BRPI0215775A2 - toluidine blue o substance (toluidine blue o) and its application for in vivo dyeing and chemotherapeutic treatment of dysplastic tissues. - Google Patents

toluidine blue o substance (toluidine blue o) and its application for in vivo dyeing and chemotherapeutic treatment of dysplastic tissues.

Info

Publication number
BRPI0215775A2
BRPI0215775A2 BRPI0215775A BR0215775A BRPI0215775A2 BR PI0215775 A2 BRPI0215775 A2 BR PI0215775A2 BR PI0215775 A BRPI0215775 A BR PI0215775A BR 0215775 A BR0215775 A BR 0215775A BR PI0215775 A2 BRPI0215775 A2 BR PI0215775A2
Authority
BR
Brazil
Prior art keywords
toluidine blue
dyeing
vivo
substance
application
Prior art date
Application number
BRPI0215775A
Other languages
Portuguese (pt)
Inventor
Karl Okolotowicz
Original Assignee
Zila Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zila Inc filed Critical Zila Inc
Publication of BRPI0215775A2 publication Critical patent/BRPI0215775A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B21/00—Thiazine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Optics & Photonics (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
BRPI0215775A 2002-06-04 2002-06-04 toluidine blue o substance (toluidine blue o) and its application for in vivo dyeing and chemotherapeutic treatment of dysplastic tissues. BRPI0215775A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2002/017720 WO2003103569A2 (en) 2002-06-04 2002-06-04 Toluidine blue o drug substance and use thereof for in vivo staining and chemotherapeutic treatment of dysplastic tissues

Publications (1)

Publication Number Publication Date
BRPI0215775A2 true BRPI0215775A2 (en) 2016-07-05

Family

ID=29731309

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0215775A BRPI0215775A2 (en) 2002-06-04 2002-06-04 toluidine blue o substance (toluidine blue o) and its application for in vivo dyeing and chemotherapeutic treatment of dysplastic tissues.

Country Status (9)

Country Link
EP (1) EP1534346A4 (en)
JP (1) JP2005535605A (en)
CN (1) CN1302815C (en)
AU (1) AU2002312319A1 (en)
BR (1) BRPI0215775A2 (en)
IL (1) IL165516A0 (en)
MX (1) MXPA04012031A (en)
TW (1) TW200733956A (en)
WO (1) WO2003103569A2 (en)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH071257B2 (en) * 1985-09-09 1995-01-11 エスエス製薬株式会社 Simultaneous determination of water-soluble vitamins in mixed vitamin preparations
JPS6410171A (en) * 1987-07-03 1989-01-13 Shimadzu Corp Analysis of amino acid
ES2133143T3 (en) * 1991-10-31 1999-09-01 Zila Inc COMPOSITION OF BIOLOGICAL STAINING, PREPARATION PROCEDURE AND USE PROCEDURE FOR THE DETECTION OF EPITHELIAL CANCER.
US6086852A (en) * 1997-11-13 2000-07-11 Zila, Inc. In vivo stain composition, process of manufacture, and methods of use to identify dysplastic tissue
US6194573B1 (en) * 1997-11-13 2001-02-27 Zila, Inc. Process for manufacture of in vivo stain composition
AU5357498A (en) * 1997-11-13 1999-06-07 Zila, Inc. (in vivo) stain composition, process of manufacture, and methods of use to identify dysplastic tissue
WO2001064110A1 (en) * 2000-02-28 2001-09-07 Zila, Inc. Method for detecting and killing epithelial cancer cells
JP4424838B2 (en) * 2000-08-31 2010-03-03 株式会社トクヤマ Analysis method for quaternary ammonium salts

Also Published As

Publication number Publication date
AU2002312319A1 (en) 2003-12-22
EP1534346A4 (en) 2007-07-25
MXPA04012031A (en) 2005-03-07
CN1627961A (en) 2005-06-15
TW200733956A (en) 2007-09-16
IL165516A0 (en) 2006-01-15
WO2003103569A2 (en) 2003-12-18
CN1302815C (en) 2007-03-07
WO2003103569A3 (en) 2004-05-21
JP2005535605A (en) 2005-11-24
EP1534346A2 (en) 2005-06-01

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Legal Events

Date Code Title Description
B06H Technical and formal requirements: requirement cancelled [chapter 6.8 patent gazette]

Free format text: ANULACAO DA PUBLICACAO CODIGO 6.7 NA RPI NO 2132 DE 16/11/2011, POR TER SIDO INDEVIDA

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 10A, 11A, 12A, 13A E 14A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B350 Update of information on the portal [chapter 15.35 patent gazette]