BR9915983A - Process for preparing pyrimidinone derivatives - Google Patents

Process for preparing pyrimidinone derivatives

Info

Publication number
BR9915983A
BR9915983A BR9915983-0A BR9915983A BR9915983A BR 9915983 A BR9915983 A BR 9915983A BR 9915983 A BR9915983 A BR 9915983A BR 9915983 A BR9915983 A BR 9915983A
Authority
BR
Brazil
Prior art keywords
formula
compound
preparing
pyrimidinone derivatives
cycloalkyl
Prior art date
Application number
BR9915983-0A
Other languages
Portuguese (pt)
Inventor
Harald Walter
Original Assignee
Syngenta Participations Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Participations Ag filed Critical Syngenta Participations Ag
Publication of BR9915983A publication Critical patent/BR9915983A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Patente de Invenção: <B>"PROCESSO PARA PREPARAçãO DE DERIVADOS DE PIRIMIDINONA"<D>. A invenção compreende um processo para preparação de um composto da fórmula I em que A é um anel heterocíclico de 5 elementos, fundido, que pode ser saturado ou insaturado, aromático ou não aromático e que pode conter um ou dois heteroátomos O, S e/ou N, ou é benzo, pirido ou piridazino fundido; R~1~ e R~ 2~ são grupos que são inertes às reações; R~ 3~ é C~ 1~-C~ 8~ alquila, C~ 2~-C~ 8~ alquenila, C~ 2~-C~ 8~ alquinila, C~ 3~-C~ 6~ cicloalquila ou C~ 3~-C~ 6~ cicloalquila-C~ 1~-C~ 6~ alquila, cada uma das quais é substituída ou não substituída, no qual processo (a) um composto da fórmula II, em que A, R~ 1~ e R~ 2~ são conforme definidos para a fórmula I e R~ 5~ é um grupo que não prejudica as reações, é reagido com um imidocarbonato da fórmula III, em que R~ 3~ e R~ 4~ são conforme definidos na fórmula I, para fornecer o composto intermediário da fórmula IV e subseq³entemente (b) o composto da fórmula IV é ciclizado no composto da fórmula IInvention Patent: <B> "PROCESS FOR PREPARING PYRIMIDINONE DERIVATIVES" <D>. The invention comprises a process for preparing a compound of formula I in which A is a fused 5-element heterocyclic ring, which may be saturated or unsaturated, aromatic or non-aromatic and which may contain one or two O, S and / or heteroatoms or N, or it is fused benzo, pyrido or pyridazine; R ~ 1 ~ and R ~ 2 ~ are groups that are inert to reactions; R ~ 3 ~ is C ~ 1 ~ -C ~ 8 ~ alkyl, C ~ 2 ~ -C ~ 8 ~ alkenyl, C ~ 2 ~ -C ~ 8 ~ alkynyl, C ~ 3 ~ -C ~ 6 ~ cycloalkyl or C ~ 3 ~ -C ~ 6 ~ cycloalkyl-C ~ 1 ~ -C ~ 6 ~ alkyl, each of which is substituted or unsubstituted, in which process (a) a compound of formula II, wherein A, R ~ 1 ~ and R ~ 2 ~ are as defined for formula I and R ~ 5 ~ is a group that does not harm the reactions, is reacted with an imidocarbonate of formula III, in which R ~ 3 ~ and R ~ 4 ~ are as defined in formula I, to provide the intermediate compound of formula IV and subsequently (b) the compound of formula IV is cyclized into the compound of formula I

BR9915983-0A 1998-12-10 1999-12-09 Process for preparing pyrimidinone derivatives BR9915983A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9827162.0A GB9827162D0 (en) 1998-12-10 1998-12-10 Organic compounds
PCT/EP1999/009707 WO2000034286A2 (en) 1998-12-10 1999-12-09 Process for the preparation of pyrimidinone derivatives

Publications (1)

Publication Number Publication Date
BR9915983A true BR9915983A (en) 2001-09-11

Family

ID=10843958

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9915983-0A BR9915983A (en) 1998-12-10 1999-12-09 Process for preparing pyrimidinone derivatives

Country Status (6)

Country Link
EP (1) EP1137649A2 (en)
JP (1) JP2002531570A (en)
AU (1) AU1657900A (en)
BR (1) BR9915983A (en)
GB (1) GB9827162D0 (en)
WO (1) WO2000034286A2 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0698013B1 (en) * 1993-05-12 2001-10-04 E.I. Du Pont De Nemours And Company Fungicidal fused bicyclic pyrimidinones
EP0836602B1 (en) * 1995-07-05 2002-01-30 E.I. Du Pont De Nemours And Company Fungicidal pyrimidinones
DK0888359T3 (en) * 1996-03-11 2002-08-12 Syngenta Participations Ag Pyrimidin-4-one derivative as pesticide
TW434228B (en) * 1996-06-18 2001-05-16 Du Pont Preparation of fungicidal quinazolinones and useful intermediates

Also Published As

Publication number Publication date
WO2000034286A2 (en) 2000-06-15
EP1137649A2 (en) 2001-10-04
WO2000034286A3 (en) 2000-10-26
GB9827162D0 (en) 1999-02-03
AU1657900A (en) 2000-06-26
JP2002531570A (en) 2002-09-24

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Legal Events

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B08F Application fees: dismissal - article 86 of industrial property law

Free format text: REFERENTE A 5A, 6A, 7A E 8A ANUIDADES.

B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007.