BRPI0206903B8 - método de prognóstico de uma predisposição para o desenvolvimento de hipertensão e lesões no coração, sistema nervoso, sistema vascular ou rins, e uso da isoforma de 90 kda da enzima conversora de angiotensina i no referido método - Google Patents

método de prognóstico de uma predisposição para o desenvolvimento de hipertensão e lesões no coração, sistema nervoso, sistema vascular ou rins, e uso da isoforma de 90 kda da enzima conversora de angiotensina i no referido método

Info

Publication number
BRPI0206903B8
BRPI0206903B8 BRPI0206903A BR0206903A BRPI0206903B8 BR PI0206903 B8 BRPI0206903 B8 BR PI0206903B8 BR PI0206903 A BRPI0206903 A BR PI0206903A BR 0206903 A BR0206903 A BR 0206903A BR PI0206903 B8 BRPI0206903 B8 BR PI0206903B8
Authority
BR
Brazil
Prior art keywords
converting enzyme
predisposition
development
angiotensin
kidneys
Prior art date
Application number
BRPI0206903A
Other languages
English (en)
Other versions
BRPI0206903B1 (pt
BR0206903A (pt
Inventor
Elena Casarini Dulce
Liane Plavnik Frida
Eduardo Krieger Jose
Marson Odair
Original Assignee
Fund De Amparo A Pesquisa Do Estado De Sao Paulo Fapesp
Univ Federal De Sao Paulo Unifesp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fund De Amparo A Pesquisa Do Estado De Sao Paulo Fapesp, Univ Federal De Sao Paulo Unifesp filed Critical Fund De Amparo A Pesquisa Do Estado De Sao Paulo Fapesp
Priority to BRPI0206903A priority Critical patent/BRPI0206903B8/pt
Priority to JP2004560930A priority patent/JP2006510365A/ja
Priority to ES03779591T priority patent/ES2310251T3/es
Priority to EP03779591A priority patent/EP1573059B1/en
Priority to DE60321487T priority patent/DE60321487D1/de
Priority to PT03779591T priority patent/PT1573059E/pt
Priority to AT03779591T priority patent/ATE397671T1/de
Priority to US10/540,193 priority patent/US7687237B2/en
Priority to AU2003287794A priority patent/AU2003287794A1/en
Priority to PCT/BR2003/000202 priority patent/WO2004057020A1/en
Publication of BR0206903A publication Critical patent/BR0206903A/pt
Priority to US12/710,770 priority patent/US20100209954A1/en
Publication of BRPI0206903B1 publication Critical patent/BRPI0206903B1/pt
Publication of BRPI0206903B8 publication Critical patent/BRPI0206903B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/007—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving isoenzyme profiles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2410/00—Assays, e.g. immunoassays or enzyme assays, involving peptides of less than 20 animo acids
    • G01N2410/02—Angiotensins; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"método de identificação e quantificação de proteínas, isoformas da enzima conversora de angiotensina, i, marcador molecular genético a base das referidas proteínas, uso do referido marcador molecular, método analítico para diagnóstico, estratificação de risco, decisão terapêutica em portadores de hipertensão arterial e lesões renais e kit para uso no diagnóstico". a presente invenção trata de um método de identificação e quantificação de proteínas, isoformas da enzima conversora de angiotensina i especificamente eca, 19-kda, especialmente 90 kda em tecidos, células e fluidos biológicos , especialmente na urina, marcador genético e agente prognóstico de hipertensão a base das referidas proteínas, uso do referido marcador e agente em portadores de hipertensão arterial e lesões renais primárias ou secundária e kit para uso no diagnóstico, estratificação de risco e decisão terapêutica na hipertensão arterial. um dos objetivos da presente invenção consiste em verificar o potencial da isoforma de 90 kda como um marcador genético de hipertensão e como um prognóstico de hipertensão.
BRPI0206903A 2002-12-20 2002-12-20 método de prognóstico de uma predisposição para o desenvolvimento de hipertensão e lesões no coração, sistema nervoso, sistema vascular ou rins, e uso da isoforma de 90 kda da enzima conversora de angiotensina i no referido método BRPI0206903B8 (pt)

Priority Applications (11)

Application Number Priority Date Filing Date Title
BRPI0206903A BRPI0206903B8 (pt) 2002-12-20 2002-12-20 método de prognóstico de uma predisposição para o desenvolvimento de hipertensão e lesões no coração, sistema nervoso, sistema vascular ou rins, e uso da isoforma de 90 kda da enzima conversora de angiotensina i no referido método
PT03779591T PT1573059E (pt) 2002-12-20 2003-12-22 Método de identificação e quantificação de proteínas, isoformas da enzima conversora de angiotensina i
ES03779591T ES2310251T3 (es) 2002-12-20 2003-12-22 Metodo de identificacion y cuantificacion de proteinas, isoformas de la enzima convertidora de angiotensina i.
EP03779591A EP1573059B1 (en) 2002-12-20 2003-12-22 Method of identification and quantification of proteins, isoforms of the angiotensin i converting enzyme
DE60321487T DE60321487D1 (de) 2002-12-20 2003-12-22 Verfahren zur identifizierung und quantifizierung von proteinen, isoformen des angiotensin i umsetzenden enzyms
JP2004560930A JP2006510365A (ja) 2002-12-20 2003-12-22 アンギオテンシンｉ転換酵素のアイソフォームであるタンパク質の同定および定量方法、このタンパク質に基づく分子遺伝子マーカー、このマーカーの使用、動脈高血圧および腎病変の保有者における診断、危険性の層別、治療的決定のための分析方法、ならびに診断において使用するためのキット
AT03779591T ATE397671T1 (de) 2002-12-20 2003-12-22 Verfahren zur identifizierung und quantifizierung von proteinen, isoformen des angiotensin i umsetzenden enzyms
US10/540,193 US7687237B2 (en) 2002-12-20 2003-12-22 Method of identification and quantification of proteins, isoforms of the angiotensin I converting enzyme
AU2003287794A AU2003287794A1 (en) 2002-12-20 2003-12-22 Method of identification and quantification of proteins, isoforms of the angiotensin i converting enzyme
PCT/BR2003/000202 WO2004057020A1 (en) 2002-12-20 2003-12-22 Method of identification and quantification of proteins, isoforms of the angiotensin i converting enzyme
US12/710,770 US20100209954A1 (en) 2002-12-20 2010-02-23 Method of identification and quantification of proteins, isoforms of the angiotensin i converting enzyme, molecular genetic marker based on said proteins, use of mentioned marker, analytical method for diagnosis, risk stratification, therapeutical decision in carriers of arterial hypertension and renal lesion and kit for using in the diagnosie

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI0206903A BRPI0206903B8 (pt) 2002-12-20 2002-12-20 método de prognóstico de uma predisposição para o desenvolvimento de hipertensão e lesões no coração, sistema nervoso, sistema vascular ou rins, e uso da isoforma de 90 kda da enzima conversora de angiotensina i no referido método

Publications (3)

Publication Number Publication Date
BR0206903A BR0206903A (pt) 2004-08-10
BRPI0206903B1 BRPI0206903B1 (pt) 2015-09-08
BRPI0206903B8 true BRPI0206903B8 (pt) 2021-07-27

Family

ID=36165445

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0206903A BRPI0206903B8 (pt) 2002-12-20 2002-12-20 método de prognóstico de uma predisposição para o desenvolvimento de hipertensão e lesões no coração, sistema nervoso, sistema vascular ou rins, e uso da isoforma de 90 kda da enzima conversora de angiotensina i no referido método

Country Status (10)

Country Link
US (2) US7687237B2 (pt)
EP (1) EP1573059B1 (pt)
JP (1) JP2006510365A (pt)
AT (1) ATE397671T1 (pt)
AU (1) AU2003287794A1 (pt)
BR (1) BRPI0206903B8 (pt)
DE (1) DE60321487D1 (pt)
ES (1) ES2310251T3 (pt)
PT (1) PT1573059E (pt)
WO (1) WO2004057020A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080074190A (ko) * 2005-11-30 2008-08-12 모자이크 다이아그노스틱스 앤드 쎄라퓨틱스 아게 혈관성 질환의 진단 및 평가를 위한 폴리펩티드 마커
US20160003857A1 (en) * 2014-07-02 2016-01-07 Cecil Bennett Methods and systems for detecting polypharmacy
RU2600442C1 (ru) * 2015-11-13 2016-10-20 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт медицины труда" (ФГБНУ "НИИ МТ") Способ определения риска развития артериальной гипертензии

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6153386A (en) * 1992-09-30 2000-11-28 University Of Utah Research Foundation Method to determine predisposition to hypertension
AU740021B2 (en) * 1996-10-04 2001-10-25 Stephen J. Fey Hypertension markers
US6610497B1 (en) * 1997-12-11 2003-08-26 Millennium Pharmaceuticals, Inc. Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therefor
GB9810085D0 (en) * 1998-05-11 1998-07-08 Gemini Research Limited Polymorphism in a nitric oxide synthase gene
US7028537B2 (en) * 2001-09-20 2006-04-18 Esa Biosciences, Inc. Coupling electrochemistry to mass spectrometry and high performance liquid chromatography

Also Published As

Publication number Publication date
EP1573059B1 (en) 2008-06-04
EP1573059A1 (en) 2005-09-14
JP2006510365A (ja) 2006-03-30
DE60321487D1 (de) 2008-07-17
ES2310251T3 (es) 2009-01-01
ATE397671T1 (de) 2008-06-15
AU2003287794A8 (en) 2004-07-14
US20060057739A1 (en) 2006-03-16
AU2003287794A1 (en) 2004-07-14
PT1573059E (pt) 2008-09-16
BRPI0206903B1 (pt) 2015-09-08
US20100209954A1 (en) 2010-08-19
US7687237B2 (en) 2010-03-30
WO2004057020A8 (en) 2004-09-30
BR0206903A (pt) 2004-08-10
WO2004057020A1 (en) 2004-07-08

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