BRPI0409906A - l-histidina protegida, metálica e orgánica derivatizada em nepsilon e/ou nalfa para acoplar ás biomoléculas para marcação altamente eficiente com [m(oh2)3(co)3]+ por coordenação de fac - Google Patents

l-histidina protegida, metálica e orgánica derivatizada em nepsilon e/ou nalfa para acoplar ás biomoléculas para marcação altamente eficiente com [m(oh2)3(co)3]+ por coordenação de fac

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Publication number
BRPI0409906A
BRPI0409906A BRPI0409906-0A BRPI0409906A BRPI0409906A BR PI0409906 A BRPI0409906 A BR PI0409906A BR PI0409906 A BRPI0409906 A BR PI0409906A BR PI0409906 A BRPI0409906 A BR PI0409906A
Authority
BR
Brazil
Prior art keywords
derivatized
nepsilon
protected
histidine
nalpha
Prior art date
Application number
BRPI0409906-0A
Other languages
English (en)
Inventor
Roger Alberto
Jaw Kyoung Pak
Original Assignee
Univ Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Zuerich filed Critical Univ Zuerich
Publication of BRPI0409906A publication Critical patent/BRPI0409906A/pt

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5421—IL-8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/595—Gastrins; Cholecystokinins [CCK]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/68—Melanocyte-stimulating hormone [MSH]
    • C07K14/685—Alpha-melanotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C07K7/083—Neurotensin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C07K7/086—Bombesin; Related peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

"L-HISTIDINA PROTEGIDA, METáLICA E ORGáNICA DERIVATIZADA EM N¬ epsilon¬ E/OU N¬ alfa¬ PARA ACOPLAR àS BIOMOLéCULAS PARA MARCAçãO ALTAMENTE EFICIENTE COM ¢M(OH~ 2~)~ 3~(CO)~ 3~!¬ +¬ POR COORDENAçãO DE fac". A presente invenção refere-se aos novos derivados de histidina que podem ser usados para a marcação de biomoléculas com tricarbonilas de metal radioativo. Os novos derivados têm uma histidina que é submetida à derivatização no N¬ <sym>¬ e pelo menos protegida no N¬ <244>¬ e opcionalmente no N¬ <sym>¬; ou submetida à derivatização no N¬ <244>¬ e pelo menos protegida no N¬ <244>¬ e opcionalmente no N¬ <sym>¬; ou submetida à derivatização no N¬ <sym>¬ e N¬ <244>¬ e pelo menos protegida no N¬ <244>¬ e opcionalmente no N¬ <sym>¬; ou submetida à derivatização no N¬ <sym>¬; ou submetida à derivatização no N¬ <244>¬; ou submetida à derivatização no N¬ <sym>¬ e N¬ <244>¬; ou pelo menos protegida no N¬ <244>¬ e opcionalmente no N¬ <sym>¬.
BRPI0409906-0A 2003-04-29 2004-04-29 l-histidina protegida, metálica e orgánica derivatizada em nepsilon e/ou nalfa para acoplar ás biomoléculas para marcação altamente eficiente com [m(oh2)3(co)3]+ por coordenação de fac BRPI0409906A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03076252 2003-04-29
PCT/EP2004/004683 WO2004097406A2 (en) 2003-04-29 2004-04-29 N&epsiv; AND/OR Nα DERIVATIZED, METAL AND ORGANIC PROTECTED L-HISTIDINE FOR COUPLING TO BIOMOLECULES FOR HIGHLY EFFICIENT LABELING WITH [M(OH2)3(CO)3]+ BY FAC COORDINATION

Publications (1)

Publication Number Publication Date
BRPI0409906A true BRPI0409906A (pt) 2006-04-25

Family

ID=33395905

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409906-0A BRPI0409906A (pt) 2003-04-29 2004-04-29 l-histidina protegida, metálica e orgánica derivatizada em nepsilon e/ou nalfa para acoplar ás biomoléculas para marcação altamente eficiente com [m(oh2)3(co)3]+ por coordenação de fac

Country Status (11)

Country Link
US (1) US8512675B2 (pt)
EP (1) EP1618380B1 (pt)
JP (1) JP4866233B2 (pt)
KR (1) KR20060003064A (pt)
CN (1) CN100507563C (pt)
AT (1) ATE453865T1 (pt)
AU (1) AU2004235488A1 (pt)
BR (1) BRPI0409906A (pt)
CA (1) CA2524222C (pt)
DE (1) DE602004024879D1 (pt)
WO (1) WO2004097406A2 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070071672A1 (en) * 2003-10-20 2007-03-29 Roger Alberto Use of metal tricarbonyl complexes as radiotherapeutic chemotoxic agents
EP2032590A1 (en) * 2006-06-20 2009-03-11 Paul Scherrer Institut Triazole containing metal chelating agents
WO2008125618A1 (en) * 2007-04-11 2008-10-23 Merck Eprova Ag Folate-conjugates and corresponding metal-chelate complexes for use in diagnostic imaging and radiotherapy
KR101383655B1 (ko) * 2010-05-24 2014-04-10 주식회사 바이오이미징코리아 트리카르보닐 테크네슘-99ｍ 또는 레늄-188 표지 고리 알지디 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 신생혈관 관련 질환의 진단 또는 치료용 약학적 조성물
US11257630B2 (en) 2013-07-06 2022-02-22 Blue Horizons Innovations, Llc Primary nanoparticle fabrication

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991007430A1 (en) * 1989-11-15 1991-05-30 The Upjohn Company Peptides containing cyclic tripeptides
NZ238688A (en) * 1990-06-28 1992-05-26 Smithkline Beecham Corp Substituted histidines: pharmaceutical compositions, preparation and uses thereof
US5571792A (en) * 1994-06-30 1996-11-05 Warner-Lambert Company Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
AU1529997A (en) 1996-01-16 1997-08-11 Warner-Lambert Company Substituted histidine inhibitors of protein farnesyltransferase
US6344178B1 (en) * 1997-04-25 2002-02-05 Mallinckrodt Inc. Method for the preparation of facial metal tricarbonyl compounds and their use in the labelling of biologically active substrates
EP0879606A1 (en) * 1997-04-25 1998-11-25 Paul Scherrer Institut Method for the preparation of facial metal tricarbonyl compounds and their use in the labelling of biologically active substrates
US5824803A (en) * 1997-09-30 1998-10-20 The United States Of America As Represented By The Secretary Of The Navy Compounds labeled with cyanate or thiocyanate metal complexes for detection by infrared spectroscopy
US6844425B1 (en) * 1999-02-24 2005-01-18 Mallinckrodt Inc. Combination of intercalating organometallic complexes and tumor seeking biomolecules for DNA cleavage and radiotherapy
EP1192166B1 (en) * 1999-06-29 2004-09-29 Mallinckrodt Inc. Group(vii) transition-metal complexes with multidentate aminopolycarboxylate ligands and a kit for producing them
US6926883B1 (en) * 1999-06-29 2005-08-09 Mallinckrodt Inc Group (VII) transition-metal complexes with multidentate aminopolycarboxylate ligands and a kit for producing them
WO2002014285A1 (en) * 2000-08-17 2002-02-21 Pfizer Limited Substituted imidazoles as tafia inhibitors
CN1143864C (zh) * 2001-06-28 2004-03-31 中国人民解放军军事医学科学院基础医学研究所 肿瘤坏死因子－α受体的亲和肽及其应用

Also Published As

Publication number Publication date
JP2006527167A (ja) 2006-11-30
WO2004097406A2 (en) 2004-11-11
US8512675B2 (en) 2013-08-20
CN1781021A (zh) 2006-05-31
ATE453865T1 (de) 2010-01-15
KR20060003064A (ko) 2006-01-09
WO2004097406A3 (en) 2005-05-19
CN100507563C (zh) 2009-07-01
AU2004235488A1 (en) 2004-11-11
EP1618380A2 (en) 2006-01-25
US20070077195A1 (en) 2007-04-05
CA2524222A1 (en) 2004-11-11
CA2524222C (en) 2012-02-07
EP1618380B1 (en) 2009-12-30
DE602004024879D1 (de) 2010-02-11
JP4866233B2 (ja) 2012-02-01

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]