteinsInfo
- Publication number
- BRPI0511624A BRPI0511624A BRPI0511624-4A BRPI0511624A BRPI0511624A BR PI0511624 A BRPI0511624 A BR PI0511624A BR PI0511624 A BRPI0511624 A BR PI0511624A BR PI0511624 A BRPI0511624 A BR PI0511624A
- Authority
- BR
- Brazil
- Prior art keywords
- psca
- antibodies
- bind
- related molecules
- variants
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 abstract 5
- 102100036735 Prostate stem cell antigen Human genes 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 230000008105 immune reaction Effects 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Abstract
ANTICORPOS E MOLéCULAS RELACIONADAS QUE SE LIGAM à PROTEìNAS DE PSCA. A presente invenção refere-se a anticorpos e moléculas derivados dos mesmos que ligam a nova proteína de PSCA, e variantes das mesmas, em que PSCA apresenta expressão tecido específica em tecido adulto normal, e é expressado de modo aberrante nos cânceres listados na Tabela 1. Conseqüentemente, PSCA proporciona um alvo diagnóstico, prognóstico, profilático e/ou terapêutico para câncer. O gene PSCA ou fragmento do mesmo, ou sua proteína codificada, ou variantes da mesma, ou um framento da mesma, podem ser usados para provocar uma reação imune humoral ou celular; anticorpos ou células T reativas com PSCA podem ser usados em imunização ativa ou passiva.Antibodies and related molecules that bind to PSCA PROTEINS. The present invention relates to antibodies and molecules derived therefrom which bind the novel PSCA protein, and variants thereof, wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table 1. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and / or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, may be used to elicit a humoral or cellular immune reaction; PSCA-reactive antibodies or T cells can be used for active or passive immunization.
Applications Claiming Priority (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/857,484 US7622564B2 (en) | 2003-05-30 | 2004-05-28 | Prostate stem cell antigen (PSCA) variants and subsequences thereof |
PCT/US2004/017231 WO2005014780A2 (en) | 2003-05-30 | 2004-05-28 | Prostate stem cell antigen (psca) variants and subsequences thereof |
US61638104P | 2004-10-05 | 2004-10-05 | |
US60/616,381 | 2004-10-05 | ||
US61788104P | 2004-10-12 | 2004-10-12 | |
US60/617,881 | 2004-10-12 | ||
US62131004P | 2004-10-21 | 2004-10-21 | |
US60/621,310 | 2004-10-21 | ||
US63307704P | 2004-12-02 | 2004-12-02 | |
US60/633,077 | 2004-12-02 | ||
US67200005P | 2005-04-14 | 2005-04-14 | |
US60/672,000 | 2005-04-14 | ||
PCT/US2005/017412 WO2005118864A2 (en) | 2004-05-28 | 2005-05-17 | Antibodies and related molecules that bind to psca proteins |
Publications (2)
Publication Number | Publication Date |
---|---|
BRPI0511624A true BRPI0511624A (en) | 2008-01-02 |
BRPI0511624B1 BRPI0511624B1 (en) | 2022-02-08 |
Family
ID=44210117
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0511624-4A BRPI0511624B1 (en) | 2004-05-28 | 2005-05-17 | MONOCLONAL ANTIBODY THAT BINDS TO PSCA PROTEIN, USE OF IT, HYBRIDOMA, VECTOR, PHARMACEUTICAL COMPOSITION, AS WELL AS ASSAY AND METHOD FOR DETECTION OF THE PRESENCE OF A PSCA PROTEIN IN A BIOLOGICAL SAMPLE |
BR122018073034-0A BR122018073034B1 (en) | 2004-05-28 | 2005-05-17 | ANTIBODIES AND RELATED MOLECULES THAT BIND TO PSCA PROTEINS |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR122018073034-0A BR122018073034B1 (en) | 2004-05-28 | 2005-05-17 | ANTIBODIES AND RELATED MOLECULES THAT BIND TO PSCA PROTEINS |
Country Status (6)
Country | Link |
---|---|
KR (2) | KR101282396B1 (en) |
CN (1) | CN102344493B (en) |
BR (2) | BRPI0511624B1 (en) |
IL (1) | IL214210A (en) |
NO (1) | NO341404B1 (en) |
SI (1) | SI1753871T1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008117067A2 (en) | 2007-03-27 | 2008-10-02 | Carl Arne Krister Borrebaeck | Protein signature/markers for the detection of adenocarcinoma |
SG10201701424QA (en) * | 2012-08-23 | 2017-04-27 | Agensys Inc | Antibody drug conjugates (adc) that bind to 158p1d7 proteins |
KR20210088741A (en) * | 2012-12-13 | 2021-07-14 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | Dna antibody constructs and method of using same |
GB201319878D0 (en) * | 2013-11-11 | 2013-12-25 | Immunovia Ab | Method, Array and use thereof |
CN105829341A (en) | 2013-12-13 | 2016-08-03 | 宾夕法尼亚大学理事会 | DNA antibody constructs and method of using same |
CN107427566B (en) | 2014-12-01 | 2021-08-17 | 宾夕法尼亚大学理事会 | DNA antibody constructs and methods of use thereof |
GB202010970D0 (en) | 2020-07-16 | 2020-09-02 | Immunovia Ab | Methods, arrays and uses thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6541212B2 (en) * | 1997-03-10 | 2003-04-01 | The Regents Of The University Of California | Methods for detecting prostate stem cell antigen protein |
US6258939B1 (en) * | 1997-03-10 | 2001-07-10 | The Regents Of The University Of California | PSCA antibodies and hybridomas producing them |
NZ337413A (en) * | 1997-03-10 | 2003-02-28 | Univ California | Antibodies that bind to Prostate Stem Cell Antigen (PSCA) to treat prostate cancer. |
IL149116A0 (en) * | 1999-10-29 | 2002-11-10 | Genentech Inc | Anti-prostate stem cell antigen (psca) antibody compositions and methods of use |
-
2005
- 2005-05-17 BR BRPI0511624-4A patent/BRPI0511624B1/en active IP Right Grant
- 2005-05-17 CN CN201110118165.5A patent/CN102344493B/en active Active
- 2005-05-17 SI SI200532000T patent/SI1753871T1/en unknown
- 2005-05-17 KR KR1020117010832A patent/KR101282396B1/en active IP Right Grant
- 2005-05-17 BR BR122018073034-0A patent/BR122018073034B1/en active IP Right Grant
-
2006
- 2006-12-28 KR KR1020067027763A patent/KR101215611B1/en active IP Right Grant
-
2011
- 2011-04-29 NO NO20110647A patent/NO341404B1/en unknown
- 2011-07-20 IL IL214210A patent/IL214210A/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
CN102344493A (en) | 2012-02-08 |
KR101282396B1 (en) | 2013-07-04 |
SI1753871T1 (en) | 2016-01-29 |
NO20110647L (en) | 2006-12-19 |
KR101215611B1 (en) | 2012-12-28 |
IL214210A (en) | 2013-01-31 |
BR122018073034B1 (en) | 2021-10-13 |
NO341404B1 (en) | 2017-10-30 |
KR20070047251A (en) | 2007-05-04 |
BR122018073034B8 (en) | 2022-10-11 |
KR20110056564A (en) | 2011-05-30 |
BRPI0511624B1 (en) | 2022-02-08 |
CN102344493B (en) | 2014-09-03 |
IL214210A0 (en) | 2011-08-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001 |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/05/2005, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO. |