BRPI0506698A - método cromatográfico para a análise tanto no processo quanto no sevoflurano acabado - Google Patents

método cromatográfico para a análise tanto no processo quanto no sevoflurano acabado

Info

Publication number
BRPI0506698A
BRPI0506698A BRPI0506698-0A BRPI0506698A BRPI0506698A BR PI0506698 A BRPI0506698 A BR PI0506698A BR PI0506698 A BRPI0506698 A BR PI0506698A BR PI0506698 A BRPI0506698 A BR PI0506698A
Authority
BR
Brazil
Prior art keywords
sevoflurane
crude
chromatographic column
crude sevoflurane
finished
Prior art date
Application number
BRPI0506698-0A
Other languages
English (en)
Inventor
Barry Jones
Ashot Khrimian
Joel Swinson
Paul Cross
Original Assignee
Halocarbon Prod Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Halocarbon Prod Corp filed Critical Halocarbon Prod Corp
Publication of BRPI0506698A publication Critical patent/BRPI0506698A/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/34—Separation; Purification; Stabilisation; Use of additives
    • C07C41/38—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/285—Porous sorbents based on polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/34—Separation; Purification; Stabilisation; Use of additives
    • C07C41/40—Separation; Purification; Stabilisation; Use of additives by change of physical state, e.g. by crystallisation
    • C07C41/42—Separation; Purification; Stabilisation; Use of additives by change of physical state, e.g. by crystallisation by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/12—Saturated ethers containing halogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/025—Gas chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/884—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/884—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds
    • G01N2030/8845—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds involving halogenated organic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

MéTODO CROMATOGRáFICO PARA A ANáLISE TANTO NO PROCESO QUANTO NO SEVOFLURANO ACABADO. Um método em que a substância orgânica encontrada em um sevoflurano bruto pode ser separada, identificada e quantificada com o uso de uma coluna cromatográfica gasosa capilar de CARBOWAX<3> (polietileno glicol) ou uma coluna cromatográfica gasosa capilar de polissiloxano alquílico. é igualmente fornecido um método de controle do processo para a produção de sevoflurano, em que o conteúdo de um componente particular em uma das seguintes etapas seja determinado, e em que, admitindo-se este como uma variável, a condição de tratamento da etapa seja ajustada: 1) uma etapa de extração, ou resfriamento, para formar duas camadas, e/ou de destilação de uma mistura de sevoflurano bruto e fluoreto de hidrogênio (HF) de modo a isolar a maior parte do sevoflurano e 2) uma etapa opcional de purificar o sevoflurano bruto e 3) uma etapa de destilar sevoflurano bruto. é igualmente fornecido um método para determinar o nível de impurezas de um sevoflurano purificado, que seja aceitável para uso em anestesia humana/animal.
BRPI0506698-0A 2004-01-05 2005-01-04 método cromatográfico para a análise tanto no processo quanto no sevoflurano acabado BRPI0506698A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53434004P 2004-01-05 2004-01-05
PCT/US2005/000062 WO2005068997A1 (en) 2004-01-05 2005-01-04 Chromatographic method for the analysis of both in process and finished sevoflurane

Publications (1)

Publication Number Publication Date
BRPI0506698A true BRPI0506698A (pt) 2007-05-02

Family

ID=34794271

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0506698-0A BRPI0506698A (pt) 2004-01-05 2005-01-04 método cromatográfico para a análise tanto no processo quanto no sevoflurano acabado

Country Status (10)

Country Link
US (1) US7230143B2 (pt)
EP (1) EP1704411A4 (pt)
JP (1) JP2007518078A (pt)
KR (1) KR20060132685A (pt)
CN (1) CN1914506A (pt)
BR (1) BRPI0506698A (pt)
CA (1) CA2552617A1 (pt)
CZ (1) CZ2006444A3 (pt)
PL (1) PL380525A1 (pt)
WO (1) WO2005068997A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7732647B2 (en) * 2007-12-27 2010-06-08 Halocarbon Products Corporation Process for the purification of fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane)
KR100977991B1 (ko) * 2009-12-17 2010-08-25 테크노세미켐 주식회사 염화티타늄의 분석 방법
US9102604B1 (en) 2010-02-15 2015-08-11 Baxter International Inc. Methods for cleaning distilling columns
CN104198607B (zh) * 2010-12-16 2015-09-09 宜昌人福药业有限责任公司 一种色谱法测定样品中挥发性麻醉药浓度的方法
US8729313B2 (en) 2011-08-15 2014-05-20 Baxter International Inc. Process for the manufacturing of sevoflurane
JP6299905B1 (ja) * 2017-02-06 2018-03-28 セントラル硝子株式会社 セボフルランの製造方法
CN116908334B (zh) * 2023-07-27 2024-01-16 河北一品生物医药有限公司 一种七氟烷或其吸入制剂中有关物质的检测方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3689571A (en) 1970-07-31 1972-09-05 Baxter Laboratories Inc Fluorinated ether
US4966785A (en) * 1989-07-03 1990-10-30 Associated Universities, Inc. Method for making a non-extractable stationary phase of polymer within a capillary column
US5262052A (en) * 1992-03-09 1993-11-16 Brigham Young University Polysiloxanes containing pendant cyano substituted biphenyls as stationary phases for chromatographic columns
US5391579A (en) 1993-01-28 1995-02-21 University Of Iowa Research Foundation Deuterated sevoflurane as an inhalational anesthetic
US5492111A (en) 1993-01-28 1996-02-20 University Of Iowa Research Foundation Method of elimination of volatile degradation products of sevoflurane during anesthesia
JP2865554B2 (ja) * 1994-04-08 1999-03-08 セントラル硝子株式会社 フルオロメチル−１，１，１，３，３，３−ヘキサフルオロイソプロピルエーテルのガスクロマトグラフ分析
US5969193A (en) 1997-08-18 1999-10-19 Medeva Pharmaceuticals Pa, Inc. Method for the preparation of sevoflurane
US6469219B1 (en) * 2000-03-16 2002-10-22 Halocarbon Products Corporation Production of fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether

Also Published As

Publication number Publication date
CA2552617A1 (en) 2005-07-28
WO2005068997A1 (en) 2005-07-28
CN1914506A (zh) 2007-02-14
US20050234268A1 (en) 2005-10-20
PL380525A1 (pl) 2007-02-19
KR20060132685A (ko) 2006-12-21
EP1704411A4 (en) 2007-11-14
EP1704411A1 (en) 2006-09-27
JP2007518078A (ja) 2007-07-05
US7230143B2 (en) 2007-06-12
CZ2006444A3 (cs) 2007-02-07

Similar Documents

Publication Publication Date Title
BRPI0508378A (pt) processo para a separação de acetaldeìdo de iodeto de metila e processo para a produção de ácido acético
BR112012019032A2 (pt) &#34;processo para purificação de etanol&#34;
BR0110721A (pt) Processo para tratar uma fração c4, e, dispositivo para realizar o mesmo
DE60237225D1 (de) Verfahren zur herstellung einer zusammensetzung enthaltend mindenstens ein dehydratisierungsprodukt eines hydrogenisierten zuckers
BRPI0506698A (pt) método cromatográfico para a análise tanto no processo quanto no sevoflurano acabado
EA200702376A1 (ru) Устройства и способы для абсорбции кислых газов и регенерации растворителя
BRPI0906015A2 (pt) &#34;processo de separação de uma mistura que compreende o hf e hfc-1234ze, processo para a separação de um e-hfc-1234ze a partir de uma mistura que inclui o fluoreto de hidrogênio e dito e-hfc-1234ze, processo para a separação do fluoreto de hidrogênio a partir de uma mistura contendo fluoreto de hidrogênio e e-hfc-1234ze, processo para a purificação de um e-hfc-1234ze a partir de uma mistura de e-hfc-1234ze e hf, processo para a purificação do hf a partir de uma mistura que compreende e-hfc-1234ze e hf, processo para a separação do e-hfc-1234ze de uma mistura de e-hfc-1234ze, hf e pelo menos um dos hfc-245fa ou hfc-245eb e processo para a separação do hfc-1234yf do hfc-1234ze&#34;
NZ590425A (en) Process for removing contaminant from a gaseous stream of carbon dioxide using liquid carbon dioxide as an absorbent
NO20050520L (no) Rensingav N,N-dimetylacetamdi
BR112012028507A2 (pt) processo para recuperação de etanol com extrações laterais para regular as concentrações de c3 + alcoóis
BR112013027340A2 (pt) processo para recuperar álcool com redução de água do topo de uma coluna de ácido
BR112013018041A2 (pt) método e aparelho para separar uma alimentação de gás misturada
ATE447539T1 (de) Verfahren zur herstellung von chlor
BRPI0518868A2 (pt) processo para a desidrataÇço de gases
FR2845392B1 (fr) Procede de desacidification d&#39;un gaz naturel
BRPI0507886A (pt) método de purificação de albumina compreendendo uma etapa de nanofiltração, solução e composição para uso terapêutico contendo-o
ATE370925T1 (de) Verfahren zur auftrennung eines roh-c4-schnittes
ATE378593T1 (de) Verfahren zur bestimmung der auswirkung eines aus mehreren komponenten bestehenden naturproduktgemischs auf das biologische profil einer krankheit in einer gruppe lebender systeme sowie entwicklung und qualitätskontrolle von medizin auf naturproduktbasis
DE602008003541D1 (de) Verfahren und vorrichtung zur stickstofferzeugung
BRPI0515517A (pt) processo para a preparação de ciclopentanona, e, uso de uma mistura de hidrocarboneto contendo ciclopenteno
ATE400540T1 (de) Verfahren zur herstellung von einem gereinigten hydrofluoralkan
ATE343561T1 (de) Destillative verfahren zur herstellung von ipda mit einem hohen cis/trans-isomerenverhältnis
BRPI0820753B8 (pt) processo para a produção de 1,2-propanodiol
DE602008004753D1 (de) Verfahren zur herstellung eines 1,2-alkylencarbonats
BR9903274A (pt) Processo para isolar vitamina d3

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 6A E 7A ANUIDADES.