BRPI0407901A - diarylcycloalkyl derivatives, processes for their preparation and use as medicines - Google Patents

diarylcycloalkyl derivatives, processes for their preparation and use as medicines

Info

Publication number
BRPI0407901A
BRPI0407901A BRPI0407901-9A BRPI0407901A BRPI0407901A BR PI0407901 A BRPI0407901 A BR PI0407901A BR PI0407901 A BRPI0407901 A BR PI0407901A BR PI0407901 A BRPI0407901 A BR PI0407901A
Authority
BR
Brazil
Prior art keywords
derivatives
processes
disorders
medicines
preparation
Prior art date
Application number
BRPI0407901-9A
Other languages
Portuguese (pt)
Inventor
Jochen Goerlitzer
Heiner Glombik
Eugen Falk
Dirk Gretzke
Stefanie Keil
Hans-Ludwig Schaefer
Christian Stapper
Wolfgang Wendler
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of BRPI0407901A publication Critical patent/BRPI0407901A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS DE DIARILCICLOALQUILA, PROCESSOS PARA PREPARAçãO DOS MESMOS E USO DOS MESMOS COMO MEDICAMENTOS". A invenção refere-se a derivados de diarilcicloalquila, a seus sais fisiologicamente compatíveis, racematos e derivados fisiologicamente funcionais. A invenção refere-se a compostos da fórmula (I), nos quais os grupos estão definidos tal como citado na descrição, além de seus sais fisiologicamente compatíveis e a um método para a produção dos mesmos. Os compostos são apropriados para tratamento e/ou prevenção de distúrbios do metabolismo de ácidos graxos e distúrbios de utilização de glicose, além de distúrbios, nos quais a resistência à insulina desempenha um papel."DIARYLYCYCLALCHILLA DERIVATIVES, PROCESSES FOR PREPARING THEMSELVES AND USING THEMSELVES AS MEDICINAL PRODUCTS". The invention relates to diarylcycloalkyl derivatives, their physiologically compatible salts, racemates and physiologically functional derivatives. The invention relates to compounds of formula (I) wherein the groups are as defined in the description, in addition to their physiologically compatible salts and a method for their production. The compounds are suitable for treating and / or preventing fatty acid metabolism disorders and glucose utilization disorders, as well as disorders in which insulin resistance plays a role.

BRPI0407901-9A 2003-02-27 2004-02-19 diarylcycloalkyl derivatives, processes for their preparation and use as medicines BRPI0407901A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10308353A DE10308353A1 (en) 2003-02-27 2003-02-27 Diarylcycloalkyl derivatives, processes for their preparation and their use as medicines
PCT/EP2004/001584 WO2004075815A2 (en) 2003-02-27 2004-02-19 Diarylcycloalkyl derivatives, method for their production and their use as medicaments

Publications (1)

Publication Number Publication Date
BRPI0407901A true BRPI0407901A (en) 2006-02-14

Family

ID=32920627

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0407901-9A BRPI0407901A (en) 2003-02-27 2004-02-19 diarylcycloalkyl derivatives, processes for their preparation and use as medicines

Country Status (21)

Country Link
US (1) US7160911B2 (en)
EP (1) EP1599454B1 (en)
JP (1) JP2006519197A (en)
KR (1) KR20050106053A (en)
CN (1) CN100439346C (en)
AR (1) AR043430A1 (en)
AU (1) AU2004216520B2 (en)
BR (1) BRPI0407901A (en)
CA (1) CA2516573A1 (en)
CO (1) CO5690579A2 (en)
DE (1) DE10308353A1 (en)
HR (1) HRP20050740A2 (en)
IL (1) IL170313A (en)
MA (1) MA27741A1 (en)
MX (1) MXPA05008993A (en)
NO (1) NO20054382L (en)
PL (1) PL377741A1 (en)
RU (1) RU2005129999A (en)
TW (1) TW200505880A (en)
WO (1) WO2004075815A2 (en)
ZA (1) ZA200505763B (en)

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Also Published As

Publication number Publication date
EP1599454B1 (en) 2012-12-26
EP1599454A2 (en) 2005-11-30
WO2004075815A3 (en) 2004-12-29
CA2516573A1 (en) 2004-09-10
AU2004216520B2 (en) 2010-01-07
PL377741A1 (en) 2006-02-20
IL170313A (en) 2010-11-30
AR043430A1 (en) 2005-07-27
CO5690579A2 (en) 2006-10-31
HRP20050740A2 (en) 2006-08-31
DE10308353A1 (en) 2004-12-02
US7160911B2 (en) 2007-01-09
RU2005129999A (en) 2006-03-27
NO20054382L (en) 2005-09-21
JP2006519197A (en) 2006-08-24
MA27741A1 (en) 2006-02-01
TW200505880A (en) 2005-02-16
MXPA05008993A (en) 2005-10-18
ZA200505763B (en) 2006-05-31
AU2004216520A1 (en) 2004-09-10
KR20050106053A (en) 2005-11-08
US20040204462A1 (en) 2004-10-14
WO2004075815A2 (en) 2004-09-10
CN100439346C (en) 2008-12-03
CN1753880A (en) 2006-03-29

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