BRPI0407256A - Use of the milnacipran enantiomer (1s, 2r) for the preparation of a medicament - Google Patents

Use of the milnacipran enantiomer (1s, 2r) for the preparation of a medicament

Info

Publication number
BRPI0407256A
BRPI0407256A BR0407256-1A BRPI0407256A BRPI0407256A BR PI0407256 A BRPI0407256 A BR PI0407256A BR PI0407256 A BRPI0407256 A BR PI0407256A BR PI0407256 A BRPI0407256 A BR PI0407256A
Authority
BR
Brazil
Prior art keywords
active
serotonin
noradrenaline
capture
enantiomer
Prior art date
Application number
BR0407256-1A
Other languages
Portuguese (pt)
Inventor
Jean Deregnaucourt
Richard Grosse
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0301849A external-priority patent/FR2851163B1/en
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of BRPI0407256A publication Critical patent/BRPI0407256A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

The use of a mixture of enantiomers of Milnacipran and/or its metabolites or salts, enriched in the dextrorotatory enantiomer F2695, is claimed in medicines for treating pathological disorders treated by the double inhibition of serotonin and noradrenaline recapture, while limiting the risk of cardiovascular disturbance. ACTIVITY : Antidepressant; Muscular-Gen; Immunomodulator; Analgesic; Antiinflammatory; Uropathic; Antiaddictive. MECHANISM OF ACTION : Serotonin inhibitor; Noradrenaline recapture inhibitor. In tests used to determine the capture of noradrenaline and serotonin and the binding of paroxetine in rats, results showed that F2695 was twice as active as the racemic mixture (F2207) and 25 times as active as the levorotatory enantiomer (F2696) in the capture of noradrenaline, that F2695 was three times as active as F2207 and 12 times as active as F2696 in the capture of serotonin and that F2695 was twice as active as F2207 and 10 times as active as F2696 in binding paroxetine.
BR0407256-1A 2003-02-14 2004-02-16 Use of the milnacipran enantiomer (1s, 2r) for the preparation of a medicament BRPI0407256A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0301849A FR2851163B1 (en) 2003-02-14 2003-02-14 USE OF DEXTROGYAN ENANTIOMER OF MILNACIPRAN FOR THE PREPARATION OF A MEDICINAL PRODUCT
US10/453,574 US7005452B2 (en) 2003-02-14 2003-06-03 Use of the dextrogyral enantiomer of milnacipran for the preparation of a drug
PCT/FR2004/000347 WO2004075886A1 (en) 2003-02-14 2004-02-16 Use of the enantiomer (1s, 2r) of milnacipran for the preparation of a medicament

Publications (1)

Publication Number Publication Date
BRPI0407256A true BRPI0407256A (en) 2006-01-31

Family

ID=32929266

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0407256-1A BRPI0407256A (en) 2003-02-14 2004-02-16 Use of the milnacipran enantiomer (1s, 2r) for the preparation of a medicament

Country Status (20)

Country Link
US (2) US7074833B2 (en)
EP (2) EP1601349B1 (en)
KR (1) KR101185322B1 (en)
AT (1) ATE401872T1 (en)
AU (1) AU2004216452B2 (en)
BR (1) BRPI0407256A (en)
CA (1) CA2514948C (en)
DE (1) DE602004015257D1 (en)
DK (1) DK1601349T3 (en)
ES (1) ES2310715T3 (en)
HK (1) HK1079117A1 (en)
MA (1) MA27655A1 (en)
MX (1) MXPA05008652A (en)
NO (1) NO333987B1 (en)
NZ (1) NZ541733A (en)
PL (1) PL219671B1 (en)
PT (1) PT1601349E (en)
RU (1) RU2317817C2 (en)
SI (1) SI1601349T1 (en)
WO (1) WO2004075886A1 (en)

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Also Published As

Publication number Publication date
PL378057A1 (en) 2006-02-20
WO2004075886A1 (en) 2004-09-10
RU2005128548A (en) 2006-01-20
ATE401872T1 (en) 2008-08-15
NO20054228L (en) 2005-09-12
AU2004216452B2 (en) 2008-10-16
MXPA05008652A (en) 2005-10-18
SI1601349T1 (en) 2008-10-31
EP1601349A1 (en) 2005-12-07
AU2004216452A1 (en) 2004-09-10
DK1601349T3 (en) 2008-10-27
KR20050096190A (en) 2005-10-05
CA2514948A1 (en) 2004-09-10
NO333987B1 (en) 2013-11-04
PL219671B1 (en) 2015-06-30
EP1601349B1 (en) 2008-07-23
PT1601349E (en) 2008-10-27
EP1908461B9 (en) 2011-08-31
EP1908461A1 (en) 2008-04-09
US7074833B2 (en) 2006-07-11
EP1908461B1 (en) 2011-03-16
RU2317817C2 (en) 2008-02-27
US20040259953A1 (en) 2004-12-23
CA2514948C (en) 2013-04-02
HK1079117A1 (en) 2006-03-31
KR101185322B1 (en) 2012-09-21
US20060014837A1 (en) 2006-01-19
DE602004015257D1 (en) 2008-09-04
NZ541733A (en) 2009-03-31
ES2310715T3 (en) 2009-01-16
MA27655A1 (en) 2005-12-01

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