BRPI0506498A - composições compreendendo inibidor de hiv protease e inibidor de atividade de enzima de citocromo p450 - Google Patents
composições compreendendo inibidor de hiv protease e inibidor de atividade de enzima de citocromo p450Info
- Publication number
- BRPI0506498A BRPI0506498A BRPI0506498-8A BRPI0506498A BRPI0506498A BR PI0506498 A BRPI0506498 A BR PI0506498A BR PI0506498 A BRPI0506498 A BR PI0506498A BR PI0506498 A BRPI0506498 A BR PI0506498A
- Authority
- BR
- Brazil
- Prior art keywords
- cytochrome
- hiv protease
- inhibitor
- enzyme activity
- compositions
- Prior art date
Links
- 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 title abstract 4
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 title abstract 4
- 230000000694 effects Effects 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 229940122440 HIV protease inhibitor Drugs 0.000 title abstract 2
- 239000004030 hiv protease inhibitor Substances 0.000 title abstract 2
- 108010010369 HIV Protease Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyrrole Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
"COMPOSIçõES COMPREENDENDO INIBIDOR DE HIV PROTEASE E INIBIDOR DE ATIVIDADE DE ENZIMA DE CITOCROMO P450". A presente invenção refere-se a métodos para aperfeiçoamento da farmacocinética de certos compostos úteis como inibidores da enzima HIV protease, por inibição da atividade de enzima de citocromo P450. A presente invenção também se refere a composições compreendendo cedos compostos úteis como inibidores da enzima HIV protease e pelo menos um agente que inibe a atividade de enzima de citocromo P450.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54074604P | 2004-01-30 | 2004-01-30 | |
US61499704P | 2004-10-01 | 2004-10-01 | |
PCT/IB2005/000110 WO2005082364A1 (en) | 2004-01-30 | 2005-01-17 | Compositions comprising hiv protease inhibitor and cytochrome p450 enzyme activity inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0506498A true BRPI0506498A (pt) | 2007-02-13 |
Family
ID=34915539
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0506498-8A BRPI0506498A (pt) | 2004-01-30 | 2005-01-17 | composições compreendendo inibidor de hiv protease e inibidor de atividade de enzima de citocromo p450 |
Country Status (15)
Country | Link |
---|---|
US (1) | US20050171037A1 (pt) |
EP (1) | EP1713478A1 (pt) |
JP (1) | JP2007519706A (pt) |
KR (1) | KR20060127939A (pt) |
AR (1) | AR047584A1 (pt) |
AU (1) | AU2005216712A1 (pt) |
BR (1) | BRPI0506498A (pt) |
CA (1) | CA2555173A1 (pt) |
CO (1) | CO5700739A2 (pt) |
IL (1) | IL176675A0 (pt) |
MX (1) | MXPA06008598A (pt) |
NO (1) | NO20063826L (pt) |
RU (1) | RU2006127429A (pt) |
TW (1) | TW200530204A (pt) |
WO (1) | WO2005082364A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2009279520A1 (en) * | 2008-08-07 | 2010-02-11 | Merck Sharp & Dohme Corp. | Pharmaceutical formulations of an HCV protease inhibitor in a solid molecular dispersion |
JP6421873B2 (ja) * | 2014-07-18 | 2018-11-14 | ジェイダブリュ ファーマセウティカル コーポレーション | テノホビルジソプロキシルの新規塩 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
US5539122A (en) * | 1989-05-23 | 1996-07-23 | Abbott Laboratories | Retroviral protease inhibiting compounds |
JP2637847B2 (ja) * | 1992-12-29 | 1997-08-06 | アボツト・ラボラトリーズ | レトロウィルス蛋白分解酵素を阻害する化合物 |
US6037157A (en) * | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
GEP20043251B (en) * | 1999-04-07 | 2004-06-25 | Pfizer Prod Inc | Use of CYP2D6 Inhibitors in Combination Therapies |
MXPA03010054A (es) * | 2001-05-01 | 2004-04-02 | Abbott Lab | Composiciones que comprenden lopinavir y metodos para aumentar la biodisponibilidad de agentes farmaceuticos. |
US7094909B2 (en) * | 2001-06-11 | 2006-08-22 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis |
US7169932B2 (en) * | 2001-06-11 | 2007-01-30 | Pfizer Inc. | HIV protease inhibitors, compositions containing the same, their pharmaceutical uses, material for their synthesis |
HN2002000136A (es) * | 2001-06-11 | 2003-07-31 | Basf Ag | Inhibidores de la proteasa del virus hiv, compuestos que contienen a los mismos, sus usos farmaceuticos y los materiales para su sintesis |
WO2005026114A1 (en) * | 2003-09-17 | 2005-03-24 | Pfizer Inc. | Hiv protease inhibitors, compositions containing the same and their pharmaceutical uses |
-
2005
- 2005-01-17 BR BRPI0506498-8A patent/BRPI0506498A/pt not_active Application Discontinuation
- 2005-01-17 JP JP2006550333A patent/JP2007519706A/ja not_active Withdrawn
- 2005-01-17 CA CA002555173A patent/CA2555173A1/en not_active Abandoned
- 2005-01-17 WO PCT/IB2005/000110 patent/WO2005082364A1/en active Application Filing
- 2005-01-17 KR KR1020067015292A patent/KR20060127939A/ko not_active Application Discontinuation
- 2005-01-17 AU AU2005216712A patent/AU2005216712A1/en not_active Abandoned
- 2005-01-17 EP EP05702272A patent/EP1713478A1/en not_active Withdrawn
- 2005-01-17 RU RU2006127429/15A patent/RU2006127429A/ru unknown
- 2005-01-17 MX MXPA06008598A patent/MXPA06008598A/es not_active Application Discontinuation
- 2005-01-27 AR ARP050100282A patent/AR047584A1/es unknown
- 2005-01-28 TW TW094102732A patent/TW200530204A/zh unknown
- 2005-01-28 US US11/046,025 patent/US20050171037A1/en not_active Abandoned
-
2006
- 2006-07-03 IL IL176675A patent/IL176675A0/en unknown
- 2006-07-26 CO CO06073030A patent/CO5700739A2/es not_active Application Discontinuation
- 2006-08-28 NO NO20063826A patent/NO20063826L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TW200530204A (en) | 2005-09-16 |
NO20063826L (no) | 2006-10-24 |
JP2007519706A (ja) | 2007-07-19 |
MXPA06008598A (es) | 2006-08-28 |
WO2005082364A1 (en) | 2005-09-09 |
IL176675A0 (en) | 2006-10-31 |
CO5700739A2 (es) | 2006-11-30 |
EP1713478A1 (en) | 2006-10-25 |
RU2006127429A (ru) | 2008-02-10 |
KR20060127939A (ko) | 2006-12-13 |
AU2005216712A1 (en) | 2005-09-09 |
US20050171037A1 (en) | 2005-08-04 |
AR047584A1 (es) | 2006-01-25 |
CA2555173A1 (en) | 2005-09-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |