BRPI0414203A - combination of phenylcarboxylic acid amides with beta-adrenoceptor blockers and their use for treating atrial arrhythmias - Google Patents

combination of phenylcarboxylic acid amides with beta-adrenoceptor blockers and their use for treating atrial arrhythmias

Info

Publication number
BRPI0414203A
BRPI0414203A BRPI0414203-9A BRPI0414203A BRPI0414203A BR PI0414203 A BRPI0414203 A BR PI0414203A BR PI0414203 A BRPI0414203 A BR PI0414203A BR PI0414203 A BRPI0414203 A BR PI0414203A
Authority
BR
Brazil
Prior art keywords
combination
acid amides
beta
atrial arrhythmias
phenylcarboxylic acid
Prior art date
Application number
BRPI0414203-9A
Other languages
Portuguese (pt)
Inventor
Klaus Wirth
Joachim Brendel
Heinz Goegelein
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34202398&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0414203(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of BRPI0414203A publication Critical patent/BRPI0414203A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"COMBINAçãO DE AMIDAS DE ACIDO FENIL-CARBOXìLICO COM BLOQUEADORES DE BETA-ADRENOCEPTORES E SEU EMPREGO PARA TRATAMENTO DE ARRITMIAS DO áTRIO". A presente invenção refere-se à combinação de um ou mais beta bloqueadores e de um ou mais bloqueadores Kv1,5, particularmente amidas de ácido fenilcarboxílico de fórmula (Ia) e/ou (Ib) e/ou seus sais farmacologicamente compatíveis, e ao emprego da combinação para tratamento de arritmias do átrio."COMBINATION OF PHENYL-CARBOXYL ACID AMIDES WITH BETA ADRENOCEPTOR LOCKERS AND THEIR USE FOR TREATMENT OF ART ARRYTHMIA". The present invention relates to the combination of one or more beta blockers and one or more Kv1,5 blockers, particularly phenylcarboxylic acid amides of formula (Ia) and / or (Ib) and / or pharmacologically compatible salts thereof, and to use of the combination to treat atrial arrhythmias.

BRPI0414203-9A 2003-09-08 2004-09-03 combination of phenylcarboxylic acid amides with beta-adrenoceptor blockers and their use for treating atrial arrhythmias BRPI0414203A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10341233A DE10341233A1 (en) 2003-09-08 2003-09-08 Composition, useful to treat e.g. atrial fibrillation, atrial flutter and atrial arrhythmia, comprises at least one beta-blocker and at least one compound of a phenylcarboxylic acid amide derivative
PCT/EP2004/009837 WO2005025674A1 (en) 2003-09-08 2004-09-03 Combination of phenylcarboxamides with beta-adrenergic receptor blockers and use thereof for the treatment of atrial arrhythmias

Publications (1)

Publication Number Publication Date
BRPI0414203A true BRPI0414203A (en) 2006-10-31

Family

ID=34202398

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414203-9A BRPI0414203A (en) 2003-09-08 2004-09-03 combination of phenylcarboxylic acid amides with beta-adrenoceptor blockers and their use for treating atrial arrhythmias

Country Status (12)

Country Link
EP (1) EP1670551A1 (en)
JP (1) JP2007505036A (en)
AR (1) AR045601A1 (en)
AU (1) AU2004271697A1 (en)
BR (1) BRPI0414203A (en)
CA (1) CA2538009A1 (en)
DE (1) DE10341233A1 (en)
IL (1) IL173919A0 (en)
MX (1) MXPA06002103A (en)
PE (1) PE20050373A1 (en)
TW (1) TW200526580A (en)
WO (1) WO2005025674A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005028862A1 (en) * 2005-06-22 2007-01-11 Sanofi-Aventis Deutschland Gmbh Substituted heterocycles, their use as medicament and pharmaceutical compositions containing them
TW200812962A (en) * 2006-07-12 2008-03-16 Astrazeneca Ab New compounds I/418
CN105254557A (en) 2009-05-29 2016-01-20 拉夸里亚创药株式会社 Aryl substituted carboxamide derivatives as calcium or sodium channel blockers

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6194458B1 (en) * 1998-10-30 2001-02-27 Merck & Co., Inc. Benzamide potassium channel inhibitors
DE19947457A1 (en) * 1999-10-02 2001-04-05 Aventis Pharma Gmbh New 2'-aminomethyl-biphenyl-2-carboxamide derivatives, are potassium channel blockers especially useful for treating re-entry or supraventricular arrhythmia or atrial fibrillation or flutter
DE10059418A1 (en) * 2000-11-30 2002-06-20 Aventis Pharma Gmbh Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments and pharmaceutical preparations containing them
DE10060807A1 (en) * 2000-12-07 2002-06-20 Aventis Pharma Gmbh Ortho, ortho-substituted nitrogen-containing bisaryl compounds, processes for their preparation, their use as medicaments and pharmaceutical preparations containing them
DE10121003A1 (en) * 2001-04-28 2002-12-19 Aventis Pharma Gmbh Anthranilic acid amides, processes for their preparation, their use as medicaments and pharmaceutical preparations containing them
DE10128331A1 (en) * 2001-06-12 2002-12-19 Aventis Pharma Gmbh New 2-(heteroarylsulfonyl-amino)-benzamide derivatives, which are potassium ion channel blocking antiarrhythmic agents, useful for e.g. treating atrial fibrillation or flutter

Also Published As

Publication number Publication date
AU2004271697A1 (en) 2005-03-24
EP1670551A1 (en) 2006-06-21
CA2538009A1 (en) 2005-03-24
WO2005025674A1 (en) 2005-03-24
JP2007505036A (en) 2007-03-08
AR045601A1 (en) 2005-11-02
DE10341233A1 (en) 2005-03-24
MXPA06002103A (en) 2006-05-31
PE20050373A1 (en) 2005-07-05
TW200526580A (en) 2005-08-16
IL173919A0 (en) 2006-07-05

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: A61K 31/00 (2006.01), A61P 9/06 (2006.01), A61K 31