BRPI0506865A - unusual imidazole-based hmg-coa reductase inhibitors - Google Patents
unusual imidazole-based hmg-coa reductase inhibitorsInfo
- Publication number
- BRPI0506865A BRPI0506865A BRPI0506865-7A BRPI0506865A BRPI0506865A BR PI0506865 A BRPI0506865 A BR PI0506865A BR PI0506865 A BRPI0506865 A BR PI0506865A BR PI0506865 A BRPI0506865 A BR PI0506865A
- Authority
- BR
- Brazil
- Prior art keywords
- coa reductase
- reductase inhibitors
- unusual
- imidazole
- hmg
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
INIBIDORES DE HMG-COA REDUTASE INUSITADOS, BASEADOS EM IMIDAZóIS A presente invenção fornece compostos inibidores de HMG CO-A redutase, úteis como agentes hipocolesterolêmicos e hipolipidêmicos. são fornecidas também composições farmacêuticas dos compostos. Métodos para fabricar e métodos para usar os compostos também são fornecidos.UNUSED, IMMIDAZOLE BASED HMG-COA REDUCTASE INHIBITORS The present invention provides HMG CO-A reductase inhibitor compounds useful as hypocholesterolemic and hypolipidemic agents. Also provided are pharmaceutical compositions of the compounds. Methods for manufacturing and methods for using the compounds are also provided.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53752504P | 2004-01-20 | 2004-01-20 | |
US62905804P | 2004-11-18 | 2004-11-18 | |
PCT/IB2005/000030 WO2005079790A1 (en) | 2004-01-20 | 2005-01-10 | Imidazole-based hmg-coa reductase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0506865A true BRPI0506865A (en) | 2007-05-29 |
Family
ID=34890439
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0506865-7A BRPI0506865A (en) | 2004-01-20 | 2005-01-10 | unusual imidazole-based hmg-coa reductase inhibitors |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1727541A1 (en) |
JP (1) | JP2007518787A (en) |
BR (1) | BRPI0506865A (en) |
CA (1) | CA2548218A1 (en) |
MX (1) | MXPA06006396A (en) |
WO (1) | WO2005079790A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0427491D0 (en) * | 2004-12-16 | 2005-01-19 | Avecia Ltd | Process and compounds |
WO2007051065A2 (en) * | 2005-10-28 | 2007-05-03 | Numerate, Inc. | Compositions and treatments for inhibiting kinase and/or hmg-coa reductase |
WO2008022281A1 (en) | 2006-08-16 | 2008-02-21 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Small molecule inhibitors of kynurenine-3-monooxygenase |
WO2008022286A2 (en) | 2006-08-16 | 2008-02-21 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Small molecule inhibitors of kynurenine-3-monooxygenase |
US8877221B2 (en) | 2010-10-27 | 2014-11-04 | Warsaw Orthopedic, Inc. | Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same |
US9107983B2 (en) | 2010-10-27 | 2015-08-18 | Warsaw Orthopedic, Inc. | Osteoconductive matrices comprising statins |
WO2012170417A2 (en) | 2011-06-06 | 2012-12-13 | Warsaw Orthopedic, Inc. | Methods and compositions to enhance bone growth comprising a statin |
USD721807S1 (en) | 2011-09-08 | 2015-01-27 | Ams Research Corporation | Surgical indicators |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4808607A (en) * | 1985-05-22 | 1989-02-28 | Sandoz Pharm. Corp. | Imidazole analogs of mevalonolactone and derivatives thereof for use in inhibiting cholesterol biosynthesis and lowering blood cholesterol level |
DE3817808A1 (en) * | 1987-07-21 | 1989-02-02 | Bayer Ag | METHOD FOR PRODUCING 2-SUBSTITUTED PYRROL |
DE3739882A1 (en) * | 1987-11-25 | 1989-06-08 | Bayer Ag | SUBSTITUTED HYDROXYLAMINE |
-
2005
- 2005-01-10 BR BRPI0506865-7A patent/BRPI0506865A/en not_active IP Right Cessation
- 2005-01-10 MX MXPA06006396A patent/MXPA06006396A/en unknown
- 2005-01-10 JP JP2006550325A patent/JP2007518787A/en not_active Withdrawn
- 2005-01-10 CA CA002548218A patent/CA2548218A1/en not_active Abandoned
- 2005-01-10 EP EP05702201A patent/EP1727541A1/en not_active Withdrawn
- 2005-01-10 WO PCT/IB2005/000030 patent/WO2005079790A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2548218A1 (en) | 2005-09-01 |
EP1727541A1 (en) | 2006-12-06 |
JP2007518787A (en) | 2007-07-12 |
MXPA06006396A (en) | 2006-08-23 |
WO2005079790A1 (en) | 2005-09-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0506865A (en) | unusual imidazole-based hmg-coa reductase inhibitors | |
BRPI0413468A (en) | pyrrol-based hmg-coa reductase inhibitors | |
BRPI0509184A (en) | pharmaceutical compositions | |
TW200634018A (en) | Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and uses | |
DK1578733T3 (en) | Process for the preparation of rosuvastatin | |
DK1942898T4 (en) | Dipeptidyl peptidase inhibitors for the treatment of diabetes | |
BRPI0509926A (en) | imidazoles | |
WO2005087724A3 (en) | Sulphonylpyrroles as hdac inhibitors | |
WO2008002676A3 (en) | Biaryl compositions and methods for modulating a kinase cascade | |
WO2007103366A3 (en) | Hmg co-a reductase inhibitor enhancement of bone and cartilage | |
TW200722427A (en) | Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods | |
EA200500201A1 (en) | A NEW METHOD OF SYNTHESIS (7-METHOXY-1-NAFTYL) ACETONITRILE AND ITS APPLICATION IN THE SYNTHESIS OF AGOMELATINE | |
BRPI0713031B8 (en) | dihydro-pyran-2-one compound, pharmaceutical composition, and use thereof | |
TW200738649A (en) | Calcilytic compounds | |
EA200801413A1 (en) | HETEROCYCLIC CETR INHIBITORS | |
DE602007005372D1 (en) | TWO-TABLE TABLET FOR PREVENTING CARDIOVASCULAR EVENTS | |
EA200500202A1 (en) | NEW METHOD OF SYNTHESIS (7-METHOXY-3,4-DIHYDRO-1-NAPHTHALINIL) ACETONITRILE AND ITS APPLICATION IN THE SYNTHESIS OF AGOMELATIN | |
TW200724688A (en) | Process for producing atorvastatin, pharmaceutically acceptable salts thereof and intermediates thereof | |
ATE544769T1 (en) | 2-(SUBSTITUTED AMINO)-BENZOTHIAZOLESULFONAMIDE COMPOUNDS AS HIV PROTEASE INHIBITORS | |
BRPI0507859A (en) | use of cholinesterase inhibitors | |
ATE496025T1 (en) | MAGNESIUM SALTS OF HMG-COA REDUCTASE INHIBITORS | |
CR9521A (en) | NEW METHOD OF TREATMENT OF HYPERLIPEDEMIA | |
CY1111768T1 (en) | New Triglyceride Reduction Factor | |
SI2341054T1 (en) | Process for the synthesis of HMG-CoA reductase inhibitors | |
UY28653A1 (en) | N-RENT PIRROLES AS INHIBITORS OF HMG-COA REDUCTASA |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application fees: dismissal - article 86 of industrial property law |
Free format text: REFERENTE A 4A,5AE 6A ANUIDADES |
|
B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2099 DE 29/03/2011. |