BR9916043A - Compound, use of the same and its pharmaceutically acceptable salts, and pharmaceutical composition for the treatment of viral herpes infections in patients - Google Patents
Compound, use of the same and its pharmaceutically acceptable salts, and pharmaceutical composition for the treatment of viral herpes infections in patientsInfo
- Publication number
- BR9916043A BR9916043A BR9916043-9A BR9916043A BR9916043A BR 9916043 A BR9916043 A BR 9916043A BR 9916043 A BR9916043 A BR 9916043A BR 9916043 A BR9916043 A BR 9916043A
- Authority
- BR
- Brazil
- Prior art keywords
- patients
- compound
- treatment
- pharmaceutical composition
- same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Furan Compounds (AREA)
Abstract
"COMPOSTO, USO DO MESMO E DE SEUS SAISFARMACêUTICAMENTE ACEITáVEIS E, COMPOSIçãOFARMACêUTICA PARA TRATAMENTO DE INFECçõES DEHERPES VIRAL EM PACIENTES". A presente invenção refere-sea compostos poliaromáticos tendo atividade antiviral útil contravírus da família do herpes, a uma composição que os contém, e aum processo de usá-los para o tratamento de infecções de vírusde herpes."COMPOUND, USE OF THE SAME AND ITS ACCEPTABLE SAISPharmacy AND, PHARMACEUTICAL COMPOSITION FOR TREATING DEHERPES VIRAL INFECTIONS IN PATIENTS". The present invention relates to polyaromatic compounds having useful antiviral activity against the herpes family, to a composition containing them, and to a process of using them for the treatment of herpes virus infections.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20816498A | 1998-12-09 | 1998-12-09 | |
PCT/US1999/028916 WO2000034261A2 (en) | 1998-12-09 | 1999-12-06 | Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing a substituted phenylenediamine group |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9916043A true BR9916043A (en) | 2001-12-04 |
Family
ID=22773466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9916043-9A BR9916043A (en) | 1998-12-09 | 1999-12-06 | Compound, use of the same and its pharmaceutically acceptable salts, and pharmaceutical composition for the treatment of viral herpes infections in patients |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP1144399A3 (en) |
JP (1) | JP2002533301A (en) |
KR (1) | KR20010086091A (en) |
CN (1) | CN1367785A (en) |
AU (1) | AU2353900A (en) |
BR (1) | BR9916043A (en) |
CA (1) | CA2351690A1 (en) |
CZ (1) | CZ20012063A3 (en) |
EA (1) | EA200100639A1 (en) |
HU (1) | HUP0203405A2 (en) |
IL (1) | IL143263A0 (en) |
NO (1) | NO20012835L (en) |
WO (1) | WO2000034261A2 (en) |
ZA (1) | ZA200104322B (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
ATE311366T1 (en) | 2000-02-29 | 2005-12-15 | Millennium Pharm Inc | BENZAMIDE AND SIMILAR FACTOR XA INHIBITORS |
EA010017B1 (en) * | 2003-07-10 | 2008-06-30 | Ачиллион Фармасьютикалз, Инк. | Substituted arylthiourea derivatives useful as inhibitors of viral replication |
DE102004015007A1 (en) | 2004-03-26 | 2005-10-13 | Bayer Healthcare Ag | Substituted imidazoles |
TW200600492A (en) | 2004-05-18 | 2006-01-01 | Achillion Pharmaceuticals Inc | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication |
DE102005008183A1 (en) | 2005-02-23 | 2006-08-31 | Bayer Healthcare Ag | New heterocyclylamide-substituted imidazole compounds useful to treat or prevent viral infections |
ES2382055T3 (en) | 2006-11-02 | 2012-06-04 | Millennium Pharmaceuticals, Inc. | Methods for synthesizing pharmaceutical salts of a factor Xa inhibitor |
EP2914592B1 (en) * | 2012-11-03 | 2017-10-11 | Boehringer Ingelheim International GmbH | Inhibitors of cytomegalovirus |
US9284310B2 (en) | 2012-11-03 | 2016-03-15 | Boehringer Ingelheim International Gmbh | Inhibitors of cytomegalovirus |
CN112807294B (en) * | 2019-11-18 | 2023-09-05 | 武汉大学 | Application of acyl thiourea compound in preparation of medicines for treating or preventing herpes simplex virus type I infection |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2243370T3 (en) * | 1997-04-10 | 2005-12-01 | PHARMACIA & UPJOHN COMPANY LLC | POLYAROMATIC COMPOSITIONS FOR THE TREATMENT OF INFECTIONS BY VIRUS HERPES. |
-
1999
- 1999-12-06 KR KR1020017007117A patent/KR20010086091A/en not_active Application Discontinuation
- 1999-12-06 CN CN99815998A patent/CN1367785A/en active Pending
- 1999-12-06 IL IL14326399A patent/IL143263A0/en unknown
- 1999-12-06 EP EP99967213A patent/EP1144399A3/en not_active Withdrawn
- 1999-12-06 JP JP2000586708A patent/JP2002533301A/en active Pending
- 1999-12-06 AU AU23539/00A patent/AU2353900A/en not_active Abandoned
- 1999-12-06 HU HU0203405A patent/HUP0203405A2/en unknown
- 1999-12-06 CA CA002351690A patent/CA2351690A1/en not_active Abandoned
- 1999-12-06 WO PCT/US1999/028916 patent/WO2000034261A2/en not_active Application Discontinuation
- 1999-12-06 EA EA200100639A patent/EA200100639A1/en unknown
- 1999-12-06 CZ CZ20012063A patent/CZ20012063A3/en unknown
- 1999-12-06 BR BR9916043-9A patent/BR9916043A/en not_active Application Discontinuation
-
2001
- 2001-05-25 ZA ZA200104322A patent/ZA200104322B/en unknown
- 2001-06-08 NO NO20012835A patent/NO20012835L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2351690A1 (en) | 2000-06-15 |
KR20010086091A (en) | 2001-09-07 |
WO2000034261A3 (en) | 2002-01-31 |
NO20012835D0 (en) | 2001-06-08 |
CN1367785A (en) | 2002-09-04 |
ZA200104322B (en) | 2002-10-25 |
EP1144399A2 (en) | 2001-10-17 |
AU2353900A (en) | 2000-06-26 |
EA200100639A1 (en) | 2002-06-27 |
EP1144399A3 (en) | 2002-09-11 |
CZ20012063A3 (en) | 2001-10-17 |
IL143263A0 (en) | 2002-04-21 |
JP2002533301A (en) | 2002-10-08 |
WO2000034261A2 (en) | 2000-06-15 |
NO20012835L (en) | 2001-07-19 |
HUP0203405A2 (en) | 2003-02-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |