BRPI0409444A - pyrrolo [1,2-b] pyridazine compounds and their uses - Google Patents

pyrrolo [1,2-b] pyridazine compounds and their uses

Info

Publication number
BRPI0409444A
BRPI0409444A BRPI0409444-1A BRPI0409444A BRPI0409444A BR PI0409444 A BRPI0409444 A BR PI0409444A BR PI0409444 A BRPI0409444 A BR PI0409444A BR PI0409444 A BRPI0409444 A BR PI0409444A
Authority
BR
Brazil
Prior art keywords
crf
pyrrolo
formula
pharmaceutically acceptable
receptor antagonists
Prior art date
Application number
BRPI0409444-1A
Other languages
Portuguese (pt)
Inventor
Jian-Min Fu
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Publication of BRPI0409444A publication Critical patent/BRPI0409444A/en

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Addiction (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Molecular Biology (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)

Abstract

"COMPOSTOS DE PIRROLO¢1,2-B!PIRIDAZINA E SUAS UTILIZAçõES". São descritos novos antagonistas do receptor de CRF e a sua utilização como tratamento de uma diversidade de perturbações, incluindo perturbações que apresentam hipersecreção de CRF ou associadas ao CRF ou aos receptores de CRF, tais como ansiedade e depressão. Os antagonistas do receptor de CRF da invenção têm a estrutura de fórmula (I): incluindo estereoisómeros ou misturas de estereoisómeros, pró-fármacos farmaceuticamente aceitáveis ou sais farmaceuticamente aceitáveis daquele, em que na fórmula (I) R¬ 1¬ e R¬ 2¬ são independentemente seleccionados de H, Me ou OMe."PYROROLO ¢ 1,2-B COMPOUNDS! PYRIDAZINE AND ITS USES". New CRF receptor antagonists and their use for treating a variety of disorders, including disorders that exhibit CRF hypersecretion or associated with CRF or CRF receptors such as anxiety and depression, are described. CRF receptor antagonists of the invention have the structure of formula (I): including stereoisomers or mixtures of stereoisomers, pharmaceutically acceptable prodrugs or pharmaceutically acceptable salts thereof, wherein in formula (I) R 1 and R 2 ¬ are independently selected from H, Me or OMe.

BRPI0409444-1A 2003-04-15 2004-04-05 pyrrolo [1,2-b] pyridazine compounds and their uses BRPI0409444A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46300203P 2003-04-15 2003-04-15
PCT/IB2004/001250 WO2004092176A1 (en) 2003-04-15 2004-04-05 Pyrrolo[1,2-b]pyridazine compounds and their uses

Publications (1)

Publication Number Publication Date
BRPI0409444A true BRPI0409444A (en) 2006-04-18

Family

ID=33300027

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409444-1A BRPI0409444A (en) 2003-04-15 2004-04-05 pyrrolo [1,2-b] pyridazine compounds and their uses

Country Status (6)

Country Link
EP (1) EP1615929A1 (en)
JP (1) JP2006523675A (en)
BR (1) BRPI0409444A (en)
CA (1) CA2520805A1 (en)
MX (1) MXPA05010833A (en)
WO (1) WO2004092176A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2523072A1 (en) * 2003-05-07 2004-11-18 Pharmacia & Upjohn Company Llc Pyrrolo (1,2-b) pyridazine compounds and their use as crf-1 receptor antagonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU735401B2 (en) * 1996-08-28 2001-07-05 Pfizer Inc. Substituted 6,5-hetero-bicyclic derivatives
US20010007867A1 (en) * 1999-12-13 2001-07-12 Yuhpyng L. Chen Substituted 6,5-hetero-bicyclic derivatives
EP1085021A4 (en) * 1998-05-21 2003-01-08 Shionogi & Co PYRROLO 1,2-b]PYRIDAZINE DERIVATIVES HAVING sPLA 2? INHIBITORY EFFECT
US20030125330A1 (en) * 2001-03-13 2003-07-03 Gilligan Paul J. 4 - (2-butylamino) - 2, 7-dimethyl-8- (2-methyl-6-methoxypyrid-3-yl) pyrazolo- [1,5-A] - 1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands
WO2002072101A1 (en) * 2001-03-13 2002-09-19 Bristol-Myers Squibb Pharma Company A corticotropin releasing factor receptor ligand, its enantiomer and pharmaceutically acceptable salts

Also Published As

Publication number Publication date
CA2520805A1 (en) 2004-10-28
WO2004092176A1 (en) 2004-10-28
EP1615929A1 (en) 2006-01-18
MXPA05010833A (en) 2005-12-05
JP2006523675A (en) 2006-10-19

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